References of "Collette, Fabienne"
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See detailCapacités d'inhibition et vieillissement normal
Grandjean, Julien ULg; Collette, Fabienne ULg

in Brouillet, Denis (Ed.) Le vieillissement cognitif normal. Maintenir l'autonomie de la personne âgée. (2011)

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See detailRecollection and familiarity processes in probable Alzheimer's disease: an fMRI study
Genon, Sarah ULg; Collette, Fabienne ULg; Salmon, Eric ULg et al

in Proceedings of the 5th International Conference on Memory (2011)

Cerebral activity associated with recollection and familiarity in 28 patients with Alzheimer’s disease (AD) and 17 healthy controls was directly measured in an event-related fMRI experiment during ... [more ▼]

Cerebral activity associated with recollection and familiarity in 28 patients with Alzheimer’s disease (AD) and 17 healthy controls was directly measured in an event-related fMRI experiment during performance of a recognition memory task with the process dissociation procedure. Brain regions associated to recollection were evidenced by contrasting activations for inclusion and exclusion conditions whereas brain regions related to familiarity were explored with the mean effect of the two conditions (at P < .05 corrected). Twelve patients had null recollection estimates (AD-), whereas 16 patients did experience some recollection although significantly less than controls (AD+). In AD+ and controls, recollection activated the posterior cingulate cortex (PCC). In contrast, familiarity estimates were equivalent in the 3 groups and were associated with brain activations around the intraparietal sulcus (IPS). Thus, in AD, impaired recollection is related to damage of the PCC whereas preserved familiarity is supported by the IPS. [less ▲]

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See detailNeural correlates of cognitive control at the item level in the Stroop task.
Grandjean, Julien ULg; D'Ostilio, Kevin ULg; Fias, Wim et al

Poster (2010, November 15)

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See detailModifications de l’activité cérébrale et troubles mnésiques dans le vieillissement
Collette, Fabienne ULg

Scientific conference (2010, November)

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See detailDéficits d’inhibition dans le vieillissement normal et la maladie d’Alzheimer: pas d’atteinte spécifique aux niveaux de traitement perceptif ou moteur
Stawarczyk, David ULg; Grandjean, Julien ULg; Salmon, Eric ULg et al

Poster (2010, September 24)

Introduction. Une diminution des capacités d’inhibition est fréquemment observée dans le vieillissement normal et la maladie d’Alzheimer. Toutefois, peu d’études ont exploré la généralité de ces déficits ... [more ▼]

Introduction. Une diminution des capacités d’inhibition est fréquemment observée dans le vieillissement normal et la maladie d’Alzheimer. Toutefois, peu d’études ont exploré la généralité de ces déficits au sein d’un groupe unique de participants. Objectif. Déterminer si les déficits d’inhibition présents dans le vieillissement normal et la maladie d’Alzheimer sont en accord avec la distinction entre inhibition perceptive et inhibition motrice proposée par Dempster et Corkill (1999). Méthode. Nous avons administré une large batterie d’épreuves d’inhibition à un groupe de participants jeunes, de participants âgés sains et de patients souffrant de maladie d’Alzheimer. L’inhibition perceptive a été évaluée au moyen des épreuves de Stroop et de priming négatif, de la tâche des ailiers et d’une tâche de résolution de conflit perceptif ; l’inhibition motrice a quant à elle été évaluée au moyen de tâches de go/no-go, de stop-signal, d’antisaccade et de résolution de conflit moteur. Résultats. Les résultats obtenus indiquent la présence d’un pattern mixte de déficits, incluant à la fois des épreuves d’inhibition motrice et d’inhibition perceptive, aussi bien chez les sujets âgés sains que chez les patients souffrant de la maladie d’Alzheimer. Des différences qualitatives de performance ont également été observées entre les deux groupes de sujets âgés. Discussion. Nos résultats ne sont pas en la faveur d’une distinction entre inhibition motrice et perceptive. Les déficits d’inhibition observés dans le vieillissement normal peuvent être interprétés dans le sens d’une diminution générale des ressources de traitement tandis que les déficits des patients Alzheimer peuvent être attribués à une capacité réduite de résistance à l’interférence provenant d’informations non pertinentes dans l’environnement externe de la personne. La présence de différences qualitatives de performance entre les deux groupes de sujets âgés semble indiquer que la maladie d’Alzheimer ne consiste pas en une simple accentuation des difficultés déjà observées lors du vieillissement normal. [less ▲]

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See detailControlled Memory Processes in Questionable Alzheimer's Disease: A View from Neuroimaging Research
Bastin, Christine ULg; Kerrouche N; Lekeu, Françoise ULg et al

in Journal of Alzheimer's Disease [=JAD] (2010), 20(2), 547-560

Alzheimer's disease (AD) is characterized by a progressive loss of controlled cognitive processes, and neuroimaging studies at early stages of AD provide an opportunity to tease out the neural correlates ... [more ▼]

Alzheimer's disease (AD) is characterized by a progressive loss of controlled cognitive processes, and neuroimaging studies at early stages of AD provide an opportunity to tease out the neural correlates of controlled processes. Accordingly, controlled and automatic memory performance was assessed with the Process Dissociation Procedure in 50 patients diagnosed with questionable Alzheimer's disease (QAD). The patients' brain glucose metabolism was measured using FDG-PET. After a follow-up period of 36 months, 27 patients had converted to AD, while 23 remained stable. Both groups showed a similar decrease in controlled memory processes but preserved automatic processes at entry into the study. Voxel-based cognitive and metabolic correlations showed that a decrease in controlled memory processes was preferentially correlated with lower activity in the dorsomedial prefrontal and posterior cingulate cortices in very early AD patients. In stable QAD patients, reduced controlled performance in verbal memory correlated with impaired activity in the left anterior hippocampal structure. The results demonstrated the central role of a medial frontal-posterior cingulate network for controlled processing of episodic memory in the early stages of AD. [less ▲]

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See detailIs Anosognosia in Alzheimer disease also observed for behavioural and personality changes?
Feyers, Dorothée ULg; Bastin, Christine ULg; Jaspar, Mathieu ULg et al

Poster (2010, May 28)

Anosognosia is a frequent manifestation in Alzheimer disease (AD) but its extent is not yet clearly established. While anosognosia for memory deficit has been widely reported, no study has simultaneously ... [more ▼]

Anosognosia is a frequent manifestation in Alzheimer disease (AD) but its extent is not yet clearly established. While anosognosia for memory deficit has been widely reported, no study has simultaneously explored anosognosia for personality and behaviour changes. We have tackled this question with 20 AD patients and 20 matched elderly subjects (ES). Participants (AD and ES) assessed their personality and their reactions in social situation both in current (S1) and past (S1_bef) time period. Assessment of these characteristics was also performed by relatives of the participants (R2 and R2_bef). Mann-Whitney test (p<0.05) were performed between discrepancy scores (calculated by comparing answers of subjects and relatives) obtained for AD and ES. A specific measure of anosognosia was also calculated by comparing S1 and R2. Statistical analyses demonstrated (1) that relatives of AD patients report more personality and behavioural changes across time (S1-S1_bef) than relatives of ES (R2–R2_bef); (2) that self-reported changes were not significantly different between AD patients and ES; (3) that anosognosia (S1-R2) was observed in AD patients for personality changes only. Results obtained support the hypothesis that anosognosia does not affect all domain in AD. Indeed, even if AD patients are no more able to assess their current personality, they perceive adequately their current reactions in social situations. [less ▲]

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See detailConsciousness of memory functioning in Alzheimer’s disease
Jaspar, Mathieu ULg; Feyers, Dorothée ULg; Bastin, Christine ULg et al

Poster (2010, May 28)

Metamemory is a multi-faceted concept which deals with the individual’s knowledge and control of memory functioning. Previous studies that have examined the ability of Alzheimer’s disease (AD) patients to ... [more ▼]

Metamemory is a multi-faceted concept which deals with the individual’s knowledge and control of memory functioning. Previous studies that have examined the ability of Alzheimer’s disease (AD) patients to monitor efficiently their memory processes provided contradictory results. These discrepancies between studies could be the result of two factors: the kind of memory task used (episodic, semantic) and the kind of memory process on which memory monitoring is assessed (encoding, maintenance, retrieval). In the present study, different aspects of memory monitoring in 21 AD patients and 21 healthy elderly participants were explored with two tasks : a semantic memory task assessing the feeling-of-knowing (FOK) accuracy for general knowledge and an episodic memory task assessing judgment-of-learning (JOL) and FOK accuracy for information associated to a specific spatiotemporal encoding context By comparison to healthy participants, AD patients exhibit impaired performance on episodic FOK accuracy but not on semantic FOK accuracy. Moreover, no difference was observed between the two groups on the JOL post-encoding accuracy. These results confirm that not all aspects of memory monitoring are impaired in AD. Indeed, although there exists an impairment of episodic FOK performance, semantic FOK and JOL post-encoding appear preserved. The dissociation between the two FOK performance could be due to recruitment of more automatic processes for metacognitive judgment on general knowledge (semantic FOK) than for metacognitive judgment based on specific recent experience (episodic FOK). Similarly, a global prediction during maintenance (JOL) could be based on more automatic processes than an item-by-item judgment during retrieval. [less ▲]

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See detailSleep-dependent consolidation of declarative memories is triggered by hippocampal activation at encoding
Collette, Fabienne ULg; Rauchs, Géraldine; Feyers, Dorothée ULg et al

in Proceedings of Annul Meeting of the Belgian Association for Psychological Sciences (2010, May 28)

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See detailNeural correlates of cognitive control at the item specific level in the Stroop task
Grandjean, Julien ULg; D'Ostilio, Kevin ULg; Fias, Wim et al

Poster (2010, May 04)

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See detailWorking memory load affects chronotype- and time-of-day dependent cerebral activity modulations
Schmidt, Christina ULg; Peigneux, Philippe ULg; Leclercq, Yves ULg et al

in Journal of Sleep Research (2010), 19(Suppl. 2),

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