References of "De Tullio, Pascal"
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See detailEvaluation de la sélectivité COX-1 vs COX-2 de drogues à potentialités anti-inflammatoires
De Leval, X.; Dogne, J. M.; Neven, Ph. et al

Poster (1999, May)

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See detailImpact d’antagonistes du thromboxane A2 dérivés du torasémide sur la fonction plaquettaire
Dogne, J. M.; Neven, Ph.; Rolin, S. et al

Poster (1999, May)

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See detailDerivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use
Dorwald, F. Z.; Hansen, J. B.; Mogensen, J. P. et al

Patent (1999)

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See detailPreparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2’-butylamino)-4H- and 3-(3’-methyl-2’-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers
Khelili, S.; De Tullio, Pascal ULg; Lebrun, P. et al

in Bioorganic & Medicinal Chemistry (1999), 7(8), 1513-1520

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4 ... [more ▼]

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 44), two potassium channel openers, is described. Their optical purity was estimated by means of capillary electrophoresis (R- and S-BPDZ 42) and chiral HPLC (R- and S-BPDZ 44). The absolute configuration of each isomer of BPDZ 44 was deduced from crystallographic data. Pharmacological assays performed with the R- and S-isomers of BPDZ 44 revealed only slight differences in their activity on pancreatic B-cells but significant differences in their activity on vascular smooth muscle cells: the R-isomer being sixfold more potent than its corresponding S-isomer. The R-isomer of BPDZ 42 was shown to be more potent than its corresponding S-isomer on the endocrine pancreas. S-BPDZ 44 as well as R- and S-BPDZ 42 were found to exhibit tissue selectivity for the pancreatic versus the vascular smooth muscle tissue. [less ▲]

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See detailThe effect of hydroxypropyl-b-cyclodextrins on the pharamacokinetics of albendazole in sheep
Evrard, Brigitte ULg; De Tullio, Pascal ULg; Chiap, Patrice ULg et al

in Proceedings of 26th International Symposium on Controlled Release of Bioactive Materials (1999)

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See detailPharmacological evaluation of 3-alkylsulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to the KATP channel opener diazoxide
Boverie, S.; Nguyen, Q.-A.; De Tullio, Pascal ULg et al

in Fundamental & Clinical Pharmacology (1999), 13

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See detail7-Iodo-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg

in Acta Crystallographica (1999), C55

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See detailEffective resolution of racemic pirlindole at the preparative scale
De Tullio, Pascal ULg; Ceccato, A.; Liégeois, Jean-François ULg et al

in Chirality (1999), 11

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See detail4-Ethyl-2,3-dihydro-4H-pyrido[3,2-e]-1,2,4-thiadiazine 1,1-dioxide and 4-ethyl-2,3-dihydro-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; Podona, T. et al

in Acta Crystallographica (1999), C55

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See detailPharmacological study of original 3-alkylamino-2-methyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides
Ouedraogo, R.; Nguyen, Q.-A.; Antoine, M.-H. et al

in Fundamental & Clinical Pharmacology (1999), 13

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See detailRecent advances in the chemistry of cholecystokinin receptor ligands (agonists and antagonists)
De Tullio, Pascal ULg; Delarge, J.; Pirotte, Bernard ULg

in Current Medicinal Chemistry (1999), 6

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See detailNew 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as putative KATP channel openers: design, synthesis and pharmacological evaluation
Somers, F.; De Tullio, Pascal ULg; Boverie, S. et al

in Fundamental & Clinical Pharmacology (1999), 13

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See detail3-Alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potent KATP-channel activators: structural study and influence of stereochemistry
De Tullio, Pascal ULg; Khelili, S.; Ouedraogo, R. et al

in Pharmacy and Pharmacology Communications (1999), 5

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