Acute-phase proteins and proteases-antiproteases in the inflammatory reaction

in New Horizons: Multiple Organ Failure (1989)

Postoperative Changes in Lipid Profile: Their Relations with Inflammatory Markers and Endocrine Mediators

in Acta Anaesthesiologica Belgica (1989), 40(4), 263-8

ive changes in plasma lipid profile have been studied in six patients undergoing aortobifemoral bypass. The second day after surgery, significant changes were: decreased levels of high density lipoprotein ... [more ▼]

ive changes in plasma lipid profile have been studied in six patients undergoing aortobifemoral bypass. The second day after surgery, significant changes were: decreased levels of high density lipoprotein (HDL) cholesterol (by 55%), non HDL cholesterol (by 60%) phospholipid (by 50%), pre-beta-lipoprotein (by 70%), beta-lipoprotein (by 50%), apolipoprotein A1 (by 60%) and apolipoprotein B (by 55%). The magnitude of these changes correlated positively with serum levels of transferrin and negatively with serum levels of C-reactive protein. Triglyceride levels also showed a significant decrease (by 60%) while free fatty acids increased by 70%. Changes in triglyceride levels were not correlated with serum transferrin and C-reactive protein but showed a significant negative correlation with insulin levels. Our results suggest that both inflammatory and endocrine mediators are likely implicated in the postoperative changes in lipid profile. [less ▲]

Pseudomonas aeruginosa et unités de soins intensifs chirurgicaux

in Annales de Biologie Clinique (1988), 46(2), 145-150

The prevalence of Pseudomonas aeruginosa in intensive care unit (ICU) is 19 per cent although its incidence in blood culture is only 3.5 per cent and remains the same even though the total prevalence of ... [more ▼]

The prevalence of Pseudomonas aeruginosa in intensive care unit (ICU) is 19 per cent although its incidence in blood culture is only 3.5 per cent and remains the same even though the total prevalence of this bacterium increases. A review of the clinical results shows that this germ causes severe complications in only 3 per cent of patients. A study by epidemiological markers reveals the presence of 16 different IATS serotypes in the ICU, this distribution of the serotypes being similar to this observed in ambulatory patients. The serotype 12 of Ps. aeruginosa is multiresistant. In 1984, it represented 22 per cent of the isolated Ps. aeruginosa, its incidence decreases in 1985 and in 1986 (14.5%). Ps. aeruginosa seems weakly pathogenic for the surgical patients in the ICU. On the other hand, the incidence of Klebsiella pneumoniae, Serratia marcescens (014 imm. serotype resistant to tobramycin), Enterobacter aerogenes and Enterobacter cloacae increases in blood cultures proportionally to their total prevalence in ICU. These bacteria are probably responsible for hospital epidemics. [less ▲]

Justification biochimique du drainage du canal thoracique au cours de la pancréatite aiguë nécrotico-hémorragique

in Acta Gastro-Enterologica Belgica (1988), 51(1), 31-40

Shock pancreas

in Intensive Care News (1988), 1

Un cas de maladie métabolique hépatique de Wilson traité radicalement par une transplantation de foie

in Revue Médicale de Liège (1988), 43

Les auteurs présentent un cas de cirrhose, développée sur une maladie de Wilson. Une greffe orthotopique de foie a été réalisée avec succès. Ils reprennent les principales indications de cette technique ... [more ▼]

Les auteurs présentent un cas de cirrhose, développée sur une maladie de Wilson. Une greffe orthotopique de foie a été réalisée avec succès. Ils reprennent les principales indications de cette technique et décrivent également les manifestations de la maladie de Wilson en général et son diagnostic. [less ▲]

A direct enzyme-linked immunosorbent assay (Elisa) for antibodies to enterobacterial score glycolipid and lipid A. Results in Healthy Subjects and in Patients Infected by Gram-Negative Bacteria

in Medical Microbiology & Immunology (1987), 176(5), 257-271

We have developed an ELISA for IgM and IgG antibodies to the core glycolipid (CGL) of the Re mutant Salmonella minnesota R 595, and to lipid A. Anti-CGL antibodies have been detected in sera from 37% of ... [more ▼]

We have developed an ELISA for IgM and IgG antibodies to the core glycolipid (CGL) of the Re mutant Salmonella minnesota R 595, and to lipid A. Anti-CGL antibodies have been detected in sera from 37% of healthy blood donors, whereas anti-lipid A activities were found in 13% of individuals only. The anti-CGL and anti-lipid A activities were examined in patients in a surgical intensive care unit, selected on the basis of a definite risk of infectious complications due to Gram-negative bacteria. Of the patients who developed such infections, the rate of favourable outcome was significantly higher in patients with either stable positive or increasing anti-CGL activities than in patients found to be negative. Our results provide clear evidence that anti-CGL antibodies contribute to host defence against various Gram-negative bacteria. [less ▲]

In-vivo studies on Haemaccel-fibronectin interaction in man.

in European Journal of Clinical Investigation (1987), 17(2), 166-73

An enzyme-linked immunoassay has been recently set up for direct measurement of the binding capacity of plasma fibronectin to gelatin. This binding capacity could be completely inhibited in vitro by an ... [more ▼]

An enzyme-linked immunoassay has been recently set up for direct measurement of the binding capacity of plasma fibronectin to gelatin. This binding capacity could be completely inhibited in vitro by an eight-fold excess of gelatin, of Haemaccel, but not of Geloplasma. On the contrary, the levels of immunoreactive fibronectin measured by laser nephelometry did not change, in presence of 10 to 1000 micrograms ml-1 of gelatin, of Haemaccel or of Geloplasma. When infused into normal volunteers, Haemaccel provoked a strong and immediate inhibition of the plasma fibronectin binding capacity to gelatin. This inhibition was dose-dependent and maximal after infusion of 500 ml of Haemaccel. Twenty-four hours after this infusion, there was a progressive recovery of the gelatin-binding capacity, which was almost completely achieved 96 h later. The formation of complexes between Haemaccel and fibronectin was demonstrated by gel filtration chromatography and by affinity chromatography. Immunoreactive plasma fibronectin levels remained unchanged up to 24 h after infusion of 500 ml of Haemaccel. A transient decline to 50% of its initial value then occurred the second day after the infusion. Therefore, a delay existed between the formation of fibronectin-Haemaccel complexes and their elimination from the bloodstream. This delay decreased when smaller volumes of Haemaccel were infused, which strongly suggests that plasma fibronectin is cleared by means of Haemaccel and does not seem to play a role of opsonin in these conditions.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

Biochemical patways of acute lung injury

in Bulletin Européen de Physiopathologie Respiratoire (1985), 21

Specific risks of anesthesia in patients with osteoarticular disease

in Acta Anaesthesiologica Belgica (1984), 35(2), 105-121

Anesthesia in patients with either treated or untreated osteoarttcular disorders poses a number of specific problems. The authors deal with risks resulting from mechanical deformities produced by these ... [more ▼]

Anesthesia in patients with either treated or untreated osteoarttcular disorders poses a number of specific problems. The authors deal with risks resulting from mechanical deformities produced by these disorders, by the involvement of a large number of functional systems, by changes in the immune status of such patients and by alterations in the reactions of arthritic patients resulting from prior or concurrent treatments. The authors emphasise the crucial points which require evaluation and observation before and during anesthesia [less ▲]