References of "De Tullio, Pascal"
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See detailDesign, synthesis and biological evaluation of sulfonylureas as original non-prostanoïd thromboxane A2 receptor antagonists
Dogne, J. M.; De Leval, X.; Damas, J. et al

Conference (1998, November 27)

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See detailDesign, synthesis and biological evaluation of sulfonylureas as original non-prostanoid thromboxane A2 receptor antagonists
Dogne, J. M.; De Leval, X.; Damas, J. et al

Poster (1998, November 27)

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See detailPharmacological study of original 3-alkylamino-2-methyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides
Ouedraogo, R.; Nguyen, Q. A.; Antoine, M. H. et al

Poster (1998, November 21)

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See detailSimultaneous Determination of Pirlindole Enantiomers and Dehydropirlindole by Chiral Liquid Chromatography
Ceccato, Attilio ULg; Hubert, Philippe ULg; De Tullio, Pascal ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (1998), 17(6-7), 1071-9

Liquid chromatography was employed for the determination of pirlindole enantiomers and its oxidation product dehydropirlindole (DHP). The direct separation of pirlindole enantiomers and DHP was achieved ... [more ▼]

Liquid chromatography was employed for the determination of pirlindole enantiomers and its oxidation product dehydropirlindole (DHP). The direct separation of pirlindole enantiomers and DHP was achieved on a cellulose tris-(3,5-dimethylphenylcarbamate) chiral stationary phase (Chiralcel OD-R). Acetonitrile was used as the organic modifier and sodium perchlorate was used as an ionic additive in the mobile phase. The influence of acetonitrile and sodium perchlorate concentrations on enantioselectivity and achiral selectivity towards DHP was investigated in order to find suitable conditions for the determination of low amounts of each analyte. The mobile phase selected consisted of a mixture of acetonitrile and phosphate buffer (pH 5.0) containing sodium perchlorate (0.05 M) (35:65, v/v) and the UV detector was set at 220 nm. The method developed was validated and was found to be linear in the 0.1-5 microg ml(-1) range (r2 = 0.999 for the three compounds). Repeatability and the intermediate precision for the three analytes at a concentration of 0.1 microg ml(-1) were about 3 and 4%, respectively. This concentration corresponds to the quantification of 0.1% for the minor enantiomer. Actual determinations of enantiomeric purity for single enantiomers of pirlindole were performed. [less ▲]

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See detailEffective resolution of racemic pirlindole at the preparative scale: derivatization method and absolute configuration
De Tullio, Pascal ULg; Ceccato, Attilio ULg; Liégeois, Jean-François ULg et al

Poster (1998, September)

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See detailPreparative resolution of racemic pirlindole: chromatographic methods and determination of the absolute configuration
De Tullio, Pascal ULg; Ceccato, Attilio ULg; Liégeois, Jean-François ULg et al

Poster (1998, September)

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See detail3-Alkylamino-7-halogeno-4H-1,2,4-benzothiadiazine 1,1-dioxides as new potent KATP channels activators
De Tullio, Pascal ULg; Somers, F.; Boverie, S. et al

Poster (1998, September)

See detail2,3-Dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors
Pirotte, Bernard ULg; Diouf, O.; Podona, T. et al

Poster (1998, September)

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See detailSynthesis and biological evaluation of the 3-alkylamino-7-halogeno-4H-1,2,4-benzothiadiazine 1,1-dioxides: new potential KATP channels openers
De Tullio, Pascal ULg; Somers, F.; Boverie, S. et al

Poster (1998, September)

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See detailLes 3-alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes en tant quactivateurs de canaux KATP: étude structurale et influence de la stéréochimie
De Tullio, Pascal ULg; Somers, F.; Boverie, S. et al

Conference (1998, May)

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See detailLes arylthiadiazinedioxydes en tant qu’activateurs des canaux potassiques: etude pharmacologique des 3-alkylamino-2-méthyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes
Ouedraogo, R.; Nguyen, Q. A.; Fontaine, J. et al

Poster (1998, May)

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See detailLes 3-alkylamino[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes en tant qu’activateurs des canaux KATP: détermination de la position de la liaison double du cycle thiadiazine
De Tullio, Pascal ULg; Somers, F.; Boverie, S. et al

Poster (1998, May)

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See detailUtilisation du 1,1’-thiocarbonyldiimidazole comme agent de cyclisation des aminoarylsulfonamides en vue de l’obtention d’intermédiaires utilisables dans la synthèse de nouveaux activateurs de canaux KATP
Boverie, S.; Pirotte, Bernard ULg; Somers, F. et al

Poster (1998, May)

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See detailRésolutions énantiomériques et évaluations biologiques des isomères du BPDZ 42 et du BPDZ 44
De Tullio, Pascal ULg; Khelili, S.; Fillet, Marianne ULg et al

Poster (1998, May)

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See detailLes 3-alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxydes structuralement apparentés au diazoxide et au pinacidil: conception, synthèse et évaluation biologique
Pirotte, Bernard ULg; Ouedraogo, R.; De Tullio, Pascal ULg et al

Poster (1998, May)

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See detailNew quinazolinones structurally related to diazoxide and pinacidil as potential KATP channel openers
Somers, F.; Ouedraogo, R.; De Tullio, Pascal ULg et al

Conference (1998, February 14)

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See detailNouvelles 2-alkylamino-quinazoline-4-ones, synthèse et évaluation pharmacologique en tant qu’isostères potentiels de 3-alkylamino-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes
Somers, F.; Ouedraogo, R.; Lebrun, P. et al

Conference (1998, January 16)

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See detailSéparation énantiomérique du pirlindole à l’échelle préparative
De Tullio, Pascal ULg; Ceccato, A.; Felekidis, Apostolos ULg et al

Poster (1998, January 16)

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See detailComparative study of pirlindole, a selective RIMA, and its two enantiomers using biochemical and behavioural techniques.
Bruhwyler, J.; Liégeois, Jean-François ULg; Gerardy, J. et al

in Behavioural Pharmacology (1998), 9(8), 731-7

The interaction with monoamine oxidase A (MAO-A) and B has been shown to be sensitive to the absolute configuration of molecules. Therefore, the aim of this study was to compare the effects of the racemic ... [more ▼]

The interaction with monoamine oxidase A (MAO-A) and B has been shown to be sensitive to the absolute configuration of molecules. Therefore, the aim of this study was to compare the effects of the racemic pirlindole (a selective and reversible MAO-A inhibitor) and its two enantiomers using biochemical techniques (in vitro and ex vivo determination of rat brain MAO-A and MAO-B activity) and behavioural models (forced swimming test and reserpine-induced hypothermia and palpebral ptosis test). In vitro, the MAO-A IC50 of (+/-)-pirlindole, R-(-)-pirlindole and S-(+)-pirlindole were 0.24, 0.43 and 0.18 microM, respectively. Ex vivo, their ID50 were 24.4, 37.8 and 18.7 mg/kg i.p. The differences between the three compounds were not significant, with a ratio between the two enantiomers [R-(-)/S-(+)] of 2.2 in vitro and 2.0 ex vivo. MAO-B was only slightly inhibited. In the forced swimming test and the reserpine-induced hypothermia and ptosis model, the three compounds had an antidepressant profile. In the forced swimming test, the minimal effective dose ratio between the R-(-) and the S-(+) was again around 2.0. The behavioural observations were thus clearly in accordance with the biochemical data. [less ▲]

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See detailLiquid chromatographic separation of pirlindole enantiomers using different types of chiral stationary phases
Ceccato, Attilio ULg; Hubert, Philippe ULg; De Tullio, Pascal ULg et al

in Journal de Pharmacie de Belgique (1998), 53

Detailed reference viewed: 7 (0 ULg)