References of "Crielaard, Jean-Michel"
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See detailStrontium ranelate increases cartilage matrix formation.
Henrotin, Yves ULiege; Labasse, Alain; Zheng, S. X. et al

in Journal of Bone and Mineral Research (2001), 16(2), 299-308

Based on previous studies showing that strontium ranelate (S12911) modulates bone loss in osteoporosis, it could be hypothesized that this drug also is effective on cartilage degradation in osteoarthritis ... [more ▼]

Based on previous studies showing that strontium ranelate (S12911) modulates bone loss in osteoporosis, it could be hypothesized that this drug also is effective on cartilage degradation in osteoarthritis (OA). This was investigated in vitro on normal and OA human chondrocytes treated or not treated with interleukin-1beta (IL-1beta). This model mimics, in vitro, the imbalance between chondroformation and chondroresorption processes observed in vivo in OA cartilage. Chondrocytes were isolated from cartilage by enzymatic digestion and cultured for 24-72 h with 10(-4)-10(-3) M strontium ranelate, 10(-3) M calcium ranelate, or 2 x 10(-3) M SrCl2 with or without IL-1beta or insulin-like growth factor I (IGF-I). Stromelysin activity and stromelysin quantitation were assayed by spectrofluorometry and enzyme amplified sensitivity immunoassay (EASIA), respectively. Proteoglycans (PG) were quantified using a radioimmunoassay. Newly synthesized glycosaminoglycans (GAGs) were quantified by labeled sulfate (Na2(35)SO4) incorporation. This method allowed the PG size after exclusion chromatography to be determined. Strontium ranelate, calcium ranelate, and SrCl2 did not modify stromelysin synthesis even in the presence of IL-1beta. Calcium ranelate induced stromelysin activation whereas strontium compounds were ineffective. Strontium ranelate and SrCl2 both strongly stimulated PG production suggesting an ionic effect of strontium independent of the organic moiety. Moreover, 10(-3) M strontium ranelate increased the stimulatory effect of IGF-I (10(-9) M) on PG synthesis but did not reverse the inhibitory effect of IL-1beta. Strontium ranelate strongly stimulates human cartilage matrix formation in vitro by a direct ionic effect without stimulating the chondroresorption processes. This finding provides a preclinical basis for in vivo testing of strontium ranelate in OA. [less ▲]

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See detailTreatment of recurrent tendinitis by isokinetic eccentric exercises
Croisier, Jean-Louis ULiege; Forthomme, Bénédicte ULiege; Foidart-Dessalle, Marguerite ULiege et al

in Isokinetics & Exercise Science (2001), 9(2-3), 133-141

The purpose of this study was to determine the effectiveness of eccentric training models in treating various types of tendinitis and evaluate protection from re-injury when returning to causal activities ... [more ▼]

The purpose of this study was to determine the effectiveness of eccentric training models in treating various types of tendinitis and evaluate protection from re-injury when returning to causal activities, Isokinetic eccentric training was administered to 34 patients with chronic tendinitis (9 Achilles, 10 patellar and 15 epicondyllar) with a long duration of symptoms and failure of conventional treatment. Following training which consisted of 20 to 30 sessions of progressive increase of load and speed parameters, a significant reduction of pain indicated by the visual analog scale (average initial value > 6.5, final score less than or equal to 2.5). Seventy four percent of the patients were completely relieved or presented marked decrease in symptoms when returning to sport and occupational activities. and only 12% reported no change in their functional state. At the end of treatment. isokinetic assessment revealed no significant concentric or eccentric peak torque asymmetries between involved and non-involved sides. In comparison with pretreatment ultrasound observations which showed systematic hypoechoic lesions and thickness, 14/34 patients recovered homogeneous tendon structure and normalization of the diameter and 15 presented improvement in echostructure. Our treatment model proposing isokinetic eccentric exercises presents a very satisfactory short-term effect on three different localizations of chronic tendinitis. [less ▲]

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See detailVademecum pour la bonne pratique d'une activite physique.
Scheen, André ULiege; Crielaard, Jean-Michel ULiege

in Revue Médicale de Liège (2001), 56(5), 396-400

The present closing article summarizes some guidelines for the good practice of physical activities in order to develop and maintain cardiorespiratory and muscular fitness, and flexibility. Advice is ... [more ▼]

The present closing article summarizes some guidelines for the good practice of physical activities in order to develop and maintain cardiorespiratory and muscular fitness, and flexibility. Advice is given regarding the recommended quantity and quality of exercise in term of intensity, duration and frequency of training with the aim to optimize the risk/benefit ratio for health, in both aerobic endurance and resistance exercises. The crucial role of an appropriate warm-up and cool-down period, which would include flexibility exercises, is also emphasized. Finally, some practical examples illustrate this vademecum of physical activities. [less ▲]

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See detailAspects délétères des épreuves isocinétiques de résistance à la fatigue musculaire
Croisier, Jean-Louis ULiege; Maquet, Didier ULiege; Camus, Gérard et al

in Science & Sports (2000, December), 15

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See detailEtude électromyographique paravertébrale dorso-lombaire. Analyse multi-MUP et établissement de normes au sein d'une population de référence.
TOMASELLA, Marco ULiege; WANG, François-Charles ULiege; CRIELAARD, Jean-Michel ULiege

in Abstract Book of 17° Symposium d'Electromyographie et de Réhabilitation neuromusculaire (2000, November 18)

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See detailLa fibromyalgie en l'an 2000
Maquet, Didier ULiege; Croisier, Jean-Louis ULiege; Crielaard, Jean-Michel ULiege

in Revue Médicale de Liège (2000), 55(11), 991-7

Musculoskeletal pain is common in the population. Several pathologies like fibromyalgia (FM), chronic fatigue syndrome (CFS) or spasmophilia are associated with functional myalgia. The etiology of FM ... [more ▼]

Musculoskeletal pain is common in the population. Several pathologies like fibromyalgia (FM), chronic fatigue syndrome (CFS) or spasmophilia are associated with functional myalgia. The etiology of FM remains elusive, but the diagnosis is well established. The criteria for the classification are widespread pain combined with tenderness at 11 or more of the 18 specific tender points sites. The prevalence is 2% in the general population. This article reviews recent data on the pathophysiology and treatment of FM. [less ▲]

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See detailIn Vitro Study of the Antioxidant Properties of Nimesulide and 4-Oh Nimesulide: Effects on Hrp- and Luminol-Dependent Chemiluminescence Produced by Human Chondrocytes
Zheng, S. X.; Mouithys-Mickalad, Ange ULiege; Deby-Dupont, G. P. et al

in Osteoarthritis and Cartilage (2000), 8(6), 419-25

OBJECTIVES: Reactive oxygen species (ROS) are now recognized to play an important role in the pathogenesis of rheumatic diseases and constitute an interesting therapeutic target for drugs. This in vitro ... [more ▼]

OBJECTIVES: Reactive oxygen species (ROS) are now recognized to play an important role in the pathogenesis of rheumatic diseases and constitute an interesting therapeutic target for drugs. This in vitro study was designed to evaluate the antioxidant properties of nimesulide (NIM), a nonsteroidal antiinflammatory drug of the sulfonanilide class, and its main metabolite 4-OH nimesulide (4-OHNIM). METHODS: The scavenging effects of NIM and 4-OH NIM on hydroxyl radical ((.)OH) and superoxide anions (O(minusd)(2)) were investigated by electron spin resonance (ESR), using 5, 5-dimethylpyrroline-N-oxide (DMPO) as the spin trap agent. The quenching properties of these drugs on hypochlorite anion was studied by luminol enhanced chemiluminescence. Finally, the effects of NIM and 4-OHNIM on the reactive oxygen species production by human articular chondrocytes were recorded by HRP and luminol-enhanced chemiluminescence. RESULTS: By this method it has been demonstrated that NIM and 4-OHNIM, at concentrations ranging from 10 to 100 microM, are potent scavengers of(.)OH whereas only 4-OHNIM was capable to scavenge O(minusd)(2). Chemiluminescence generated by HOCl was also significantly and dose-dependently inhibited by both NIM and 4-OHNIM. Nevertheless, at each concentration tested, the inhibitory effect of 4-OHNIM was significantly more marked, even at the highest concentration (100 microM). Furthermore, when chondrocytes were pre-incubated for 48-96 h with NIM or 4-OHNIM, the luminol- and HRP-dependent CL produced by the cells was significantly inhibited in a dose-dependent manner. CONCLUSIONS: NIM and 4-OHNIM may protect cartilage against oxidative stress, not only by scavenging ROS but also by inhibiting their production by chondrocytes. [less ▲]

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See detailContribution à l’étude de la fonction musculaire du sujet fibromyalgique
Maquet, Didier ULiege; Croisier, Jean-Louis ULiege; Renard, Cindy ULiege et al

in Actes du symposium « Evidence Based Physiotherapy » de la Fédération Nationale des Docteurs et Licenciés en Kinésithérapie (2000, October)

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See detailEvaluation isocinétique des muscles rotateurs externes et internes de l’épaule après transfert coracoïdien. Influence de la ténotomie du sous-scapulaire.
Willems, S.; Berger, J. P.; Houben, G. et al

in Proceedings of the 14th Congress of the European Society for Surgery of the Shoulder and the Elbow (2000, September)

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See detailMuscle damage induced by concentric fatigue protocol. Comparative study between males and females
Croisier, Jean-Louis ULiege; Maquet, Didier ULiege; Camus, Gérard et al

in Proceedings of the 5th Annual Congress of the European College of Sport Science (2000, July)

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See detailSpatial Distribution of Blood Flow in Electrically Stimulated Human Muscle: A Positron Emission Tomography Study
Vanderthommen, Marc ULiege; Depresseux, J. C.; Dauchat, L. et al

in Muscle & Nerve (2000), 23(4), 482-9

Neuromuscular electrical stimulation (NMES) was studied with positron emission tomography (PET) and H(2)(15)O in the quadriceps muscle of 11 men. The subjects were submitted to simultaneous bilateral ... [more ▼]

Neuromuscular electrical stimulation (NMES) was studied with positron emission tomography (PET) and H(2)(15)O in the quadriceps muscle of 11 men. The subjects were submitted to simultaneous bilateral isometric contraction (5 s)-rest (5 s) cycles for 12 min, with a workload corresponding to 5% of quadriceps maximal isometric voluntary torque (QMIVT) for one thigh (5%T) and 10% of QMIVT for the other (10%T). Scans were centered at the electrodes and tissue blood flow (TBF) was evaluated in square regions of interest (ROIs) (3.5 cm(2)) in the transverse section (TS) of both thighs. The mean TBF reached 8.9 mL min(-1) 100 g(-1) in the TS of the 5%T and 11.5 mL min(-1) 100 g(-1) in the TS of the 10%T (P > 0.05). A negative linear relationship was found for both thighs between the ROI-electrode distance and the TBF (P </= 0.009). The mean percentage of activated ROIs (TBF > 5 mL min(-1) 100 g(-1)) was lower in the 5%T than in the 10%T (50.6% vs. 62.2%; P = 0.017). With NMES, the pattern of spatial recruitment appears linked to electrode proximity and is spatially extended. These results confirm the utility of combining NMES with voluntary exercise in the treatment of atrophied muscle. [less ▲]

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See detailExercices excentriques appliqués au traitement des tendinites
Forthomme, Bénédicte ULiege; Croisier, Jean-Louis ULiege; Godon, Bernard ULiege et al

in Kine 2000, Revue Européenne de la Kinésithérapie (2000), 11

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See detailIsokinetic measurement of forearm pronators-supinators and wrist flexors-extensors in normal subjects
Forthomme, Bénédicte ULiege; Croisier, Jean-Louis ULiege; Heinzius, C. et al

in Isokinetics & Exercise Science (2000, March), 8

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See detailInterest of a specific training to reduce DOMS
Croisier, Jean-Louis ULiege; Camus, Gérard; Crielaard, Jean-Michel ULiege

in Isokinetics & Exercise Science (2000, March), 8

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See detailHamstring muscle strain: interest of the eccentric assessment and preventive aspects
Croisier, Jean-Louis ULiege; Crielaard, Jean-Michel ULiege

in Isokinetics & Exercise Science (2000, March), 8

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See detailIsokinetic evaluation of knee extensors and flexors in patients with unilateral symptomatic gonarthrosis
Henrotin, Yves ULiege; Croisier, Jean-Louis ULiege; Dumont, R. et al

in Isokinetics & Exercise Science (2000, March), 8

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See detailIsokinetic evaluation of hip strength muscle groups in unilateral lower limb amputees
Croisier, Jean-Louis ULiege; Maertens De Noordhout, Benoît; Camus, Gérard et al

in Isokinetics & Exercise Science (2000, March), 8

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See detailModulation of human chondrocyte metabolism by recombinant human interferon.
Henrotin, Yves ULiege; Zheng, S X; Labasse, A H et al

in Osteoarthritis and Cartilage (2000), 8(6), 474-82

OBJECTIVES: Interferon gamma (IFN gamma) is found to be elevated in the synovial fluid of patients with rheumatoid arthritis and osteoarthritis, suggesting its implication in joint disease pathogenesis ... [more ▼]

OBJECTIVES: Interferon gamma (IFN gamma) is found to be elevated in the synovial fluid of patients with rheumatoid arthritis and osteoarthritis, suggesting its implication in joint disease pathogenesis. In this study, we investigated the effects of IFN gamma on the production of cytokines (IL-6, IL-8, IL-10), prostaglandin E(2)(PGE(2)), proteoglycans (PG), nitric oxide (NO), interleukin-1 receptor antagonist (IL-1ra) and stromelysin by non-stimulated and IL-1 beta-treated human chondrocytes. The role played by NO in the responses of chondrocytes to IFN gamma was also examined by incubation of chondrocytes with N(G)-monomethyl-L-arginine (L-NMMA), a competitive inhibitor of NO synthase. METHODS: Enzymatically isolated human chondrocytes were cultured for 48 h in the absence or presence of IL-1 beta, IFN gamma or N(G)-monomethyl-L-arginine (L-NMMA) added solely or in combination. The productions of IL-6, IL-8, IL-10, IL-1ra and stromelysin were measured by enzyme amplified sensitivity immunoassays (EASIA). PG and PGE(2)were quantified by specific radioimmunoassays (RIA). Nitrite concentrations in the culture supernatants were determined by a spectrophotometric method based upon the Griess reaction. RESULTS: As expected, IL-1 beta highly stimulated NO, IL-6, IL-8, IL-10, IL-1ra, PGE(2)and stromelysin synthesis, but dramatically decreased PG production. NO, IL-6, IL-1ra and PGE(2)production by non-stimulated chondrocytes was dose-dependently increased by IFN gamma while PG production was inhibited. In the absence of IL-1 beta, IL-10 was undetectable in the culture supernatants. At the doses of 10 and 100 U/ml, IFN gamma markedly inhibited the constitutive and IL-1 beta-stimulated IL-8, IL-10 and stromelysin productions. Interestingly, IFN gamma synergized with IL-1 beta to increase NO, IL-6, IL-1ra and to depress PG production. As previously reported, the inhibition of NO synthesis by the competitive inhibitor L-NMMA led to enhancement of IL-6, IL-8 and PGE(2)production by IL-1 beta treated chondrocytes, but did not significantly modify IL-10, PG and MMP-3 productions. Inhibition of NO synthase significantly inhibited the stimulating effect of IFN gamma on IL-6 and IL-1ra but did not affect the inhibitory effect of IFN gamma on IL-8, PG or stromelysin production. CONCLUSIONS: These findings suggest that IFN gamma and IL-1 synergistically stimulate the production of IL-6, IL-1ra, NO and PGE(2)and inhibit PG synthesis. By contrast, IL-1 beta and IFN gamma have opposite effects on IL-8, IL-10 and stromelysin productions. These effects are not reversed by L-NMMA, suggesting that NO is not the principal mediator involved in responses of chondrocytes to IFN gamma. [less ▲]

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See detailBases scientifiques du traitement physique de la gonarthrose
Henrotin, Yves ULiege; Croisier, Jean-Louis ULiege; Reginster, Jean-Yves ULiege et al

in KINE 2000 (2000), 11(4), 86-94

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