References of "Collette, Fabienne"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailComparison of inhibitory functioning in mild Alzheimer's disease and frontotemporal dementia
Collette, Fabienne ULg; Amieva, Hélène; Adam, Stéphane ULg et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2007), 43(7), 866-874

Executive dysfunction is frequently reported in Alzheimer's disease (AD) and the frontal variant of frontotemporal dementia (FTD). More specifically, inhibitory dysfunction is observed early in AD and ... [more ▼]

Executive dysfunction is frequently reported in Alzheimer's disease (AD) and the frontal variant of frontotemporal dementia (FTD). More specifically, inhibitory dysfunction is observed early in AD and inhibitory deficits are also prominent in patients with FTD. However, few studies have simultaneously explored and compared inhibitory abilities in both degenerative diseases. Consequently, the aim of this study was to compare verbal and motor inhibitory processes in the initial stages of AD and the frontal variant of FTD. Stroop and Go/No-go tasks were administered. The results demonstrate that, on the Go/No-go task, AD and FTD patients do not produce more errors than control subjects. However, both groups are impaired on the Stroop task (mainly with regard to the error score) but do not differ from each other. These results indicate that AD and FTD patients do not present a general impairment of their inhibitory abilities. Moreover, these two kinds of dementia present similar quantitative and qualitative inhibitory impairments on the two tasks, although their patterns of structural and functional cerebral impairments are known to be different. The presence of similar inhibitory deficits despite very different patterns of brain damage is in agreement with the hypothesis that inhibitory dysfunction in the two groups of patients depends on a disconnection process between anterior and posterior cerebral areas, rather than on the presence of focal metabolism decreases in different regions. [less ▲]

Detailed reference viewed: 117 (12 ULg)
See detailExploration of the neuronal substrates of Directed Forgetting with fMRI.
Feyers, Dorothée ULg; Hogge, Michaël; Salmon, Eric ULg et al

Conference (2007, June 26)

Detailed reference viewed: 4 (2 ULg)
Peer Reviewed
See detailExploration of the neuronal substrates of Directed Forgetting with fMRI
Feyers, Dorothée ULg; Hogge, Michaël; Salmon, Eric ULg et al

Conference (2007, June 01)

Detailed reference viewed: 10 (4 ULg)
Full Text
Peer Reviewed
See detailDistinct regions of the medial prefrontal cortex are associated with self-referential processing and perspective taking
D'Argembeau, Arnaud ULg; Ruby, Perinne; Collette, Fabienne ULg et al

in Journal of Cognitive Neuroscience (2007), 19(6), 935-944

The medial prefrontal cortex (MPFC) appears to play a prominent role in two fundamental aspects of social cognition, that is, self-referential processing and perspective taking. However, it is currently ... [more ▼]

The medial prefrontal cortex (MPFC) appears to play a prominent role in two fundamental aspects of social cognition, that is, self-referential processing and perspective taking. However, it is currently unclear whether the same or different regions of the MPFC mediate these two interdependent processes. This functional magnetic resonance imaging study sought to clarify the issue by manipulating both dimensions in a factorial design. Participants judged the extent to which trait adjectives described their own personality (e.g., 'Are you sociable?') or the personality of a close friend (e.g., 'Is Caroline sociable?') and were also asked to put themselves in the place of their friend (i.e., to take a third-person perspective) and estimate how this person would judge the adjectives, with the target of the judgments again being either the self (e.g., 'According to Caroline, are you sociable?') or the other person (e.g., 'According to Caroline, is she sociable?'). We found that self-referential processing (i.e., judgments targeting the self vs. the other person) yielded activation in the ventral and dorsal anterior MPFC, whereas perspective taking (i.e., adopting the other person's perspective, rather than one's own, when making judgments) resulted in activation in the posterior dorsal MPFC; the interaction between the two dimensions yielded activation in the left dorsal MPFC. These findings show that self-referential processing and perspective taking recruit distinct regions of the MPFC and suggest that the left dorsal MPFC may be involved in decoupling one's own from other people's perspectives on the self. [less ▲]

Detailed reference viewed: 76 (13 ULg)
See detailExploration des substrats cérébraux du fonctionnement exécutif
Collette, Fabienne ULg

Scientific conference (2007, May 29)

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailSocial mind representation: Where does it fail in frontotemporal dementia?
Ruby, P.; Schmidt, Christina ULg; Hogge, Michaël et al

in Journal of Cognitive Neuroscience (2007), 19(4), 671-683

We aimed at investigating social disability and its cerebral correlates in frontotemporal dementia (FTD). To do so, we contrasted answers of patients with early-stage FTD and of their relatives on ... [more ▼]

We aimed at investigating social disability and its cerebral correlates in frontotemporal dementia (FTD). To do so, we contrasted answers of patients with early-stage FTD and of their relatives on personality trait judgment and on behavior prediction in social and emotional situations. Such contrasts were compared to control contrasts calculated with answers of matched controls tested with their relatives. in addition, brain metabolism was measured in patients with positron emission tomography and the [F-18]fluorodeoxyglucose method. Patients turned out to be as accurate as controls in describing their relative's personality, but they failed to predict their relative's behavior in social and emotional circumstances. Concerning the self, patients were impaired both in Current personality assessment and in prediction of their own behavior. Those two self-evaluation measures did not correlate. Only patients' anosognosia for social behavioral disability was found to be related to decreased metabolic activity in the left temporal pole. Such results suggest that anosognosia for social disability in FTD originates in impaired processing of emotional autobiographical information, leading to a self-representation that does not match current behavior. Moreover, we propose that perspective-taking disability participates in anosognosia, preventing patients from correcting their inaccurate self-representation based on their relative's perspective. [less ▲]

Detailed reference viewed: 49 (13 ULg)
See detailAdministrateur central et fonctions exécutives
Collette, Fabienne ULg

Conference (2007, March 27)

Detailed reference viewed: 18 (4 ULg)
Full Text
Peer Reviewed
See detailShort-term memory and the left intraparietal sulcus: Focus of attention? Further evidence from a face short-term memory paradigm
Majerus, Steve ULg; Bastin, Christine ULg; Poncelet, Martine ULg et al

in NeuroImage (2007), 35(1), 353-367

This study explored the validity of an attentional account for the involvement of the left intraparietal sulcus (IPS) in visual STM tasks. This account considers that during STM tasks, the IPS acts as an ... [more ▼]

This study explored the validity of an attentional account for the involvement of the left intraparietal sulcus (IPS) in visual STM tasks. This account considers that during STM tasks, the IPS acts as an attentional modulator, maintaining activation in long-term memory networks that underlie the initial perception and processing of the specific information to be retained. In a recognition STM paradigm, we presented sequences of unfamiliar faces and instructed the participants to remember different types of information: either the identity of the faces or their order of presentation. We hypothesized that, if the left IPS acts as an attentional modulator, it should be active in both conditions, but connected to different neural networks specialized in serial order or face identity processing. Our results showed that the left IPS was activated during both order and identity encoding conditions, but for different reasons. During order encoding, the left IPS showed functional connectivity with order processing areas in the right IPS, bilateral premotor and cerebellar cortices, reproducing earlier results obtained in a verbal STM experiment. During identity encoding, the left IPS showed preferential functional connectivity with right temporal, inferior parietal and medial frontal areas involved in detailed face processing. These results not only support an attentional account of left IPS involvement in visual STM, but given their similarity with previous results obtained for a verbal STM task, they further highlight the importance of the left IPS as an attentional modulator in a variety of STM tasks. [less ▲]

Detailed reference viewed: 119 (29 ULg)
Full Text
Peer Reviewed
See detailMapping the updating process: common and specific brain activations across different versions of the running span task
Collette, Fabienne ULg; Van der Linden, Martial ULg; Laureys, Steven ULg et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2007), 43(1), 146-158

Neuroimaging studies exploring the neural substrates of executive functioning have only rarely investigated whether the non-executive characteristics of the experimental executive tasks could contribute ... [more ▼]

Neuroimaging studies exploring the neural substrates of executive functioning have only rarely investigated whether the non-executive characteristics of the experimental executive tasks could contribute to the observed brain activations. The aim of this study was to determine cerebral activity in three different tasks involving the updating executive function. The experimental updating tasks required subjects to process strings of items (respectively letters, words, and sounds) of unknown lengths, and then to recall or identify a specific number of presented items. Conjunction and functional connectivity analyses demonstrated that the cerebral areas activated by all three experimental tasks are the left frontopolar cortex, bilateral dorsolateral prefrontal and premotor cortex, bilateral intraparietal sulcus, right inferior parietal lobule and cerebellum. Some regions of this network appear to be more specific to each updating task. These results clearly indicate that the neural substrates underlying a specific executive process (in this case, updating) are modulated by the exact requirements of the task (such as the material to process or the kind of response) and the specific cognitive processes associated with updating. [less ▲]

Detailed reference viewed: 60 (5 ULg)
Full Text
See detailMémoire de travail et maladie d'Alzheimer
Adam, Stéphane ULg; Collette, Fabienne ULg

in Vallat-Azouvi, Claire; Aubin, Ghislaine; Coyette, Françoise (Eds.) et al Neuropsychologie de la mémoire de travail (2007)

Detailed reference viewed: 297 (16 ULg)
Peer Reviewed
See detailMémoire de travail et vieillissement normal
Collette, Fabienne ULg

in Aubin, Ghislaine; Coyette, Françoise; Pradat-Diehl, P (Eds.) et al Neuropsychologie de la mémoire de travail (2007)

Detailed reference viewed: 18 (3 ULg)
Full Text
Peer Reviewed
See detailA multicomponent exploration of verbal short-term storage deficits in normal aging and Alzheimer’s disease
Peters, Frédéric; Majerus, Steve ULg; Olivier, Laurence et al

in Journal of Clinical & Experimental Neuropsychology (2007), 29(4), 405-417

Although many studies have shown diminished performance in verbal short-term memory tasks in normal aging and Alzheimer's disease (AD), the cognitive processes responsible for this verbal short-term ... [more ▼]

Although many studies have shown diminished performance in verbal short-term memory tasks in normal aging and Alzheimer's disease (AD), the cognitive processes responsible for this verbal short-term storage (STS) impairment are still unclear for both populations. We explored verbal STS functioning in patients with AD, elderly participants, and young participants, by investigating a series of processes that could underlie STS impairments in normal elderly and AD populations. The processes we investigated were (a) the influence of lexical and sublexical language knowledge on short-term storage performance, (b) functioning of the phonological loop component via word length and phonological similarity effects, and (c) executive control processes (coordination and integration). For the AD and elderly groups, the influence of language knowledge on verbal STS performance and the functioning of the phonological loop were preserved. In contrast, the AD group showed deficits for coordination and integration processes. Our results suggest that the verbal STS deficit observed in AD patients is related to impaired executive control processes. On the other hand, language-related processes underlying passive storage capacity seem to be preserved. [less ▲]

Detailed reference viewed: 58 (9 ULg)
Full Text
Peer Reviewed
See detailSleep-related hippocampo-cortical interplay during emotional memory recollection.
Sterpenich, Virginie ULg; Albouy, Geneviève ULg; Boly, Mélanie ULg et al

in PLoS Biology (2007), 5(11), 282

Emotional events are usually better remembered than neutral ones. This effect is mediated in part by a modulation of the hippocampus by the amygdala. Sleep plays a role in the consolidation of declarative ... [more ▼]

Emotional events are usually better remembered than neutral ones. This effect is mediated in part by a modulation of the hippocampus by the amygdala. Sleep plays a role in the consolidation of declarative memory. We examined the impact of sleep and lack of sleep on the consolidation of emotional (negative and positive) memories at the macroscopic systems level. Using functional MRI (fMRI), we compared the neural correlates of successful recollection by humans of emotional and neutral stimuli, 72 h after encoding, with or without total sleep deprivation during the first post-encoding night. In contrast to recollection of neutral and positive stimuli, which was deteriorated by sleep deprivation, similar recollection levels were achieved for negative stimuli in both groups. Successful recollection of emotional stimuli elicited larger responses in the hippocampus and various cortical areas, including the medial prefrontal cortex, in the sleep group than in the sleep deprived group. This effect was consistent across subjects for negative items but depended linearly on individual memory performance for positive items. In addition, the hippocampus and medial prefrontal cortex were functionally more connected during recollection of either negative or positive than neutral items, and more so in sleeping than in sleep-deprived subjects. In the sleep-deprived group, recollection of negative items elicited larger responses in the amygdala and an occipital area than in the sleep group. In contrast, no such difference in brain responses between groups was associated with recollection of positive stimuli. The results suggest that the emotional significance of memories influences their sleep-dependent systems-level consolidation. The recruitment of hippocampo-neocortical networks during recollection is enhanced after sleep and is hindered by sleep deprivation. After sleep deprivation, recollection of negative, potentially dangerous, memories recruits an alternate amygdalo-cortical network, which would keep track of emotional information despite sleep deprivation. [less ▲]

Detailed reference viewed: 85 (8 ULg)
Full Text
Peer Reviewed
See detailA Synthesis of Functional Neuroimaging in the Frontal Variant of Frontotemporal Dementia
Salmon, Eric ULg; Garraux, Gaëtan ULg; Collette, Fabienne ULg

in Current Medical Imaging Reviews (2007), 3(2), 117-121

The frontal variant of frontotemporal dementia (fvFTD) is clinically characterized by a disruption of the social behaviour. Frontotemporal decrease of activity on functional imaging is an independent ... [more ▼]

The frontal variant of frontotemporal dementia (fvFTD) is clinically characterized by a disruption of the social behaviour. Frontotemporal decrease of activity on functional imaging is an independent marker of the disease. Principal component analysis of cerebral functional images reveals one ensemble comprising both frontal lobes, and two lateralized clusters comprising temporal and subcallosal frontal regions. Executive dysfunction and verbal difficulties are shown to interact in fvFTD, and they are related to large scale frontal and temporal neural networks in the disease. The neural substrate of the memory impairments in patients with fvFTD is also heterogeneous, since correlations were observed with frontal activity, but also with medial temporal atrophy. Behavioural changes are the hallmarks of fvFTD. Apathy is consistently related to frontal involvement, while disinhibition occurs in patients with predominant posterior orbitofrontal and temporal involvement. The consequences of lateralized brain lesions remain a matter of debate, since impulsive and compulsive behaviour was evenly related to right or left temporal involvement in fvFTD. Those patients know social rules, but they are impaired in assessing the importance of social transgressions and in recognizing emotions. Processing transgressions of social norms results in a complex activation of medial prefrontal, orbitofrontal and temporal regions in control populations. The variable decrease in these regional activities observed in different fvFTD patients would explain their complex, individual social disturbance. [less ▲]

Detailed reference viewed: 21 (4 ULg)
Full Text
See detailMémoire de travail et vieillissement normal.
Collette, Fabienne ULg; Péters, Fréderic; Hogge, Michaël et al

in Aubin, Ghislaine; Coyette, Françoise; Pradat-Diehl, Pascale (Eds.) et al Neuropsychologie de la mémoire de travail (2007)

Detailed reference viewed: 665 (20 ULg)