References of "DELVENNE, Philippe"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailThe cross-talk between dendritic and regulatory T cells: good or evil?
Hubert, Pascale ULg; Jacobs, Nathalie ULg; Caberg, Jean-Hubert ULg et al

in Journal of Leukocyte Biology (2007), 82(4), 781-94

Immune responses against pathogens require fine regulation in order to avoid excessive inflammation, which could be harmful to the host. Moreover, the immune system must be tolerant to non-pathogenic ... [more ▼]

Immune responses against pathogens require fine regulation in order to avoid excessive inflammation, which could be harmful to the host. Moreover, the immune system must be tolerant to non-pathogenic antigens in order to prevent allergy, autoimmunity and transplant rejection. There is accumulating evidence that interactions between dendritic cells (DC) and regulatory T (Treg) cells play a crucial role in the balance between immune response and tolerance. Communications between these cells are complex, bi-directional and mediated by soluble or cell surface molecules. The maturation status of DC, which may be influenced by different microenvironmental factors, is considered as an important checkpoint for the induction of peripheral tolerance through modifications of the activation status of T cells. Moreover, several lines of experimental evidence suggest that different subsets or the functional status of DC are also involved in the promotion of Treg cell differentiation. A better knowledge of the regulatory mechanisms of the immune response induced or inhibited by DC via their interactions with Treg cells could be relevant for the development of new immunotherapeutic approaches. [less ▲]

Detailed reference viewed: 68 (13 ULg)
Full Text
Peer Reviewed
See detailNK CELLS AND NKG2D LIGANDS IN HPV-ASSOCIATED CERVICAL CANCER
Jacobs, Nathalie ULg; Renoux, Virginie ULg; Dortu, Estelle ULg et al

Poster (2007, April 12)

Detailed reference viewed: 30 (3 ULg)
Full Text
Peer Reviewed
See detailLe cancer du col de l'utérus: du virus au traitement
Delvenne, Philippe ULg; Goffin, Frédéric ULg; Kridelka, Frédéric ULg et al

in Revue Médicale de Liège (2007), 62(S1)

Squamous cell cancer of the uterine cervix is associated with a high morbidity and mortality worldwide and in Belgium. New therapeutic approaches have been recently proposed. The development of this ... [more ▼]

Squamous cell cancer of the uterine cervix is associated with a high morbidity and mortality worldwide and in Belgium. New therapeutic approaches have been recently proposed. The development of this cancer is related to the infection by oncogenic human papillomavirus (HPV) types. The link between cervical cancer and HPV has, in recent years, generated, a great interest for studies aiming to better understand the role of the immune system in the control of these infections and for the development of prophylactic anti-HPV vaccines. [less ▲]

Detailed reference viewed: 173 (25 ULg)
Full Text
Peer Reviewed
See detailRole of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix
Delvenne, Philippe ULg; Herman, Ludivine ULg; Kholod, Natalia et al

in Molecular & Cellular Endocrinology (2007), 264(1-2), 1-5

If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells ... [more ▼]

If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the induction of squamous metaplasia in the transformation zone of the cervix, interactions between steroid hormones and HPV gene expression and alterations of the local immune microenvironment. [less ▲]

Detailed reference viewed: 47 (10 ULg)
Full Text
Peer Reviewed
See detailDefensis induce the recruitment of dendritic cells in cervical human papillomavirus-associated (pre)neoplastic lesions formed in vitro and transplanted in vivo
Hubert, Pascale ULg; Herman, Ludivine ULg; Maillard, Catherine ULg et al

in FASEB Journal (2007), 21(11), 2765-75

In addition to their direct antimicrobial activity, defensins might also influence adaptive immunity by attracting immature dendritic cells (DC). As these cells have been shown to be deficient in uterine ... [more ▼]

In addition to their direct antimicrobial activity, defensins might also influence adaptive immunity by attracting immature dendritic cells (DC). As these cells have been shown to be deficient in uterine cervix carcinogenesis, we evaluated the ability of -defensin (HNP-2, human neutrophil defensin 2) and ß-defensin (HßD2, human beta defensin 2) to stimulate their migration in human papillomavirus (HPV)-associated (pre)cancers. We first observed, using RT-PCR and immunohistology, that HßD2 is absent in HPV-transformed keratinocytes and that it is weakly expressed in cervical (pre)neoplastic lesions in comparison with normal keratinocytes. We next demonstrated that defensins exert a chemotactic activity for DC in a Boyden Chamber assay and stimulate their infiltration in an in vitro-formed (pre)neoplastic epithelium (organotypic culture of HPV-transformed keratinocytes). To evaluate the ability of defensins also to recruit DC in vivo, we developed a model of immunodeficient mice grafted with organotypic cultures of HPV+ keratinocytes, which form an epithelium similar to a high-grade neoplastic lesion, with tumoral invasion and neovascularization. Intravenously injected human DC were able to infiltrate grafts of HPV+ keratinocytes after administration of HNP-2 in the transplantation chamber. Taken together, these results suggest that defensins could reverse a frequent immune alteration observed in cancer development. [less ▲]

Detailed reference viewed: 55 (19 ULg)
Full Text
See detailExperimental models/cell model: organotypic cultures
Jacobs, Nathalie ULg; Delvenne, Philippe ULg

Conference (2007)

Detailed reference viewed: 19 (0 ULg)
Full Text
Peer Reviewed
See detailPerspective de vaccination contre les papillomavirus humains et conséquences pour le dépistage du cancer du col de l'utérus
Delvenne, Philippe ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2007), 162(10-12), 483-8

Detailed reference viewed: 11 (1 ULg)
Full Text
Peer Reviewed
See detailDendritic Cells: More Than Just Adaptive Immunity Inducers?
Jacobs, Nathalie ULg; Boniver, Jacques ULg; Hubert, Pascale ULg et al

in Current Immunology Reviews (2007), 2

Dendritic cells (DC) are well known for their capacity to induce immune responses and there is also accumulating evidence of their ability to interact with various cell types of the innate system, such as ... [more ▼]

Dendritic cells (DC) are well known for their capacity to induce immune responses and there is also accumulating evidence of their ability to interact with various cell types of the innate system, such as NK, NKT or TCR gamma-delta cells. These interactions are bi-directional, mediated by soluble or cell surface molecules and have been mainly described in the context of immune responses to infectious agents and tumors. NK, NKT or TCR gamma-delta cells induce the maturation of DC, as shown by the increased expression of CD86, IL12 production and priming of T cell responses. On the other hand, mature DC have the ability to activate NK, NKT or TCR gamma-delta cells for sustained innate immune responses and activated NK cells may kill immature DC. In addition, DC and NK or TCR gamma-delta cells share similar functions such as cytotoxic and antitumor activity, interferon production and antigen presentation capacity. [less ▲]

Detailed reference viewed: 35 (7 ULg)
Full Text
Peer Reviewed
See detailL'image du mois. Oesophagite infectieuse majeure mise en evidence par tomodensitometrie thoracique
Henroteaux, A.; Hoyoux, M.; Ghaye, Benoît ULg et al

in Revue Médicale de Liège (2006), 61(12), 793-4

Detailed reference viewed: 65 (2 ULg)
Full Text
Peer Reviewed
See detailAnti-HPV vaccination : perspectives and potential consequences for the screening of cervical cancer
Delvenne, Philippe ULg

in Annales de Pathologie (2006), 26(Sp. Iss. 1), 41-42

Detailed reference viewed: 25 (3 ULg)
Full Text
Peer Reviewed
See detailPericardite aspergillaire avec tamponnade cardiaque et syndrome hemophagocytaire: un cas non classique d'immunodeficience
Delcroix, Geoffrey ULg; Vanstraelen, G.; Hustinx, Roland ULg et al

in Revue Médicale de Liège (2006), 61(10), 713-8

We report the case of a 31-year-old woman who died in a context of haemophagocytic syndrome with multiple opportunist infections:viral, mycobacterial and fungal. To our knowledge, this is the tenth case ... [more ▼]

We report the case of a 31-year-old woman who died in a context of haemophagocytic syndrome with multiple opportunist infections:viral, mycobacterial and fungal. To our knowledge, this is the tenth case of invasive aspergillosis manifested by an aspergillus pericarditis with cardiac tamponade. Search for HIV infection, neoplasia, haematological malignancies was negative. In addition, the patient carried on a nonviral, non-ethylic cirrhosis, the etiology of which remained unknow. We will particularly develop the aspergillus pericarditis with cardiac tamponade and the haemophagocytic syndrome. [less ▲]

Detailed reference viewed: 125 (11 ULg)
Full Text
Peer Reviewed
See detailProduction of large numbers of Langerhans' cells with intraepithelial migration ability in vitro
Hubert, Pascale ULg; Bousarghin, Latifa; Greimers, Roland ULg et al

in Experimental Dermatology (2005), 14(6), 469-477

Detailed reference viewed: 19 (5 ULg)
Full Text
Peer Reviewed
See detailAltered expression of type I insulin-like growth factor receptor in Crohn's disease
El Yafi, F.; Winkler, Rose ULg; Delvenne, Philippe ULg et al

in Clinical & Experimental Immunology (2005), 139(3), 526-533

The fibrotic and antiapoptotic effects of insulin-like growth factors (IGF) are mediated by type I IGF receptor (IGF-1R). IGFs could play a role in intestinal stricturing and in the maintenance of ... [more ▼]

The fibrotic and antiapoptotic effects of insulin-like growth factors (IGF) are mediated by type I IGF receptor (IGF-1R). IGFs could play a role in intestinal stricturing and in the maintenance of inflammation in Crohn's disease (CD). We aimed to describe IGF-1R expression in CD intestinal lesions, to compare it to other intestinal inflammatory diseases and to correlate it with fibrosis and apoptosis. IGF-1R expression and apoptosis (active caspase-3) were studied by immunohistochemistry. Surgical intestinal specimens [17 CD, nine controls, six diverticulitis and four ulcerative colitis (UC)] were used. IGF-1R was expressed transmurally mainly by inflammatory cells (IC) and smooth muscle cells, both in diseased intestine and controls. IGF-1R positive IC were increased in the mucosa and the submucosa of CD (P < 0.007), and in involved areas compared to uninvolved areas (P = 0.03). In UC, the number of IGF-1R positive IC was only increased in the mucosa, and was not different from controls in the submucosa. In diverticulitis, the number of IGF-1R positive IC did not differ from controls. In CD submucosa, IGF-1R expression in IC was inversely correlated with apoptosis in uninvolved areas (P = 0.01). Expression of IGF-1R in submucosal fibroblast-like cells, subserosal adipocytes and hypertrophic nervous plexi was specific for CD. We have shown a transmural altered expression of IGF-1R in CD. This may suggest a role for IGF-1R in the maintenance of chronic inflammation and stricture formation in CD. [less ▲]

Detailed reference viewed: 14 (1 ULg)