Modeling the instantaneous pressure-volume relationship in the left ventricle

in 9th Belgian Day on Biomedical Engineering, Friday November 26th 2010 in the Academy Palace, Hertogstraat 1, 1000 Brussels (2010, November 26)

Models and simulations are very useful to study interactions between anatomic structures and physical cardiac phenomena. In this work, we are interested in models of the instantaneous pressure-volume ... [more ▼]

Models and simulations are very useful to study interactions between anatomic structures and physical cardiac phenomena. In this work, we are interested in models of the instantaneous pressure-volume relationship, i.e. isochrone models. More precisely, we concentrate on the 6 models considered by Lankhaar et al. [1]. We propose a critical analysis of the work of these authors and suggest some improvement of their procedure. [1] Lankhaar J.-W. et al. Modeling the Instantaneous Pressure–Volume Relation of the Left Ventricle: A Comparison of Six Models. Annals of Biomedical Engineering, Volume 37, Number 9, 1710-1726, 2009. [less ▲]

minimal cardiovascular system model including physiological mitral valve opening

in 9th Belgian National Day on Biomedical Engineering, Bruxelles, 26th november (2010, November 26)

A minimal cardiovascular system (CVS) model has been previously validated in silico, and in several animal model studies. It accounts for valve dynamics by means of a Heaviside function to simulate the ... [more ▼]

A minimal cardiovascular system (CVS) model has been previously validated in silico, and in several animal model studies. It accounts for valve dynamics by means of a Heaviside function to simulate the “open on pressure, close on flow” law. However, this model does not describe the progressive valve opening and therefore, it is not suitable for studying valve dysfunctions. [less ▲]

Modeling the instantaneous pressure-volume relationship in the left ventricle

Poster (2010, November 26)

Pressure-volume loops are a common modeling tool of the cardiovascular system. They are very useful because they characterize the global function of the cardiac pump and can also be analyzed ... [more ▼]

Pressure-volume loops are a common modeling tool of the cardiovascular system. They are very useful because they characterize the global function of the cardiac pump and can also be analyzed by considering the various phases of the cardiac cycle and marking each point of a cycle with the corresponding time. When several loops are considered, the points corresponding to the same time t in each loop can be joined to define a curve named isochrone. In this work, we are interested in models of the instantaneous pressure-volume relationship, i.e. isochrone models. More precisely, we concentrate on the 6 models considered by Lankhaar et al. [1] and we propose a critical analysis of the work of these authors and suggest some improvement of their procedure. [1] Lankhaar J.W. et al. Annals of Biomedical Engineering, Volume 37, Number 9, 1710-1726, 2009. [less ▲]

Mathematical model of the mitral valve and the cardiovascular system, application for studying, monitoring and in the diagnosis of valvular pathologies

in UKACC international Conference on Control 2010 : Coventry, 7-10 september 2010 (2010, September 07)

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics using Heaviside functions to simulate a physiological ... [more ▼]

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics using Heaviside functions to simulate a physiological accurate “open on pressure, close on flow” law. Thus, it does not consider the real time scale of the valve aperture dynamics and thus doesn’t fully capture valve dysfunction particularly where the dysfunction involves partial closure. This research describes a new closed-loop CVS model including a model describing the progressive aperture of the mitral valve and valid over the full cardiac cycle. This new model is solved for a healthy and diseased mitral valve. [less ▲]

Time varying elastance estimation in an 8 camber cardiovascular system model

in Intensive Care Medicine (2010), 36(2), 151-151

Using time-dependent reference profiles for an instability analysis of an evaporating binary liquid layer

in Proceedings of the International Conference on Multiscale Comples Fluid Flows and Interfacial Phenomena, 16 (2010)

This study treats an evaporating horizontal binary-liquid layer (aqueous solution of 10 % wt ethanol) in contact with air with an imposed transfer distance. Solutal and thermal Rayleigh-B´enard-Marangoni ... [more ▼]

This study treats an evaporating horizontal binary-liquid layer (aqueous solution of 10 % wt ethanol) in contact with air with an imposed transfer distance. Solutal and thermal Rayleigh-B´enard-Marangoni instabilities are taken into account together with the Soret effect. The critical times with corresponding liquid thicknesses are calculated, showing that a critical liquid thickness can be found under which no instability can occur. [less ▲]

Linear stability analysis of an evaporating binary liquid layer with fully transient reference profiles

in Bulletin of the American Physical Society, Vol. 55, n°16 (2010)

Patient-specific modelling of the cardiovascular system – application to septic shock with a minimal data set,

in World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany (2010)

Mitral valve dynamics in a closed-loop model of the cardiovascular system

Poster (2009, December 17)

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics by means of Heaviside function to simulate “open on ... [more ▼]

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics by means of Heaviside function to simulate “open on pressure, close on flow” law. Thus, it does not consider the real time scale of the valve aperture and thus doesn’t fully capture valve dysfunction. This research couples the CVS model with a model describing the progressive aperture of the mitral valve. [less ▲]

Patient specific model of the cardiovascular system during septic shock

in Intensive Care Medicine (2009), 35(suppl. 1), 80