Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 2: Why to measure glomerular filtration rate with iohexol?
DELANAYE, Pierre ; ; et al
in Clinical Kidney Journal (2016)
2 | P. Delanaye et al. Abstract A reliable assessment of glomerular filtration rate (GFR) is of paramount importance in clinical practice as well as epidemiological and clinical research settings. It is ... [more ▼]
2 | P. Delanaye et al. Abstract A reliable assessment of glomerular filtration rate (GFR) is of paramount importance in clinical practice as well as epidemiological and clinical research settings. It is recommended by Kidney Disease: Improving Global Outcomes guidelines in specific populations (anorectic, cirrhotic, obese, renal and non-renal transplant patients) where estimation equations are unreliable. Measured GFR is the only valuable test to confirm or confute the status of chronic kidney disease (CKD), to evaluate the slope of renal function decay over time, to assess the suitability of living kidney donors and for dosing of potentially toxic medication with a narrowtherapeutic index. Abnormally elevatedGFRor hyperfiltration in patients with diabetes or obesity can be correctly diagnosed only by measuring GFR. GFR measurement contributes to assessing the true CKD prevalence rate, avoiding discrepancies duetoGFRestimation with different equations. Usingmeasured GFR, successfullyaccomplished in large epidemiological studies, is the onlyway to study the potential link between decreased renal functionand cardiovascular or total mortality, being sure that this association is not due to confounders, i.e. non-GFR determinants of biomarkers. In clinical research, it has been shown that measured GFR (or measured GFR slope) as a secondary endpoint as compared with estimated GFR detected subtle treatment effects and obtained these results with a comparatively smaller sample size than trials choosing estimated GFR. Measuring GFR by iohexol has several advantages: simplicity, low cost, stability and low interlaboratory variation. Iohexol plasma clearance represents the best chance for implementing a standardized GFR measurement protocol applicable worldwide both in clinical practice and in research. [less ▲]Detailed reference viewed: 15 (3 ULg)
La standardisation des dosages de cystatine C améliore l'estimation du DFG au stade 3: une étude multicentrique conduite par la société française de biologie clinique (SFBC)
; ; DELANAYE, Pierre et al
Poster (2016, September)Detailed reference viewed: 22 (2 ULg)
Evaluation du débit de filtration glomérulaire estimé à l'aide d'un dosage de créatinine par analyseur de biologie délocalisé (Point of Care)
STOJKOVIC, Violeta ; SCHLECK, Marie-Louise ; CAVALIER, Etienne et al
Poster (2016, September)Detailed reference viewed: 27 (4 ULg)
Mesure du débit de filtration glomérulaire par la clearance plasmatique de l'iohexol: comparaison d'une procédure à prélèvements multiples & à un prélèvement unique
DELANAYE, Pierre ; CAVALIER, Etienne
Poster (2016, September)Detailed reference viewed: 15 (2 ULg)
Mesure du débit de filtration glomérulaire par la clearance plasmatique de l'iohexol: comparaison d'une procédure à prélèvements multiples et à un prélèvement unique
DELANAYE, Pierre ; CAVALIER, Etienne
Poster (2016, September)Detailed reference viewed: 11 (1 ULg)
Valeurs de référence de débit de filtration glomérulaire en population noire-africaine
; ; et al
in Néphrologie & Thérapeutique (2016, September), 12(5), 273Detailed reference viewed: 22 (2 ULg)
The role of biochemical of bone turnover markers in osteoporosis and metabolic bone disease: a consensus paper of the Belgian Bone Club.
Cavalier, Etienne ; ; Bruyère, Olivier et al
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2016), 27
The exact role of biochemical markers of bone turnover in the management of metabolic bone diseases remains a topic of controversy. In this consensus paper, the Belgian Bone Club aimed to provide a state ... [more ▼]
The exact role of biochemical markers of bone turnover in the management of metabolic bone diseases remains a topic of controversy. In this consensus paper, the Belgian Bone Club aimed to provide a state of the art on the use of these biomarkers in different clinical or physiological situations like in postmenopausal women, osteoporosis in men, in elderly patients, in patients suffering from bone metastasis, in patients with chronic renal failure, in pregnant or lactating women, in intensive care patients, and in diabetics. We also gave our considerations on the analytical issues linked to the use of these biomarkers, on potential new emerging biomarkers, and on the use of bone turnover biomarkers in the follow-up of patients treated with new drugs for osteoporosis. [less ▲]Detailed reference viewed: 36 (5 ULg)
Vitamin D for the prevention of vascular calcification in normal renal function and CKD patients
Scientific conference (2016, June)Detailed reference viewed: 20 (1 ULg)
Kidney-Failure Risk Projection for the Living Kidney-Donor candidate.
DELANAYE, Pierre ;
in New England Journal of Medicine (2016), 374(21), 2093-2094Detailed reference viewed: 22 (3 ULg)
Cystatin C standardization decreases assay variation and improves assessment of glomerular filtration rate
; DELANAYE, Pierre ; et al
in Clinica Chimica Acta (2016), 456Detailed reference viewed: 16 (2 ULg)
The Uptake of 18F-FDG by Renal Allograft in Kidney Transplant Recipients is not Influenced by Renal Function
; LOVINFOSSE, Pierre ; WEEKERS, Laurent et al
Conference (2016, April 28)Detailed reference viewed: 39 (13 ULg)
Concordance between Iothalamate and Iohexol Plasma Clearance
DELANAYE, Pierre ; LE GOFF, Caroline ; JOURET, François et al
in American Journal of Kidney Diseases (2016), 68(2), 329-330Detailed reference viewed: 19 (6 ULg)
A simple LC-MS method for the determination of iohexol and iothalamate in serum, using ioversol as an internal standard.
Nyssen, Laurent ; DELANAYE, Pierre ; Le Goff, Caroline et al
in Clinica Chimica Acta (2016), 463
BACKGROUND: Chronic kidney disease (CKD) is diagnosed and explored through the determination of the glomerular filtration rate (GFR). Our goal was to develop a simple LC-MS method for the determination in ... [more ▼]
BACKGROUND: Chronic kidney disease (CKD) is diagnosed and explored through the determination of the glomerular filtration rate (GFR). Our goal was to develop a simple LC-MS method for the determination in serum of 2 popular GFR markers, contrast agents iohexol and iothalamate, for routine use and comparison studies between the two markers. A similar contrast agent, ioversol, was used as an internal standard and the method underwent a rigorous validation protocol based on beta-expectation tolerance intervals. METHODS: We adapted the HPLC-UV method from Cavalier et al. to our LC-MS system. Data treatment for the validation was performed using Multiquant 3.0 (Sciex, Framingham, MA, USA) and e.noval 3.0 software (Arlenda, Liege, Belgium). RESULTS: According to the validation results our method will give accurate and reliable results for concentrations ranging from 6.8 to 250mug/ml for iohexol and 6.15mug/ml to 250mug/ml for iothalamate. In our practice these intervals are sufficient to determine both compounds in most patient samples. Samples with higher detected concentrations can always be diluted into range. CONCLUSION: With its internal standard and extensive validation, our method is now ready for routine and clinical research use. [less ▲]Detailed reference viewed: 21 (2 ULg)
Inadéquation du facteur ethnique pour l’estimation du débit de filtration glomérulaire en population générale noire-africaine : résultats en Côte d’Ivoire.
; ; et al
in Néphrologie & Thérapeutique (2016), 12(6), 454-459Detailed reference viewed: 18 (3 ULg)
Bone markers during acute burn care: Relevance to clinical practice?
ROUSSEAU, Anne-Françoise ; Damas, Pierre ; DELANAYE, Pierre et al
in Burns : Journal of the International Society for Burn Injuries (2016)
OBJECTIVE: Bone changes are increasingly described after burn. How bone markers could help to detect early bone changes or to screen burn patients at higher risk of demineralization is still not made ... [more ▼]
OBJECTIVE: Bone changes are increasingly described after burn. How bone markers could help to detect early bone changes or to screen burn patients at higher risk of demineralization is still not made clear. We performed an observational study assessing the changes in serum bone markers after moderate burn. METHODS: Adults admitted in the first 24h following burn extended on >10% body surface area were included. Serum levels of collagen type 1 cross-linked C-telopeptide (CTX), tartrate-resistant acid phosphatase 5b (TRAP), type 1 procollagen N-terminal (P1NP) and bone alkaline phosphatase (b-ALP) were measured at admission and every week during the first month. Data are expressed as median [min-max]. RESULTS: Bone markers were measured in 20 patients: 18 men, 2 women (including one post-menopausal). Age was 46 [19-86] years old, burn surface area reached 15 [7-85] %. Twelve patients completed the study. All biomarkers mainly remained into normal ranges during evolution. A huge variability was observed regarding biomarkers evolution. Patient's evolution was not linear and could fluctuate from a decrease to an increase of blood concentrations. There was not necessarily a consistency between the two formation or the two resorption markers. Variations observed between two consecutive measurements were lesser than the accepted critical difference in almost one third of the cases. CONCLUSIONS: Considering available data, role and interest of bone markers in management of burn related bone disease remain unclear. [less ▲]Detailed reference viewed: 14 (4 ULg)
Sclérostine & insuffisance rénale: que nous apprennent les différents méthodes de dosage?
PAQUOT, Francois ; BOUQUEGNEAU, Antoine ; CAVALIER, Etienne et al
in Néphrologie & Thérapeutique (2016), 12(5), 374Detailed reference viewed: 20 (4 ULg)
Analytical and clinical evaluation of the new Fujirebio Lumipulse G non-competitive assay for 25(OH)-vitamin D and three immunoassays for 25(OH)D in healthy subjects, osteoporotic patients, third trimester pregnant women, healthy African subjects, hemodialyzed and intensive care patients
CAVALIER, Etienne ; LUKAS, Pierre ; BEKAERT, Anne-Catherine et al
in Clinical Chemistry & Laboratory Medicine (2016)Detailed reference viewed: 60 (19 ULg)
The uptake of 18F-FDG by renal allograft in kidney transplant recipients is not influenced by renal function.
JADOUL, Alexandre ; LOVINFOSSE, Pierre ; WEEKERS, Laurent et al
Poster (2016)Detailed reference viewed: 25 (9 ULg)
Cystatin C standardization decreases assay variation and improves assessment of GFR
; DELANAYE, Pierre ; et al
Poster (2016)Detailed reference viewed: 16 (2 ULg)