Showing results 221 to 226 of 226
  Radiosensitizing and repair-inhibiting properties of dipyridamole.COUCKE, Philippe  ; ; et alin Radiotherapy & Oncology (1992), 24(24), 246-250 Radioresistance and postirradiation repair of potentially lethal damage (PLD repair) are important factors underlying failure to control local disease in cancer. Dipyridamole (DP) is known as a modifier ... [more ▼] Radioresistance and postirradiation repair of potentially lethal damage (PLD repair) are important factors underlying failure to control local disease in cancer. Dipyridamole (DP) is known as a modifier of the action of cytotoxic drugs. We therefore investigated DP as a potential radiosensitizer and inhibitor of PLD repair in X-irradiated Chinese hamster ovary (CHO) cells in vitro. Exposure to the drug alone resulted in a slight reduction of the clonogenic capacity of the cells. Preincubation for 18 h with 10 and 20 microM DP in cells subcultured at low density, led to a significant radiosensitization. In confluent density-inhibited cultures, preincubation alone as well as pre- and postincubation with 20 microM DP resulted in a significant inhibition of PLD repair. Dipyridamole and related compounds may thus be useful tools for modifying and investigating the response of mammalian cells to radiation. [less ▲] Detailed reference viewed: 10 (4 ULg) Postoperative Radiation Therapy for Rectal Cancer: An Interim Analysis of a Prospective, Randomized Multicenter Trial in The NetherlandsCoucke, Philippe in Cancer (1992), 68(12), 3016-3019 Detailed reference viewed: 9 (0 ULg)Small bowel protection with "STEP". Silastic tissue expander prosthesis.Coucke, Philippe ; ; in Strahlentherapie und Onkologie (1992), 168(4), 226229 Il s'agit d'un cas clinique d'un patient présentant un cancer du rectum et de la maladie de Crohn. Adjuvant treatment was considered to be mandatory on the basis of local extension. Traitement adjuvant a ... [more ▼] Il s'agit d'un cas clinique d'un patient présentant un cancer du rectum et de la maladie de Crohn. Adjuvant treatment was considered to be mandatory on the basis of local extension. Traitement adjuvant a été considérée comme obligatoire sur la base de l'extension locale. Therefore a Silastic Tissue Expander Prosthesis (STEP), connected with a subcutaneously located self-sealing valve system, was introduced surgically to push small bowel up out of the treatment portals. Par conséquent, un Silastic Tissue Expander Prothèses (STEP), liée à un sous-cutanée située auto-obturant le système de valve, a été introduit chirurgicalement à pousser jusqu'à l'intestin grêle sur les portails de traitement. Patient received 55 Gy without any acute or late complication. Patient a reçu 55 Gy sans aucune complication aiguë ou tardive. This easy technique allows radiotherapy in conditions where complete elimination of small bowel outside the treatment volume is required. Cette technique simple permet de radiothérapie dans des conditions où l'élimination complète de l'intestin grêle en dehors du volume de traitement est nécessaire. [less ▲] Detailed reference viewed: 12 (0 ULg) Rectal cancer: need for radiotherapy in determining the treatment planCoucke, Philippe ; ; in Helvetica Chirurgica Acta (1991), 58(3), 345-58 Postoperative radiotherapy is highly effective in the prevention of local recurrence in rectal cancer. Nevertheless, the results remain disappointing for Locally Advanced Rectal Cancer. New approaches ... [more ▼] Postoperative radiotherapy is highly effective in the prevention of local recurrence in rectal cancer. Nevertheless, the results remain disappointing for Locally Advanced Rectal Cancer. New approaches include introduction of chemotherapy to postoperative radiotherapy or combined radiotherapeutic treatment with preoperative irradiation, surgery and intraoperative irradiation, along with elective postoperative treatment in function of surgical and pathological data. Based on recent advances in radiobiology we are able to modify treatment parameters to enhance efficacy without increasing the toxicity. The reduction of dose per fraction, the application of radiosensitizers, the optimal protection of healthy tissue will increase the therapeutic ratio while keeping results constant or even reduce the incidence of local failure. [less ▲] Detailed reference viewed: 7 (2 ULg)A linear-quadratic model of cell survival considering both sublethal and potentially lethal radiation damage; COUCKE, Philippe ; in Radiotherapy & Oncology (1991), 21(4), 273-276 We assessed the dose-dependence of repair of potentially lethal damage in Chinese hamster ovary cells x-irradiated in vitro. The recovery ratio (RR) by which survival (SF) of the irradiated cells was ... [more ▼] We assessed the dose-dependence of repair of potentially lethal damage in Chinese hamster ovary cells x-irradiated in vitro. The recovery ratio (RR) by which survival (SF) of the irradiated cells was enhanced increased exponentially with a linear and a quadratic component, namely xi and psi: RR = e xi D + psi D2. Survival of irradiated cells can thus be expressed by a combined linear-quadratic model considering four variable, namely alpha and beta for the capacity of the cells to accumulate sublethal damage, and xi and psi for their capacity to repair potentially lethal damage: SF = e(xi - alpha)D + (psi - beta)D2. [less ▲] Detailed reference viewed: 27 (0 ULg)Radioprotection de l'intestin grele dans le petit bassin par implantation de prothese siliconee gonflable; ; COUCKE, Philippe et alin Schweizerische Medizinische Wochenschrift (1991), 121(29), 1055-61 The combination of radiotherapy and surgery plays a major role in treating pelvic cancer. However, this technique is chiefly limited by the radiosensitivity of the small bowel following postoperative ... [more ▼] The combination of radiotherapy and surgery plays a major role in treating pelvic cancer. However, this technique is chiefly limited by the radiosensitivity of the small bowel following postoperative radiotherapy. In this situation the small bowel is not protected because of its lack of mobility. A radioprotective prosthesis is presented which is readily removable and whose purpose is to push the small bowel out of the pelvis during radiotherapy, thus protecting it from radiotherapy. If required, a simple system allows the prosthesis to be emptied and refilled between courses of radiotherapy, if required, without reoperation. This technique has been used in 4 patients: 2 had rectal carcinoma secondary to ulcerative colitis in one case and to Crohn's disease in the other; the other 2 cases were recurrent rectal carcinoma, one of which was partially resectable. When radiotherapy was completed the prosthesis could be deflated and removed through a short incision under local anesthetic. In the medium term, no small bowel complications were observed in spite of high-dose radiotherapy. When used for radiosensitive pelvic tumors, this technique combines low cost and ease of use with very low morbidity and the possibility of administering high-dose radiotherapy [less ▲] Detailed reference viewed: 129 (0 ULg) |
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