References of "DETRY, Olivier"
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See detailNiertransplantatie: de ingreep zelf
Detry, Olivier ULg; Bonnet, Pierre ULg; Meurisse, Michel ULg

in Horizon (1998), 70

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See detailLiver assist systems: state of the art.
Arkadopoulos, N.; Detry, Olivier ULg; Rozga, J. et al

in International Journal of Artificial Organs (1998), 21(12), 781-7

Attempts to develop liver support systems for the treatment of patients with liver failure have ranged from use of plasma exchange to utilization of charcoal columns and extracorporeal devices loaded with ... [more ▼]

Attempts to develop liver support systems for the treatment of patients with liver failure have ranged from use of plasma exchange to utilization of charcoal columns and extracorporeal devices loaded with liver tissue. However, no system has achieved wide clinical use and - in the absence of liver transplantation - severe hepatic failure continues to be associated with significant morbidity and mortality. In this paper, the authors review the current status of liver assist systems and summarize their clinical experience with a xenogeneic cell based-bioartificial liver. [less ▲]

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See detailDifferential display of gene expression in cerebral edema induced by fulminant hepatic failure
Margulies, J. E.; Detry, Olivier ULg; Rozga, J. et al

in Surgical Forum (1998), 45

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See detailTransplantation of hepatocytes for prevention of intracranial hypertension in pigs with ischemic liver failure
Arkadopoulos, N.; Chen, S. C.; Khalili, T. M. et al

in Cell Transplantation (1998), 7

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See detailComparison between Three- and Four-Element Windkessel Models to Characterize Vascular Properties of Pulmonary Circulation
Lambermont, Bernard ULg; Gérard, Paul ULg; Detry, Olivier ULg et al

in Archives of Physiology & Biochemistry (1997), 105(7), 625-32

In 11 anaesthetised pigs the accuracy of the three-element (WK3) and the four-element (WK4) Windkessel models to describe hemodynamic properties of the pulmonary circulation was compared during six ... [more ▼]

In 11 anaesthetised pigs the accuracy of the three-element (WK3) and the four-element (WK4) Windkessel models to describe hemodynamic properties of the pulmonary circulation was compared during six different experimental conditions increasing pulmonary arterial pressure: increase in left atrial pressure, increase in alveolar pressure, increase in pulmonary blood flow, endotoxin shock, mechanical obstruction of left pulmonary artery or histamine infusion. Our results showed that WK4 fitted better the data than did WK3 because values of 1-R2 decreased from 6 percent (WK3) to 1.4 percent (WK4) when WK4 was used (P < 0.0005). 1-R2 was an adequate marker of the accuracy of the linear regression used to solve equations of both models. Compliance values estimated by WK4 were decreased by 5% comparatively to WK3 (P = 0.008). However, this difference can be considered as not physiologically relevant. Values of characteristic resistance corresponding to R1 + (L/R2C) in WK4 and to R1 in WK3 were not different (P = 0.22). The relative changes in R1, R2, and C observed due to the different experimental conditions were comparable regardless of the model. In conclusion, the conversion of WK3 in WK4 by adding an inductance, whose physiological meaning is not clear, resulted in an increased statistical accuracy of the model, but did not seem to have relevant influence on parameters or their evolution during experimental conditions. [less ▲]

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See detailConsequences of Cold and Warm Ischemia on Pulmonary Mitochondrial Respiratory Function
Detry, Olivier ULg; Willet, K.; Lambermont, Bernard ULg et al

in Transplantation Proceedings (1997), 29(5), 2338-9

IN RECENT years, pulmonary transplantation has become the treatment of choice for several end-stage lung diseases, but remains limited by the scarcity of suitable donors and the lack of reliable prolonged ... [more ▼]

IN RECENT years, pulmonary transplantation has become the treatment of choice for several end-stage lung diseases, but remains limited by the scarcity of suitable donors and the lack of reliable prolonged method of lung preservation.1 Transplantation of lung 6 hours postharvest leads to an increased incidence of primary graft dysfunction, due in part to ischemic damage of pulmonary cell structure and metabolism, and to acute reperfusion injury. However, very little is known about the real mechanisms of pulmonary cell injuries before, during, and after lung transplantation. <br /> <br />During ischemia, the cytosolic and mitochondrial adenine nucleotide content falls,2,3 phospholipids are degraded, membrane permeabilities are increased, and the cytosolic levels of Na+, Ca2+ and phosphate are raised.4 Thus, cold and warm ischemia may induce cell dysfunctions and irreversible injuries responsible for necrosis. As mitochondia are believed to be the site of the determinants of irreversibility,5 the study of permanent oxidative phosphorylation damage after ischemia should be of great interest. <br /> <br />The aim of this present study was to investigate the consequences of warm and cold ischemia on the oxidative phosphorylation of isolated lung mitochondria [less ▲]

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See detailSuccessful Management of Acute Aortic Dissection in a Heart Transplant Recipient
Defraigne, Jean-Olivier ULg; Demoulin, J. C.; Detry, Olivier ULg et al

in Acta Chirurgica Belgica (1997), 97(3), 141-4

A case of type III aortic dissection which occurred fourteen months after heart transplantation is presented. Medical therapy was instituted to achieve controlled hypotension. The evolution was favorable ... [more ▼]

A case of type III aortic dissection which occurred fourteen months after heart transplantation is presented. Medical therapy was instituted to achieve controlled hypotension. The evolution was favorable and the patient could be discharged after one month. Hypertension and increased ejection fraction after transplantation could have been predisposing factors via an increase of the shear stress in the aorta. [less ▲]

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See detailSequential successful surgical management of extracranial internal carotid stenosis and ipsilateral intracranial aneurysm. Case reports.
Detry, Olivier ULg; Defraigne, Jean-Olivier ULg; Desiron, Quentin ULg et al

in Vascular Surgery (1997), 31

The coexistence of extracranial internal carotid stenosis and ipsilateral intracranial aneurysm is a rare event whose management is controversial. Theoretically, the correction of a significant stenosis ... [more ▼]

The coexistence of extracranial internal carotid stenosis and ipsilateral intracranial aneurysm is a rare event whose management is controversial. Theoretically, the correction of a significant stenosis of the extracranial internal carotid may lead to an increase in the downstream pressure in the intracranial carotid, and may consequently increase the risk of rupture of the ipsilateral aneurysm. Moreover, dramatic increase of blood pressure is not uncommon after carotid endarterectomy, and may promote aneurysmal rupture. Intracranial surgical correction of a hypoperfused aneurysm down to extracranial carotid stenosis should carry an increased risk of inadequate cerebral flow during procedure, and unspecific postoperative stimulation of platelets aggregation and coagulation may complete obstruction of a subtotal carotid stenosis. We report the cases of two patients successfully treated by a two-stage surgical procedure. In a first step, the intracerebral aneurysms were controlled and electively excluded by clipping. In a second step, carotid endarteriectomies were performed some days later without any neurological complications. Postoperative recoveries were uneventful and six months after these surgical procedures, clinical examination of both patients did not reveal any worsening of the preoperative neurological status. [less ▲]

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See detail"Pont a la transplantation" par ventricules pulsatiles de Pierce-Donachy (Thoratec)
Defraigne, Jean-Olivier ULg; DETRY, Olivier ULg; Chevolet, C. et al

in Revue Médicale de Liège (1997), 52(2), 110-5

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See detailComparison of results of carotid artery surgery after either direct closure or use of a vein patch.
Desiron, Quentin ULg; Detry, Olivier ULg; Van Damme, Hendrik ULg et al

in Cardiovascular Surgery (1997), 5(3), 295-303

In order to assess the benefit of vein patching versus direct closure after carotid endarterectomy, a series of 2271 carotid operations were analysed retrospectively. Apart from 114 procedures consisting ... [more ▼]

In order to assess the benefit of vein patching versus direct closure after carotid endarterectomy, a series of 2271 carotid operations were analysed retrospectively. Apart from 114 procedures consisting of saphenous vein bypass (n = 29) and eversion endarterectomy (n = 85), 2157 open endarterectomies were performed. They were closed either directly (n = 837) or using a vein patch (n = 1320). The combined mortality-major neurological morbidity rate was 1.7%, i.e. 1% mortality (0.2% neurological) and 0.7% permanent neurological morbidity (0.5% ipsilateral to the operated artery). Early symptomatic internal carotid thrombosis was documented in six cases (four following direct closure and two after vein patching). A total of 827 carotid arteries were followed up by duplex scanning on an annual basis (244 direct closure and 583 vein patching). The mean follow-up was 44 months; 69 months for direct closure and 35 months for vein patching. In direct closure, there were 21 stenoses (9%) and 10 occult thromboses (4%); in vein patching carotids, there were 17 stenoses (3%), nine thromboses (1.8%) [corrected] and six pseudoaneurysms (1%). Annual incidence of poor results was 2.4% in direct closure, and 0.87% in vein patching. The only other factor responsible for a significant difference was gender (3.4% in women versus 2.1% in men). In this retrospective study, vein patching appears to be beneficial for the prevention of acute postoperative thrombosis and late stenosis or thrombosis. [less ▲]

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See detailSelection of lumped parameter models to characterize vascular properties of pulmonary circulation
LAMBERMONT, Bernard ULg; GERARD, P; DETRY, Olivier ULg et al

in American Journal of Respiratory & Critical Care Medicine (1997), 2

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See detailA method to correct the shape of pressure waves obtained from pulmonary fluid-filled catheters
LAMBERMONT, Bernard ULg; GERARD, P; DETRY, Olivier ULg et al

in American Journal of Respiratory & Critical Care Medicine (1997), 2

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See detailAdvantages of Inferior Vena Caval Flow Preservation in Combined Transplantation of the Liver and Heart
Detry, Olivier ULg; Honore, Pierre ULg; Meurisse, Michel ULg et al

in Transplant International (1997), 10(2), 150-1

Only a few cases of combined liver and heart transplantation have been reported in the literature, and no standard surgical procedure has yet been established. We report the successful transplantation of ... [more ▼]

Only a few cases of combined liver and heart transplantation have been reported in the literature, and no standard surgical procedure has yet been established. We report the successful transplantation of both liver and heart in a 28-year-old patient suffering from homozygous beta-thalassemia. We used Belghiti's technique of inferior vena caval flow preservation for liver transplantation, which avoids inferior vena cava occlusion by a side-to-side caval anastomosis. Applied to combined liver and heart transplantation, preservation of caval flow during liver transplantation may allow early discontinuation of cardiopulmonary bypass and, thus, minimize the general consequences of prolonged bypass. [less ▲]

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See detailFatal Mural Endocarditis and Cutaneous Botryomycosis after Heart Transplantation
Defraigne, Jean-Olivier ULg; Demoulin, J. C.; Pierard, Gérald ULg et al

in American Journal of Dermatopathology (1997), 19(6), 602-5

Fatal mural endocarditis and botryomycosis occurred concurrently in a 62-year-old women 4 months after orthotopic heart transplantation. Subsequent to mild mitral regurgitation, infection developed on a ... [more ▼]

Fatal mural endocarditis and botryomycosis occurred concurrently in a 62-year-old women 4 months after orthotopic heart transplantation. Subsequent to mild mitral regurgitation, infection developed on a left atrial thrombus and was complicated by cerebral embolization. Simultaneously, skin nodules manifested on both forearms. Histologic examination revealed typical aspects of early evolving botryomycosis with massive infiltration of the dermis and hypodermis by necrotic granulomas framed by grains of Gram-positive coccoid forms. Bacteria were decorated by a nonspecific polyclonal antibody to Mycobacterium bovis. [less ▲]

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See detailTransplantation combinée du foie et du coeur chez un patient souffrant de thalassémie majeure
Detry, Olivier ULg; Defechereux, Thierry ULg; Honore, Pierre ULg et al

in Revue Médicale de Liège (1997), 52(8), 532-4

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See detailHepatocyte transplantation in anhepatic rats: effect on survival, blood chemistry and growth factor profile
Khalili, T.; Arkadopoulos, N.; Detry, Olivier ULg et al

in Surgical Forum (1997), 44

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See detailHepatocyte transplantation prolongs survival and prevent development of brain edema in pigs with ischemic liver failure
Arkadopoulos, N.; Chen, S.; Khalili, T. et al

in Surgical Forum (1997), 44

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See detailWhat Is the Risk of Transferral of an Undetected Neoplasm During Organ Transplantation?
Detry, Olivier ULg; Bonnet, Pierre ULg; Honore, Pierre ULg et al

in Transplantation Proceedings (1997), 29(5), 2410-1

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See detailAcute Diverticulitis in Heart Transplant Recipients
Detry, Olivier ULg; Defraigne, Jean-Olivier ULg; Meurisse, Michel ULg et al

in Transplant International (1996), 9(4), 376-9

Immunosuppressed patients are susceptible to complicated diverticulitis, but reports of this complication are scarce in heart graft recipients. To estimate the prevalence of acute diverticulitis in heart ... [more ▼]

Immunosuppressed patients are susceptible to complicated diverticulitis, but reports of this complication are scarce in heart graft recipients. To estimate the prevalence of acute diverticulitis in heart graft recipients, we retrospectively reviewed the cases of diverticulitis in a series of 143 patients who underwent orthotopic heart transplantation in a period of 10 years. Six (4%) of these developed acute diverticulitis and required colectomy. All of them were male patients and were older than 50 years. Four patients underwent urgent laparotomy and colon resection with end colostomy (Hartmann procedure). The two other patients suffered from diverticulitis without generalized peritonitis and underwent laparoscopic sigmoidectomy with direct transanal end-to-end anastomosis. The postoperative outcomes of these six patients were satisfactory. As are other immunosuppressed patients, heart graft recipients are susceptible to diverticulitis. Early surgical management may be safe in well-compensated patients. [less ▲]

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