References of "De Tullio, Pascal"
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See detail3-Alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potent KATP-channel activators: structural study and influence of stereochemistry
De Tullio, Pascal ULg; Khelili, S.; Ouedraogo, R. et al

in Pharmacy and Pharmacology Communications (1999), 5

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See detailEnantiomeric Separation of Pirlindole by Liquid Chromatography Using Different Types of Chiral Stationary Phases
Ceccato, Attilio ULg; Hubert, Philippe ULg; De Tullio, Pascal ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (1998), 18(4-5), 605-14

The enantioseparation of pirlindole by liquid chromatography (LC) was investigated using three different chiral stationary phases (CSPs) containing either cellulose tris-(3,5-dimethylphenylcarbamate ... [more ▼]

The enantioseparation of pirlindole by liquid chromatography (LC) was investigated using three different chiral stationary phases (CSPs) containing either cellulose tris-(3,5-dimethylphenylcarbamate) (Chiralcel OD-R), ovomucoid (OVM) or beta-cyclodextrin (beta-CD). The effects of the mobile phase pH on retention, enantioselectivity and resolution were studied. Methanol and acetonitrile were tested as organic modifiers while the influence of the addition to the mobile phase of sodium alkanesulfonates or sodium perchlorate was also investigated. Sodium perchlorate was only used on the Chiralcel OD-R column while sodium alkanesulfonates were tested as mobile phase additives on the three kinds of CSPs. The enantioseparation of pirlindole could be obtained on all CSPs tested, the best results with respect to chiral resolution being achieved on the Chiralcel OD-R and the OVM columns. The use of sodium octanesulfonate (NaOS) was found to improve the enantioseparation of pirlindole on the OVM column while enantioselectivity was considerably enhanced by addition of sodium perchlorate on the Chiralcel OD-R column. [less ▲]

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See detailDesign, synthesis and biological evaluation of sulfonylureas as original non-prostanoïd thromboxane A2 receptor antagonists
Dogne, J. M.; De Leval, X.; Damas, J. et al

Conference (1998, November 27)

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See detailDesign, synthesis and biological evaluation of sulfonylureas as original non-prostanoid thromboxane A2 receptor antagonists
Dogne, J. M.; De Leval, X.; Damas, J. et al

Poster (1998, November 27)

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See detailPharmacological study of original 3-alkylamino-2-methyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides
Ouedraogo, R.; Nguyen, Q. A.; Antoine, M. H. et al

Poster (1998, November 21)

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See detailSimultaneous Determination of Pirlindole Enantiomers and Dehydropirlindole by Chiral Liquid Chromatography
Ceccato, Attilio ULg; Hubert, Philippe ULg; De Tullio, Pascal ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (1998), 17(6-7), 1071-9

Liquid chromatography was employed for the determination of pirlindole enantiomers and its oxidation product dehydropirlindole (DHP). The direct separation of pirlindole enantiomers and DHP was achieved ... [more ▼]

Liquid chromatography was employed for the determination of pirlindole enantiomers and its oxidation product dehydropirlindole (DHP). The direct separation of pirlindole enantiomers and DHP was achieved on a cellulose tris-(3,5-dimethylphenylcarbamate) chiral stationary phase (Chiralcel OD-R). Acetonitrile was used as the organic modifier and sodium perchlorate was used as an ionic additive in the mobile phase. The influence of acetonitrile and sodium perchlorate concentrations on enantioselectivity and achiral selectivity towards DHP was investigated in order to find suitable conditions for the determination of low amounts of each analyte. The mobile phase selected consisted of a mixture of acetonitrile and phosphate buffer (pH 5.0) containing sodium perchlorate (0.05 M) (35:65, v/v) and the UV detector was set at 220 nm. The method developed was validated and was found to be linear in the 0.1-5 microg ml(-1) range (r2 = 0.999 for the three compounds). Repeatability and the intermediate precision for the three analytes at a concentration of 0.1 microg ml(-1) were about 3 and 4%, respectively. This concentration corresponds to the quantification of 0.1% for the minor enantiomer. Actual determinations of enantiomeric purity for single enantiomers of pirlindole were performed. [less ▲]

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See detailNew quinazolinones structurally related to diazoxide and pinacidil as potential KATP channel openers
Somers, F.; Ouedraogo, R.; De Tullio, Pascal ULg et al

Conference (1998, February 14)

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See detailSéparation énantiomérique du pirlindole à l’échelle préparative
De Tullio, Pascal ULg; Ceccato, A.; Felekidis, Apostolos ULg et al

Poster (1998, January 16)

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