References of "DUBOIS, Nathalie"
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See detailSevrage rapide aux opiacés sous anesthésie (RODA)
DUBOIS, Nathalie ULg; HALLET, Claude ULg; LUPPENS, David ULg et al

in Revue Médicale de Liège (2013), 68(5-6), 298-302

Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measure ... [more ▼]

Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measure the plasma concentrations of heroin metabolites and methadone during anesthesia and patient stay at the hospital in order to assess the amount of active substances at each protocol step. Plasma concentrations of antagonists were also quantified and compared to the recommended target values. Blood samples were drawn in 10 patients undergoing RODA at different times of the procedure (during anesthesia, in post-anesthesia care unit and in psychiatry unit). The plasma concentrations of heroin metabolites, methadone and antagonists were measured using a previously described method. Heroin active metabolites were no longer detected in the patient blood when he/she left the hospital; by contrast, methadone was still present at significant concentrations 3 days after the beginning of the detoxification procedure. Naltrexone analysis allowed us to adjust doses to insure opiate receptor blockade. [less ▲]

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See detailEtude de l'imprégnation d'une population générale belge en bisphénol A, triclosan et 4-nonylphénol
PIRARD, Catherine ULg; SAGOT, Clémence ULg; DEVILLE, Marine ULg et al

in Annales de Toxicologie Analytique (2012), 24(4),

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See detailUrinary levels of bisphenol A, triclosan and 4-nonylphenol in a general Belgian population
PIRARD, Catherine ULg; SAGOT, Clémence ULg; DEVILLE, Marine ULg et al

in Environment International (2012), 48

Bisphenol A, triclosan and 4-nonylphenol are among the endocrine disruptors which are widely used in daily products. In this study, we reported total urinary levels of bisphenol A, triclosan and 4 ... [more ▼]

Bisphenol A, triclosan and 4-nonylphenol are among the endocrine disruptors which are widely used in daily products. In this study, we reported total urinary levels of bisphenol A, triclosan and 4-nonylphenol, in order to evaluate the baseline contamination of a general population in Belgium. Bisphenol A and triclosan were detected in respectively 97.7% and 74.6% of the samples examined demonstrating that the general Belgian population is extensively exposed to both chemicals. On the other hand, 4-nonylphenol was not detected in any urine samples analyzed, suggesting either low exposure, inadequate biomarker, or that urine is an inappropriate biological matrix for assessing exposure to nonylphenol commercial mixtures. Geometric mean concentration was determined for bisphenol A at 2.55μg/l and for triclosan at 2.70μg/l. No significant difference was observed between levels and gender for both bisphenol A and triclosan. When classified by age, the 20-39year group showed the highest triclosan levels, while all age groups seemed to be similarly exposed to bisphenol A. Both bisphenol A and triclosan urinary levels were not correlated with creatinine excretion in our healthy population, questioning the relevance of the creatinine adjustment in reporting these chemical levels. Bisphenol A levels in urine of people living in the same home and collected on the same time were fairly correlated, confirming the assumption that dietary intake would be the primary route of exposure. Triclosan urinary levels were not correlated with bisphenol A levels. [less ▲]

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See detailValidation of the quantitative determination of tetrahydrocannabinol and its two major metabolites in plasma by UHPLC/MS-MS according to the total error approach
DUBOIS, Nathalie ULg; Paccau, A.; DE BACKER, Benjamin ULg et al

in Journal of Analytical Toxicology (2012), 36(1), 25-29

In Belgium, driving under the influence (DUI) of cannabis is prohibited and has severe legal consequences for the driver if the blood plasma concentration of Δ9-tetrahydrocannabinol (THC) exceeds 1 µg/L ... [more ▼]

In Belgium, driving under the influence (DUI) of cannabis is prohibited and has severe legal consequences for the driver if the blood plasma concentration of Δ9-tetrahydrocannabinol (THC) exceeds 1 µg/L. A method to quantify low concentrations of THC and its hydroxylated (THC-OH) and carboxylated (THC-COOH) metabolites in plasma was developed for DUI but also for other applications. Ultra-high-performance liquid chromatography coupled to mass spectrometry seems to be a very convenient method to combine fast chromatographic separation and good sensitivity. The method was validated according to total error approach. Chromatographic separation was achieved in a 3-min total run time. The limits of quantitation were lower or equal to 1 µg/L for all compounds. The linearity of the method was acceptable in the validated range of concentrations (from 0.5 to 50 µg/L for THC, from 0.9 to 50 µg/L for THC-OH and from 1.1 to 100 µg/L for THC-COOH). The biases were lower than 13%, and the relative standard deviations for repeatability and intermediate precision did not exceed 15%. Lower and upper β-expectation tolerance limits did not exceed the acceptance limits of 20% for concentrations higher than 2 µg/L for THC and THC-OH and higher than 4 µg/L for THC-COOH. The acceptance limits were 30% for THC and THC-OH concentrations lower than 2 µg/L and for THC-COOH concentrations lower than 4 µg/L. [less ▲]

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See detailEvaluation de la pharmacocinétique des opiacés lors des protocoles RODA
DUBOIS, Nathalie ULg

Scientific conference (2011, February)

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See detailDétermination de la composition de l'héroïne par UHPLC/MS-MS
DUBOIS, Nathalie ULg; CHARLIER, Corinne ULg

Conference (2010, June)

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See detailQuantitative determination of cannabinoids in serum by UHPLC/MS-MS
Dubois, Nathalie ULg; Paccou, A.; DE BACKER, Benjamin ULg et al

Poster (2010, April)

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See detailDosage par GC/QQQ de huit pesticides organochlorés dans le sérum
Dubois, Nathalie ULg; Elbaz, A.; Charlier, Corinne ULg

in Acta Clinica Belgica (2010), 65(1), 58-64

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See detailDosage des opiacés, cocaïne et amphéramines dans le sérum par UPLC/MSMS
Dubois, Nathalie ULg; Debrus, Benjamin ULg; Charlier, Corinne ULg

in Acta Clinica Belgica (2010), 65(1), 75-84

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See detailQuantitative Determination of eight organochlorine pesticides in serum by GC coupled to tandem mass spectrometry
Dubois, Nathalie ULg; Elbaz, E.; Charlier, Corinne ULg

in Acta Clinica Belgica (2010), 65(1), 58-64

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See detailInnovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material
De Backer, Benjamin ULg; Debrus, Benjamin ULg; Lebrun, Pierre ULg et al

in Journal of Chromatography. B : Analytical Technologies in the Biomedical & Life Sciences (2009), 877(32), 4115-4124

GC is commonly used for the analysis of cannabis samples, e.g. in forensic chemistry. However, as this method is based on heating of the sample, acidic forms of cannabinoids are decarboxylated into their ... [more ▼]

GC is commonly used for the analysis of cannabis samples, e.g. in forensic chemistry. However, as this method is based on heating of the sample, acidic forms of cannabinoids are decarboxylated into their neutral counterparts. Conversely, HPLC permits the determination of the original composition of plant cannabinoids by direct analysis. Several HPLC methods have been described in the literature, but most of them failed to separate efficiently all the cannabinoids or were not validated according to general guidelines. By use of an innovative methodology for modelling chromatographic responses, a simple and accurate HPLC/DAD method was developed for the quantification of major neutral and acidic cannabinoids present in cannabis plant material: Δ9-tetrahydrocannabinol (THC), THC-acid (THCA), cannabidiol (CBD), CBD-acid (CBDA), cannabigerol (CBG), CBG-acid (CBGA) and cannabinol (CBN). Δ8-tetrahydrocannabinol (∆8-THC) was determined qualitatively. Following the practice of design of experiments, predictive multilinear models were developed and used in order to find optimal chromatographic analytical conditions. The method was validated following an approach using accuracy profiles based on β-expectation tolerance intervals for the total error measurement, and assessing the measurements uncertainty. This analytical method can be used for diverse applications, e.g. plant phenotype determination, evaluation of psychoactive potency and control of material quality. [less ▲]

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See detailMéthadone - Détermination du délai entre le prélèvement et la consommation
Dubois, Nathalie ULg

Scientific conference (2009, December)

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