References of "De Tullio, Pascal"
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See detailEvaluation de la sélectivité COX-1 vs COX-2 de drogues à potentialités anti-inflammatoires
De Leval, X.; Dogne, J. M.; Neven, Ph. et al

Poster (1999, May)

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See detailImpact d’antagonistes du thromboxane A2 dérivés du torasémide sur la fonction plaquettaire
Dogne, J. M.; Neven, Ph.; Rolin, S. et al

Poster (1999, May)

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See detailDerivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use
Dorwald, F. Z.; Hansen, J. B.; Mogensen, J. P. et al

Patent (1999)

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See detailPreparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2’-butylamino)-4H- and 3-(3’-methyl-2’-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers
Khelili, S.; De Tullio, Pascal ULg; Lebrun, P. et al

in Bioorganic & Medicinal Chemistry (1999), 7(8), 1513-1520

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4 ... [more ▼]

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 44), two potassium channel openers, is described. Their optical purity was estimated by means of capillary electrophoresis (R- and S-BPDZ 42) and chiral HPLC (R- and S-BPDZ 44). The absolute configuration of each isomer of BPDZ 44 was deduced from crystallographic data. Pharmacological assays performed with the R- and S-isomers of BPDZ 44 revealed only slight differences in their activity on pancreatic B-cells but significant differences in their activity on vascular smooth muscle cells: the R-isomer being sixfold more potent than its corresponding S-isomer. The R-isomer of BPDZ 42 was shown to be more potent than its corresponding S-isomer on the endocrine pancreas. S-BPDZ 44 as well as R- and S-BPDZ 42 were found to exhibit tissue selectivity for the pancreatic versus the vascular smooth muscle tissue. [less ▲]

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See detailThe effect of hydroxypropyl-b-cyclodextrins on the pharamacokinetics of albendazole in sheep
Evrard, Brigitte ULg; De Tullio, Pascal ULg; Chiap, Patrice ULg et al

in Proceedings of 26th International Symposium on Controlled Release of Bioactive Materials (1999)

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See detailPharmacological evaluation of 3-alkylsulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to the KATP channel opener diazoxide
Boverie, S.; Nguyen, Q.-A.; De Tullio, Pascal ULg et al

in Fundamental & Clinical Pharmacology (1999), 13

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See detail7-Iodo-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg

in Acta Crystallographica (1999), C55

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See detailEffective resolution of racemic pirlindole at the preparative scale
De Tullio, Pascal ULg; Ceccato, A.; Liégeois, Jean-François ULg et al

in Chirality (1999), 11

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See detail4-Ethyl-2,3-dihydro-4H-pyrido[3,2-e]-1,2,4-thiadiazine 1,1-dioxide and 4-ethyl-2,3-dihydro-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; Podona, T. et al

in Acta Crystallographica (1999), C55

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See detailPharmacological study of original 3-alkylamino-2-methyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides
Ouedraogo, R.; Nguyen, Q.-A.; Antoine, M.-H. et al

in Fundamental & Clinical Pharmacology (1999), 13

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See detailRecent advances in the chemistry of cholecystokinin receptor ligands (agonists and antagonists)
De Tullio, Pascal ULg; Delarge, J.; Pirotte, Bernard ULg

in Current Medicinal Chemistry (1999), 6

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See detailNew 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as putative KATP channel openers: design, synthesis and pharmacological evaluation
Somers, F.; De Tullio, Pascal ULg; Boverie, S. et al

in Fundamental & Clinical Pharmacology (1999), 13

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See detail3-Alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potent KATP-channel activators: structural study and influence of stereochemistry
De Tullio, Pascal ULg; Khelili, S.; Ouedraogo, R. et al

in Pharmacy and Pharmacology Communications (1999), 5

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See detailEnantiomeric Separation of Pirlindole by Liquid Chromatography Using Different Types of Chiral Stationary Phases
Ceccato, Attilio ULg; Hubert, Philippe ULg; De Tullio, Pascal ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (1998), 18(4-5), 605-14

The enantioseparation of pirlindole by liquid chromatography (LC) was investigated using three different chiral stationary phases (CSPs) containing either cellulose tris-(3,5-dimethylphenylcarbamate ... [more ▼]

The enantioseparation of pirlindole by liquid chromatography (LC) was investigated using three different chiral stationary phases (CSPs) containing either cellulose tris-(3,5-dimethylphenylcarbamate) (Chiralcel OD-R), ovomucoid (OVM) or beta-cyclodextrin (beta-CD). The effects of the mobile phase pH on retention, enantioselectivity and resolution were studied. Methanol and acetonitrile were tested as organic modifiers while the influence of the addition to the mobile phase of sodium alkanesulfonates or sodium perchlorate was also investigated. Sodium perchlorate was only used on the Chiralcel OD-R column while sodium alkanesulfonates were tested as mobile phase additives on the three kinds of CSPs. The enantioseparation of pirlindole could be obtained on all CSPs tested, the best results with respect to chiral resolution being achieved on the Chiralcel OD-R and the OVM columns. The use of sodium octanesulfonate (NaOS) was found to improve the enantioseparation of pirlindole on the OVM column while enantioselectivity was considerably enhanced by addition of sodium perchlorate on the Chiralcel OD-R column. [less ▲]

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See detailDesign, synthesis and biological evaluation of sulfonylureas as original non-prostanoïd thromboxane A2 receptor antagonists
Dogne, J. M.; De Leval, X.; Damas, J. et al

Conference (1998, November 27)

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