References of "Daly, Adrian"
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See detailAdénomes hypophysaires thyréotropes
Valdes Socin, Hernan Gonzalo ULg; Daly, Adrian ULg; Beckers, Albert ULg

in Chanson, Philippe; Young, Jacques (Eds.) Traité d'Endocrinologie (2007)

C’est le traité de référence dans la discipline : livre unique, sans concurrent de cette envergure. Il couvre toute l’endocrinologie moderne, qui s’appuie sur l’apport de la biologie moléculaire, de la ... [more ▼]

C’est le traité de référence dans la discipline : livre unique, sans concurrent de cette envergure. Il couvre toute l’endocrinologie moderne, qui s’appuie sur l’apport de la biologie moléculaire, de la biochimie, de l’immunocytochimie, de l’imagerie moderne avec, en particulier la T.E.P. La physiopathologie, les symptômes, les éléments du diagnostic, les orientations pronostiques, les choix thérapeutiques sont exposés de façon exhaustive pour les affections touchant toutes les glandes endocrines : thyroïde, parathyroïde, surrénales, testicules, ovaires, hypophyse. Au total, il s’agit d’un ouvrage complet, moderne et pratique ; la richesse des illustrations, des arbres décisionnels, l’abondante bibliographie contribuent à en faire un outil indispensable au quotidien. Ce Traité d'endocrinologie conçu par et maintenant publié sous la direction de Philippe Chanson et Jacques Young est remarquable, par son contenu, d'abord, ensuite, par le fait qu'il est écrit en français, ce qui en fait un ouvrage unique. En effet, les grands traités d'endocrinologie de ces dernières années sont en anglais. La liste des 154 chapitres couvre la totalité de l'endocrinologie d'aujourd'hui dans tous ses aspects, depuis la biologie moléculaire à la pratique du clinicien, interniste ou chirurgien. Et le texte, les textes, sont d'enseignement fondamental pour l'étudiant autant que de présentations et discussions diagnostiques pour le clinicien averti comme pour celui qui cherche à s'instruire. Comme la nostalgie, pour reprendre le cliché bien connu, l'endocrinologie n'est plus ce qu'elle était. Le concept de glandes endocrines, s'il reste vrai dans son ensemble, est cependant dépassé par ces nouvelles découvertes qui montrent sécrétion et utilisation in loto de ces mêmes substances (hormones ?) par des organes aussi variés que le cerveau ou le tissu adipeux. Et le Traité d'endocrinologie présente et discute, nombreuses références à l'appui, les nouveaux concepts des mécanismes d'action des différentes classes d'hormones tant au niveau du soma que du psyché. Les implications pour la thérapeutique sont considérables et ce sera le malade qui finalement, bénéficiera de toutes ces connaissances présentées ici à son médecin. L'endocrinologie et son ouverture sur la neuro-endocrinologie constituent plus que jamais la science de nous-mêmes, dans la santé comme dans la maladie. Ce Traité d'endocrinologie est une magnifique présentation de l'état des choses. [less ▲]

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See detailCharacteristics of familial isolated pituitary adenomas (FIPA) - Review
Daly, Adrian ULg; Vanbellinghen, Jean-François ULg; Beckers, Albert ULg

in Expert Review of Endocrinology & Metabolism (2007), 2(6), 725-733

The familial occurrence of pituitary adenomas has been recognized for many years and currently accounts for approximately 5% of all cases. Molecular, genetic and clinical features of familial pituitary ... [more ▼]

The familial occurrence of pituitary adenomas has been recognized for many years and currently accounts for approximately 5% of all cases. Molecular, genetic and clinical features of familial pituitary adenomas have been well characterized in multiple endocrine neoplasia type 1 (MEN-1) and Carney's complex (CNC), which account for the majority of familial pituitary tumor cases. These conditions are caused by MEN1 and PRKAR1A gene mutations, respectively, and the clinical and pathological features of pituitary pathology in these diseases differ from those of sporadic pituitary tumors. Familial acromegaly has been recognized for many years and, more recently, the clinical features of this clinical phenotype, referred to as isolated familial somatotropinoma, have been clarified. Over the past decade, the concept of non-MEN-1/CNC familial pituitary tumors has been expanded significantly to include all phenotypes, a condition known as familial isolated pituitary adenomas (FIPA). In FIPA, tumors can present homogeneously (same phenotype) or heterogeneously (different tumor phenotypes) within the same family. Compared with sporadic pituitary adenomas, patients with FIPA have a younger age at diagnosis and have larger tumors. The clinical features of FIPA differ from those of MEN-1 in terms of a higher frequency of somatotropinomas and a lower frequency of prolactinomas. The recent discovery of the involvement of mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene in association with pituitary tumors has provided new information regarding potential mechanisms of tumorigenesis in FIPA patients. While very infrequent in sporadic pituitary tumors, approximately 15% of FIPA patients have AIP mutations, rising to half of patients with familial acromegaly. In this review, we detail the clinical features of FIPA and discuss tumor pathology and genetic findings in this increasingly recognized clinical condition. [less ▲]

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See detailHigh prevalence of pituitary adenomas: A cross-sectional study in the province of Liege, Belgium
Daly, Adrian ULg; Rixhon, M.; Adam, Christelle et al

in Journal of Clinical Endocrinology and Metabolism (2006), 91(12), 4769-4775

Context: Prevalence data are important for assessing the burden of disease on the health care system; data on pituitary adenoma prevalence are very scarce. Objective: The objective of the study was to ... [more ▼]

Context: Prevalence data are important for assessing the burden of disease on the health care system; data on pituitary adenoma prevalence are very scarce. Objective: The objective of the study was to measure the prevalence of clinically relevant pituitary adenomas in a well-defined population. Design: This was a cross-sectional, intensive, case-finding study performed in three regions of the province of Liège, Belgium, to measure pituitary adenoma prevalence as of September 30, 2005. Setting: The study was conducted in specialist and general medical practitioner patient populations, referral hospitals, and investigational centers. Methods: Three demographically and geographically distinct districts of the province of Liège were delineated precisely using postal codes. Medical practitioners in these districts were recruited, and patients with pituitary adenomas under their care were identified. Diagnoses were confirmed after retrieval of clinical, hormonal, radiological, and pathological data; full demographic and therapeutic follow-up data were collected in all cases. Results: Sixty-eight patients with clinically relevant pituitary adenomas were identified in a population of 71,972 individuals; the mean (± SD) prevalence was 94 ± 19.3 cases per 100,000 population (95% confidence interval, 72.2 to 115.8). The group was 67.6% female and had a mean age at diagnosis of 40.3 yr; 42.6% had macroadenomas and 55.9% underwent surgery. Prolactinomas comprised 66% of the group, with the rest having nonsecreting tumors (14.7%), somatotropinomas (13.2%), or Cushing’s disease (5.9%); 20.6% had hypopituitarism. Conclusion: The prevalence of pituitary adenomas in the study population (one case in 1064 individuals) was more than 3.5–5 times that previously reported. This increased prevalence may have important implications when prioritizing funding for research and treatment of pituitary adenomas. [less ▲]

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See detailClinical characterization of familial isolated pituitary adenomas.
Daly, Adrian ULg; Jaffrain-Rea, M.-L.; Ciccarelli, A. et al

in Journal of Clinical Endocrinology and Metabolism (2006), 91(9), 3316-23

CONTEXT: Familial pituitary adenomas occur rarely in the absence of multiple endocrine neoplasia type 1 (MEN1) and Carney complex (CNC). OBJECTIVE: Our objective was to characterize the clinical and ... [more ▼]

CONTEXT: Familial pituitary adenomas occur rarely in the absence of multiple endocrine neoplasia type 1 (MEN1) and Carney complex (CNC). OBJECTIVE: Our objective was to characterize the clinical and genealogical features of non-MEN1/CNC familial isolated pituitary adenomas (FIPA). DESIGN AND SETTING: We conducted a retrospective study of clinical and genealogical characteristics of FIPA cases and performed a comparison with a sporadic population at 22 university hospitals in Belgium, Italy, France, and The Netherlands. RESULTS: Sixty-four FIPA families including 138 affected individuals were identified [55 prolactinomas, 47 somatotropinomas, 28 nonsecreting adenomas (NS), and eight ACTH-secreting tumors]. Cases were MEN1/PRKAR1A-mutation negative. First-degree relationships predominated (75.6%) among affected individuals. A single tumor phenotype occurred in 30 families (homogeneous), and heterogeneous phenotypes occurred in 34 families. FIPA cases were younger at diagnosis than sporadic cases (P = 0.015); tumors were diagnosed earlier in the first vs. the second generation of multigenerational families. Macroadenomas were more frequent in heterogeneous vs. homogeneous FIPA families (P = 0.036). Prolactinomas from heterogeneous families were larger and had more frequent suprasellar extension (P = 0.004) than sporadic cases. Somatotropinomas occurred as isolated familial somatotropinoma cases and within heterogeneous FIPA families; isolated familial somatotropinoma cases represented 18% of FIPA cases and were younger at diagnosis than patients with sporadic somatotropinomas. Familial NS cases were younger at diagnosis (P = 0.03) and had more frequently invasive tumors (P = 0.024) than sporadic cases. CONCLUSIONS: Homogeneous and heterogeneous expression of prolactinomas, somatotropinomas, NS, and Cushing's disease can occur within families in the absence of MEN1/CNC. FIPA and sporadic cases have differing clinical characteristics. FIPA may represent a novel endocrine neoplasia classification that requires further genetic characterization. [less ▲]

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See detailLes grandes tailles: quelques grands syndromes et revue de la litterature
Gusbin, Natacha ULg; Verloes, Alain ULg; Daly, Adrian ULg et al

in Revue Médicale de Liège (2006), 61(7-8, Jul-Aug), 572-80

We describe the findings of XYY syndrome in the setting of encountering an individual with this particular condition in the endocrinology clinic. XYY syndrome is a relatively frequent if unfamiliar ... [more ▼]

We describe the findings of XYY syndrome in the setting of encountering an individual with this particular condition in the endocrinology clinic. XYY syndrome is a relatively frequent if unfamiliar condition, which is characterized by taller than average height. The extra Y chromosome may play a role in determining the height of these individuals. From this case, a differential diagnosis of tall stature is outlined, in addition to a description of the principal syndromes associated with gigantism. These primarily include Klinefelter syndrome, Marfan syndrome, androgen resistance and growth hormone excess. These various entities are described from the point of view of their symptomatology, biology, pathophysiology and therapeutic characteristics. [less ▲]

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See detailIdentification of a family harboring a novel LHBéta subunit mutation associated with hypogonadism
Daly, Adrian ULg; Salvi, R.; Ménagé, J.-J. et al

in The Endocrine Society's - 88th Annual Meeting - Abstract book (2006, June)

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See detailDiagnostic Characteristics and Therapeutic Responses in Acromegaly : The Liège Acromegaly Survey
Tikhomirova, M.; Petrossians, Patrick ULg; Daly, Adrian ULg et al

in 50th Meeting of the German Endocrine Society and 23rd Meeting of Dutch Endocrine Society : Essen, Germany, 1-4 March 2006 (2006, March)

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See detailSomatostatin analogs in the gastroentestinal tract
Harris, A.; Daly, Adrian ULg; Tichomirowa, M. A. et al

in The handbook of Biologically Active Peptides (2006)

Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience ... [more ▼]

Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar. [less ▲]

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See detailCommentary on : Does the nadir growth-hormone level predict response to somatostatin-analogue therapy?
Beckers, Albert ULg; Daly, Adrian ULg; Petrossians, Patrick ULg

in Nature Clinical Practice Endocrinology and Metabolism (2006), 2(1), 12-13

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See detailSerum levels of soluble CD163 correlate with the inflammatory process in coeliac disease.
Daly, Adrian ULg; Walsh, C.; Feighery, C. et al

in Alimentary Pharmacology & Therapeutics (2006), 24(3), 553-9

BACKGROUND: In coeliac disease, following the introduction of a gluten-free diet, monitoring mucosal disease activity requires repeated small intestinal biopsies. If a test measuring a circulating ... [more ▼]

BACKGROUND: In coeliac disease, following the introduction of a gluten-free diet, monitoring mucosal disease activity requires repeated small intestinal biopsies. If a test measuring a circulating inflammatory marker was available, this would be clinically valuable. AIM: To determine if levels of soluble CD163, a scavenger receptor shed by tissue macrophages, correlated with the inflammatory lesion in coeliac disease. METHODS: Serum samples were collected from 131 patients with untreated coeliac disease, 40 patients with treated coeliac disease, 92 non-coeliac disease control subjects and 131 healthy controls. A capture enzyme linked immunosorbance assay was established to measure levels of soluble CD163 in sera. The extent of the histological lesion in coeliac biopsies was assessed using a Marsh grading system. RESULTS: Levels of CD163 in untreated coeliac subjects were significantly elevated when compared with the treated coeliac patients, the disease control group and the healthy control subjects (P < 0.0001 in each instance). Moreover, coeliac patients with the most marked histological lesion (Marsh 3) had significantly higher levels of soluble CD163 than patients with Marsh grade 2 lesions (P < 0.0004), with grade 1 lesions (P < 0.0001) and grade 0 lesions (P < 0.0001). CONCLUSIONS: Measurement of soluble CD163 may be a useful method of monitoring the inflammatory lesion in coeliac disease. [less ▲]

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See detailDesloratadine for allergic rhinitis.
Wilken, Jeffrey A.; Daly, Adrian ULg; Sullivan, Cynthia L. et al

in Expert Review of Clinical Immunology (2006), 2(2), 209-24

Seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR) affect up to 40% of the population (depending on geographical area), and are associated with significant morbidity, socioeconomic ... [more ▼]

Seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR) affect up to 40% of the population (depending on geographical area), and are associated with significant morbidity, socioeconomic costs and reductions in quality of life. Antihistamines are a first-line therapy, with newer nonsedating agents having superseded sedating first-generation drugs. Desloratadine is a nonsedating, nonimpairing antihistamine that is effective in relieving nasal and non-nasal symptoms of SAR and PAR, including nasal congestion. Desloratadine has a 24-h duration of action, enabling once-daily dosing and providing relief of morning symptoms. Clinical trials have demonstrated that it has no performance impairment, cardiovascular effects or clinically relevant interactions with other tested medications. This article reviews the use of desloratadine in the treatment of SAR and PAR. [less ▲]

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See detailPituitary Diseases in Daily Clinical Pratice : Prevalence and Relevance 2006
Jaffrain-Réa, M. L.; Valle, L.; Daly, Adrian ULg et al

in Congrès Italien d'Endocrinologie : Florence, 2006 (2006)

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See detailEndocrine abnormalities in McCune-Albright syndrome
Tamagno, G.; Petrossians, Patrick ULg; Daly, Adrian ULg et al

in 23ème Congrès de la Société Française d'Endocrinologie - Abstract book (2006)

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See detailLes patients acromégales sont-il mal pris en charge? De la mauvaise utilisation des bases de données
Petrossians, Patrick ULg; Tichomirova, M.; Daly, Adrian ULg et al

in 23ème Congrès de la Société Française d'Endocrinologie - Abstract book (2006)

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See detailThe Liège Acromegaly Survey
Tichomirova, M.; Daly, Adrian ULg; Petrossians, Patrick ULg et al

in 23ème Congrès de la Société Française d'Endocrinologie - Abstract book (2006)

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See detailIdentification d'une famille porteuse d'une nouvelle mutation bêta-LH accompagnée d'hypogonadisme
Daly, Adrian ULg; Salvi, R.; Ménagé, J.-J. et al

in 23ème Congrès de la Société Française d'Endocrinologie - Abstract book (2006)

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See detailPathologie inflammatoire de l'hypophyse et grossesse
Hansen, Isabelle ULg; Vroonen, Laurent ULg; Tichomirova, M. et al

in Pathologie hypophysaire et grossesse (2006)

Les affections hypophysaires, tumorales ou non tumorales, sont classiquement responsables d'infertilité. Grâce aux progrès des traitements médicaux et chirurgicaux développés pour le traitement de ces ... [more ▼]

Les affections hypophysaires, tumorales ou non tumorales, sont classiquement responsables d'infertilité. Grâce aux progrès des traitements médicaux et chirurgicaux développés pour le traitement de ces affections hypophysaires, les grossesses sont de plus en plus fréquentes chez les patientes ayant en particulier un adénome hypophysaire sécrétant ou une insuffisance anté-hypophysaire ou un diabète insipide central. Cependant, les conséquences de l'affection hypophysaire et des traitements pour la mère ou le f¿tus sont toujours discutés par les endocrinologues, les gynécologues, les obstétriciens et les pédiatres. Le but de cet ouvrage unique en français est une mise au point de nos connaissances sur le sujet, et tout particulièrement sur le diagnostic hormonal et radiologique d'un syndrome d'hypersécrétion ou d'une insuffisance hypophysaire au cours d'une grossesse, ainsi que sur la prise en charge des patientes présentant une pathologie hypophysaire tumorale ou non tumorale, désirant ou présentant une grossesse. [less ▲]

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See detailComment j'explore... Une valeur élevée de calcitonine?
Rikir, Estelle ULg; Valdes Socin, Hernan Gonzalo ULg; Vroonen, Laurent ULg et al

in Revue Médicale de Liège (2006), 61(3), 195-200

This article describes a case of lung cancer with associated hypercalcitoninemia in a man with a goitre. The case raises the problem of the differential diagnosis between medullary thyroid carcinoma and a ... [more ▼]

This article describes a case of lung cancer with associated hypercalcitoninemia in a man with a goitre. The case raises the problem of the differential diagnosis between medullary thyroid carcinoma and a neuroendocrine neoplasm with ectopic calcitonin secretion. The article first reviews the physiology of calcitonin, then outlines the diagnostic tests that are required to investigate hypercalcitoninemia and finally discusses the interpretation of test results. [less ▲]

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See detailA multicenter collaborative study to measure the prevalence of pituitary disease : methodology and preliminary findings
Tikhomirova, M.; Daly, Adrian ULg; Petrossians, Patrick ULg et al

in 15th Meeting of the Belgian Endocrine Society : Bruxelles, 26 novembre 2005 (2005, November)

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See detailTreatment of pituitary tumors: somatostatin.
Tichomirowa, M. A.; Daly, Adrian ULg; Beckers, Albert ULg

in Endocrine (2005), 28(1), 93-99

Somatostatin is an important physiological regulator of neuroendocrine function across multiple biological systems, including the brain and the gastrointestinal tract. In the pituitary gland, somatostatin ... [more ▼]

Somatostatin is an important physiological regulator of neuroendocrine function across multiple biological systems, including the brain and the gastrointestinal tract. In the pituitary gland, somatostatin regulates the secretion of hormones such as growth hormone and thyroid-stimulating hormone in healthy and pathological states. The short half-life of somatostatin makes it unsuitable for clinical use in chronic diseases, which led to the development of long-acting somatostatin analogs for the treatment of acromegaly and thyroid-stimulating hormone-secreting adenomas, which were administered by intermittent injection twice or three times a day. More recently, depot versions have been developed that permit dosing once every month. This review assesses the efficacy of somatostatin analogs in the treatment of pituitary adenomas, including acromegaly, thyroid-stimulating hormone-secreting tumors, non-functioning adenomas, and Cushing's disease. [less ▲]

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