Reduction in VAP incidence by subglottic secretion drainage and antibiotic consumption in ICU patients
VAN CAUWENBERGE, Isabelle ; ANCION, Arnaud ; LAMBERMONT, Bernard et al
in Intensive Care Medicine (2013), 39(Suppl 2), 465-4660898Detailed reference viewed: 23 (7 ULg)
La prise en charge précoce du patient brûlé en kinésithérapie.
REMY, Christophe ; JACQUEMIN, Denise ; MASSAGE, Patrick et al
in Réanimation (2013), 22(5), 543-551
Profonde ou atteignant une large surface cutanée, la brûlure engendre souvent des séquelles fonctionnelles impor- tantes. Ces séquelles se constituent précocement et ont des répercussions non négligeables ... [more ▼]
Profonde ou atteignant une large surface cutanée, la brûlure engendre souvent des séquelles fonctionnelles impor- tantes. Ces séquelles se constituent précocement et ont des répercussions non négligeables sur la qualité de vie des patients. Pour les prévenir et les traiter, le kinésithérapeute est un acteur important dans leur prise en charge précoce. Il devra évaluer les fonctions respiratoires, musculaires, orthopédiques mais également cutanées. L’objectif est de définir des stratégies de traitement faisant appel à des techniques de kinésithérapie classiques adaptées à cette pathologie spécifique. [less ▲]Detailed reference viewed: 82 (27 ULg)
From point prevalence surveys to continuous quality improvement in a teaching hospital in Belgium
VERCHEVAL, Christelle ; Van Hees, Thierry ; DAMAS, Pierre
Poster (2013)Detailed reference viewed: 10 (1 ULg)
Hypovitaminosis D and osteoporosis in burn patients: are the current practices enough ?
ROUSSEAU, Anne-Françoise ; LEDOUX, Didier ; DAMAS, Pierre et al
in Osteoporosis International (2013), 24(Suppl 1), 377Detailed reference viewed: 47 (17 ULg)
Evaluation d'un protocole de prise en charge nutritionnelle interdisciplinaire chez des patients brulés
MALHERBE, Christian ; VERBRUGGE, Anne-Marie ; MAGNETTE, André et al
in Nutrition Clinique et Metabolisme (2012, December), 26-Supp1Detailed reference viewed: 37 (10 ULg)
Clinical sedation and bispectral index in burn children receiving gamma-hydroxybutyrate.
ROUSSEAU, Anne-Françoise ; LEDOUX, Didier ; et al
in Paediatric Anaesthesia (2012), 22(8), 799-804
Background: Gamma-hydroxybutyrate (GHB) may be an interesting hypnotic agent in burn patients because of its good respiratory or hemodynamic tolerance. However, its clinical and electroencephalographic ... [more ▼]
Background: Gamma-hydroxybutyrate (GHB) may be an interesting hypnotic agent in burn patients because of its good respiratory or hemodynamic tolerance. However, its clinical and electroencephalographic (EEG) sedative effects are not yet described in children. The aim of this prospective and randomized study was to assess clinical and EEG effects of increasing intravenous (IV) doses of GHB in burn children requiring sedation for burn wound cares. Methods: Thirty six children hospitalized in a burn care unit were included and randomly assigned into three groups (G) according to the single IV dose of GHB they received before burn wound care: 10 mg·kg(-1) in G10, 25 mg·kg(-1) in G25, or 50 mg·kg(-1) in G50. All patients received oral premedication (morphine and hydroxyzine) 30 min before GHB injection. Respiratory rate, heart rate, pulse oximetry, and bispectral index (BIS) were continuously monitored. Depth of sedation was clinically assessed using Observer's Assessment of Alertness and Sedation (OAAS) Score, every 2 min until recovery (i.e., OAAS = 4). Results: Median age was 17.5 [12-34] months. Whatever the dose, BIS decreased after IV GHB. Nadir value of BIS was significantly lower in G25 and G50 than in G10, as was for OAAS score. Nadir values were reached after same delays in G25 and G50. Duration of sedation was dose-dependant. Conclusion: Bispectral index decreased after GHB injection and was correlated with OAAS score. Deep sedation can be safely achieved with IV doses of 25 or 50 mg·kg(-1) , but the last dose was associated with prolonged duration of clinical sedation. [less ▲]Detailed reference viewed: 52 (19 ULg)
Prise en charge des brûlés en phase aigue : enquête européenne.
ROUSSEAU, Anne-Françoise ; LEDOUX, Didier ; MASSION, Paul et al
in Brûlures. Revue Française de Brûlologie (2012, June), XIII(2), 60Detailed reference viewed: 43 (14 ULg)
Adaptation des traitements antibiotiques après 72 heures lors d'infection acquise en USI
; VERCHEVAL, Christelle ; NYS, Monique et al
in Réanimation (2012), 22(Suppl 2), 250033Detailed reference viewed: 16 (8 ULg)
Measuring end expiratory lung volume after cardiac surgery
MICHIELS, Grégoire ; ; LEDOUX, Didier et al
in Acta Anaesthesiologica Belgica (2012), 63(3), 115-120Detailed reference viewed: 14 (3 ULg)
Procalcitonin usefulness for the initiation of antibiotic treatment in intensive care unit patients.
LAYIOS, Nathalie ; LAMBERMONT, Bernard ; CANIVET, Jean-Luc et al
in Critical Care Medicine (2012), 40(8), 2304-9
OBJECTIVES: : To test the usefulness of procalcitonin serum level for the reduction of antibiotic consumption in intensive care unit patients. DESIGN: : Single-center, prospective, randomized controlled ... [more ▼]
OBJECTIVES: : To test the usefulness of procalcitonin serum level for the reduction of antibiotic consumption in intensive care unit patients. DESIGN: : Single-center, prospective, randomized controlled study. SETTING: : Five intensive care units from a tertiary teaching hospital. PATIENTS: : All consecutive adult patients hospitalized for > 48 hrs in the intensive care unit during a 9-month period. INTERVENTIONS: : Procalcitonin serum level was obtained for all consecutive patients suspected of developing infection either on admission or during intensive care unit stay. The use of antibiotics was more or less strongly discouraged or recommended according to the Muller classification. Patients were randomized into two groups: one using the procalcitonin results (procalcitonin group) and one being blinded to the procalcitonin results (control group). The primary end point was the reduction of antibiotic use expressed as a proportion of treatment days and of daily defined dose per 100 intensive care unit days using a procalcitonin-guided approach. Secondary end points included: a posteriori assessment of the accuracy of the infectious diagnosis when using procalcitonin in the intensive care unit and of the diagnostic concordance between the intensive care unit physician and the infectious-disease specialist. MEASUREMENTS AND MAIN RESULTS: : There were 258 patients in the procalcitonin group and 251 patients in the control group. A significantly higher amount of withheld treatment was observed in the procalcitonin group of patients classified by the intensive care unit clinicians as having possible infection. This, however, did not result in a reduction of antibiotic consumption. The treatment days represented 62.6 +/- 34.4% and 57.7 +/- 34.4% of the intensive care unit stays in the procalcitonin and control groups, respectively (p = .11). According to the infectious-disease specialist, 33.8% of the cases in which no infection was confirmed, had a procalcitonin value >1microg/L and 14.9% of the cases with confirmed infection had procalcitonin levels <0.25 microg/L. The ability of procalcitonin to differentiate between certain or probable infection and possible or no infection, upon initiation of antibiotic treatment was low, as confirmed by the receiving operating curve analysis (area under the curve = 0.69). Finally, procalcitonin did not help improve concordance between the diagnostic confidence of the infectious-disease specialist and the ICU physician. CONCLUSIONS: : Procalcitonin measuring for the initiation of antimicrobials did not appear to be helpful in a strategy aiming at decreasing the antibiotic consumption in intensive care unit patients. [less ▲]Detailed reference viewed: 57 (6 ULg)
Le débit de filtration glomérulaire est-il un déterminant de la concentration plasmatique du NGAL aux soins intensifs ?
DELANAYE, Pierre ; ; et al
Poster (2012)Detailed reference viewed: 22 (4 ULg)
Detection of decreased glomerular filtration rate in intensive care units: interest of cystatin C
DELANAYE, Pierre ; CAVALIER, Etienne ; et al
Poster (2012)Detailed reference viewed: 18 (9 ULg)
Persistent hypocoagulability in patients with septic shock predicts greater hospital mortality: impact of impaired thrombin generation.
MASSION, Paul ; PETERS, Pierre ; LEDOUX, Didier et al
in Intensive Care Medicine (2012), 38(8), 1326-35
PURPOSE: Sepsis induces hypercoagulability, hypofibrinolysis, microthrombosis, and endothelial dysfunction leading to multiple organ failure. However, not all studies reported benefit from anticoagulation ... [more ▼]
PURPOSE: Sepsis induces hypercoagulability, hypofibrinolysis, microthrombosis, and endothelial dysfunction leading to multiple organ failure. However, not all studies reported benefit from anticoagulation for patients with severe sepsis, and time courses of coagulation abnormalities in septic shock are poorly documented. Therefore, the aim of this prospective observational cohort study was to describe the coagulation profile of patients with septic shock and to determine whether alterations of the profile are associated with hospital mortality. METHODS: Thirty-nine patients with septic shock on ICU admission were prospectively included in the study. From admission to day 7, analytical coagulation tests, thrombin generation (TG) assays, and thromboelastometric analyses were performed and tested for association with survival. RESULTS: Patients with septic shock presented on admission prolongation of prothrombin time, activated partial thromboplastin time (aPTT), increased consumption of most procoagulant factors as well as both delay and deficit in TG, all compatible with a hypocoagulable state compared with reference values (P < 0.001). Time courses revealed a persistent hypocoagulability profile in non-survivors as compared with survivors. From multiple logistic regression, prolonged aPTT (P = 0.007) and persistence of TG deficit (P = 0.024) on day 3 were strong predictors of mortality, independently from disease severity scores, disseminated intravascular coagulation score, and standard coagulation tests on admission. CONCLUSIONS: Patients with septic shock present with hypocoagulability at the time of ICU admission. Persistence of hypocoagulability assessed by prolonged aPTT and unresolving deficit in TG on day 3 after onset of septic shock is associated with greater hospital mortality. [less ▲]Detailed reference viewed: 45 (15 ULg)
Les prélèvements microbiologiques ont-ils encore une place dans le diagnostic de pneumopathie acquise sous ventilation mécanique ?
LAYIOS, Nathalie ; DAMAS, Pierre
in Réanimation (2012), 21
Diagnosis of ventilator-associated pneumonia (VAP) is based on non-specific clinical signs. Several indicators have been tested in order to improve the accuracy of VAP diagnosis. The quantification of ... [more ▼]
Diagnosis of ventilator-associated pneumonia (VAP) is based on non-specific clinical signs. Several indicators have been tested in order to improve the accuracy of VAP diagnosis. The quantification of clinical parameters by using the clinical pulmonary infection score (CPIS), however, failed to improve the specificity of the diagnosis. This was the same for all the biomarkers tested either in the serum (procalcitonin, C-reactive protein) or in the bronchoalveolar lavage (BAL) fluid [soluble triggering receptor expressed on myeloid cells 1 (sTREM 1), elastin fibers, endotoxin, pro-inflammatory cytokines, Clara cell protein 10]. The microscopic examination of endotracheal samples alone, especially of the BAL fluid, may provide useful information for the detection of infected cells. Thus, microbiology is still needed. [less ▲]Detailed reference viewed: 28 (9 ULg)
Severity of ICU-acquired pneumonia according to infectious microorganisms
DAMAS, Pierre ; LAYIOS, Nathalie ; SEIDEL, Laurence et al
in Intensive Care Medicine (2011), 37(7), 1128-35Detailed reference viewed: 32 (6 ULg)