References of "Compère, Philippe"
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See detailOrgano-mineral imprints in fossil cyanobacterial mats of an Antarctic lake
Javaux, Emmanuelle ULg; Lepot, Kevin ULg; Deremiens, Leo et al

Poster (2010, December)

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See detailParticularities of Aphidius ervi embryo development and main limitations of its in vitro culture
Sabri, Ahmed ULg; Leroy, Pascal ULg; Hance, Thierry et al

Poster (2010, May 05)

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See detailStructure composition and mechanical relations to function in sea urchin spine
Moureaux, Claire; Pérez-Huerta, A.; Compère, Philippe ULg et al

in Journal of Structural Biology (2010), 170

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See detailDevelopment of a new topical system: Drug-in-cyclodextrin-in-deformable liposome
Gillet, Aline ULg; Grammenos, Angeliki ULg; Compère, Philippe ULg et al

in International Journal of Pharmaceutics (2009), 380(1-2), 174-180

A new delivery system for cutaneous administration combining the advantages of cyclodextrin inclusion complexes and those of deformable liposomes was developed, leading to a new concept: drug ... [more ▼]

A new delivery system for cutaneous administration combining the advantages of cyclodextrin inclusion complexes and those of deformable liposomes was developed, leading to a new concept: drug-incyclodextrin-in-deformable liposomes. Deformable liposomes made of soybean phosphatidylcholine (PC) or dimyristoylphosphatidylcholine (DMPC) and sodium deoxycholate as edge activator were compared to classical non-deformable liposomes. Liposomes were prepared by the film evaporation method. Betamethasone, chosen as the model drug,was encapsulated in the aqueous cavity of liposomes by the use of cyclodextrins. Cyclodextrins allowan increase in the aqueous solubility of betamethasone and thus, the encapsulation efficiency in liposome vesicles. Liposome size, deformability and encapsulation efficiency were calculated. The best results were obtained with deformable liposomes made of PC in comparison with DMPC. The stability of PC vesicles was evaluated by measuring the leakage of encapsulated calcein on the one hand and the leakage of encapsulated betamethasone on the other hand. In vitro diffusion studies were carried out on Franz type diffusion cells through polycarbonate membranes. In comparison with non-deformable liposomes, these new vesicles showed improved encapsulation efficiency, good stability and higher in vitro diffusion percentages of encapsulated drug. They are therefore promising for future use in ex vivo and in vivo experiments. [less ▲]

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See detailComparison of microleakage of photo-cured composites using three different light sources: halogen lamp, LED and argon laser: an in vitro study
Tielemans, M.; Compère, Philippe ULg; Geerts, Sabine ULg et al

in Lasers in Medical Science (2009), 24(1), 1-5

In this study, we compared the microleakage of composite fillings cured with halogen bulb, LED and argon ion laser (488 nm). Twenty-four extracted human molars were divided randomly in three groups. Six ... [more ▼]

In this study, we compared the microleakage of composite fillings cured with halogen bulb, LED and argon ion laser (488 nm). Twenty-four extracted human molars were divided randomly in three groups. Six cavities were prepared on the coronal part of each tooth. Standard cavities (1.7 x 2 mm) were prepared. Cavities were acid etched, sealed with Scotch Bond 1 and filled by a hybrid composite. Cavities were exposed to one light source, thermocycled and immersed in a 2% methylene blue dye solution. Dye penetration in the leakage of cavities was recorded using a digital optical microscope. Mean values of percentage of dye penetrations in microleakages of cavities were 49.303 +/- 5.178% for cavities cured with LED, 44.486 +/- 6.075% with halogen bulb and 36.647 +/- 5.936% for those cured by argon laser. Statistically significant difference exists between cavities cured by halogen vs LED (P < 0.01), halogen vs laser (P < 0.001) and LED vs laser (P < 0.001). The lowest microleakage was observed in the cavities and composites cured with argon ion laser. [less ▲]

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See detailINPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse
Jacoby, Monique; Cox, James J.; Gayral, Stéphanie et al

in Nature Genetics (2009), 41

The primary cilium is an antenna-like structure that protrudes from the cell surface of quiescent/differentiated cells and participates in extracellular signal processing1–3. Here, we report that mice ... [more ▼]

The primary cilium is an antenna-like structure that protrudes from the cell surface of quiescent/differentiated cells and participates in extracellular signal processing1–3. Here, we report that mice deficient for the lipid 5-phosphatase Inpp5e develop a multiorgan disorder associated with structural defects of the primary cilium. In ciliated mouse embryonic fibroblasts, Inpp5e is concentrated in the axoneme of the primary cilium. Inpp5e inactivation did not impair ciliary assembly but altered the stability of pre-established cilia after serum addition. Blocking phosphoinositide 3-kinase (PI3K) activity or ciliary platelet-derived growth factor receptor a (PDGFRa) restored ciliary stability. In human INPP5E, we identified a mutation affecting INPP5E ciliary localization and cilium stability in a family with MORM syndrome, a condition related to Bardet-Biedl syndrome. Together, our results show that INPP5E plays an essential role in the primary cilium by controlling ciliary growth factor and PI3K signaling and stability, and highlight the consequences of INPP5E dysfunction. [less ▲]

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See detailFirst insights into the gut microflora associated with an echinoid from wood falls environments
Becker, Pierre; Samadi, Sarah; Zbinden, Magali et al

in Cahiers de Biologie Marine (2009), 50

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See detailWood-based diet and gut microflora of a galatheid crab associated with Pacific deep-sea wood falls
Hoyoux, Caroline ULg; Zbinden, Magali; Samadi, Sarah et al

in Marine Biology (2009)

Wood falls in the deep sea have recently become the focus of studies showing their importance as nutrients on the deep-sea Xoor. In such environments, Crustaceans constitute numerically the second-largest ... [more ▼]

Wood falls in the deep sea have recently become the focus of studies showing their importance as nutrients on the deep-sea Xoor. In such environments, Crustaceans constitute numerically the second-largest group after Mollusks. Many questions have arisen regarding their trophic role therein. A careful examination of the feeding appendages, gut contents, and gut lining of Munidopsis andamanica caught with wood falls revealed this species as a truly original detritivorous species using wood and the biofilm covering it as two main food sources. Comparing individuals from other geographic areas from substrates not reported highlights the galatheid crab as specialist of refractory substrates, especially vegetal remains. M. andamanica also exhibits a resident gut microXora consisting of bacteria and fungi possibly involved in the digestion of wood fragments. The results suggest that Crustaceans could be full-fledged actors in the food chains of sunken-wood ecosystems and that feeding habits of some squat lobsters could be different than scavenging. [less ▲]

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See detailPolyolefin matrixes with permanent antibacterial activity: preparation, antibacterial activity, and action mode of the active species
Lenoir, Sandrine; Pagnoulle, Christophe; Galleni, Moreno ULg et al

Poster (2008, May 22)

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See detailKarsts in sandstones and quartzites of Minas Gerais, Brazil
Willems, Luc ULg; Rodet, Joël; Pouclet, André et al

in Cadernos do Laboratorio Xeolóxico de Laxe (2008), 33

The state of Minas Gerais (Brazil) is characterized by significant karst regions, which develop <br /><br />in both sandstone and quartzite terrains and display complex suites of underground and ... [more ▼]

The state of Minas Gerais (Brazil) is characterized by significant karst regions, which develop <br /><br />in both sandstone and quartzite terrains and display complex suites of underground and surfaceforms. In the Espinhaço Ridge, Central Minas Gerais, several caves of up to a few hundred metres long, occur in the surroundings of the town of Diamantina. Some of these caves, such as Salitre actually consist of swallow-holes. Other horizontal caves are characterized by corrosion forms generated in the phreatic zone. In some places, such as in the Rio Preto area, these phreatic forms are overprinted by ceiling tubes, suggesting a polyphase karst evolution, prior to the draining in the cave. Remains of paths, with circular cross section up to one metre in diameter, can be found through residual tower-like surface landforms widely present in the landscapes. Their dissection is due to a generalised karstification in the area, resulting in closed canyons, megakarrens and kamenitzas. In Southern Minas Gerais, close to the Mantiqueira Ridge, the caves of the Ibitipoca state park can reach more than 2 km in length. These caves are associated with a very large hanging geological syncline. Several of these caves contain active streams, which flow for hundreds of metres before disappearing in sand-choked passages. Keyhole cross sections characterize steeply descending passages in these caves, indicatinga chan ge from slow phreatic flow towards a faster vadose flow responsible for the vertical incision of the passage. Such change is probably related to base level lowering and/or to turn in the direction of the water flow. Several generations of wall-pockets, from a few centimetres to over a metre long, occur into the caves. These features are good indicators of the initial phase of speleogenesis, generating the initial conduits by their coalescence. This mechanism is also responsible for cut-off meanders. In the area, the main river flows along the syncline axis and cuts through a rock barrier, generating a tunnel-like passage. This cave drains, through resurgences in its walls, part of the water that flows in other caves located in the flank of the syncline. [less ▲]

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See detailMorphological alterations of zooxanthellae in bleached cnidarian hosts
Ladrière, Ophélie ULg; Compère, Philippe ULg; Decloux, Nicole ULg et al

in Cahiers de Biologie Marine (2008), 49(3), 215-227

Studying the morphological changes of zooxanthellae in the host gastroderm is essential to understand the mechanisms of bleaching. Transmission electron microscopy was used to observe samples from four ... [more ▼]

Studying the morphological changes of zooxanthellae in the host gastroderm is essential to understand the mechanisms of bleaching. Transmission electron microscopy was used to observe samples from four coral species-three collected from a barrier reef in Madagascar (Acropora digitifera (Dana, 1846), Echinopora hirsutissima Milne-Edwards & Haime, 1849 and Porites (Synaraea) rus Forskal, 1775)) and one cut from an aquarium-grown coral (Pocillopora damicornis (Linnaeus, 1758)-and from the hermatypic (zooxanthellae-containing) sea anemone Aiptasia pulchella (Carlgren, 1943). Zooxanthellae from bleached animals showed different stages of degradation or disorganization. Some were free, detached from the host gastroderm, associated or not with host-cell remains. Others were vacuolated, with abundant reserve material globules and angular holes probably created by the loss of crystalline material during cutting. Experimentally heat-shocked P. damicornis harboured, moreover, a greater number of dividing algae. Bleached individuals were found to vary as regards their response to stress, and zooxanthellae expelled from heat-shocked anemones showed a greater mitotic index and a higher survival rate than algae extracted or naturally externalized from healthy individuals. We propose a combination of morphological criteria for use in diagnosing the health state of algae-cnidarian symbiosis, so vulnerable in the case of bleaching. [less ▲]

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See detailThe rocker bone: a new kind of mineralised tissue?
Parmentier, Eric ULg; Compère, Philippe ULg; Casadevall, Margarida et al

in Cell & Tissue Research (2008), 334

In some Ophidiiform fishes, the anterior part of the swimbladder is thickened into a hard structure called the “rocker bone”, which is thought to play a role in sound production. Although this structure ... [more ▼]

In some Ophidiiform fishes, the anterior part of the swimbladder is thickened into a hard structure called the “rocker bone”, which is thought to play a role in sound production. Although this structure has been described as cartilage or bone, its nature is still unknown. We have made a thorough analysis of the rocker bone in Ophidion barbatum and compared it with both classical bone and cartilage. The rocker bone appears to be a new example of mineralisation. It consists of (1) a ground substance mainly composed of proteoglycans (mucopolysaccharide acid) and fibres and (2) a matrix containing small mineralised spherules composed of a bioapatite and fibrils. These spherules are embedded in mineralised cement of a similar composition to the spherules themselves. The rocker bone grows via the apposition of new apatite spherules at its periphery. These spherules are first secreted by the innermost fibroblast layer of the capsule contained in the rocker bone and then grow extracellularly. Blood vessels, which represent the only means of transport for matrix and mineral material, are numerous. They enter the rocker bone via the hyle and ramify towards the capsule. We propose to call this new kind of mineralised tissue constituting the rocker bone “frigolite” (the Belgian name for styrofoam) in reference to the presence of spherules of different sizes and the peculiarity of the rocker bone in presenting a smooth surface when fractured. [less ▲]

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See detailThe tropical sea anemone Aiptasia pallida as a lab model for the study of coral bleaching
Ladrière, Ophélie ULg; Roberty, Stéphane ULg; Baudesson, Charlotte et al

Poster (2008)

Bleaching is still among major events threatening coral reefs. New tools have to be developped to better understand the mechanisms leading to this pathology : we studied the use of the hermatypic anemone ... [more ▼]

Bleaching is still among major events threatening coral reefs. New tools have to be developped to better understand the mechanisms leading to this pathology : we studied the use of the hermatypic anemone Aiptasia pallida as experimental model for coral bleaching. Aiptasia appears as a good candidate as it is easy to maintain in aquarium and subjected to bleaching like corals. Both morphological and physiological approaches were performed to investigate the ultrastructure of the anemone tissues (TEM) and the zooxanthellae photophysiology (chlorophyll a fluorescence, respiration and pigmentation). Experiments under light and dark stress reveal that anemone tissues ultrastructure can be differently affected. In darkness, the ectoderm activity is reoriented to capture prey by increasing cnidocyte density. In contrast, intense light affects especially the gastroderm : intercellular spaces increase, the expulsion of intact algae in the gastric cavity and the degradation of zooxanthellae inside vacuoles seem to reduce the zooxanthellae density, chloroplast thylakoids lose their parallel arrangement. The analysis of the fluorescence induction curve appears as a powerful tool to analyse the physiological events series previous to bleaching. Although no significant zooxanthellae density reduction was observed, the decrease of pigments concentrations indicates that light or dark stresses induce anemone bleaching. Under strong light intensity, A. pallida zooxanthellae show an increased proportion of PSII QB non reducing, leading to partial photoinhibition. This phenomenon favours the ROS production that damages cellular structures of host and zooxanthellae. In darkness, there is no photosynthesis; anemones have therefore to find other feeding sources, as suggested by the ultrastructural approach. As the present results confirm some of those obtained on scleractinians, A. pallida can be regarded as a good model for coral bleaching studies and has numerous advantages for experimentation. [less ▲]

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See detailIron oxide deposits associated with the ectosymbiotic bacteria in the hydrothermal vent shrimp Rimicaris exoculata
Corbari, Laure; Cambon-Bonavita, Marie-Anne; Long, Gary et al

in Biogeosciences (2008), 5

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See detailBacterial symbionts and mineral deposits in the branchial chamber of the hydrothermal vent shrimp Rimicaris exoculata: relationship to moult cycle
Corbari, Laure; Zbinden, Magali; Cambon-Bonavita, Marie-Anne et al

in Aquatic Biology (2008), 1

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See detailDiet of crustaceans species associated to deep-sea wood falls
Hoyoux, Caroline ULg; Samadi, Sarah; Zbinden, Magali et al

Poster (2007, November 16)

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See detailKarsts in sandstones and quatrzites of Minas Gerais, Brazil
Willems, Luc ULg; Rodet, J.; Pouclet, A. et al

Poster (2007)

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See detailPolyphase karst system in Cretaceous chalk and calcarenite of the Belgian-Dutch border
Willems, Luc ULg; Rodet, Joël; Fournier, Matthieu et al

in Zeitschrift für Geomorphologie (2007), 51(3), 361-376

Along the Belgian-Dutch border, underground and surface quarries dug in Cretaceous calcarenite and chalk intersect many karst features as well as deep large nodes of weathered rock. Their observation ... [more ▼]

Along the Belgian-Dutch border, underground and surface quarries dug in Cretaceous calcarenite and chalk intersect many karst features as well as deep large nodes of weathered rock. Their observation allows the reconstruction of the genesis of an original karst system resulting from the merging of initially independent endokarsts and exokarsts. Deep weathering has developed within the Cretaceous formations, creating nodes of weathered chalk and closed cavities. These phenomena are expanded over time and can form interconnected voids. Near the surface, solution pipes are generated under the coarsest deposits of a fluvial terrace capping the Cretaceous formations. These pipes develop vertically and may be related to the progressive lowering of the water table in connection with the incision of the Meuse valley. Some of these phenomena cut up the older endokarsts and organize complex systems of out-flow within the chalk. [less ▲]

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