References of "Collette, Fabienne"
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See detailIs Anosognosia in Alzheimer disease also observed for behavioural and personality changes?
Feyers, Dorothée ULg; Bastin, Christine ULg; Jaspar, Mathieu ULg et al

Poster (2010, May 28)

Anosognosia is a frequent manifestation in Alzheimer disease (AD) but its extent is not yet clearly established. While anosognosia for memory deficit has been widely reported, no study has simultaneously ... [more ▼]

Anosognosia is a frequent manifestation in Alzheimer disease (AD) but its extent is not yet clearly established. While anosognosia for memory deficit has been widely reported, no study has simultaneously explored anosognosia for personality and behaviour changes. We have tackled this question with 20 AD patients and 20 matched elderly subjects (ES). Participants (AD and ES) assessed their personality and their reactions in social situation both in current (S1) and past (S1_bef) time period. Assessment of these characteristics was also performed by relatives of the participants (R2 and R2_bef). Mann-Whitney test (p<0.05) were performed between discrepancy scores (calculated by comparing answers of subjects and relatives) obtained for AD and ES. A specific measure of anosognosia was also calculated by comparing S1 and R2. Statistical analyses demonstrated (1) that relatives of AD patients report more personality and behavioural changes across time (S1-S1_bef) than relatives of ES (R2–R2_bef); (2) that self-reported changes were not significantly different between AD patients and ES; (3) that anosognosia (S1-R2) was observed in AD patients for personality changes only. Results obtained support the hypothesis that anosognosia does not affect all domain in AD. Indeed, even if AD patients are no more able to assess their current personality, they perceive adequately their current reactions in social situations. [less ▲]

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See detailConsciousness of memory functioning in Alzheimer’s disease
Jaspar, Mathieu ULg; Feyers, Dorothée ULg; Bastin, Christine ULg et al

Poster (2010, May 28)

Metamemory is a multi-faceted concept which deals with the individual’s knowledge and control of memory functioning. Previous studies that have examined the ability of Alzheimer’s disease (AD) patients to ... [more ▼]

Metamemory is a multi-faceted concept which deals with the individual’s knowledge and control of memory functioning. Previous studies that have examined the ability of Alzheimer’s disease (AD) patients to monitor efficiently their memory processes provided contradictory results. These discrepancies between studies could be the result of two factors: the kind of memory task used (episodic, semantic) and the kind of memory process on which memory monitoring is assessed (encoding, maintenance, retrieval). In the present study, different aspects of memory monitoring in 21 AD patients and 21 healthy elderly participants were explored with two tasks : a semantic memory task assessing the feeling-of-knowing (FOK) accuracy for general knowledge and an episodic memory task assessing judgment-of-learning (JOL) and FOK accuracy for information associated to a specific spatiotemporal encoding context By comparison to healthy participants, AD patients exhibit impaired performance on episodic FOK accuracy but not on semantic FOK accuracy. Moreover, no difference was observed between the two groups on the JOL post-encoding accuracy. These results confirm that not all aspects of memory monitoring are impaired in AD. Indeed, although there exists an impairment of episodic FOK performance, semantic FOK and JOL post-encoding appear preserved. The dissociation between the two FOK performance could be due to recruitment of more automatic processes for metacognitive judgment on general knowledge (semantic FOK) than for metacognitive judgment based on specific recent experience (episodic FOK). Similarly, a global prediction during maintenance (JOL) could be based on more automatic processes than an item-by-item judgment during retrieval. [less ▲]

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See detailNeural correlates of cognitive control at the item specific level in the Stroop task
Grandjean, Julien ULg; D'Ostilio, Kevin ULg; Fias, Wim et al

Poster (2010, May 04)

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See detailSleep-dependent consolidation of declarative memories is triggered by hippocampal activation at encoding
Collette, Fabienne ULg; Rauchs, Géraldine; Feyers, Dorothée ULg et al

in Proceedings of the Annual Meeting of th Belgian Association for Psychological Science (2010)

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See detailWorking memory load affects chronotype- and time-of-day dependent cerebral activity modulations
Schmidt, Christina ULg; Peigneux, Philippe ULg; Leclercq, Yves ULg et al

in Journal of Sleep Research (2010), 19(Suppl. 2),

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See detailDéficits d’inhibition dans le vieillissement normal et la maladie d’Alzheimer : conséquences de l’atteinte de processus distincts
Collette, Fabienne ULg

in Proceedings de la Société Française de Psychologie "cognition, émotion et société" (2010)

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See detailThe commonality of neural networks for verbal and visual short-term memory.
Majerus, Steve ULg; D'Argembeau, Arnaud ULg; Martinez Perez, Trecy ULg et al

in Journal of Cognitive Neuroscience (2010), 22(11), 2570-2593

Although many neuroimaging studies have considered verbal and visual short-term memory (STM) as relying on neurally segregated short-term buffer systems, the present study explored the existence of shared ... [more ▼]

Although many neuroimaging studies have considered verbal and visual short-term memory (STM) as relying on neurally segregated short-term buffer systems, the present study explored the existence of shared neural correlates supporting verbal and visual STM. We hypothesized that networks involved in attentional and executive processes, as well as networks involved in serial order processing, underlie STM for both verbal and visual list information, with neural specificity restricted to sensory areas involved in processing the specific items to be retained. Participants were presented sequences of nonwords or unfamiliar faces, and were instructed to maintain and recognize order or item information. For encoding and retrieval phases, null conjunction analysis revealed an identical fronto-parieto-cerebellar network comprising the left intraparietal sulcus, bilateral dorsolateral prefrontal cortex, and the bilateral cerebellum, irrespective of information type and modality. A network centered around the right intraparietal sulcus supported STM for order information, in both verbal and visual modalities. Modality-specific effects were observed in left superior temporal and mid-fusiform areas associated with phonological and orthographic processing during the verbal STM tasks, and in right hippocampal and fusiform face processing areas during the visual STM tasks, wherein these modality effects were most pronounced when storing item information. The present results suggest that STM emerges from the deployment of modality-independent attentional and serial ordering processes toward sensory networks underlying the processing and storage of modality-specific item information. [less ▲]

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See detailNeural substrates of recollection and familiarity in Alzheimer’s disease
Genon, Sarah ULg; Salmon, Eric ULg; Collette, Fabienne ULg et al

in Proceedings of the 16th annual meeting of the Organization for Human Brain Mapping (2010)

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See detailLes corrélats cérébraux de le recollection et de la familiarité dans la maladie d’Alzheimer
Genon, Sarah ULg; Salmon, Eric ULg; Collette, Fabienne ULg et al

in Proceedings du XIeme colloque international sur le vieillissement cognitif (2010)

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See detailRecollection and familiarity memory processes in probable Alzheimer's disease: an fMRI study
Genon, Sarah ULg; Salmon, Eric ULg; Collette, Fabienne ULg et al

Scientific conference (2010)

Cerebral activity associated with recollection and familiarity in 28 patients with Alzheimer’s disease (AD) and 17 healthy controls was directly measured in an event-related fMRI experiment during ... [more ▼]

Cerebral activity associated with recollection and familiarity in 28 patients with Alzheimer’s disease (AD) and 17 healthy controls was directly measured in an event-related fMRI experiment during performance of a recognition memory task with the process dissociation procedure. Brain regions associated to recollection were evidenced by contrasting activations for inclusion and exclusion conditions whereas brain regions related to familiarity were explored with the mean effect of the two conditions (at P < .05 corrected). Twelve patients had null recollection estimates (AD-), whereas 16 patients did experience some recollection although significantly less than controls (AD+). In AD+ and controls, recollection activated the posterior cingulate cortex (PCC). In contrast, familiarity estimates were equivalent in the 3 groups and were associated with brain activations around the intraparietal sulcus (IPS). Thus, in AD, impaired recollection is related to damage of the PCC whereas preserved familiarity is supported by the IPS. [less ▲]

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See detailL’anosognosie dans la maladie d’Alzheimer est-elle observée pour les modifications de comportement et de personnalité?
Feyers, Dorothée ULg; Bastin, Christine ULg; Jaspar, Mathieu ULg et al

in Proceedings du XIème Colloque International sur le Vieillissement Cognitif (2010)

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See detailConscience du fonctionnement de la mémoire dans la maladie d’Alzheimer
Jaspar, Mathieu ULg; Feyers, Dorothée ULg; Bastin, Christine ULg et al

in Proceedings du XIeme colloque international sur le vieillissement cognitif (2010)

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See detailNeural networks involved in self-judgement in young and elderly adults
Feyers, Dorothée ULg; Collette, Fabienne ULg; D'Argembeau, Arnaud ULg et al

in NeuroImage (2010)

Recent studies have shown that both young and elderly subjects activate the ventromedial prefrontal cortex (VMPFC) when they make self-referential judgements. However, the VMPFC might interact with ... [more ▼]

Recent studies have shown that both young and elderly subjects activate the ventromedial prefrontal cortex (VMPFC) when they make self-referential judgements. However, the VMPFC might interact with different brain regions during self-referencing in the two groups. In this study, based on data from Ruby et al (2009), we have explored this issue using psychophysiological interaction analyses. Young and elderly participants had to judge adjectives describing personality traits in reference to the self versus a close friend or relative (the other), taking either a first-person or a third-person perspective. The physiological factor was the VMPFC activity observed in all participants during self judgement, and the psychological factor was the self versus other referential process. The main effect of first-person perspective in both groups revealed that the VMPFC was coactivated with the left parahippocampal gyrus and the precuneus for self versus other judgments. The main effect of age showed a stronger correlation between activity in the VMPFC and the lingual gyrus in young compared to elderly subjects. Finally, in the interaction, the VMPFC was specifically co-activated with the orbitofrontal gyrus and the precentral gyrus when elderly subjects took a first-person perspective for self judgements. No significant result was observed for the interaction in young subjects. These findings show that, although the VMPFC is engaged by both young and older adults when making self-referential judgements, this brain structure interacts differently with other brain regions as a function of age and perspective. These differences might reflect a tendency by older people to engage in more emotional/social processing than younger adults when making self-referential judgements with a first-person perspective [less ▲]

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