References of "De Tullio, Pascal"
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See detailTherapeutic and chemical developments of cholecystokinin receptor ligands
De Tullio, Pascal ULg; Delarge, J.; Pirotte, Bernard ULg

in Exp. Opin. Invest. Drugs (2000), 9

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See detailSynthesis and biological effects of new 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides on insulin-secreting cells
Somers, F.; De Tullio, Pascal ULg; Boverie, S. et al

in Pharmacy and Pharmacology Communications (2000), 6

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See detail1,2,4-Benzothiadiazine derivatives, their preparation and use
De Tullio, Pascal ULg; Nielsen, F. E.; Hansen, J. B. et al

Patent (1999)

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See detailPyrido 1,2,4-thiadiazine derivatives, their preparation and use
De Tullio, Pascal ULg; Boverie, S.; Somers, F. et al

Patent (1999)

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See detailEvaluation de la sélectivité COX-1 vs COX-2 de drogues à potentialités anti-inflammatoires
De Leval, X.; Dogne, J. M.; Neven, Ph. et al

Poster (1999, May)

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See detailImpact d’antagonistes du thromboxane A2 dérivés du torasémide sur la fonction plaquettaire
Dogne, J. M.; Neven, Ph.; Rolin, S. et al

Poster (1999, May)

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See detailDerivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use
Dorwald, F. Z.; Hansen, J. B.; Mogensen, J. P. et al

Patent (1999)

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See detailPreparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2’-butylamino)-4H- and 3-(3’-methyl-2’-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers
Khelili, S.; De Tullio, Pascal ULg; Lebrun, P. et al

in Bioorganic & Medicinal Chemistry (1999), 7(8), 1513-1520

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4 ... [more ▼]

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 44), two potassium channel openers, is described. Their optical purity was estimated by means of capillary electrophoresis (R- and S-BPDZ 42) and chiral HPLC (R- and S-BPDZ 44). The absolute configuration of each isomer of BPDZ 44 was deduced from crystallographic data. Pharmacological assays performed with the R- and S-isomers of BPDZ 44 revealed only slight differences in their activity on pancreatic B-cells but significant differences in their activity on vascular smooth muscle cells: the R-isomer being sixfold more potent than its corresponding S-isomer. The R-isomer of BPDZ 42 was shown to be more potent than its corresponding S-isomer on the endocrine pancreas. S-BPDZ 44 as well as R- and S-BPDZ 42 were found to exhibit tissue selectivity for the pancreatic versus the vascular smooth muscle tissue. [less ▲]

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