References of "Daly, Adrian"
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See detailAbsence d'hypogonadisme chez un patient masculin avec prolactinome géant : un paradoxe clinique
Tamagno, Gianluca; Daly, Adrian ULg; Deprez, Manuel ULg et al

in Annales d'Endocrinologie (2008), 69(1), 47-52

Background Impotence and decreased libido are the cardinal features of prolactinomas in males. We describe the unusual clinical, pathological and biochemical features in a male patient with a giant ... [more ▼]

Background Impotence and decreased libido are the cardinal features of prolactinomas in males. We describe the unusual clinical, pathological and biochemical features in a male patient with a giant prolactinoma and normal gonadal function. Case Report A 57 year-old man presented with visual symptoms related to a 30 × 25 × 60 mm tumor of the sella and skull base. Biopsy revealed a pituitary adenoma and subsequent hormone profiles demonstrated grossly elevated serum prolactin (131,412 ng/ml), LH at the upper limit of normal and normal testosterone. The patient had no symptoms of decreased libido or impotence related to this giant prolactinoma. Immunohistochemistry revealed a tumor that was positive for prolactin, alpha-subunit and LH. Cabergoline greatly reduced prolactin levels but these remained above normal. LH, testosterone and alpha-subunit levels were decreased in parallel. Loss of libido and impotence became apparent when testosterone fell below normal, a situation that resolved with further cabergoline treatment and prolactin inhibition and testosterone therapy. Conclusions Sexual dysfunction is a hallmark of prolactinomas in males. Tumors that co-secrete prolactin and LH are extremely rare and this is the first such case reported in an adult male. In this case, normal testosterone was maintained by intact LH levels even in the face of the highest prolactin level reported to date. [less ▲]

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See detailToll-like receptor-4 is expressed in meningiomas and mediates the antiproliferative action of paclitaxel.
Tichomirowa, Maria A.; Theodoropoulou, Marily; Daly, Adrian ULg et al

in International Journal of Cancer = Journal International du Cancer (2008), 123(8), 1956-63

Meningiomas are the second most common type of brain and CNS tumors by histology. Surgery and radiotherapy are main treatment options, but meningiomas may be impossible to adequately resect or may regrow ... [more ▼]

Meningiomas are the second most common type of brain and CNS tumors by histology. Surgery and radiotherapy are main treatment options, but meningiomas may be impossible to adequately resect or may regrow after surgery. In spite of many experimental attempts, there is no generally accepted chemotherapeutic approach. We have studied in a series of meningiomas the expression of the Toll-like receptor 4 (TLR4), which apart from its major role as a key factor of the innate immune system, is believed to play a role in tumorigenesis. All meningiomas studied expressed TLR4 mRNA and protein at variable degree. Paclitaxel, a ligand of TLR4, exhibited a dose- and time-dependent growth suppression in both monolayer and spheroid meningioma cell cultures. The knockdown of TLR4 with siRNA in meningioma cell cultures abrogated the inhibitory effect of paclitaxel. The suppressive action of paclitaxel on meningioma cell growth was enhanced in the presence of fluvastatin or the mitogen-actvated protein kinase (ERK1/2) inhibitor PD98059. At least part of the growth suppressive effect was mediated by the induction of apoptosis in meningioma cells by paclitaxel alone or in combination with fluvastatin. In conclusion, our in vitro results suggest that paclitaxel alone or in combination with other inhibitors of cell growth (statins, MAPK inhibitors) could provide a potential tool for the treatment of TLR4 expressing meningiomas. [less ▲]

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See detailAn International, Collaborative Study of the Disease Characteristics and Response to Therapy in 60 Pituitary Adenoma Patients with Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene Mutations
Daly, Adrian ULg; Tichomirowa, M. A.; Ebeling, T. M. L. et al

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

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See detailAryl Hydrocarbon Receptor (AHR) and AHR Interacting Protein (AIP) expression in human GH/PRL-secreting pituitary adenomas
Jaffrain-Réa, M. L.; Gargano, D.; D'Innocenzo, E. et al

in Italian Congress of Endocrinology - Giornate Endocrinologiche Pisane GEP 2008 : Pisa 2008 (2008)

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See detailAryl Hydrocarbon Receptor interacting protein (AIP) mutations in a cohort of Brazilian Familial isolated pituitary adenomas : relation to aggressive behaviour
Naves, L. A.; Azevedo, M. F.; Casulari, L. A. et al

in XIV Simposo Internacinal de Neuroendocrinologia - Endocrinologia and Metabologia - Arquivos Brasileiros de Endocrinologia e Metabologia : Fevereiro 2008, 52, suplemento 1 (2008)

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See detailPathological and clinical features of a large brazilian family harboring a frameshift mutation in the aryl hydrocarbon receptor interacting protein gene
Naves, L. A.; Azevedo, M. F.; Casulari, L. A. et al

in XIV Simposo Internacinal de Neuroendocrinologia - Endocrinologia and Metabologia - Arquivos Brasileiros de Endocrinologia e Metabologia : Fevereiro 2008, 52, suplemento 1 (2008)

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See detailOccurrence of AIP Mutations in Sporidic Pituitary Adenomas and Familial Isolated Pituitary Adenomas Kindreds in Valencia, Spain
Fajardo Montanaña, C.; Daly, Adrian ULg; Tichomirowa, M. A. et al

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

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See detailFamilial Acromegaly : Family screening and assetment in the familial isolated pituitary adenoma (FIPA)
Fajardo, C.; Camara, R.; Daly, Adrian ULg et al

in 10th European Congress of Endocrinology - Abstract book (2008)

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See detailGenetic Causes of Pituitary Adenmas; Focus on the Roe of AIF Status in Multiple Tumor Types
Ansaneli Naves, L.; Ferreira Azevedo, M.; Faria de Castro, L. et al

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

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See detailAryl Hydrocarbon Receptor interacting Protein Gene Mutations in Bulgarian FIPA and Young Sporadic Pituitary Adenoma Patients
Yaneva, M.; Daly, Adrian ULg; Tichomirowa, M. A. et al

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

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See detailZac1 Immunoreactivity in Acromegalic Tumors is Associated with the Response to Somatostatin Analog 11 Treatment
Theodoropoulou, M.; Tichomirowa, M. A.; Sievers, C. et al

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

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See detailAryl Hydrocarbon receptor interacting protein (AIP) expression in human pituitary adenomas
Jaffrain-Rea, M. L.; Spilioti, C.; Vanbellinghen, Jean-François ULg et al

in 10th European Congress of Endocrinology - Abstract book (2008)

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See detailTwo Novel Mutations of the Calcium Sensing Receptor gene
Livadariu, E.; Rydlewski, C.; Hamoir, Etienne ULg et al

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

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See detailAIP protein expression can predict treatment response to somatostatin analogs in sporadic GH secreting adenomas in women
Tichomirowa, M. A.; Theodoropoulou, M.; Sievers, C. et al

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

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See detailLes microprolactinomes : diagnostic clinique, biologique et radiologique
Burlacu, M. C.; Daly, Adrian ULg; Beckers, Albert ULg

in Young, Jacques (Ed.) Hyperprolactinémies (2008)

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See detailEpidemiology and Genetics of Pituitary Tumours
Daly, Adrian ULg

Doctoral thesis (2008)

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See detailCharacterization of a family harboring a novel LHBéta subunit mutation associated with hypogonadism
Burlacu, M. C.; Daly, Adrian ULg; Salvi, R. et al

in 17th Meeting of the Belgian Endocrine Society : Bruxelles, 25 novembre 2007 (2007, November)

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See detailTherapeutic and clinical outcome of cabergoline-resistant prolactinomas
Vroonen, Laurent ULg; Livadariu, E.; Tamagno, G. et al

in 17th Meeting of the Belgian Endocrine Society : Bruxelles, 25 novembre 2007 (2007, November)

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See detailVitex agnus castus might enrich the pharmacological armamentarium for medical treatment of prolactinoma
Tamagno, G.; Burlacu, M. C.; Daly, Adrian ULg et al

in European Journal of Obstetrics & Gynecology & Reproductive Biology (2007), 135(1), 139-140

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