Vitamin D for the prevention of vascular calcification in normal renal function and CKD patients
Scientific conference (2016, June)Detailed reference viewed: 20 (1 ULg)
Kidney-Failure Risk Projection for the Living Kidney-Donor candidate.
DELANAYE, Pierre ;
in New England Journal of Medicine (2016), 374(21), 2093-2094Detailed reference viewed: 22 (3 ULg)
Cystatin C standardization decreases assay variation and improves assessment of glomerular filtration rate
; DELANAYE, Pierre ; et al
in Clinica Chimica Acta (2016), 456Detailed reference viewed: 16 (2 ULg)
The Uptake of 18F-FDG by Renal Allograft in Kidney Transplant Recipients is not Influenced by Renal Function
; LOVINFOSSE, Pierre ; WEEKERS, Laurent et al
Conference (2016, April 28)Detailed reference viewed: 38 (12 ULg)
Concordance between Iothalamate and Iohexol Plasma Clearance
DELANAYE, Pierre ; LE GOFF, Caroline ; JOURET, François et al
in American Journal of Kidney Diseases (2016), 68(2), 329-330Detailed reference viewed: 19 (6 ULg)
A simple LC-MS method for the determination of iohexol and iothalamate in serum, using ioversol as an internal standard.
Nyssen, Laurent ; DELANAYE, Pierre ; Le Goff, Caroline et al
in Clinica Chimica Acta (2016), 463
BACKGROUND: Chronic kidney disease (CKD) is diagnosed and explored through the determination of the glomerular filtration rate (GFR). Our goal was to develop a simple LC-MS method for the determination in ... [more ▼]
BACKGROUND: Chronic kidney disease (CKD) is diagnosed and explored through the determination of the glomerular filtration rate (GFR). Our goal was to develop a simple LC-MS method for the determination in serum of 2 popular GFR markers, contrast agents iohexol and iothalamate, for routine use and comparison studies between the two markers. A similar contrast agent, ioversol, was used as an internal standard and the method underwent a rigorous validation protocol based on beta-expectation tolerance intervals. METHODS: We adapted the HPLC-UV method from Cavalier et al. to our LC-MS system. Data treatment for the validation was performed using Multiquant 3.0 (Sciex, Framingham, MA, USA) and e.noval 3.0 software (Arlenda, Liege, Belgium). RESULTS: According to the validation results our method will give accurate and reliable results for concentrations ranging from 6.8 to 250mug/ml for iohexol and 6.15mug/ml to 250mug/ml for iothalamate. In our practice these intervals are sufficient to determine both compounds in most patient samples. Samples with higher detected concentrations can always be diluted into range. CONCLUSION: With its internal standard and extensive validation, our method is now ready for routine and clinical research use. [less ▲]Detailed reference viewed: 16 (1 ULg)
Inadéquation du facteur ethnique pour l’estimation du débit de filtration glomérulaire en population générale noire-africaine : résultats en Côte d’Ivoire.
; ; et al
in Néphrologie & Thérapeutique (2016), 12(6), 454-459Detailed reference viewed: 17 (3 ULg)
Bone markers during acute burn care: Relevance to clinical practice?
ROUSSEAU, Anne-Françoise ; Damas, Pierre ; DELANAYE, Pierre et al
in Burns : Journal of the International Society for Burn Injuries (2016)
OBJECTIVE: Bone changes are increasingly described after burn. How bone markers could help to detect early bone changes or to screen burn patients at higher risk of demineralization is still not made ... [more ▼]
OBJECTIVE: Bone changes are increasingly described after burn. How bone markers could help to detect early bone changes or to screen burn patients at higher risk of demineralization is still not made clear. We performed an observational study assessing the changes in serum bone markers after moderate burn. METHODS: Adults admitted in the first 24h following burn extended on >10% body surface area were included. Serum levels of collagen type 1 cross-linked C-telopeptide (CTX), tartrate-resistant acid phosphatase 5b (TRAP), type 1 procollagen N-terminal (P1NP) and bone alkaline phosphatase (b-ALP) were measured at admission and every week during the first month. Data are expressed as median [min-max]. RESULTS: Bone markers were measured in 20 patients: 18 men, 2 women (including one post-menopausal). Age was 46 [19-86] years old, burn surface area reached 15 [7-85] %. Twelve patients completed the study. All biomarkers mainly remained into normal ranges during evolution. A huge variability was observed regarding biomarkers evolution. Patient's evolution was not linear and could fluctuate from a decrease to an increase of blood concentrations. There was not necessarily a consistency between the two formation or the two resorption markers. Variations observed between two consecutive measurements were lesser than the accepted critical difference in almost one third of the cases. CONCLUSIONS: Considering available data, role and interest of bone markers in management of burn related bone disease remain unclear. [less ▲]Detailed reference viewed: 14 (4 ULg)
Sclérostine & insuffisance rénale: que nous apprennent les différents méthodes de dosage?
PAQUOT, Francois ; BOUQUEGNEAU, Antoine ; CAVALIER, Etienne et al
in Néphrologie & Thérapeutique (2016), 12(5), 374Detailed reference viewed: 19 (4 ULg)
Analytical and clinical evaluation of the new Fujirebio Lumipulse G non-competitive assay for 25(OH)-vitamin D and three immunoassays for 25(OH)D in healthy subjects, osteoporotic patients, third trimester pregnant women, healthy African subjects, hemodialyzed and intensive care patients
CAVALIER, Etienne ; LUKAS, Pierre ; BEKAERT, Anne-Catherine et al
in Clinical Chemistry & Laboratory Medicine (2016)Detailed reference viewed: 51 (15 ULg)
The uptake of 18F-FDG by renal allograft in kidney transplant recipients is not influenced by renal function.
JADOUL, Alexandre ; LOVINFOSSE, Pierre ; WEEKERS, Laurent et al
Poster (2016)Detailed reference viewed: 24 (9 ULg)
Cystatin C standardization decreases assay variation and improves assessment of GFR
; DELANAYE, Pierre ; et al
Poster (2016)Detailed reference viewed: 16 (2 ULg)
Concordance between iothalamate and iohexol plasma clearances
JOURET, François ; CAVALIER, Etienne ; DELANAYE, Pierre
Poster (2016)Detailed reference viewed: 12 (1 ULg)
Drug dosing in chronic kidney disease: is the Cockcroft-Gault formula always the best estimation of renal function to prevent overexposure?
; ; DELANAYE, Pierre
Poster (2016)Detailed reference viewed: 15 (1 ULg)
An estimated glomerular filtration rate equation for the full age spectrum
; ; et al
in Nephrology Dialysis Transplantation (2016), 31(5), 798-806Detailed reference viewed: 32 (7 ULg)
Creatinine-based equations for the adjustment of drug dosage in an obese population.
BOUQUEGNEAU, Antoine ; ; et al
in British Journal of Clinical Pharmacology (2016), 81(2), 349-361Detailed reference viewed: 33 (16 ULg)
An age-calibrated definition of chronic kidney disease: Rationale and benefits.
DELANAYE, Pierre ; ; et al
in Clinical Biochemist. Reviews (2016), 37(1),Detailed reference viewed: 17 (2 ULg)
Efficiency of delivery observed treatment in hemodialysis patients: the example of the native vitamin D therapy
DELANAYE, Pierre ; CAVALIER, Etienne ; et al
in Journal of Nephrology (2016), 29(1), 99-103
Introduction Adherence to therapy is a relevant challenge in chronic hemodialysis patients. The directly observed therapy (DOT) could be an effective method to increase adherence for specific therapies ... [more ▼]
Introduction Adherence to therapy is a relevant challenge in chronic hemodialysis patients. The directly observed therapy (DOT) could be an effective method to increase adherence for specific therapies. We aimed to study the performance of DOT versus home medication. We follow the impact of providing native vitamin D directly by the nurse after a dialysis session on the 25-hydroxyvitamin [25(OH)D] concentrations. Methods In this observational study, we included 38 dialysis patients treated by stable dosage of cholecalciferol. DOT was implemented in December 2010. We considered the concentrations of 25-OH vitamin D three times before (T1 = June 2010, T2 = July 2010 and T3 = September 2010) and three times after the modification of prescription (T4 = February 2011, T5 = March 2011 and T6 = April 2011). Results Median age was 72 [62; 79] years and 48 % were diabetics. Mean body mass index was 26 ± 5 kg/m2 and median dialysis vintage was 20 [8; 46] months. The patients were compared to themselves. Before DOT, median concentrations of 25(OH)D were 27 (14–36), 23 (17–31), 31 (22–38) ng/mL at T1, T2 and T3, respectively. When DOT was effective, the concentrations significantly increased to 34 (28–44), 35 (29–41), 39 (32–47) ng/mL at T4, T5 and T6, respectively. Before DOT, 19 patients (50 %) reached the target of 30 ng/mL. After DOT, 29 patients (76 %) reached the target concentration of 30 ng/ mL. Conclusions In hemodialysis patients, DOT is both simple and effective to increase the therapeutic impact to native vitamin D. [less ▲]Detailed reference viewed: 32 (13 ULg)
Concordance between iohexol and iothalamate plasma clearance
DELANAYE, Pierre ; JOURET, François ; LE GOFF, Caroline et al
in American Journal of Kidney Diseases (2016)Detailed reference viewed: 19 (4 ULg)