Variation of PTH and bone biomarkers in hemodialysis patients.
DELANAYE, Pierre ; ; et al
Poster (2015)Detailed reference viewed: 6 (4 ULg)
Guidelines about CKD classification: a provocative point of view
Conference (2015)Detailed reference viewed: 4 (0 ULg)
Renal function assessment. Techniques, clinical applications, populations, limitations.
Scientific conference (2015)Detailed reference viewed: 2 (0 ULg)
Place de la vitamine D native dans le traitement des patients dialysés
Conference given outside the academic context (2015)Detailed reference viewed: 6 (2 ULg)
Pourquoi et comment corriger les anomalies de la PTH ?
Conference given outside the academic context (2015)Detailed reference viewed: 3 (0 ULg)
Rituximab (MabThera®) : nouveau médicament dans les vascularites associées à ANCA
VON FRENCKELL, Christian ; DELANAYE, Pierre
in Revue Médicale de Liège (2015), 70(2), 92-100Detailed reference viewed: 13 (1 ULg)
Exploration de la fonction glomérulaire rénale : estimation du débit de filtration glomérulaire
; DELANAYE, Pierre ;
in Néphrologie & Thérapeutique (2015), 11(1), 54-67Detailed reference viewed: 4 (0 ULg)
An Age-Calibrated Classification of Chronic Kidney Disease.
; DELANAYE, Pierre ;
in JAMA : Journal of the American Medical Association (2015), 314(6), 559-560Detailed reference viewed: 12 (2 ULg)
Safety of living kidney donation: another brick in the wall…and a solid (physiologic) one.
DELANAYE, Pierre ; ;
in American Journal of Kidney Diseases (2015), 66(1), 1-3Detailed reference viewed: 5 (1 ULg)
The myth of the future burden of CKD in United States.
DELANAYE, Pierre ; ;
in American Journal of Kidney Diseases (2015), 66(1), 171-172Detailed reference viewed: 6 (1 ULg)
Glomerular Filtration Rate and Aging: Another Longitudinal Study--A Long Time Coming!
DELANAYE, Pierre ;
in Nephron (2015), 131(1), 1-4Detailed reference viewed: 2 (0 ULg)
Abnormal glomerular filtration rate in children, adolescents and young adults starts below 75 mL/min/1.73 m2
; ; DELANAYE, Pierre
in Pediatric Nephrology : Journal of the International Pediatric Nephrology Association (2015), 30(5), 821-828Detailed reference viewed: 17 (1 ULg)
KDIGO Guidelines and Kidney Transplantation: Is the cystatin-C Based Recommendation relevant?
; ; CAVALIER, Etienne et al
in American Journal of Transplantation (2015), 15(8), 2211-4
The KDIGO guidelines propose a new approach to diagnose chronic kidney disease (CKD) based on estimated glomerular ®ltration rate (GFR). In patients with a GFR value comprised between 45 and 59 mL/ min/1 ... [more ▼]
The KDIGO guidelines propose a new approach to diagnose chronic kidney disease (CKD) based on estimated glomerular ®ltration rate (GFR). In patients with a GFR value comprised between 45 and 59 mL/ min/1.73m2 as estimated by the CKD-EPI creatinine equation (eGFRcreat), it is suggested to con®rm the diagnosis with a second estimation using the CKD-EPI cystatin C-based equations (eGFRcys/eGFRcreat-cys). We sought to determine whether this new diagnostic strategy might extend to kidney transplant recipients (KTR) and help to identify those with decreased GFR. In 670 KTR for whom a measured GFR was available, we simulated the detection of CKD using the two-steps approach recommended by the guidelines in comparison to the conventional approach relying on creatinine equation. One hundred forty-®ve patients with no albuminuria had eGFRcreat between 45 and 59 mL/ min/1.73m2. Among them, 23% had inulin clearance over 60 mL/min/1.73m2 and were thus incorrectly classi®ed as CKD patients. When applying the Kidney Disease: Improving Global Outcomes (KDIGO) strategy, 138 patients were con®rmed as having a GFR below 60 mL/min with eGFRcreat-cys. However, 21% of them were misclassi®ed in reference to measured GFR. Our data do no not support the use of cystatin C as a con®rmatory test of stage 3A CKD in KTR. [less ▲]Detailed reference viewed: 23 (4 ULg)
Critical care and vitamin D status assessment: What about immunoassays and calculated free 25OH-D?
ROUSSEAU, Anne-Françoise ; DAMAS, Pierre ; JANSSENS, Marc et al
in Clinica Chimica Acta (2014), 437Detailed reference viewed: 18 (1 ULg)
Systematic Analysis of two cystatin C assays using samples of 2057 older adults - The Berlin initiative study
; DELANAYE, Pierre ; et al
Poster (2014, November)Detailed reference viewed: 21 (3 ULg)
Impact of the dialysis membrane on the Vitamin D metabolims markers
CAVALIER, Etienne ; DUBOIS, Bernard ; et al
Poster (2014, November)Detailed reference viewed: 16 (3 ULg)
Calibration and precision of serum creatinine and plasma cystatin C measurement: impact on the estimation of glomerular filtration rate
DELANAYE, Pierre ; CAVALIER, Etienne ; et al
in Journal of Nephrology (2014), 27(5), 467-75
Serum creatinine (SCr) is the main variable for estimating glomerular filtration rate (GFR). Due to interassay differences, the prevalence of chronic kidney disease (CKD) varies according to the assay ... [more ▼]
Serum creatinine (SCr) is the main variable for estimating glomerular filtration rate (GFR). Due to interassay differences, the prevalence of chronic kidney disease (CKD) varies according to the assay used, and calibration standardization is necessary. For SCr, isotope dilution mass spectrometry (IDMS) is the gold standard. Systematic differences are observed between Jaffe and enzymatic methods. Manufacturers subtract 0.30 mg/dl from Jaffe results to match enzymatic results (‘compensated Jaffe method’). The analytical performance of enzymatic methods is superior to that of Jaffe methods. In the original Modification of Diet in Renal Disease (MDRD) equation, SCr was measured by a Jaffe Beckman assay, which was later recalibrated. A limitation of this equation was an underestimation of GFR in the high range. The Chronic Kidney Disease Epidemiology (CKD-EPI) consortium proposed an equation using calibrated and IDMS traceable SCr. The gain in performance was due to improving the bias whereas the precision was comparable. The CKD-EPI equation performs better at high GFR levels (GFR[60 ml/ min/1.73 m2). Analytical limitations have led to the recommendation to give a grade ([60 ml/min/1.73 m2) rather than an absolute value with the MDRD equation. By using both enzymatic and calibrated methods, this cutoff-grade could be increased to 90 ml/min/1.73 m2 (with MDRD) and 120 ml/min/1.73 m2 (with CKD-EPI). The superiority of the CKD-EPI equation over MDRD is analytical, but the precision gain is limited. IDMS traceable enzymatic methods have been used in the development of the Lund– Malmo¨ (in CKD populations) and Berlin Initiative Study equations (in the elderly). The analytical errors for cystatin C are grossly comparable to issues found with SCr. Standardization is available since 2011. A reference method for cystatin C is still lacking. Equations based on standardized cystatin C or cystatin C and creatinine have been proposed. The better performance of these equations (especially the combined CKD-EPI equation) has been demonstrated. [less ▲]Detailed reference viewed: 29 (5 ULg)