References of "Collette, Fabienne"
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See detailEffet de l’âge sur l’encodage en mémoire épisodique en fonction de l’expérience recollective à la reconnaissance: étude en IRMf
François, Sarah ULg; Angel, Lucie; Salmon, Eric ULg et al

Conference (2014)

Introduction. Il est désormais communément admis que l'avancée en âge s'accompagne d'un déclin en mémoire épisodique. Plus précisément, il semblerait que, contrairement aux processus de familiarité, les ... [more ▼]

Introduction. Il est désormais communément admis que l'avancée en âge s'accompagne d'un déclin en mémoire épisodique. Plus précisément, il semblerait que, contrairement aux processus de familiarité, les processus de recollection soient particulièrement touchés (a). Chez les sujets âgés, l'encodage semble requérir une activation préfrontale bilatérale lorsqu'il est réussi, tandis que chez les sujets jeunes cette activation est latéralisée à gauche (b). Dans cette étude, nous nous sommes intéressés aux différences d'activité cérébrale entre participants jeunes et âgés lors de l'encodage en fonction du statut attribué à l'item au moment de la reconnaissance (Recollection ou Familiarité). Méthodologie. Vingt sujets jeunes (entre 19 et 29 ans) et 19 sujets âgés (entre 60 et 78 ans) ont été confrontés, lors d'un examen en IRMf, à des stimuli visuels représentant des objets à propos desquels ils devaient effectuer des jugements de taille. Lors d'une seconde phase, on présentait à nouveau aux volontaires les stimuli de la phase d'encodage ainsi que des items distracteurs. Il leur était demandé de déterminer lesquels étaient nouveaux et lesquels avaient été présentés précédemment. Parmi ces derniers, les participants effectuaient également un jugement de type Recollection- Familiarité. Les analyses statistiques ont été réalisées au moyen du logiciel SPM8, avec un plan évènementiel comparant les modifications d’activité cérébrale entre nos deux groupes de sujets lors de l’encodage (1) pour les items ayant donné lieu à un processus de recollection lors de la phase de reconnaissance par rapport à ceux associés à de la familiarité (processus de Recollection), (2) pour les items associés à de la familiarité lors de la reconnaissance par rapport à ceux non-reconnus (processus de Familiarité). Résultats. La mise en jeu de processus de recollection lors de la récupération est spécifiquement associée lors de l'encodage, chez les sujets âgés à des augmentations d'activité au niveau du gyrus frontal moyen droit, des gyri cingulaire et paracingulaire médians gauches, ainsi qu'au niveau du précuneus de manière bilatérale. Par contre, aucune activité cérébrale plus importante lors de l’encodage n’était observée dans le groupe de sujets âgés pour les items ayant induit un processus de familiarité lors de la récupération Discussion. Parmi ces régions, le précuneus semble intervenir pour favoriser des processus compensatoires permettant aux seniors d’améliorer la richesse de l’encodage, ainsi qu’il a été précédemment suggéré pour les processus de recollection lors de la récupération(c). Au contraire, les processus de familiarité, moins exigeants en ressources attentionnelles, ne semblent pas recruter de tels processus de compensation. Références (a) Bugaiska, A., Clarys, D., Jarry, C., Taconnat, L., Tapia, G., Vanneste, S., & Isingrini, M. (2007). The effect of aging in recollective experience: the processing speed and executive functioning hypothesis. Consciousness and Cognition, 16(4), 797-808. doi: 10.1016/j.concog.2006.11.007 (b) Duverne, S., Motamedinia, S., & Rugg, M. D. (2009). The relationship between aging, performance, and the neural correlates of successful memory encoding. Cerebral Cortex, 19(3), 733-744. doi: 10.1093/cercor/bhn122 (c) Angel, L., Bastin, C., Genon, S., Balteau, E., Phillips, C., Luxen, A., . . . Collette, F. (2013). Differential effects of aging on the neural correlates of recollection and familiarity. Cortex, 49(6), 1585-1597. doi: 10.1016/j.cortex.2012.10.002 [less ▲]

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See detailSleep loss changes executive brain responses in the wake maintenance zone
Jaspar, Mathieu ULg; Meyer, Christelle ULg; Muto, Vincenzo ULg et al

Conference (2014)

Objectives:Brain mechanisms underlying executive processes are regulated by circadian and sleep homeostatic processes. Furthermore, during sleep deprivation (SD), cognitive performance and neural ... [more ▼]

Objectives:Brain mechanisms underlying executive processes are regulated by circadian and sleep homeostatic processes. Furthermore, during sleep deprivation (SD), cognitive performance and neural responses are differentially modulated by a clock gene PERIOD3 polymorphism. Here, we investigated interindividual differences on executive brain responses under SD. Critically, we focused on the circadian evening wake maintenance zone (WMZ), a key time-point for sleep-wake regulation. Methods:Thirty healthy young volunteers, genotyped for the PER3 polymorphism (10 PER3 5/5;20 PER3 4/4 homozygotes), underwent42-h SD under constant routine conditions. They performed a 3-back working memorytask in 13successivefMRI sessions. To compare neural activity in the WMZ before and during SD, sessions were realigned according to individual dim light melatonin onset. Results:We tested for a group (PER3 5/5>PER3 4/4) by session effect (WMZ before vs. during SD). From the first evening WMZ(i.e. during a normal waking day) to the second (i.e. following 40h of continuous waking), PER3 5/5 individuals relative toPER3 4/4 showed significantly larger increase in responsesin the left mid-cingulate, bilateral precuneus and thalamus. Interestingly, these regions are involved in executive processes and arousal regulation (thalamus). Conclusions:These results show that the strong circadian wake-maintenance signal depends on sleep pressure, in a PER3-genotype dependent manner. Interestingly, pronounced genotype differences wereobserved in the thalamus, an area that compensates potential lower cortical activity under SD. [less ▲]

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See detailSleep loss changes executive brain responses in the wake maintenance zone
Jaspar, Mathieu ULg; Meyer, Christelle ULg; Muto, Vincenzo ULg et al

in Journal of Sleep Research (2014), 23(1), 61

Objectives: Brain mechanisms underlying executive processes are regulated by circadian and sleep homeostatic processes. Furthermore, during sleep deprivation (SD), cognitive performance and neural ... [more ▼]

Objectives: Brain mechanisms underlying executive processes are regulated by circadian and sleep homeostatic processes. Furthermore, during sleep deprivation (SD), cognitive performance and neural responses are differentially modulated by a clock gene PERIOD3 polymorphism. Here, we investigated interindividual differences on executive brain responses under SD. Critically, we focused on the circadian evening wake maintenance zone (WMZ), a key time-point for sleep-wake regulation. Methods: Thirty healthy young volunteers, genotyped for the PER3 polymorphism (10 PER3 5/5; 20 PER3 4/4 homozygotes), underwent 42-h SD under constant routine conditions. They performed a 3-back working memory task in 13 successive fMRI sessions. To compare neural activity in the WMZ before and during SD, sessions were realigned according to individual dim light melatonin onset. Results: We tested for a group (PER3 5/5 > PER3 4/4) by session effect (WMZ before vs. during SD). From the fi rst evening WMZ (i.e. during a normal waking day) to the second (i.e. following 40 h of continuous waking), PER3 5/5 individuals relative to PER3 4/4 showed significantly larger increase in responses in the left mid-cingulate, bilateral precuneus and thalamus. Interestingly, these regions are involved in executive processes and arousal regulation (thalamus). Conclusions: These results show that the strong circadian wake-maintenance signal depends on sleep pressure, in a PER3-genotype dependent manner. Interestingly, pronounced genotype differences were observed in the thalamus, an area that compensates potential lower cortical activity under SD. [less ▲]

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See detailSeasonal variation in human executive brain responses
Meyer, Christelle ULg; Jaspar, Mathieu ULg; Muto, Vincenzo ULg et al

Poster (2014)

It is well established that cognition shows daily fluctuations with changes in circadian phase and sleep pressure. The physiological impact of season changes, which is well characterized in animals ... [more ▼]

It is well established that cognition shows daily fluctuations with changes in circadian phase and sleep pressure. The physiological impact of season changes, which is well characterized in animals, remains largely unexplored in human. Here we investigated the impact of seasonal variation on human cognitive brain function. This cross-sectional study,conducted in Liège (Belgium),spanned from May 2010 to October 2011. Following 8h in-lab baseline night of sleep, 30 volunteers (age 20.9+1.5; 15F)spent 42h awake under constant routine conditions(<5lux, semi-recumbent position, no time-cues). After12h recovery night, they underwent15minfMRI recording while performing a working memory 3-back task (3b) and a letter detection 0-back task (0b). Thus, fMRI data were acquired when volunteers had been in isolation under controlled conditionsfor 63h. Executive brain responses were isolated by subtracting 0b activity from 3b responses (3b>0b).Analysis tested seasonal influence on executive brain responses at the random effects level, using a phasoranalysis across the year.Inferences were conducted at p<0.05, after correction for multiple comparisons over a priori small volume of interest. Significanteffects of season on executive responses were detected inmiddle frontal and frontopolarregions, insula, and thalamus, with a maximum response at the end of summer and a minimum response at the end of winter.These brain areas are key regions for executive control and alertness. These results constitute the first demonstration that seasonality directly impacts on human cognitive brain functions. [less ▲]

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See detailThe neural bases of proactive and reactive control processes in normal aging
Manard, Marine ULg; François, Sarah ULg; Salmon, Eric ULg et al

in Frontiers in Human Neuroscience (2014)

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See detailThe impact of aging and hearing status on verbal working memory
Verhaegen, Clémence ULg; Collette, Fabienne ULg; Majerus, Steve ULg

in Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition (2014), 21(4), 464-482

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See detailCognitive and neuroimaging evidence of impaired interaction between Self and memory in Alzheimer’s disease
Genon, Sarah ULg; Bahri, Mohamed Ali ULg; Collette, Fabienne ULg et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2014), 51

In human cognition, self and memory processes strongly interact, as evidenced by the memory advantage for self-referential materials (Self Reference Effect (SRE) and Self Reference Recollection Effect ... [more ▼]

In human cognition, self and memory processes strongly interact, as evidenced by the memory advantage for self-referential materials (Self Reference Effect (SRE) and Self Reference Recollection Effect (SRRE)). The current study examined this interaction at the behavioural level and its neural correlates in patients with Alzheimer’s disease (AD). Healthy older controls (HC) and AD patients performed trait-adjectives judgements either for self-relevance or for other-relevance (encoding phase). In a first experiment, the encoding and subsequent yes-no recognition phases were administrated in an MRI scanner. Brain activation as measured by fMRI was examined during self-relevance judgements and anatomical images were used to search for correlation between the memory advantage for self-related items and grey matter density (GMD). In a second experiment, participants described the retrieval experience that had driven their recognition decisions (familiarity vs. recollective experience). The behavioural results revealed that the SRE and SRRE were impaired in AD patients compared to HC participants. Furthermore, verbal reports revealed that the retrieval of self-related information was preferentially associated with the retrieval of contextual details, such as source memory in the HC participants, but less so in the AD patients. Our imaging findings revealed that both groups activated the medial prefrontal cortex (MPFC) at encoding during self-relevance judgments. However, the variable and limited memory advantage for self-related information was associated with GMD in the lateral prefrontal cortex in the AD patients, a region supporting high-order processes linking self and memory. These findings suggest that even if AD patients engage MPFC during self-referential judgments, the retrieval of self-related memories is qualitatively and quantitatively impaired in relation with altered high-order processes in the lateral PFC. [less ▲]

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See detailMetabolic cerebral correlates of conjunctive and relational memory in Alzheimer's disease
Bastin, Christine ULg; Bahri, Mohamed Ali ULg; Collette, Fabienne ULg et al

Poster (2014)

Introduction. Memory deficits are the clinical hallmark of typical Alzheimer’s disease. The precise nature of these deficits however remains to be fully characterized. In this study, we investigated ... [more ▼]

Introduction. Memory deficits are the clinical hallmark of typical Alzheimer’s disease. The precise nature of these deficits however remains to be fully characterized. In this study, we investigated binding in long-term episodic memory. Relational binding processes in memory create an associative link between independent items or between items and context into episodic memories (Cohen et al., 1999). An alternative process, conjunctive binding, allows associations to be encoded as a united representation of features into a single entity (O'Reilly and Rudy, 2001; Mayes et al., 2007). The current study (1) assessed whether Alzheimer’s disease disrupt both conjunctive and relational memory, and (2) related patients’ memory performance to cerebral metabolism. Methods. Thirty patients with mild Alzheimer’s disease and 24 healthy older adults performed a source memory task where items were associated to a background color (Diana et al., 2008, 2010). In one condition, relational binding was promoted by the instruction to associate the item with another object of the same color as the background. In the other condition, color had to be integrated as an item feature (conjunctive binding). Patients’ brain metabolic activity at rest (FDG-PET) was analysed with spatio-temporal Partial Least Squares (McIntosh et al., 1996) in order to assess the relation of behavioral performance and activity in functional cerebral networks. Results. Alzheimer’s disease patients had an impaired capacity to remember item-color associations, with deficits in both relational and conjunctive memory. However, performance in the two kinds of associative memory varied independently across patients. Partial least square analyses revealed a significant pattern of metabolic activity that correlated specifically with each condition (accounting for 76.48 % of the covariance in the data; p< .05). More specifically, poor conjunctive memory was related to hypometabolism in an anterior temporal-posterior fusiform brain network, whereas relational memory correlated with metabolism in regions of the default mode network. Conclusions. These findings support the hypothesis of distinct neural systems specialized in different types of associative memory and point to heterogeneous profiles of memory alteration in Alzheimer’s disease as a function of damage to the respective neural networks. [less ▲]

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See detailA Partial Least Squares Analysis of the self reference effect in Alzheimer's disease: A reply to Irish
Genon, Sarah ULg; Bastin, Christine ULg; Angel, Lucie et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2014), 54

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