References of "Daly, Adrian"
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See detailAbsence d'hypogonadisme chez un patient masculin avec prolactinome géant : un paradoxe clinique
Tamagno, Gianluca; Daly, Adrian ULg; Deprez, Manuel ULg et al

in Annales d'Endocrinologie (2008), 69(1), 47-52

Background Impotence and decreased libido are the cardinal features of prolactinomas in males. We describe the unusual clinical, pathological and biochemical features in a male patient with a giant ... [more ▼]

Background Impotence and decreased libido are the cardinal features of prolactinomas in males. We describe the unusual clinical, pathological and biochemical features in a male patient with a giant prolactinoma and normal gonadal function. Case Report A 57 year-old man presented with visual symptoms related to a 30 × 25 × 60 mm tumor of the sella and skull base. Biopsy revealed a pituitary adenoma and subsequent hormone profiles demonstrated grossly elevated serum prolactin (131,412 ng/ml), LH at the upper limit of normal and normal testosterone. The patient had no symptoms of decreased libido or impotence related to this giant prolactinoma. Immunohistochemistry revealed a tumor that was positive for prolactin, alpha-subunit and LH. Cabergoline greatly reduced prolactin levels but these remained above normal. LH, testosterone and alpha-subunit levels were decreased in parallel. Loss of libido and impotence became apparent when testosterone fell below normal, a situation that resolved with further cabergoline treatment and prolactin inhibition and testosterone therapy. Conclusions Sexual dysfunction is a hallmark of prolactinomas in males. Tumors that co-secrete prolactin and LH are extremely rare and this is the first such case reported in an adult male. In this case, normal testosterone was maintained by intact LH levels even in the face of the highest prolactin level reported to date. [less ▲]

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See detailAryl Hydrocarbon Receptor (AHR) and AHR Interacting Protein (AIP) expression in human GH/PRL-secreting pituitary adenomas
Jaffrain-Réa, M. L.; Gargano, D.; D'Innocenzo, E. et al

in Italian Congress of Endocrinology - Giornate Endocrinologiche Pisane GEP 2008 : Pisa 2008 (2008)

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See detailAryl Hydrocarbon Receptor interacting protein (AIP) mutations in a cohort of Brazilian Familial isolated pituitary adenomas : relation to aggressive behaviour
Naves, L. A.; Azevedo, M. F.; Casulari, L. A. et al

in XIV Simposo Internacinal de Neuroendocrinologia - Endocrinologia and Metabologia - Arquivos Brasileiros de Endocrinologia e Metabologia : Fevereiro 2008, 52, suplemento 1 (2008)

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See detailPathological and clinical features of a large brazilian family harboring a frameshift mutation in the aryl hydrocarbon receptor interacting protein gene
Naves, L. A.; Azevedo, M. F.; Casulari, L. A. et al

in XIV Simposo Internacinal de Neuroendocrinologia - Endocrinologia and Metabologia - Arquivos Brasileiros de Endocrinologia e Metabologia : Fevereiro 2008, 52, suplemento 1 (2008)

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See detailOccurrence of AIP Mutations in Sporidic Pituitary Adenomas and Familial Isolated Pituitary Adenomas Kindreds in Valencia, Spain
Fajardo Montanaña, C.; Daly, Adrian ULg; Tichomirowa, M. A. et al

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

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See detailFamilial Acromegaly : Family screening and assetment in the familial isolated pituitary adenoma (FIPA)
Fajardo, C.; Camara, R.; Daly, Adrian ULg et al

in 10th European Congress of Endocrinology - Abstract book (2008)

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See detailGenetic Causes of Pituitary Adenmas; Focus on the Roe of AIF Status in Multiple Tumor Types
Ansaneli Naves, L.; Ferreira Azevedo, M.; Faria de Castro, L. et al

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

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See detailAryl Hydrocarbon Receptor interacting Protein Gene Mutations in Bulgarian FIPA and Young Sporadic Pituitary Adenoma Patients
Yaneva, M.; Daly, Adrian ULg; Tichomirowa, M. A. et al

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

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See detailZac1 Immunoreactivity in Acromegalic Tumors is Associated with the Response to Somatostatin Analog 11 Treatment
Theodoropoulou, M.; Tichomirowa, M. A.; Sievers, C. et al

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

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See detailAryl Hydrocarbon receptor interacting protein (AIP) expression in human pituitary adenomas
Jaffrain-Rea, M. L.; Spilioti, C.; Vanbellinghen, Jean-François ULg et al

in 10th European Congress of Endocrinology - Abstract book (2008)

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See detailTwo Novel Mutations of the Calcium Sensing Receptor gene
Livadariu, E.; Rydlewski, C.; Hamoir, Etienne ULg et al

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

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See detailAIP protein expression can predict treatment response to somatostatin analogs in sporadic GH secreting adenomas in women
Tichomirowa, M. A.; Theodoropoulou, M.; Sievers, C. et al

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

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See detailLes microprolactinomes : diagnostic clinique, biologique et radiologique
Burlacu, M. C.; Daly, Adrian ULg; Beckers, Albert ULg

in Young, Jacques (Ed.) Hyperprolactinémies (2008)

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See detailEpidemiology and Genetics of Pituitary Tumours
Daly, Adrian ULg

Doctoral thesis (2008)

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See detailCharacterization of a family harboring a novel LHBéta subunit mutation associated with hypogonadism
Burlacu, M. C.; Daly, Adrian ULg; Salvi, R. et al

in 17th Meeting of the Belgian Endocrine Society : Bruxelles, 25 novembre 2007 (2007, November)

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See detailTherapeutic and clinical outcome of cabergoline-resistant prolactinomas
Vroonen, Laurent ULg; Livadariu, E.; Tamagno, G. et al

in 17th Meeting of the Belgian Endocrine Society : Bruxelles, 25 novembre 2007 (2007, November)

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See detailVitex agnus castus might enrich the pharmacological armamentarium for medical treatment of prolactinoma
Tamagno, G.; Burlacu, M. C.; Daly, Adrian ULg et al

in European Journal of Obstetrics & Gynecology & Reproductive Biology (2007), 135(1), 139-140

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See detailThe clinical, pathological, and genetic features of familial isolated pituitary adenomas
Beckers, Albert ULg; Daly, Adrian ULg

in European Journal of Endocrinology (2007), 157(4), 371-382

Pituitary adenomas occur in a familial setting in multiple endocrine neoplasia type 1 (MEN1) and Carney's complex (CNC), which occur due to mutations in the genes MEN1 and PRKAR1A respectively. Isolated ... [more ▼]

Pituitary adenomas occur in a familial setting in multiple endocrine neoplasia type 1 (MEN1) and Carney's complex (CNC), which occur due to mutations in the genes MEN1 and PRKAR1A respectively. Isolated familial somatotropinoma (IFS) is also a well-described clinical syndrome retated only to patients with acrogigantism. Pituitary adenomas of all types - not limited to IFS - can occur in a familial setting in the absence of MEN1 and CNC; this phenotype is tcrmed familial isolated pituitary adenomas (FIPA). Over the past 7 years, we have described over 90 FIPA kindreds. In FIPA, both homogeneous and heterogeneous pituitary adenoma phenotypes can occur within families; virtually all FIPA kindreds contain at least one prolactinoma or somatotropinoma. FIPA differs from MEN1 in terms of a lower proportion of prolactinomas and more frequent somatotropinomas in the FIPA cohort. Patients with FIPA are significantly younger at diagnosis and have significantly larger pituitary adenomas than matched sporadic pituitary adenoma counterparts. A minority of FIPA families overall (15%) exhibit mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene; AIP mutations are present in only half of IFS kindreds occurring as part of the FIPA cohort. In families with AIP mutations, pituitary adenomas have a penetrance of over 50%. AIP mutations are extremely rare in patients with sporadic pituitary adenomas. This review deals with pituitary adenomas that occur in a familial setting, describes in detail the clinical, pathological, and genetic features of FIPA, and addresses aspects of the clinical approach to FIPA families with and without AIP mutations. [less ▲]

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See detailVariable pathological and clinical features of a large Brazilian family harboring a mutation in the aryl hydrocarbon receptor-interacting protein gene
Naves, L. A.; Daly, Adrian ULg; Vanbellinghen, Jean-François ULg et al

in European Journal of Endocrinology (2007), 157(4), 383-391

Background: Germline aryl hydrocarbon receptor-interacting protein (AIP) mutations occur in 15% of familial isolated pituitary adenoma (FIPA) cases. To date, studies have focused on the identification of ... [more ▼]

Background: Germline aryl hydrocarbon receptor-interacting protein (AIP) mutations occur in 15% of familial isolated pituitary adenoma (FIPA) cases. To date, studies have focused on the identification of such mutations in large international cohorts. Detailed genetic and clinical studies within AIP mutation-positive families have been limited. Aim: To undertake a comprehensive study of a large Brazilian FIPA kindred with an E174 frameshift (E174fs) AIP mutation to assess clinical, hormonal, and radiological features in mutation carriers. Methods: The kindred included 122 subjects across six generations; all underwent clinical examination. Genetic studies were performed to identify E174fs mutation carriers. E174fs-positive subjects underwent magnetic resonance imaging (MRI) and hormonal assessments. Results: Of the ten germline AIP mutation carriers, three had pituitary tumors, while seven were asymptomatic carriers. Three patients with pituitary tumors showed variability in terms of tumor phenotype (two with acromegaly, one with prolactinoma, or mixed prolactin/GH-secreting tumor) and age at diagnosis; both patients with acromegaly had poor responses to octreotide. Tumor AIP immunohistochemistry from the operated patient showed decreased expression when compared with normal tissue. Two adult subjects with normal MRI had elevated IGF-I in the absence of other causes. A 2-year-old child with the E174fs mutation and a normal MRI had premature thelarche, ovarian development, and advanced bone age in the absence of other underlying causes. Conclusions: The penetrance of pituitary tumors in AIP mutation-positive adult subjects was 33.3%, while clinical/hormonal features were variable. The features noted in AIP-mutation carriers in this kindred suggest that clinical characteristics of such carriers may extend beyond pituitary tumors. [less ▲]

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