References of "DELWAIDE, Jean"
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See detailMycophenolate mofetil monotherapy in stable liver transplant recipients with progressive renal failure
Detry, Olivier ULg; De Roover, Arnaud ULg; Honore, Pierre ULg et al

in Transplantation Proceedings (2002), 34(3), 782-783

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See detailDiagnostic et traitement du syndrome hépatorénal
Gielen, Sabine; Delwaide, Jean ULg; Detry, Olivier ULg et al

in Médecine et Hygiène (2002), 60

Le syndrome hépatorénal (SHR) est une insuffisance rénale propre au patient porteur d’une hépatopathie chronique à un stade avancé. Le mécanisme physiopathologique, encore imparfaitement connu, associe ... [more ▼]

Le syndrome hépatorénal (SHR) est une insuffisance rénale propre au patient porteur d’une hépatopathie chronique à un stade avancé. Le mécanisme physiopathologique, encore imparfaitement connu, associe une vasoconstriction rénale à une vasodilatation splanchnique. Aucun examen n’est spécifique au SHR qui reste ainsi un diagnostic d’exclusion. Le pronostic du SHR est très sombre, l’évolution spontanée étant presque toujours fatale en moyenne dans le mois du diagnostic. La transplantation hépatique représente le traitement idéal mais est d’application limitée étant donné la courte survie des patients. Depuis peu, un traitement médical combinant un vasoconstricteur splanchnique, la terlipressine, et un expanseur plasmatique, l’albumine, donne des résultats favorables, permettant au patient de survivre jusqu’à la transplantation hépatique. [less ▲]

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See detailApproche diagnostique d'une élévation des transaminases
Delwaide, Jean ULg; Delfosse, V.; Detry, Olivier ULg

in Patient Care (2002), 18(2), 10-16

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See detailAbsolute and relative contraindications to liver transplantation. A perpetually moving frontier.
Detry, Olivier ULg; De Roover, Arnaud ULg; Delwaide, Jean ULg et al

in Acta Gastro-Enterologica Belgica (2002), 65(2), 133-4

In this paper the authors discussed the absolute and relative contraindications to liver transplantation. These contraindications are not fixed, and may change with medical progress and experience ... [more ▼]

In this paper the authors discussed the absolute and relative contraindications to liver transplantation. These contraindications are not fixed, and may change with medical progress and experience. Certainly, the recent advent of adult-to-adult living related liver transplantation may somehow change the management of patients with relative contra-indications to cadaveric liver transplantation, as they may be potential candidates for living related liver transplantation. [less ▲]

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See detailGastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome.
De Leval, Laurence ULg; Hardy, Noelle; Deprez, Manuel ULg et al

in Virchows Archiv : An International Journal of Pathology (2002), 441(5), 462-5

We report a unique case of a gastric collision tumor composed of an intramural gastrin-secreting tumor and a papillotubular adenocarcinoma of the intestinal type discovered at autopsy in a patient with ... [more ▼]

We report a unique case of a gastric collision tumor composed of an intramural gastrin-secreting tumor and a papillotubular adenocarcinoma of the intestinal type discovered at autopsy in a patient with Zollinger-Ellison syndrome. There was extensive metastatic dissemination of the neuroendocrine component to regional lymph nodes and to the liver. The unusual macroscopical, histological, and immunohistochemical features of this case and its specific clinical setting are discussed. [less ▲]

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See detailRisk factors for hepatitis C: past, present and future
Delwaide, Jean ULg; Bourgeois, N.; Colle, I. et al

in Acta Gastro-Enterologica Belgica (2002), 65(2), 87-89

Patients at risk for hepatitis C (HCV) are those exposed to a major risk factor (i.e. blood transfusion prior 1990, and intravenous drug abuse), and those exposed to a minor risk factor (sexual, mother-to ... [more ▼]

Patients at risk for hepatitis C (HCV) are those exposed to a major risk factor (i.e. blood transfusion prior 1990, and intravenous drug abuse), and those exposed to a minor risk factor (sexual, mother-to-infant transmission, household contact, nosocomial contamination). The present paper aims to review the current and past modes of transmission of the virus C. [less ▲]

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See detailEconomic evaluation of chronic hepatitis C treatment by interferon-ribavirin combination therapy in Belgium
Delwaide, Jean ULg

in Acta Gastro-Enterologica Belgica (2002), 65(4), 233-236

With present treatments for chronic hepatitis C by the combination of interferon alpha and ribavirin, it is possible to obtain a sustained viral response in a large number of patients. This viral response ... [more ▼]

With present treatments for chronic hepatitis C by the combination of interferon alpha and ribavirin, it is possible to obtain a sustained viral response in a large number of patients. This viral response is associated with long-term disappearance of the C virus, improvement of histology, improvement in quality of life and, most than likely, a reduction in the risk of premature death or infection-linked complications. This therapy is, however, expensive and the number of potentially treatable patients is high in view of the relatively high prevalence of the disease in the population. An economic evaluation is thus indispensable in order, on the one hand, to assess the cost-effectiveness ratio of the treatment (i.e. the extra cost to be paid for obtaining the greater effectiveness provided by the therapeutic combination in comparison with absence of treatment or treatment by interferon alone), and, on the other hand, to estimate practically the global cost of treatment for Belgium (i.e. the annual expense for society according to the number of patients treated per year). [less ▲]

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See detailA case of hepatic alveolar echinococcosis contracted in Belgium
Delbecque, Katty ULg; Detry, Olivier ULg; Hayette, Marie-Pierre ULg et al

in Acta Gastro-Enterologica Belgica (2002), 65(1, Jan-Mar), 55-60

We report herein the case of a Belgian 76-year-oId woman who developed a hepatic tumour suspected to be a breast cancer metastasis. Radiological imaging and guided biopsies were not contributive. The ... [more ▼]

We report herein the case of a Belgian 76-year-oId woman who developed a hepatic tumour suspected to be a breast cancer metastasis. Radiological imaging and guided biopsies were not contributive. The patient underwent an explorative laparoscopy with frozen sections that did not provide further diagnosis, and an open left bisegmentectomy was performed during the same anaesthesia. Histopathological examination of the hepatic mass showed Echinococcus multilocularis metacestodes, demonstrating alveolar echinococcosis. As our patient denied any travel in foreign countries and has undergone regular abdominal ultrasonographies since her mastectomy, it is highly likely that this alveolar echinococcosis had been contracted in Belgium. If some imported cases may be seldom managed in Belgium, to our knowledge, this case is the first occurrence of alveolar echinococcosis contracted in Belgium. This report, added to the demonstration of E. multilocaris infection of 50% of red foxes in Southern Belgium, and the potential infection of domestic cats and dogs, should attract attention of the medical community on the possible outbreak of endemic alveolar echinococcosis in Belgium, and on the related public health concerns. [less ▲]

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See detailDiagnostisch beleid bij verhoogde transaminasenspiegels
Delwaide, Jean ULg; Delfosse, V.; Detry, Olivier ULg et al

in Patient Care (Nederlandse Editie) (2001), 28(11), 33-41

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See detailLe deficit en alpha-1 antitrypsine. Une indication de transplantation hepatique pediatrique
De Roover, Arnaud ULg; Detry, Olivier ULg; Honore, Pierre ULg et al

in Revue Médicale de Liège (2001), 56(11), 753-8

Alpha-1-antitrypsin deficiency is the most common inborn error of metabolism leading to liver transplantation, and the second cause of liver transplantation in children after biliary atresia. The authors ... [more ▼]

Alpha-1-antitrypsin deficiency is the most common inborn error of metabolism leading to liver transplantation, and the second cause of liver transplantation in children after biliary atresia. The authors report the case of a 6-year-old girl, who was suffering from end-stage liver disease secondary to alpha-1-antitrypsin deficiency. She was successfully treated by whole liver transplantation, the hepatic graft coming from a 3-year-old donor. Three months later she went back to school. The authors discuss the pathogenesis and the natural history of this frequent cause of liver transplantation in children. [less ▲]

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See detailOne year experience of the Belgian Liver Intestine Comittee (BLIC) intranet database
Lerut, Jan; Roggen, F.; De Hemptinne, Bernard et al

in Acta Gastro-Enterologica Belgica (2001, January), 64(1), 7

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See detailLiver transplantation for hepatitis B virus infection: improving long-term outcomes
Detry, Olivier ULg; Delwaide, Jean ULg

in Medscape Transplantation (2001)

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See detailComment je traite une ascite
Gielen, S.; Delwaide, Jean ULg; Detry, Olivier ULg et al

in Revue Médicale de Liège (2001), 56(12), 809-815

Ascites is the most common of the major complications of cirrhosis. The initial evaluation of a patient with ascites should include a history, physical evaluation and some investigations. Treatment should ... [more ▼]

Ascites is the most common of the major complications of cirrhosis. The initial evaluation of a patient with ascites should include a history, physical evaluation and some investigations. Treatment should consist of treating the underlying liver disease, sodium restricted diet (2 g of Na+/day) and diuretics. This regimen is effective in 90 % of patients. The treatment options for the diuretic-resistant patients include serial therapeutic paracentesis, peritoneovenous shunting, TIPSand liver transplantation. The treatment and prophylaxis of spontaneous bacterial peritonitis which is a frequent and severe complication in cirrhotic patients with ascites is also important. The differential diagnosis with secondary bacterial peritonitisis is essential because the latter usually does not resolve unless patients are surgically treated. [less ▲]

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See detailFactors inftuencing ribavirin-induced hemolysis
Van Vlierberghe, H.; Delanghe, J. R.; De Vos, M. et al

in Journal of Hepatology (2001), 34

BackgroundlAims: One of the major side eft'ects of the combination therapy for chronic hepatitis C is ribavirininduced hemolytic anemia. Little is known about variables inftuencing tbis anemia. Our study ... [more ▼]

BackgroundlAims: One of the major side eft'ects of the combination therapy for chronic hepatitis C is ribavirininduced hemolytic anemia. Little is known about variables inftuencing tbis anemia. Our study tried to search for these variables in a large group of patients with hepatitis C treated with the combination therapy. Methods: Two hundred and forty-four patients chronically infected with the hepatitis C virus were treated either with induction treatment (daily dose ofinterferon) or with a standard treatment (interferon thrice weekly). Both groups received 1000-1200 mg of ribavirin from week 4 until the end of the treatment. The drop in hemoglobin level was defined as the dift'erence between the pretreatment hemoglobin level and the hemoglobin level at week 8. Seventeen variables which could possibly influencê'this drop in hemoglobin level were examined. Results: After multivariate analysis, the drop in hemoglobin level was only significant influenced by pretreatment platelet level, treatment and haptoglobin phenotype. The ribavirin dose did not influence the drop in hemoglobin level or the early virological response. Conclusions: Ribavirin-induced hemolysis is inftuenced by the pretreatment platelet level, the administered amount of a-interferon and the haptoglobin phenotype. A careful search for the minimal dose of ribavirin needed in combination treatment is necessary. [less ▲]

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See detailClinical biliary complications after adult liver transplantation: a prospective study
Detry, Olivier ULg; Maweja, Sylvie ULg; Delwaide, Jean ULg et al

in Acta Gastro-Enterologica Belgica (2000, March), 63(1), 56

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See detailL'image du mois. Thrombose de la veine porte
Ancion, G.; Delwaide, Jean ULg; Boverie, Jacques ULg

in Revue Médicale de Liège (2000), 55(8), 761-762

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See detailEvidence-Based Medicine: traitement de l'hépatite chronique C. GLEVHE. Groupe Liégeois d'Etude des Virus Hépatotropes.
Delwaide, Jean ULg; Gerard, Christiane ULg; Belaiche, Jacques ULg et al

in Revue Médicale de Liège (2000), 55(5), 337-340

The Hepatitis C virus (HCV) infects nearly 170 million people in the world. The major characteristic of virus C is its tendency to chronicity in more than 85% of cases. Generally asymptomatic, HCV ... [more ▼]

The Hepatitis C virus (HCV) infects nearly 170 million people in the world. The major characteristic of virus C is its tendency to chronicity in more than 85% of cases. Generally asymptomatic, HCV infection may also evolve with time to cirrhosis and hepatocellular carcinoma. During the last few years, HCV-related end-stage cirrhosis has become the first cause of liver transplantation. In 10 years only, very significant progress has been made in the knowledge of the virus, not only in the field of diagnosis but also in therapy. Several consensus conferences taking last discoveries into account have been organized in order to promote recommendations useful for the management of hepatitis C patients. The aim of this short overview is to summarize practical recommendations that emerged recently from consensus meetings. [less ▲]

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