References of "De Tullio, Pascal"
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See detailOriginal 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and KATP channel activity
Somers, F.; Ouedraogo, R.; Antoine, M.-H. et al

in Journal of Medicinal Chemistry (2001), 44

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See detail7-Chloro-2-methyl-3-methylamino-2H-1,2,4-benzothiadiazine 1,1-dioxide
Dupont, L.; Somers, F.; Boverie, S. et al

in Acta Crystallographica (2001), E57

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See detail3-Amino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; De Tullio, Pascal ULg; Boverie, S. et al

in Acta Crystallographica (2001), E57

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See detail(R/S)-3-(3-Methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide mono-hydrate
Dupont, L.; De Tullio, Pascal ULg; Tinant, B. et al

in Acta Crystallographica (2001), E57

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See detailAbsolute configuration of N-[(R)-3-methyl-2-butyl]-(S)-2-(6-methoxy-2-naphthyl)-propionamide
Dupont, L.; Khellili, S.; Pirotte, Bernard ULg et al

in Acta Crystallographica (2001), E57

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See detailEffect on the pancreatic endocrine system of 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to diazoxide
Boverie, S.; Antoine, M. H.; Becker, B. et al

Poster (2000, September)

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See detail7-Substituted alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as new analogues of diazoxide: effects on the insulin releasing process in vitro
Boverie, S.; Somers, F.; Ouedraogo, R. et al

Poster (2000, March 04)

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See detailDetermination of Albendazole and Its Main Metabolites in Ovine Plasma by Liquid Chromatography with Dialysis as an Integrated Sample Preparation Technique
Chiap, Patrice ULg; Evrard, Brigitte ULg; Bimazubute, M. A. et al

in Journal of Chromatography. A (2000), 870(1-2), 121-34

Albendazole is a benzimidazole derivative with a broad-spectrum activity against human and animal helminth parasites. In order to determine the main pharmacokinetic parameters in sheep after oral and ... [more ▼]

Albendazole is a benzimidazole derivative with a broad-spectrum activity against human and animal helminth parasites. In order to determine the main pharmacokinetic parameters in sheep after oral and intravenous administration of a new formulation of albendazole (an aqueous solution), a fully automated method was developed for the determination of this drug and its main metabolites, albendazole sulfoxide (active metabolite) and sulfone in ovine plasma. This method involves dialysis as purification step, followed by enrichment of the dialysate on a precolumn and liquid chromatography (LC). All sample handling operations were executed automatically by means of an ASTED XL system. After conditioning of the trace enrichment column (TEC) packed with octadecyl silica with pH 6.0 phosphate buffer containing sodium azide, the plasma sample, in which a protein releasing reagent (1 M HCl) containing Triton X-100 was automatically added, was loaded in the donor channel and dialysed on a cellulose acetate membrane in the static-pulsed mode. The dialysis liquid consisted of pH 2.5 phosphate buffer. By rotation of a switching valve, the analytes were eluted from the TEC in the back-flush mode by the LC mobile phase and transferred to the analytical column, packed with octyl silica. The chromatographic separation was performed at 35 degrees C and the analytes were monitored photometrically at 295 nm. Due to the differences in hydrophobic character between albendazole and its metabolites, a gradient elution was applied. The mobile phase consisted of a mixture of acetonitrile and pH 6.0 phosphate buffer. The proportion of organic modifier was increased from 10.0 to 50.1% in 12.30 min, then from 50.1 to 66.9% in 1.70 min. First, the gradient conditions and the temperature were optimised for the LC separation using the DryLab software. Then, the influence of some parameters of the dialysis process on analyte recovery was investigated. Finally, the method developed was validated. The mean recoveries for albendazole and its metabolites were about 70 and 65%, respectively. The limits of quantification for albendazole and its metabolites were 10 and 7.5 ng/ml, respectively. [less ▲]

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