References of "Collette, Fabienne"
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See detailRelating pessimistic memory predictions to Alzheimer’s disease brain structure
Genon, Sarah ULiege; Simon, Jessica ULiege; Bahri, Mohamed Ali ULiege et al

Poster (2017, March 23)

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory ... [more ▼]

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory retrieval and investigated the neural correlates of pessimistic predictions for successfully retrieved memories in AD patients. AD patients and healthy older participants provided predictive judgements on their recognition performance before retrieval of famous (semantic) and recently learned (episodic) names. Correlations between grey matter volume (GMV) in T1 images and behavioural scores were examined with multivariate (PLS) and univariate (GLM) analyses in AD patients. AD patients showed a significant proportion of successful name recognition preceded by pessimistic prediction (Prediction_low_hits) in episodic memory. PLS revealed that behavioural pattern in AD patients was related with a mainly right lateralized pattern of GMV decrease including medial temporal lobe and posterior cingulate cortex, but also right ventrolateral prefrontal cortex (VLPFC). GLM further confirmed that pessimistic prediction negatively correlated with GMV in VLPFC. Thus, impaired monitoring processes (possibly influenced by inaccurate beliefs) allowing inferences about one’s own memory performance are primarily related to decrease GMV in VLPFC in AD patients. [less ▲]

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See detailRecognition memory is associated with hippocampal volume in aging population: new evidence from brain imaging study
Narbutas, Justinas ULiege; Blanpain, Manon ULiege; Van Egroo, Maxime ULiege et al

Poster (2017, March 23)

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory ... [more ▼]

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory declines with aging and this has been associated with hippocampal dysfunction. The main objective of our study was to explore how performance on a recognition memory task designed to assess pattern separation is associated with hippocampal volume in aging population. Methods. Fourteen healthy late middle-aged participants (52-69 years-old) were evaluated on a Mnemonic Similarity Task (MST). In this task, participants study pictures and then have to discriminate between targets, similar lures, and unrelated foil objects. Recognition memory (RM) is assessed as the difference between hits and false alarms to unrelated foils, while pattern separation Bias metric (BPS) is the difference between the rate of ‘‘Similar’’ responses given to the lure items minus ‘‘Similar’’ responses given to the foils. Hippocampal volume was calculated using ASHS software, which uses T1-weighted and T2-weighted MRI to obtain optimal segmentation of hippocampal subfields. Results. Correlation analysis of preliminary data revealed that RM was significantly positively associated with the volume of the left subiculum and left perirhinal area 35, while there were no significant correlations in the right hemisphere. BPS was positively correlated with the volume of right CA2 region, but negatively associated with the volume of right CA3 region, what is more contradictory according to the current literature. No significant link was found between BPS and the volume of hippocampal subfields in the left hemisphere. Conclusion. In a middle-aged population, better visual recognition memory is associated with larger volume of the left subiculum and perirhinal area 35, two regions supporting representation of objects [less ▲]

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See detailNeural correlates of subsequent recollection and familiarity in ageing
François, Sarah ULiege; Angel, Lucie; Salmon, Eric ULiege et al

Poster (2017, March)

It is now commonly accepted that, in ageing, recollection processes are impaired and familiarity seems to be relatively preserved. In this study, we were interested in the differences between younger and ... [more ▼]

It is now commonly accepted that, in ageing, recollection processes are impaired and familiarity seems to be relatively preserved. In this study, we were interested in the differences between younger and older participants regarding cerebral activity during encoding depending on whether the item later elicited recollection or familiarity. Twenty young volunteers and 19 older volunteers were presented visual stimuli depicting objects. After a first fMRI session in which the items were encoded, they underwent a recognition memory task in which they judged whether items were Remembered, Familiar or New. Data were analysed using SPM8, with an event-related design comparing modifications in cerebral activity between the two subjects groups during encoding (1) for the items leading to recollection compared to those leading to familiarity, and (2) for the items associated with familiarity compared to those which were not recognized. Results showed that older adults displayed a heightened activity in regions of the default-mode network for subsequent recollection. As it does not appear to be deleterious, it could stem from a more frequent use of self-referential appraisal as an encoding strategy in older adults. Furthermore, they show supplementary contralateral activations in frontal and temporal regions, which could be indicative of dedifferentiation or attempted compensation. To conclude, it appears that despite relying less on elaborative encoding, older adults seem to be able to perform recollection using qualitatively different strategies than young adults. [less ▲]

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See detailThe need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group.
Costa, Alberto; Bak, Thomas; Caffarra, Paolo et al

in Alzheimer's Research and Therapy (2017), 9(1), 27

Cognitive, behavioural, and functional assessment is crucial in longitudinal studies of neurodegenerative dementias (NDD). Central issues, such as the definition of the study population (asymptomatic, at ... [more ▼]

Cognitive, behavioural, and functional assessment is crucial in longitudinal studies of neurodegenerative dementias (NDD). Central issues, such as the definition of the study population (asymptomatic, at risk, or individuals with dementia), the detection of change/decline, and the assessment of relevant outcomes depend on quantitative measures of cognitive, behavioural, and functional status.Currently, we are far from having available reliable protocols and tools for the assessment of dementias in Europe. The main problems are the heterogeneity of the tools used across different European countries, the lack of standardisation of administration and scoring methods across centres, and the limited information available about the psychometric properties of many tests currently in widespread use. This situation makes it hard to compare results across studies carried out in different centres, thus hampering research progress, in particular towards the contribution to a "big data" common data set.We present here the results of a project funded by the Joint Program for Neurodegenerative Diseases (JPND) and by the Italian Ministry of Health. The project aimed at providing a consensus framework for the harmonisation of assessment tools to be applied to research in neurodegenerative disorders affecting cognition across Europe. A panel of European experts reviewed the current methods of neuropsychological assessment, identified pending issues, and made recommendations for the harmonisation of neuropsychological assessment of neurodegenerative dementias in Europe.A consensus was achieved on the general recommendations to be followed in developing procedures and tools for neuropsychological assessment, with the aim of harmonising tools and procedures to achieve more reliable data on the cognitive-behavioural examination. The results of this study should be considered as a first step to enhancing a common view and practise on NDD assessment across European countries. [less ▲]

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See detailLa neuropsychologie, une discipline d’avenir aux objectifs réaffirmés
Collette, Fabienne ULiege; Amieva, Hélène; Eustache, Francis

in Revue de neuropsychologie (2017), 9(3), 145-153

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See detailLes 40 ans de la SNLF
Amieva, Hélène; Collette, Fabienne ULiege; Eustache, Francis

in Revue de neuropsychologie (2017), 9(3), 143-143

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See detailContribution of four lifelong factors of cognitive reserve on late cognition in normal aging and Parkinson’s disease
Rouillard, Maud; Audiffren, Michel; Albinet, Cédric et al

in Journal of Clinical and Experimental Neuropsychology (2017), 39

Introduction. Cognitive reserve (CR) was proposed to explain how individual differences in brain function help to cope with the effects of normal aging and neurodegenerative diseases. Education ... [more ▼]

Introduction. Cognitive reserve (CR) was proposed to explain how individual differences in brain function help to cope with the effects of normal aging and neurodegenerative diseases. Education, professional solicitations, engagement in leisure and physical activities across the lifetime are considered as major determinants of this reserve. Method. Using multiple linear regression analyses, we tested separately in healthy elderly and Parkinson's disease (PD) populations to what extent cognitive performance in several domains was explained by (1) any of these four environmental lifespan variables ; (2) demographic and clinical variables (age, gender, depression score and, for the PD group, duration of disease and dopaminergic drugs). We also tested for an interaction, if any, between these lifespan variables and brain pathology indexed by global atrophy measured from high-resolution anatomical magnetic resonance imaging. Results. Age was negatively associated with cognitive performance in the PD group. In healthy elderly participants, we observed significant positive associations between cognitive performance and 1) education, 2) leisure activities, 3) professional solicitation (decisional latitude). Furthermore, participants with greater brain atrophy benefited more from CR. In PD patients, education and professional solicitations contributed to cognitive performance but to a lesser extent than in controls. CR factors modulated the relationship between cognition and brain atrophy only in patients with a slight or moderate brain atrophy. Conclusions. Education is the CR factor that contributed the most to late cognitive functioning in both groups, closely followed by leisure activity in normal aging and professional solicitations in PD. Our results also provide evidence suggesting that the effects of CR does not express similarly in normal aging and PD. From a broader perspective, these results seem to indicate that CR factors the most consistently practiced across lifespan (education and professional solicitation) are those that are the more strongly associated to late cognitive efficiency. [less ▲]

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See detailAnosognosie et monitoring des souvenirs associés au « soi » dans la Maladie d’Alzheimer
Genon, Sarah ULiege; Mélon, Marlène; Collette, Fabienne ULiege et al

Conference (2017)

Chez les patients atteints de maladie d’Alzheimer (MA), on observe dès les stades débutants d’une part un phénomène d’anosognosie, qui peut être considéré comme une altération de la conscience de soi, et ... [more ▼]

Chez les patients atteints de maladie d’Alzheimer (MA), on observe dès les stades débutants d’une part un phénomène d’anosognosie, qui peut être considéré comme une altération de la conscience de soi, et d’autre part un dysfonctionnement des processus de monitoring mnésique [1]. En outre, l’interaction entre le soi et la mémoire (conférant un bénéfice mnésique pour les informations associées à soi), apparaît significativement altérée dans la MA. Dans la présente étude, nous avons examiné les relations entre l’anosognosie et le monitoring lors de la récupération en mémoire d’informations expérimentalement associées à soi. Nous avons évalué les processus de monitoring lors de la récupération en mémoire à l’aide d’une tâche expérimentale de 32 paires visage-prénom, ainsi que l’anosognosie à l’aide du questionnaire d’anosognosie dans la démence (AQD, [2]) chez 20 patients MA et 20 personnes âgées contrôles (AC). Durant la phase d’encodage, les paires visage-prénom ont été présentées aux participants soit comme des personnes faisant partie de leur famille (soi) soit comme des personnes faisant partie de la famille de l’expérimentateur (autrui). Ensuite, nous avons évalué les jugements de « sentiment de savoir » (FOK), les performances de rappel et de reconnaissance, ainsi que les jugements de confiance (JOC) des participants pour le nom de chaque personne lorsque son visage était présenté. Nos résultats ont confirmé l’altération de la conscience de soi (c’est-à-dire l’anosognosie mesurée par l’AQD), l’altération du bénéfice mnésique pour les informations associées à soi, ainsi que l’altération des processus de monitoring lors de la récupération en mémoire (FOK et JOC) chez les patients MA. Néanmoins, une modification de l’interaction entre le soi et les processus de monitoring chez ces patients a été observée uniquement au niveau des sentiments de confiance pour des souvenirs erronés. Nous avons également observé que l’anosognosie des troubles comportementaux était significativement corrélée à la proportion de sentiments de confiance pour des reconnaissances erronées sur les items associés à soi. En conclusion, notre étude suggère que l’altération de la conscience des troubles comportementaux chez les patients MA pourrait être liée à un déficit de monitoring des souvenirs liés à soi. C’est-à-dire que la conscience altérée du dysfonctionnement au quotidien pourrait s’appuyer sur des souvenirs personnels déformés. [less ▲]

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See detailProcessus cognitifs et neurobiologiques sous-jacents aux déficits de mémoire épisodique dans la maladie d’Alzheimer
Collette, Fabienne ULiege

Conference (2017)

Les troubles de la mémoire épisodique représentent une des caractéristiques majeures et précoces de la maladie d’Alzheimer. Ces difficultés sont classiquement attribuées à des déficits au niveau de ... [more ▼]

Les troubles de la mémoire épisodique représentent une des caractéristiques majeures et précoces de la maladie d’Alzheimer. Ces difficultés sont classiquement attribuées à des déficits au niveau de l’encodage et de la consolidation de l’information, processus dépendant notamment des régions temporales internes (et plus particulièrement de l’hippocampe) qui sont atteintes très tôt dans le décours de la maladie. Un certain nombre de données récentes ont toutefois amené à raffiner cette conceptualisation initiale. Il est en effet progressivement apparu que des processus très spécifiques sous-tendent la performance aux tâches de mémoire épisodique utilisées en clinique pour le diagnostic de la maladie, tels que la capacité à créer des liens associatifs entre les items ou à créer des représentations mnésiques très distinctives, ou encore la capacité à faire appel à des processus auto-référentiels. L’efficacité de ces processus semble par ailleurs affectée de façon relativement sélective par différents processus neuropathologiques tels que l’atrophie de certaines régions hippocampiques, la diminution de l’épaisseur corticale, la déconnexion entre réseaux cérébraux, la charge amyloide, ou même la présence de facteurs plus subjectifs tels qu’une plainte mnésique. Les troubles de mémoire épisodique associés à la maladie d’Alzheimer semblent donc clairement multidéterminés. En lien avec ces données cognitives et neurobiologiques, nous discuterons également brièvement l’intérêt des classifications actuelles des troubles cognitifs associés au vieillissement pour comprendre le fonctionnement mnésique et ses bases cérébrales. [less ▲]

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See detailThe neural bases of proactive and reactive control processes in normal aging
Manard, Marine ULiege; François, Sarah ULiege; Phillips, Christophe ULiege et al

in Behavioural Brain Research (2017), 320

Introduction. Research on cognitive control suggests an age-related decline in proactive control abilities (anticipatory control), whereas reactive control (following conflict detection) seems to remain ... [more ▼]

Introduction. Research on cognitive control suggests an age-related decline in proactive control abilities (anticipatory control), whereas reactive control (following conflict detection) seems to remain intact. As proactive and reactive control abilities are associated with specific brain networks, this study investigated age-related effects on the neural substrates associated with each kind of control. Methods. In an event-related fMRI study, a modified version of the Stroop task was administered to groups of 20 young and 20 older healthy adults. Based on the theory of dual mechanisms of control, the Stroop task has been built to induce proactive or reactive control depending on task context. Results. Behavioral results (p < .05) indicated faster processing of interfering items in the mostly incongruent (MI) than the mostly congruent (MC) context in both young and older participants. fMRI results showed that reactive control is associated with increased activity in left frontal areas for older participants. For proactive control, decreased activity in the bilateral anterior cingulate cortex was associated with more activity in the right middle frontal gyrus in the older than the younger group. Conclusion. These observations support the hypothesis that aging affects the neural networks associated with reactive and proactive cognitive control differentially. These age-related changes are very similar to those observed in young adults with low dopamine availability, suggesting that a general mechanism (prefrontal dopamine availability) may modulate brain networks associated with various kinds of cognitive control. [less ▲]

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See detailRelating pessimistic memory predictions to Alzheimer’s disease brain structure
Genon, Sarah ULiege; Simon, Jessica ULiege; Bahri, Mohamed Ali ULiege et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2016), 85

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory ... [more ▼]

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory retrieval and investigated the neural correlates of pessimistic predictions for successfully retrieved memories in AD patients. AD patients and healthy older participants provided predictive judgements on their recognition performance before retrieval of famous (semantic) and recently learned (episodic) names. Correlations between grey matter volume (GMV) in T1 images and behavioural scores were examined with multivariate (PLS) and univariate (GLM) analyses in AD patients. AD patients showed a significant proportion of successful name recognition preceded by pessimistic prediction (Prediction_low_hits) in episodic memory. PLS revealed that behavioural pattern in AD patients was related with a mainly right lateralized pattern of GMV decrease including medial temporal lobe and posterior cingulate cortex, but also right ventrolateral prefrontal cortex (VLPFC). GLM further confirmed that pessimistic prediction negatively correlated with GMV in VLPFC. Thus, impaired monitoring processes (possibly influenced by inaccurate beliefs) allowing inferences about one’s own memory performance are primarily related to decrease GMV in VLPFC in AD patients. [less ▲]

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See detailThe influence of COMT on the neural substrates of short-term memory in normal aging
Manard, Marine ULiege; Salmon, Eric ULiege; Collette, Fabienne ULiege

Conference (2016, September 02)

Working memory dopaminergic modulation is generally expressed in healthy aging by an advantage for carriers of the Met allele at behavioral and brain activity levels. However, most tasks used did not ... [more ▼]

Working memory dopaminergic modulation is generally expressed in healthy aging by an advantage for carriers of the Met allele at behavioral and brain activity levels. However, most tasks used did not allow to easily disentangle the contribution of maintenance and manipulation processes. We explored the effect of COMT genotype on the maintenance process using a Sternberg memory task varying the amount of information presented, in young and older homozygous carriers for the Val and Met alleles of the COMT gene. Although no clear behavioral difference was observed between groups, patterns of cerebral activity indicate difficulties for Met older individuals to maintain stable representations. These results will be discussed in terms of dopaminergic contribution to stability/flexibility of cognitive processes during aging. [less ▲]

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See detailAge-related changes in the modulation of attentional brain responses to sleep pressure at night
Schmidt, Christina ULiege; Reichert, Carolin; Maire, Micheline et al

in Journal of Sleep Research (2016, September)

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See detailAge-related differences in the dynamics of cortical excitability and cognitive inhibition during prolongedwakefulness
Gaggioni, Giulia ULiege; Chelllappa, S.; Ly, J. et al

Conference (2016, September)

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See detailLocal modulation of human brain responses by circadian rhythmicity and sleep debt
Muto, Vincenzo ULiege; Jaspar, Mathieu ULiege; Meyer, Christelle et al

in Science (2016), 351(6300),

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See detailEffects of aging on task- and stimulus-related cerebral attention networks
Kurth, Sophie ULiege; Majerus, Steve ULiege; Bastin, Christine ULiege et al

in Neurobiology of Aging (2016), 44

Interactions between a dorsal attention (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short term memory (STM) tasks. Since it remains an ... [more ▼]

Interactions between a dorsal attention (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short term memory (STM) tasks. Since it remains an under-investigated question, age effects on DAN and VAN activity and their functional balance were explored during performance of a STM task. Older and young groups showed similar behavioral patterns of results. At the cerebral level, DAN activation increased as a function of increasing STM load in both groups, suggesting preserved activity in DAN during healthy aging. Age-related over-recruitment in regions of the DAN in the higher task load raised the question of compensation attempt versus less efficient use of neural resources in older adults. Lesser decrease of VAN activation with increasing load and decreased stimulus-driven activation in the VAN, especially in the higher load, in older participants suggested age-related reduced response in the VAN. However, functional connectivity measures showed that VAN was still functionally connected to the DAN in older participants. [less ▲]

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See detailThe influence of COMT on the neural substrates of short-term memory in normal aging
Collette, Fabienne ULiege; Manard, Marine ULiege; Salmon, Eric ULiege

Conference (2016, July 21)

Working memory dopaminergic modulation is generally expressed in healthy aging by an advantage for carriers of the Met allele at behavioral and brain activity levels. However, most tasks used did not ... [more ▼]

Working memory dopaminergic modulation is generally expressed in healthy aging by an advantage for carriers of the Met allele at behavioral and brain activity levels. However, most tasks used did not allow to easily disentangle the contribution of maintenance and manipulation processes. We explored the effect of COMT genotype on the maintenance process using a Sternberg memory task varying the amount of information presented, in young and older homozygous carriers for the Val and Met alleles of the COMT gene. Although no clear behavioral difference was observed between groups, patterns of cerebral activity indicate difficulties for Met older individuals to maintain stable representations. These results will be discussed in terms of dopaminergic contribution to stability/flexibility of cognitive processes during aging. [less ▲]

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See detailDisrupted interaction between self and memory in patients with Alzheimer’s disease
Genon, Sarah ULiege; Salmon, Eric ULiege; Collette, Fabienne ULiege et al

Conference (2016, July)

In humans, self and memory processes interact as evidenced by the self reference (SRE) and self reference recollection effects (SRRE). However, in patients with Alzheimer’s disease (AD), this relationship ... [more ▼]

In humans, self and memory processes interact as evidenced by the self reference (SRE) and self reference recollection effects (SRRE). However, in patients with Alzheimer’s disease (AD), this relationship can be disrupted. This was evidenced by impaired SRE and SRRE in AD for recognition of adjectives previously judged for self-relevance, as well as recall of names of people previously linked to the self. For both materials, a qualitative impairment of the recollective experience for the self-related items was also observed in AD. A neuroimaging approach suggested that reduced SRE is related to decreased grey matter volume in the lateral prefrontal cortex (lPFC). Thus, retrieval of recent self-related memories is impaired in relation to altered high-order processes in lPFC in AD. [less ▲]

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