References of "De Tullio, Pascal"
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See detailToward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides
De Tullio, Pascal ULg; Becker, B.; Boverie, S. et al

in Journal of Medicinal Chemistry (2003), 46

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See detail3-Isopropylamino-7-nitro-1,4,2-benzodithiazine 1,1-dioxide
Dupont, L.; Somers, F.; De Tullio, Pascal ULg et al

in Acta Crystallographica (2003)

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See detailOral bioavailability in sheep of albendazole from a suspension and from a solution containing hydroxypropyl-beta-cyclodextrin
Evrard, Brigitte ULg; Chiap, Patrice ULg; De Tullio, Pascal ULg et al

in Journal of Controlled Release (2002), 85(1-3), 45-50

Albendazole (ABZ) is a benzimidazole derivative with a broad spectrum of activity against human and animal helminthe parasites. ABZ has a very poor aqueous solubility. This study shows that hydroxypropyl ... [more ▼]

Albendazole (ABZ) is a benzimidazole derivative with a broad spectrum of activity against human and animal helminthe parasites. ABZ has a very poor aqueous solubility. This study shows that hydroxypropyl-beta-cyclodextrin (HP-beta-CD) is able to form inclusion complexes with ABZ and that is able to increase its aqueous solubility. A synergistic effect exists between HP-beta-CD and citric acid. The combination of HP-beta-CD (200 mM) and citric acid (50 mM) allows dissolution of more than 1.5 mg of ABZ per ml. The aim of this study is the in vivo evaluation in sheep of a solution of the inclusion complex of ABZ with HP-beta-CD in comparison with a suspension of the same drug. A significant (P<0.05) increase in the relative bioavailability is obtained with the solution containing the ABZ-HP-beta-CD complex as measured by ABZSO plasma levels. The area under the curve (AUC(0--> proportional, variant )) of the solution is 37% higher than that obtained with the suspension. Likewise the peak plasma concentration (C(max)) is twice that of the solution while the time to reach C(max) (T(max)) is reduced. [less ▲]

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See detailSynthesis and pharmacological evaluation of cromakalim analogues as potassium channel activators
Sebille, S.; Boverie, S.; De Tullio, Pascal ULg et al

Poster (2002, November 15)

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See detail6,7-Disubstituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: new potent ATP-sensitive potassium channel openers
De Tullio, Pascal ULg; Boverie, S.; Becker, B. et al

Poster (2002, September)

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See detailBPDZ 154 is a potent activator of ATP-sensitive potassium channels in pancreatic β-cells.
Lee, A. T.; Cosgrove, K. E.; Barnes, P. B. et al

Poster (2002, April)

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See detailRelaxant effect of K+ATP channel openers on the uterine smooth muscle: pharmacological in vitro models
De Tullio, Pascal ULg; Boverie, S.; Dewalque, D. et al

Conference (2002, March 02)

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See detailRelaxant effect of K+ATP channel openers on the uterine smooth muscle: pharmacological in vitro models
De Tullio, Pascal ULg; Boverie, S.; Dewalque, D. et al

Poster (2002, March 02)

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See detailPharmacological evaluation of cromakalim analogues: towards the discovery of new inhibitors of insulin secretion from rat pancreatic β-cells
Sebille, S.; Becker, B.; Antoine, M. H. et al

Poster (2002, March 02)

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See detailDevelopment of 4H-1,2,4-benzothiadiazine 1,1-dioxides as putative tocolytic agents: pharmacological evaluation on different smooth muscle preparations
Boverie, S.; Becker, B.; Sebille, S. et al

Poster (2002, March 02)

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See detailBPDZ 154: a novel activator of KATP channels in β-cells.
Lee, A. T.; Cosgrove, K. E.; Barnes, P. B. et al

Poster (2002, March)

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See detailBPDZ 154 is a potent activator of ATP-sensitive potassium channels in pancreatic b-cells
Lee, A. T.; Cosgrove, K. E.; Barnes, P. D. et al

in Endocrine abstracts 2002 (2002)

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See detail3-R/S-(hydroxyalkylamino)-4H-1,2,4-benzothiadiazine 1,1-dioxides as potential K+ATP channel activators: influence of stereochemistry on biological activity and tissue selectivity
Boverie, S.; Becker, B.; Somers, F. et al

in Fundamental & Clinical Pharmacology (2002)

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See detailPharmacological evaluation of cromakalim analogues: towards the discovery of new inhibitors of insulin secretion from rat pancreatic Beta-cells
Sebille, S.; becker, B.; Antoine, M. H. et al

in Fundamental & Clinical Pharmacology (2002)

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