References of "Collette, Fabienne"
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See detailDevelopment and organization of executive functions in 4-to 11 year-old children: A factor study.
Catale, Corinne ULg; Collette, Fabienne ULg; Lejeune, Caroline ULg et al

in Books of Abstract: Annual Meeting of the Belgian Association for Psychological Science (2011)

Executive functioning (EF) is an umbrella term used to refer to the higher-order cognitive processes whose principal function is to facilitate the adaptation of an individual to new and non-routine ... [more ▼]

Executive functioning (EF) is an umbrella term used to refer to the higher-order cognitive processes whose principal function is to facilitate the adaptation of an individual to new and non-routine situations. In the present study, inhibition, mental flexibility, and working memory were assessed through 6 executive tasks administered to 329 children aged from 4 to 11 years, in order to examine the development and organization of executive functioning in both early and middle childhood. Results reveal specific developmental trends for each component, with a period of rapid general development during the preschool period. Confirmatory factor analyses were used to examine the organization of EF in our sample. First, the poorness of fit of the unitary model was found for both groups, confirming the fractionated nature of EF in preschoolers as well as in older children. Second, the analyses confirmed the adequacy of the fit of the three-dimensional model (i.e., inhibition, flexibility, and working memory), while also indicating that other specific two-dimensional models gave reasonable fits to the data from both age groups. The factor structure obtained supports both the unitary and diversity nature of the executive organisation during early and middle childhood. Furthermore, our data suggest a progressive differentiation of executive processes (in particular flexibility and working memory) in the course of development. [less ▲]

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See detailNeural correlates of controlled memory processes in questionable Alzheimer’s disease
Bastin, Christine ULg; Kerrouche, Nacer; LEKEU, Françoise ULg et al

in Ashford, J. Wesson; Rosen, Allyson; Adamson, Maheen (Eds.) et al Advances in Alzheimer's Disease. Volume 2: Handbook of imaging the Alzheimer brain (2011)

Alzheimer’s disease (AD) is characterized by a progressive loss of controlled cognitive processes (processes requiring mental effort and attentional resources), and functional neuroimaging at early stages ... [more ▼]

Alzheimer’s disease (AD) is characterized by a progressive loss of controlled cognitive processes (processes requiring mental effort and attentional resources), and functional neuroimaging at early stages of AD provides an opportunity to tease out the neural correlates of controlled processes. Controlled and automatic memory performance was assessed with the Process Dissociation Procedure in 50 patients diagnosed with questionable Alzheimer’s disease (QAD). The patients’ brain glucose metabolism was measured using FDG-PET. After a follow-up period of 36 months, 27 patients had converted to AD, while 23 remained stable. Both groups showed a similar decrease in controlled memory processes but preserved automatic processes at entry into the study, suggesting that impairment of controlled memory would not be specific for AD. Patients who subsequently converted to Alzheimer type dementia showed significantly decreased brain metabolism at baseline compared to stable QAD in associative cortices known to be involved in AD (the left precuneus, the right inferior parietal lobule and bilateral middle temporal cortex).Voxel-based cognitive and metabolic correlations showed that a decrease in controlled memory processes was preferentially correlated with lower activity in the dorsomedial prefrontal and posterior cingulate cortices in very early AD patients. The dorsomedial prefrontal cortex would play a role in controlled memory processes as they relate to reflective and monitoring processes, while the posterior cingulate cortex is involved in the controlled access to previously encoded episodes. In stable QAD patients, reduced controlled performance in verbal memory correlated with impaired activity in the left anterior hippocampal structure, which would alter the reactivation of associations created at encoding. [less ▲]

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See detailNeural precursors of delayed insight
Darsaud, Annabelle ULg; Wagner, Ullrich; Balteau, Evelyne ULg et al

in Journal of Cognitive Neuroscience (2011), 23(8), 1900-1910

The solution of a problem left unresolved in the evening can sometimes pop into mind as a sudden insight after a night of sleep in the following morning. Although favorable effects of sleep on insightful ... [more ▼]

The solution of a problem left unresolved in the evening can sometimes pop into mind as a sudden insight after a night of sleep in the following morning. Although favorable effects of sleep on insightful behavior have been experimentally confirmed, the neural mechanisms determining this delayed insight remain unknown. Here, using functional magnetic resonance imaging (fMRI), we characterize the neural precursors of delayed insight in the number reduction task (NRT), in which a hidden task structure can be learned implicitly, but can also be recognized explicitly in an insightful process, allowing immediate qualitative improvement in task performance. Normal volunteers practiced the NRT during two fMRI sessions (training and retest), taking place 12 hours apart after a night of sleep. After this delay, half of the subjects gained insight into the hidden task structure ("solvers," S), whereas the other half did not ("nonsolvers," NS). Already at training, solvers and nonsolvers differed in their cerebral responses associated with implicit learning. In future solvers, responses were observed in the superior frontal sulcus, posterior parietal cortex, and the insula, three areas mediating controlled processes and supporting early learning and novice performance. In contrast, implicit learning was related to significant responses in the hippocampus in nonsolvers. Moreover, the hippocampus was functionally coupled with the basal ganglia in nonsolvers and with the superior frontal sulcus in solvers, thus potentially biasing participants' strategy towards implicit or controlled processes of memory encoding, respectively. Furthermore, in solvers but not in nonsolvers, response patterns were further transformed overnight, with enhanced responses in ventral medial prefrontal cortex, an area previously implicated in the consolidation of declarative memory. During retest in solvers, before they gain insight into the hidden rule, significant responses were observed in the same medial prefrontal area. After insight, a distributed set of parietal and frontal areas is recruited among which information concerning the hidden rule can be shared in a so-called global workspace. [less ▲]

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See detailInfluence of response prepotency strength, general working memory resources, and specific working memory load on the ability to inhibit predominant responses: A comparison of young and elderly participants
Grandjean, Julien ULg; Collette, Fabienne ULg

in Brain & Cognition (2011), 77

One conception of inhibitory functioning suggests that the ability to successfully inhibit a predominant response depends mainly on the strength of that response, the general functioning of working memory ... [more ▼]

One conception of inhibitory functioning suggests that the ability to successfully inhibit a predominant response depends mainly on the strength of that response, the general functioning of working memory processes, and the working memory demand of the task (Roberts, Hager, and Heron, 1994). The proposal that inhibition and functional working memory capacity interact was assessed in the present study using two motor inhibition tasks (Go/No-Go and response incompatibility) in young and older participants. The strength of prepotency was assessed with a short or long training phase for the response to be inhibited. The influence of working memory resources was evaluated by administering the tasks in full versus divided attention conditions. The effect of working memory load was manipulated by increasing the number of target and distracter items in each task. Results showed no effect of prepotency strength, whereas dividing attentional resources and increasing working memory load were associated with greater inhibitory effects in both groups and for both tasks. This deleterious effect was higher for older participants, except in the working memory load condition of the Go/No-Go task. These results suggest an interactive link between working memory and response inhibition by showing that taxing working memory resources increases the difficulty of inhibiting prepotent responses in younger and older subjects. The additional detrimental effect of these factors on healthy elderly subjects was related to their decreased cognitive resources and to their shorter span size. [less ▲]

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See detailCapacités d'inhibition et vieillissement normal
Grandjean, Julien ULg; Collette, Fabienne ULg

in Brouillet, Denis (Ed.) Le vieillissement cognitif normal. Maintenir l'autonomie de la personne âgée. (2011)

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See detailRecollection and familiarity processes in probable Alzheimer's disease: an fMRI study
Genon, Sarah ULg; Collette, Fabienne ULg; Salmon, Eric ULg et al

in Proceedings of the 5th International Conference on Memory (2011)

Cerebral activity associated with recollection and familiarity in 28 patients with Alzheimer’s disease (AD) and 17 healthy controls was directly measured in an event-related fMRI experiment during ... [more ▼]

Cerebral activity associated with recollection and familiarity in 28 patients with Alzheimer’s disease (AD) and 17 healthy controls was directly measured in an event-related fMRI experiment during performance of a recognition memory task with the process dissociation procedure. Brain regions associated to recollection were evidenced by contrasting activations for inclusion and exclusion conditions whereas brain regions related to familiarity were explored with the mean effect of the two conditions (at P < .05 corrected). Twelve patients had null recollection estimates (AD-), whereas 16 patients did experience some recollection although significantly less than controls (AD+). In AD+ and controls, recollection activated the posterior cingulate cortex (PCC). In contrast, familiarity estimates were equivalent in the 3 groups and were associated with brain activations around the intraparietal sulcus (IPS). Thus, in AD, impaired recollection is related to damage of the PCC whereas preserved familiarity is supported by the IPS. [less ▲]

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See detailNeural correlates of cognitive control at the item level in the Stroop task.
Grandjean, Julien ULg; D'Ostilio, Kevin ULg; Fias, Wim et al

Poster (2010, November 15)

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See detailModifications de l’activité cérébrale et troubles mnésiques dans le vieillissement
Collette, Fabienne ULg

Scientific conference (2010, November)

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See detailDéficits d’inhibition dans le vieillissement normal et la maladie d’Alzheimer: pas d’atteinte spécifique aux niveaux de traitement perceptif ou moteur
Stawarczyk, David ULg; Grandjean, Julien ULg; Salmon, Eric ULg et al

Poster (2010, September 24)

Introduction. Une diminution des capacités d’inhibition est fréquemment observée dans le vieillissement normal et la maladie d’Alzheimer. Toutefois, peu d’études ont exploré la généralité de ces déficits ... [more ▼]

Introduction. Une diminution des capacités d’inhibition est fréquemment observée dans le vieillissement normal et la maladie d’Alzheimer. Toutefois, peu d’études ont exploré la généralité de ces déficits au sein d’un groupe unique de participants. Objectif. Déterminer si les déficits d’inhibition présents dans le vieillissement normal et la maladie d’Alzheimer sont en accord avec la distinction entre inhibition perceptive et inhibition motrice proposée par Dempster et Corkill (1999). Méthode. Nous avons administré une large batterie d’épreuves d’inhibition à un groupe de participants jeunes, de participants âgés sains et de patients souffrant de maladie d’Alzheimer. L’inhibition perceptive a été évaluée au moyen des épreuves de Stroop et de priming négatif, de la tâche des ailiers et d’une tâche de résolution de conflit perceptif ; l’inhibition motrice a quant à elle été évaluée au moyen de tâches de go/no-go, de stop-signal, d’antisaccade et de résolution de conflit moteur. Résultats. Les résultats obtenus indiquent la présence d’un pattern mixte de déficits, incluant à la fois des épreuves d’inhibition motrice et d’inhibition perceptive, aussi bien chez les sujets âgés sains que chez les patients souffrant de la maladie d’Alzheimer. Des différences qualitatives de performance ont également été observées entre les deux groupes de sujets âgés. Discussion. Nos résultats ne sont pas en la faveur d’une distinction entre inhibition motrice et perceptive. Les déficits d’inhibition observés dans le vieillissement normal peuvent être interprétés dans le sens d’une diminution générale des ressources de traitement tandis que les déficits des patients Alzheimer peuvent être attribués à une capacité réduite de résistance à l’interférence provenant d’informations non pertinentes dans l’environnement externe de la personne. La présence de différences qualitatives de performance entre les deux groupes de sujets âgés semble indiquer que la maladie d’Alzheimer ne consiste pas en une simple accentuation des difficultés déjà observées lors du vieillissement normal. [less ▲]

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See detailControlled Memory Processes in Questionable Alzheimer's Disease: A View from Neuroimaging Research
Bastin, Christine ULg; Kerrouche N; Lekeu, Françoise ULg et al

in Journal of Alzheimer's Disease [=JAD] (2010), 20(2), 547-560

Alzheimer's disease (AD) is characterized by a progressive loss of controlled cognitive processes, and neuroimaging studies at early stages of AD provide an opportunity to tease out the neural correlates ... [more ▼]

Alzheimer's disease (AD) is characterized by a progressive loss of controlled cognitive processes, and neuroimaging studies at early stages of AD provide an opportunity to tease out the neural correlates of controlled processes. Accordingly, controlled and automatic memory performance was assessed with the Process Dissociation Procedure in 50 patients diagnosed with questionable Alzheimer's disease (QAD). The patients' brain glucose metabolism was measured using FDG-PET. After a follow-up period of 36 months, 27 patients had converted to AD, while 23 remained stable. Both groups showed a similar decrease in controlled memory processes but preserved automatic processes at entry into the study. Voxel-based cognitive and metabolic correlations showed that a decrease in controlled memory processes was preferentially correlated with lower activity in the dorsomedial prefrontal and posterior cingulate cortices in very early AD patients. In stable QAD patients, reduced controlled performance in verbal memory correlated with impaired activity in the left anterior hippocampal structure. The results demonstrated the central role of a medial frontal-posterior cingulate network for controlled processing of episodic memory in the early stages of AD. [less ▲]

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See detailIs Anosognosia in Alzheimer disease also observed for behavioural and personality changes?
Feyers, Dorothée ULg; Bastin, Christine ULg; Jaspar, Mathieu ULg et al

Poster (2010, May 28)

Anosognosia is a frequent manifestation in Alzheimer disease (AD) but its extent is not yet clearly established. While anosognosia for memory deficit has been widely reported, no study has simultaneously ... [more ▼]

Anosognosia is a frequent manifestation in Alzheimer disease (AD) but its extent is not yet clearly established. While anosognosia for memory deficit has been widely reported, no study has simultaneously explored anosognosia for personality and behaviour changes. We have tackled this question with 20 AD patients and 20 matched elderly subjects (ES). Participants (AD and ES) assessed their personality and their reactions in social situation both in current (S1) and past (S1_bef) time period. Assessment of these characteristics was also performed by relatives of the participants (R2 and R2_bef). Mann-Whitney test (p<0.05) were performed between discrepancy scores (calculated by comparing answers of subjects and relatives) obtained for AD and ES. A specific measure of anosognosia was also calculated by comparing S1 and R2. Statistical analyses demonstrated (1) that relatives of AD patients report more personality and behavioural changes across time (S1-S1_bef) than relatives of ES (R2–R2_bef); (2) that self-reported changes were not significantly different between AD patients and ES; (3) that anosognosia (S1-R2) was observed in AD patients for personality changes only. Results obtained support the hypothesis that anosognosia does not affect all domain in AD. Indeed, even if AD patients are no more able to assess their current personality, they perceive adequately their current reactions in social situations. [less ▲]

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See detailConsciousness of memory functioning in Alzheimer’s disease
Jaspar, Mathieu ULg; Feyers, Dorothée ULg; Bastin, Christine ULg et al

Poster (2010, May 28)

Metamemory is a multi-faceted concept which deals with the individual’s knowledge and control of memory functioning. Previous studies that have examined the ability of Alzheimer’s disease (AD) patients to ... [more ▼]

Metamemory is a multi-faceted concept which deals with the individual’s knowledge and control of memory functioning. Previous studies that have examined the ability of Alzheimer’s disease (AD) patients to monitor efficiently their memory processes provided contradictory results. These discrepancies between studies could be the result of two factors: the kind of memory task used (episodic, semantic) and the kind of memory process on which memory monitoring is assessed (encoding, maintenance, retrieval). In the present study, different aspects of memory monitoring in 21 AD patients and 21 healthy elderly participants were explored with two tasks : a semantic memory task assessing the feeling-of-knowing (FOK) accuracy for general knowledge and an episodic memory task assessing judgment-of-learning (JOL) and FOK accuracy for information associated to a specific spatiotemporal encoding context By comparison to healthy participants, AD patients exhibit impaired performance on episodic FOK accuracy but not on semantic FOK accuracy. Moreover, no difference was observed between the two groups on the JOL post-encoding accuracy. These results confirm that not all aspects of memory monitoring are impaired in AD. Indeed, although there exists an impairment of episodic FOK performance, semantic FOK and JOL post-encoding appear preserved. The dissociation between the two FOK performance could be due to recruitment of more automatic processes for metacognitive judgment on general knowledge (semantic FOK) than for metacognitive judgment based on specific recent experience (episodic FOK). Similarly, a global prediction during maintenance (JOL) could be based on more automatic processes than an item-by-item judgment during retrieval. [less ▲]

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See detailSleep-dependent consolidation of declarative memories is triggered by hippocampal activation at encoding
Collette, Fabienne ULg; Rauchs, Géraldine; Feyers, Dorothée ULg et al

in Proceedings of Annul Meeting of the Belgian Association for Psychological Sciences (2010, May 28)

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See detailNeural correlates of cognitive control at the item specific level in the Stroop task
Grandjean, Julien ULg; D'Ostilio, Kevin ULg; Fias, Wim et al

Poster (2010, May 04)

Detailed reference viewed: 11 (4 ULg)