Showing results 201 to 220 of 306
  Modulation of brain activity during phonological familiarizationMajerus, Steve  ; Van der Linden, Martial ; Collette, Fabienne et alin Brain & Language (2005), 92(3), 320-331 We measured brain activity in 12 adults for the repetition of auditorily presented words and nonwords, before and after repeated exposure to their phonological form. The nonword phoneme combinations were ... [more ▼] We measured brain activity in 12 adults for the repetition of auditorily presented words and nonwords, before and after repeated exposure to their phonological form. The nonword phoneme combinations were either of high (HF) or low (LF) phonotactic frequency. After familiarization, we observed, for both word and nonword conditions, decreased activation in the left posterior superior temporal gyrus, in the bilateral temporal pole and middle temporal gyri. At the same time, interaction analysis showed that the magnitude of decrease of activity in bilateral posterior temporal lobe was significantly smaller for LF nonwords, relative to words and HF nonwords. Decrease of activity in this area also correlated with the size of behavioral familiarization effects for LF nonwords. The results show that the posterior superior temporal gyrus plays a fundamental role during phonological learning. Its relationship to sublexical and lexical phonological processing as well as to phonological short-term memory is discussed. (c) 2004 Elsevier Inc. All rights reserved. [less ▲] Detailed reference viewed: 32 (3 ULg) Cerebral metabolic correlates of four dementia scales in Alzheimer's diseaseSalmon, Eric ; Lespagnard, Solange ; et alin Journal of Neurology (2005), 252(3), 283-290 Different scales can be used to evaluate dementia severity in Alzheimers disease (AD). They do assess different cognitive or functional abilities, but their global scores are frequently in mutual ... [more ▼] Different scales can be used to evaluate dementia severity in Alzheimers disease (AD). They do assess different cognitive or functional abilities, but their global scores are frequently in mutual correlation. Functional imaging provides an objective method for the staging of dementia severity. Positron emission tomography was used to assess the relationship between brain metabolism and four dementia scales that reflect a patients global cognitive abilities (mini mental state), caregivers evaluation of cognitive impairment (newly designed scale), daily living functioning (instrumental activities of daily living) and global dementia (clinical dementia rating). We wondered whether different clinical dementia scales would be related to severity of metabolic impairment in the same brain regions, and might reflect impairment of common cognitive processes. 225 patients with probable AD were recruited in a prospective multicentre European study. All clinical scales were related to brain metabolism in associative temporal, parietal or frontal areas. A factorial analysis demonstrated that all scales could be classified in a single factor. That factor was highly correlated to decrease of cerebral activity in bilateral parietal and temporal cortices, precuneus, and left middle frontal gyrus. This finding suggests that global scores for all scales provided similar information on the neural substrate of dementia severity. Capitalizing on the neuroimaging literature, dementia severity reflected by reduced metabolism in posterior and frontal associative areas in AD might be related to a decrease of controlled processes. [less ▲] Detailed reference viewed: 57 (2 ULg)Time-of-day modulations of rCBF response in functional brain imaging studies: a meta-analysis; ; et al in NeuroImage (2005), 26(Suppl. 1), Detailed reference viewed: 7 (1 ULg)Neural correlates of retrieval of emotional memoriesSterpenich, Virginie ; D'Argembeau, Arnaud ; Balteau, Evelyne et alPoster (2005) Detailed reference viewed: 9 (3 ULg)EXploration des processus inhibiteurs dans le vieillissement normal et la maladie d'AlzheimerCollette, Fabienne ; Adam, Stéphane ; et alin Revue Neurologique (2005), 161(12), 467 Detailed reference viewed: 17 (3 ULg)Exploration of the neural substrates of executive functioning in neuroimagingCollette, Fabienne Conference (2005) Detailed reference viewed: 2 (1 ULg)Two Aspects of Impaired Consciousness in Alzheimer's DiseaseSalmon, Eric ; ; et alin Progress in Brain Research (2005), 150(Boundaries of Consciousness: Neurobiology and Neuropathology), 287-98 Alzheimer's disease (AD) is a degenerative dementia characterized by different aspects of impaired consciousness. For example, there is a deficit of controlled processes that require conscious processing ... [more ▼] Alzheimer's disease (AD) is a degenerative dementia characterized by different aspects of impaired consciousness. For example, there is a deficit of controlled processes that require conscious processing of information. Such an impairment is indexed by decreased performances at controlled cognitive tasks, and it is related to reduced brain metabolic activity in a network of frontal, posterior associative, and limbic regions. Another aspect of impaired consciousness is that AD patients show variable levels of anosognosia concerning their cognitive deficits. A discrepancy score between patient's and caregiver's assessment of cognitive functions is one of the most frequently used measures of anosognosia. A high discrepancy score has been related to impaired activity in the superior frontal sulcus and the parietal cortex in AD. Anosognosia for cognitive deficits in AD could be partly explained by impaired metabolism in parts of networks subserving self-referential processes (e.g., the superior frontal sulcus) and perspective-taking (e.g., the temporoparietal junction). We hypothesize that these patients are impaired in the ability to see themselves with a third-person perspective (i.e., being able to see themselves as other people see them). [less ▲] Detailed reference viewed: 80 (17 ULg)The implication of the right frontal cortex in self recognitionDevue, Christel ; Brédart, Serge ; Collette, Fabienne et alConference (2005) Detailed reference viewed: 16 (9 ULg)La mémoire de travailCollette, Fabienne ; Van der Linden, Martial in Gély-Nargeot, Marie-Christine; Ergis, Anne-Marie; Van der Linden, Martial (Eds.) Les troubles de la mémoire dans la maladie d'Alzheimer (2005) Detailed reference viewed: 75 (6 ULg)Exploration de l'administrateur central de la mémoire de travail au moyen de la tomographie par émission de positons (TEP)Collette, Fabienne in Gueguen, B.; Chauvel, P.; Touchon, J. (Eds.) Neurophysiologie des mémoires (2005) Detailed reference viewed: 29 (2 ULg)Evaluation de l’effet d’oubli induit à la récupération dans le vieillissement normal; Adam, Stéphane ; Collette, Fabienne Poster (2004, December 04) Detailed reference viewed: 3 (0 ULg)Stroop interference and negative priming in normal aging; Adam, Stéphane ; Collette, Fabienne Poster (2004, December 02) Detailed reference viewed: 12 (0 ULg)Updating information in working memory elicits both transient and sustained brain responsesCollette, Fabienne ; Salmon, Eric ; Balteau, Evelyne et alConference (2004, December) Detailed reference viewed: 20 (5 ULg)Are spatial memories strengthened in the human hippocampus during slow wave sleep?Peigneux, Philippe ; Laureys, Steven ; et alin Neuron (2004), 44(3), 535-545 In rats, the firing sequences observed in hippocampal ensembles during spatial learning are replayed during subsequent sleep, suggesting a role for posttraining sleep periods in the offline processing of ... [more ▼] In rats, the firing sequences observed in hippocampal ensembles during spatial learning are replayed during subsequent sleep, suggesting a role for posttraining sleep periods in the offline processing of spatial memories. Here, using regional cerebral blood flow measurements, we show that, in humans, hippocampal areas that are activated during route learning in a virtual town are likewise activated during subsequent slow wave sleep. Most importantly, we found that the amount of hippocampal activity expressed during slow wave sleep positively correlates with the improvement of performance in route retrieval on the next day. These findings suggest that learning-dependent modulation in hippocampal activity during human sleep reflects the offline processing of recent episodic and spatial memory traces, which eventually leads to the plastic changes underlying the subsequent improvement in performance. [less ▲] Detailed reference viewed: 30 (1 ULg)Transient and sustained cerebral responses during an updating taskCollette, Fabienne ; Salmon, Eric ; Balteau, Evelyne et alConference (2004, August) Detailed reference viewed: 15 (2 ULg)Directed forgetting in normal aging: the role of processing speed; Adam, Stéphane ; Collette, Fabienne Poster (2004, June 25) Detailed reference viewed: 8 (0 ULg)Retrieval-induced forgetting in normal aging; Adam, Stéphane ; Collette, Fabienne Poster (2004, May 05) Detailed reference viewed: 5 (0 ULg)PréambuleMeulemans, Thierry ; Collette, Fabienne ; Van der Linden, Martial in Meulemans, Thierry; Collette, Fabienne; Van der Linden, Martial (Eds.) Neuropsychologie des fonctions exécutives (2004) Detailed reference viewed: 5 (2 ULg)Exploration des fonctions exécutives par imagerie cérébraleCollette, Fabienne in Meulemans, Thierry; Collette, Fabienne; Van der Linden, Martial (Eds.) Neuropsychologie des fonctions exécutives (2004) Detailed reference viewed: 165 (3 ULg)Executive functionsCollette, Fabienne ; Van der Linden, Martial in Morris, R. G.; Becker, J. T. (Eds.) The cognitive Neuropsychology of Alzheimer's disease (2004) Detailed reference viewed: 21 (4 ULg) |
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