References of "DELANAYE, Pierre"
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See detailAcetylcysteine and enzymatic creatinine: take care for interference!
Lognard, Michaël ULg; Cavalier, Etienne ULg; Chapelle, Jean-Paul ULg et al

in Acta Clinica Belgica (2007), 62(6), 462-462

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See detailThe RIFLE criteria: are the foundations robust?
Delanaye, Pierre ULg; Krzesinski, Jean-Marie ULg; Cavalier, Etienne ULg et al

in Critical Care Medicine (2007), 35(11), 26692669-70

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See detailAnalytical validation of the new version of the Liaison N-Tact PTH assay
Cavalier, Etienne ULg; Delanaye, Pierre ULg; Carlisi, Agnès et al

in Clinical Chemistry & Laboratory Medicine (2007), 45(1), 105-107

We performed analytical validation of the new version of the Liaison N-Tact PTH (parathormone) assay according to NCCLS guidelines and compared this new generation of reagent with the Roche Elecsys PTH ... [more ▼]

We performed analytical validation of the new version of the Liaison N-Tact PTH (parathormone) assay according to NCCLS guidelines and compared this new generation of reagent with the Roche Elecsys PTH assay. We showed that this new version is a sensitive and precise method with good recovery. Significant carryover was observed, but with limited clinical implications. We demonstrated that the new version of the Liaison PTH is in reasonably good agreement with the Roche Elecsys PTH assay, and as we observed no differences in a hemodialyzed population, moving from one method to the other should not affect the daily follow-up of patients. However, one should be cautious with the highest values (> 500 pg/mL). We established reference intervals of 12-54 pg/mL for the Liaison and 14-52 pg/mL for the Elecsys assay. [less ▲]

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See detailRenal extraction of cystatin C
Delanaye, Pierre ULg; Cavalier, Etienne ULg; Chapelle, Jean-Paul ULg et al

in Nephrology Dialysis Transplantation (2006), 21(11), 3333-3333

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See detailVALIDATION ANALYTIQUE DE LA TROUSSE OCTEIA 25-HYDROXYVITAMINE D (IDS).
Cavalier, Etienne ULg; Levaux, Laetitia ULg; Carlisi, Ignazia ULg et al

in Immuno-Analyse & Biologie Spécialisée [=IBS] (2006, October)

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See detailPTH oxidation after a session of hemodialyze: myth or reality?
Cavalier, Etienne ULg; Delanaye, Pierre ULg; Carlisi, Ignazia ULg et al

in Immuno-Analyse & Biologie Spécialisée [=IBS] (2006, October)

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See detailConfirmation of high cytokine clearance by hemofiltration with a cellulose triacetate membrane with large pores: an in vivo study
Delanaye, Pierre ULg; Lambermont, Bernard ULg; Dogné, Jean-Michel ULg et al

in International Journal of Artificial Organs (2006), 29(10), 944-948

Objective: To confirm in vivo the hypothesis that hemofiltration with a large pore membrane can achieve significant cytokine clearance. Method: We used a well-known animal model of endotoxinic shock (0.5 ... [more ▼]

Objective: To confirm in vivo the hypothesis that hemofiltration with a large pore membrane can achieve significant cytokine clearance. Method: We used a well-known animal model of endotoxinic shock (0.5 mg/kg of lipopolysaccharide from Escherichia Coli over a period of 30 mins). Six pigs were hemofiltrated for 3 hours with a large pore membrane (78 angstrom pore, 80 kDa cut off) (Sureflux FH 70, Nipro, Osaka, Japan). The ultrafiltration rate was 45 ml/kg/min. Samples were taken from arterial, venous line and in the ultrafiltrate at T120 and T240. We measured concentrations of interleukin 6, interleukin 10 and albumin. Results: At T120 and T240, the IL-6 clearances were 22 +/- 7 and 15 +/- 3 ml/min, respectively. The IL-6 sieving coefficients were 0.97 and 0.7 at T120 and T240, respectively. At T120 and T240, the IL-10 clearances were 14 +/- 4 and 10 +/- 7 ml/min, respectively. The sieving coefficients were 0.63 and 0.45 at T120 and T240, respectively. The concentrations of IL-6 and IL-10 were the same at T0 and T240. At T60 and T240, the plasmatic albumin concentrations were 24 +/- 4 g/L and 23 +/- 4 g/L, respectively ( p = 0.13). Conclusions: In this animal model of endotoxinic shock, we confirm the high cytokine clearance observed when hemofiltration is applied to a large pore membrane. The loss of albumin seems negligible. The impact of such clearances on hemodynamic stability and survival remains to be proved. [less ▲]

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See detailEvaluation of different bone markers in hemodialyzed patients
Cavalier, Etienne ULg; Delanaye, Pierre ULg; Collette, Julien ULg et al

in Clinica Chimica Acta (2006), 371(1-2), 107-111

Background: Routinely, nephrologists rely on different biochemical markers like intact PTH (iPTH), bone-specific alkaline phosphatase (BALP), plasmatic calcium and phosphate. The aim of the present study ... [more ▼]

Background: Routinely, nephrologists rely on different biochemical markers like intact PTH (iPTH), bone-specific alkaline phosphatase (BALP), plasmatic calcium and phosphate. The aim of the present study was to evaluate different other bone markers like N-terminal propeptide of type I procollagen (PINP), active isoform 5b of the tartrate-resistant acid phosphatase (TRAP 5b) and beta-crossLaps (R) (CTXS) as well as full-length PTH (wPTH), presumed non-(1-84) PTH, and their ratio in the diagnosis of renal osteodystrophy with high and low turnover. We also determined 25 hydroxyvitamin D (25VTD), 1-25 dihydroxyvitamin D and homocystein (HCY). Methods: We performed those parameters on 73 patients with end-stage renal disease according to the manufacturers' instructions. Results: There were very strong correlations between the bone markers concentrations, particularly between BALP and PINP (r=0.953). We did not observe any correlation between the ratio whole PTH/non-(1-84) PTH and any of the usual bone markers. This ratio was significantly (p < 0.05) higher in low and high bone turnover patients than in normal patients according to the K/DOQI. We found a correlation between low levels of 25VTD and high levels of HCY Conclusions: BALP offers the best clinical and analytical profile as the easier marker of choice in hemodiallyzed patients for the diagnosis of bone disease. (c) 2006 Elsevier B.V All rights reserved. [less ▲]

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See detailLarge-pore membrane hemofiltration increases cytokine clearance and improves right ventricular-vascular coupling during endotoxic shock in pigs
Lambermont, Bernard ULg; Delanaye, Pierre ULg; Dogné, Jean-Michel ULg et al

in Artificial Organs (2006), 30(7), 560-564

Hemodynamic improvement in patients suffering from both septic shock and renal failure who received hemofiltration suggested that an extrarenal epuration technique could be of interest in patients with ... [more ▼]

Hemodynamic improvement in patients suffering from both septic shock and renal failure who received hemofiltration suggested that an extrarenal epuration technique could be of interest in patients with septic shock alone. However, most of the studies using continuous venovenous hemofiltration (CVVH) in this setting evidenced neither cytokine clearance nor significant reduction in their plasma level. Lack of significant clearance was explained in part by the small size of the membrane pores. Therefore, we investigated the effects of large-pore membrane hemofiltration (LPHF) during endotoxic shock in pigs on interleukin 6 (IL-6) and interleukin 10 (IL-10) clearances, and on right ventricular (RV)-vascular coupling. Thirteen anesthetized healthy pigs weighing 20-30 kg were divided into two groups. In the Endo group (n = 6), the pigs received a 0.5-mg/kg endotoxin infusion over a period of 30 mins from T0 to T30. In the EndoHF group (n = 7), LPHF (cutoff = 80 kDa) and an ultrafiltration rate of 45 mL/kg/h were started 30 mins after the end of the endotoxin infusion, from T60 to T240. In this model of porcine endotoxic shock, LPHF was responsible for a significant clearance of IL-6 (20 mL/min) and Il-10 (14 mL/min), and for an improvement in RV-vascular coupling. [less ▲]

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See detailDiarrhea induced by high doses of nicotinamide in dialysis patients
Delanaye, Pierre ULg; Weekers, Laurent ULg; Krzesinski, Jean-Marie ULg

in Kidney International (2006), 69(10), 1914-1914

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See detailImportance of the creatinine calibration in the estimation of GFR by MDRD equation
Delanaye, Pierre ULg; Cavalier, Etienne ULg; Chapelle, Jean-Paul ULg et al

in Nephrology Dialysis Transplantation (2006), 21(4), 1130-1130

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See detailIndexing glomerular filtration rate for body surface area is useful in obese subjects - Reply
Delanaye, Pierre ULg; Depas, Gisèle ULg; Radermecker, Régis ULg et al

in Nephrology Dialysis Transplantation (2006), 21(3), 821-822

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