References of "Collette, Fabienne"
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See detailSelf in Dementia
Antoine, Nicolas ULg; Genon, Sarah ULg; Bastin, Christine ULg et al

in Mishara; Corlett, P.; Fletcher, P. (Eds.) et al Phenomenological Neuropsychiatry, How Patient Experience Bridges Clinic with Clinical Neuroscience (in press)

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See detailEffects of aging on task- and stimulus-related cerebral attention networks
Kurth, Sophie ULg; Majerus, Steve ULg; Bastin, Christine ULg et al

in Neurobiology of Aging (2016), 44

Interactions between a dorsal attention (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short term memory (STM) tasks. Since it remains an ... [more ▼]

Interactions between a dorsal attention (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short term memory (STM) tasks. Since it remains an under-investigated question, age effects on DAN and VAN activity and their functional balance were explored during performance of a STM task. Older and young groups showed similar behavioral patterns of results. At the cerebral level, DAN activation increased as a function of increasing STM load in both groups, suggesting preserved activity in DAN during healthy aging. Age-related over-recruitment in regions of the DAN in the higher task load raised the question of compensation attempt versus less efficient use of neural resources in older adults. Lesser decrease of VAN activation with increasing load and decreased stimulus-driven activation in the VAN, especially in the higher load, in older participants suggested age-related reduced response in the VAN. However, functional connectivity measures showed that VAN was still functionally connected to the DAN in older participants. [less ▲]

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See detailDisrupted interaction between self and memory in patients with Alzheimer’s disease
Genon, Sarah ULg; Salmon, Eric ULg; Collette, Fabienne ULg et al

Conference (2016, July)

In humans, self and memory processes interact as evidenced by the self reference (SRE) and self reference recollection effects (SRRE). However, in patients with Alzheimer’s disease (AD), this relationship ... [more ▼]

In humans, self and memory processes interact as evidenced by the self reference (SRE) and self reference recollection effects (SRRE). However, in patients with Alzheimer’s disease (AD), this relationship can be disrupted. This was evidenced by impaired SRE and SRRE in AD for recognition of adjectives previously judged for self-relevance, as well as recall of names of people previously linked to the self. For both materials, a qualitative impairment of the recollective experience for the self-related items was also observed in AD. A neuroimaging approach suggested that reduced SRE is related to decreased grey matter volume in the lateral prefrontal cortex (lPFC). Thus, retrieval of recent self-related memories is impaired in relation to altered high-order processes in lPFC in AD. [less ▲]

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See detailSubstrats cérébraux du contrôle proactif et réactif dans le vieillissement non pathologique
Manard, Marine ULg; François, Sarah ULg; Salmon, Eric ULg et al

Poster (2016, May 27)

Les recherches sur le contrôle cognitif proposent l’apparition d’un déclin lié à l’âge dans les capacités de contrôle proactif (forme anticipatoire de contrôle comportemental) alors que le contrôle ... [more ▼]

Les recherches sur le contrôle cognitif proposent l’apparition d’un déclin lié à l’âge dans les capacités de contrôle proactif (forme anticipatoire de contrôle comportemental) alors que le contrôle réactif (forme réactionnelle à la détection d’un conflit) semble rester intact [1]. Ces deux formes de contrôle ont été associées à des aires cérébrales différentes [2], cependant peu d’études ont étudié les effets de l’âge sur les régions cérébrales sous-tendant chacun de ces deux types de contrôle. Pour ce faire, une version adaptée de la tâche de Stroop a été administrée à 16 jeunes (18-30 ans) et 16 adultes (60-75 ans) en IRM fonctionnelle. Cette version de la tâche variait la quantité d’items interférents, permettant la création de trois contextes (Mostly Congruent « MC », Mostly Incongruent « MI » et Neutre) favorisant respectivement la mise en place des deux types de contrôle (réactif = congruent / proactif = incongruent). Les analyses ont été réalisées avec SPM8 (p<.001 non-corrigé). Les résultats comportementaux révèlent un traitement plus rapide de l’interférence dans le contexte « MI » que « MC » pour les jeunes adultes uniquement. Au niveau cérébral, le traitement de l’interférence en MI semble associé à une diminution d’activité (surtout à droite) dans les régions frontales et temporales chez les volontaires âgés par rapport aux plus jeunes, alors qu’en MC, les âgés montrent une augmentation d’activité bilatérale au niveau frontal. Ainsi, les résultats comportementaux montrent que les adultes âgés semblent avoir plus de difficultés à implémenter un contrôle proactif (associé à une diminution d’activité) que les jeunes dans les régions sous-tendant la performance à cette tâche. Cependant, le recrutement supplémentaire de régions frontales observé lors du contexte MC postulé pour favoriser le contrôle réactif, suggère la présence de mécanismes de compensation. Pour conclure, le vieillissement semble affecter de manière différentielle l’activité des régions cérébrales sous-tendant les différents types de contrôle. [less ▲]

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See detailThe influence of COMT single nucleotide polymorphism (rs4680) on the neural substrates of working memory representations maintenance in healthy aging
Manard, Marine ULg; François, Sarah ULg; Bahri, Mohamed Ali ULg et al

Poster (2016, May 10)

The COMT val108/158met polymorphism was associated to the dopaminergic modulation in the brain, and therefore stimulated research on its influence for cognitive functioning and particularly working memory ... [more ▼]

The COMT val108/158met polymorphism was associated to the dopaminergic modulation in the brain, and therefore stimulated research on its influence for cognitive functioning and particularly working memory. First, a general advantage of carrying the met allele was reported. However, many studies used tasks that did not allow efficiently assessing the contribution of manipulation and maintenance processes in working memory, leading to divergent results, in both young and older populations, resulting in debates about the exact phenotypic effect of the COMT polymorphism. Using fMRI, this study was designed to assess the potential effect of the COMT polymorphism on age-related differences in working memory representations maintenance abilities (Sternberg paradigm). Partial Least Squares method was used to determine the brain-behavior correlations at low, intermediate, and high cognitive demands among young and older groups, homozygous for the val or for the met allele. First, young val/val showed some disadvantages at brain and behavioral level compared to their m/m counterparts. However, in older adults subgroups, the m/m participants tended to show greater age-related difference (when compared to younger adults with similar genotype), suggesting an advantage in carrying the val allele when dopamine signaling is not at optimal efficiency (optimal: young/middle adulthood vs suboptimal: childhood or older ages). These results will be discussed in regard to compensating theories and dopaminergic models accounting for the potential effect of COMT polymorphism on stability/flexibility abilities. [less ▲]

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See detailSeasonality in human cognitive brain responses
Meyer, Christelle ULg; Muto, Vincenzo ULg; Jaspar, Mathieu ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2016)

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See detailRelationship between grey matter integrity and executive abilities in aging
Manard, Marine ULg; Bahri, Mohamed Ali ULg; Salmon, Eric ULg et al

in Brain Research (2016), 1642

This cross-sectional study was designed to investigate grey matter changes that occur in healthy aging and the relationship between grey matter characteristics and executive functioning. Thirty-six young ... [more ▼]

This cross-sectional study was designed to investigate grey matter changes that occur in healthy aging and the relationship between grey matter characteristics and executive functioning. Thirty-six young adults (18 to 30 years old) and 43 seniors (60 to 75 years old) were included. A general executive score was derived from a large battery of neuropsychological tests assessing three major aspects of executive functioning (inhibition, updating and shifting). Age-related grey matter changes were investigated by comparing young and older adults using voxel-based morphometry and voxel-based cortical thickness methods. A widespread difference in grey matter volume was found across many brain regions, whereas cortical thinning was mainly restricted to central areas. Multivariate analyses showed age-related changes in relatively similar brain regions to the respective univariate analyses but appeared more limited. Finally, in the older adult sample, a significant relationship between global executive performance and decreased grey matter volume in anterior (i.e. frontal, insular and cingulate cortex) but also some posterior brain areas (i.e. temporal and parietal cortices) as well as subcortical structures was observed. Results of this study highlight the distribution of age-related effects on grey matter volume and show that cortical atrophy does not appear primarily in “frontal” brain regions. From a cognitive viewpoint, age-related executive functioning seems to be related to grey matter volume but not to cortical thickness. Therefore, our results also highlight the influence of methodological aspects (from preprocessing to statistical analysis) on the pattern of results, which could explain the lack of consensus in literature. [less ▲]

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See detailInfluence of COMT Genotype on Antero-Posterior Cortical Functional Connectivity Underlying Interference Resolution
Jaspar, Mathieu ULg; Manard, Marine ULg; DIDEBERG, Vinciane ULg et al

in Cerebral Cortex (2016), 26

Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val158Met) has received increasing attention as a possible modulator of executive functioning and its neural correlates ... [more ▼]

Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val158Met) has received increasing attention as a possible modulator of executive functioning and its neural correlates. However, this attention has generally centred on the prefrontal cortices because of the well-known direct impact of COMT enzyme on these cerebral regions. In this study, we were interested in the modulating effect of COMT genotype on anterior and posterior brain areas underlying interference resolution during a Stroop task. More specifically, we were interested in the functional connectivity between the right inferior frontal operculum (IFop), an area frequently associated with inhibitory efficiency, and posterior brain regions involved in reading/naming processes (the two main non-executive determinants of the Stroop effect). The Stroop task was administered during fMRI scanning to three groups of 15 young adults divided according to their COMT Val158Met genotype [Val/Val (VV), Val/Met (VM) and Met/Met (MM)]. Results indicate greater activity in the right IFop and the left middle temporal gyrus (MTG) in homozygous VV individuals than in Met allele carriers. In addition, the VV group exhibited stronger positive functional connectivity between these two brain regions and stronger negative connectivity between the right IFop and left lingual gyrus. These results confirm the impact of COMT genotype on frontal function. They also strongly suggest that differences in frontal activity influence posterior brain regions related to a non-executive component of the task. Especially, changes in functional connectivity between anterior and posterior brain areas might correspond to compensatory processes for performing the task efficiently when the available dopamine level is low. [less ▲]

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See detailLe fonctionnement exécutif dans le vieillissement normal: Quel rôle accorder aux variables attentionnelles ?
Gilsoul, Jessica ULg; Simon, Jessica ULg; Collette, Fabienne ULg

Conference (2015, December 04)

Introduction. Selon Miyake et al. (2000), le fonctionnement exécutif serait sous-tendu par trois fonctions distinctes - l’inhibition, la flexibilité et la mise à jour - alors que d’autres auteurs (Fisk ... [more ▼]

Introduction. Selon Miyake et al. (2000), le fonctionnement exécutif serait sous-tendu par trois fonctions distinctes - l’inhibition, la flexibilité et la mise à jour - alors que d’autres auteurs (Fisk & Sharp, 2004) suggèrent qu’elles seraient au nombre de quatre (coordination de tâche double). On sait aujourd’hui que l’avancée en âge s’accompagne d’un déclin exécutif. Toutefois, peu d’études ont étudié l’impact de variables non-exécutives (et plus particulièrement attentionnelles) sur la variabilité des performances exécutives dans le vieillissement. Méthode. 114 participants jeunes et 65 participants âgés ont réalisé un ensemble de tâches cognitives évaluant les quatre aspects du fonctionnement exécutif : l’inhibition (Stroop, Anti-saccade, Stop-Signal), la flexibilité (Plus et Moins, Chiffres-Lettres, Global-Local), la mise à jour (Mise à jour sonore, Mise à jour sémantique, Mise à jour de consonnes) et la coordination de tâche double (PASAT, Brown-Peterson, Attention divisée (TEA)). Par ailleurs, nous avons mesuré la vitesse de traitement de l’information (Comparaison de lettres, Stop-signal contrôle, Alerte tonique, Vitesse articulatoire), le fonctionnement attentionnel dans ses aspects d’alerte phasique, d’orientation visuelle externe (Balayage visuel, Motilité oculaire) et d’attention soutenue (Détection d’irrégularités visuelles, Détection de cibles), ainsi que le niveau d’empan. Nous avons tout d’abord comparé les performances des deux groupes sur chacune des tâches exécutives. Pour celles où nous avons observé une différence entre les groupes, nous avons tenté de déterminer si certaines variables non-exécutives pourraient expliquer une part de la variance des performances de nos participants âgés. Résultats. Les comparaisons entre groupes révèlent que les sujets jeunes ont toujours (sauf pour la tâche Stop-Signal) des performances exécutives supérieures à celles des âgés (p<0.01). Lorsque les différentes variables attentionnelles et non-attentionnelles sont introduites dans un modèle de régression multiple stepwise pas à pas, nous observons que les variables attentionnelles expliquent une part significative de la variance pour la tâche Chiffres-Lettres (alerte), la tâche de Mise à jour sémantique (orientation visuelle externe), la tâche de Mise à jour de consonnes (orientation visuelle externe) et la tâche d’attention divisée (alerte et orientation visuelle externe). Discussion. En accord avec de précédentes études, le fonctionnement exécutif décline avec l’âge. Nos résultats indiquent que le déclin de certaines fonctions (mais pas toutes) serait modulé par les capacités attentionnelles. Cette modulation attentionnelle ne serait toutefois pas un processus général, mais dépendrait des caractéristiques propres à chaque tâche. [less ▲]

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See detailMémoire et fonctions exécutives: Nouvelles pistes de recherche
Collette, Fabienne ULg

Conference (2015, October 14)

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See detailAge-related modulations in cognitive functions and its cerebral underpinnings
Collette, Fabienne ULg

Conference (2015, September 04)

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See detailSeasonality in human cognitive brain responses.
Meyer, Christelle ULg; Muto, Vincenzo ULg; Jaspar, Mathieu ULg et al

Poster (2015, September 04)

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See detailThe impact of ageing on episodic memory encoding: an fMRI study
François, Sarah ULg; Angel, Lucie; SALMON, Eric ULg et al

Poster (2015, September 04)

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See detailThe executive functioning in normal aging: Impact of the cognitive reserve
Simon, Jessica ULg; Gilsoul, Jessica ULg; Collette, Fabienne ULg

Poster (2015, September 04)

There exists a large inter-individual variability regarding the effects of aging on cognition. According to Stern (2009), people who developed a high level of reserve are more resilient to the effects of ... [more ▼]

There exists a large inter-individual variability regarding the effects of aging on cognition. According to Stern (2009), people who developed a high level of reserve are more resilient to the effects of aging that individuals with lower cognitive reserve. In this study, we describe the impact of cognitive reserve on executive functions in normal aging. Ninety healthy participants aged from 60 to 80 years were recruited. We assessed the three major executive functions: Inhibition (Stroop test, Hayling test, TAP Incompatibility subtest), Shifting (TAP Flexibility subtest, Plus-Minus task), and Updating (Letter-Number Sequencing subtest from MEM III, Letter memory task, 2-back task). Cognitive reserve was measured by questionnaires assessing educational level, occupation, leisure activities and physical activity across the life. Multiple linear regressions (p<0.05) adjusted for age, quality of sleep, processing speed showed that elderly with a high level of reserve have better performance on updating. We also assessed the effect of each factor of cognitive reserve separately after adjustment for the other. We observed that people with high level of education have better performance on flexibility (TAP Flexibility subtest and composite score) and on updating (Letter-Number Sequencing subtest, Letter memory and composite score). However, we didn’t observe any significant effect of the other factors of cognitive reserve. These results suggest that the cognitive reserve is related to abilities in some executive tests. [less ▲]

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See detailThe effect of ageing and encoding instructions on episodic memory
Hagelstein, Catherine ULg; François, Sarah ULg; Manard, Marine ULg et al

Poster (2015, May 28)

During ageing, a decline in episodic memory is observed, characterized by decreased recollection (a). In this study, we investigated the influence of encoding instructions, intentional or incidental, on ... [more ▼]

During ageing, a decline in episodic memory is observed, characterized by decreased recollection (a). In this study, we investigated the influence of encoding instructions, intentional or incidental, on the performance of younger and older adults during an episodic memory task. Twenty young volunteers (aged 18 to 30 years old) and 20 older volunteers (aged 61 to 72 years old) participated in this experiment. The stimuli consisted of 300 black-and-white drawings of common objects. The task comprised two steps. During the encoding phase, 100 items were presented once ("hard" condition) and 100 other items were presented twice ("easy" condition). During recognition, the items from the encoding phase were presented again, as well as 100 new items. In each age group, half of the participants received incidental encoding instructions (they had to make size judgements about the objects depicted) while the other half were explicitly asked to memorize the objects presented because they would be asked to recognize them later on (intentional encoding). During recognition, they performed a Remember-Know judgement for the items they believed they had seen earlier. We carried out ANOVAs in order to test for the influence of instructions, age group and number of repetitions of the items in one hand on the percentage of recollection and on the other hand on the percentage of familiarity (p<.05). Results show a significant effect of age, with more correct recollection responses in young adults, whereas more correct familiarity was found in older adults. Furthermore, it was found that the items presented twice lead to more recollection than those presented only once. Finally, these results also suggest that in the older group of participants, only for the items presented twice, intentional encoding instructions lead to more recollection and less familiarity. This finding is consistent with previous work showing that the elderly do not easily use elaborate encoding strategies, and that they need more support (here, a second exposition to the material) in order to perform a deep encoding when they are encouraged to do so with intentional learning instructions (b). (a) Bugaiska, A., Clarys, D., Jarry, C., Taconnat, L., Tapia, G., Vanneste, S., & Isingrini, M. (2007). The effect of aging in recollective experience: the processing speed and executive functioning hypothesis. Consciousness and Cognition, 16(4), 797-808. doi: 10.1016/j.concog.2006.11.007 (b) Froger, C., Bouazzaoui, B., Isingrini, M., & Taconnat, L. (2012). Study time allocation deficit of older adults: the role of environmental support at encoding? Psychology and Aging, 27(3), 577-588. doi:10.1037/a0026358 [less ▲]

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See detailThe impact of ageing on episodic memory encoding: an fMRI study
François, Sarah ULg; Angel, Lucie; Salmon, Eric ULg et al

Poster (2015, May 28)

It is now commonly accepted that a decline in episodic memory is observed with ageing: while recollection processes are impaired, familiarity seems to be relatively preserved (a). Older individuals appear ... [more ▼]

It is now commonly accepted that a decline in episodic memory is observed with ageing: while recollection processes are impaired, familiarity seems to be relatively preserved (a). Older individuals appear to recruit prefrontal areas bilaterally when their encoding is successful, while in young adults this activation is found to be left-lateralized (b). In this study, we were interested in the differences between younger and older participant regarding cerebral activity during encoding depending on whether the item elicited recollection or familiarity during the recognition phase. Twenty young volunteers (aged 19 to 29 years old) and 19 older volunteers (aged 60 to 78 years old) were presented visual stimuli depicting objects. During a first fMRI session, they were asked to make a size judgement about them. Then, in a second phase, the subjects were shown the items previously encountered during the encoding phase, as well as distractors. Participants' task was to determine which one were new and which one were seen earlier. For the latter, they also performed a Remember-Know judgement. Data were analysed using SPM8, with an event design comparing modifications in cerebral activity between the two subjects groups during encoding (1) for the items leading to recollection during the recognition phase compared to those leading to familiarity, and (2) for the items associated with familiarity during the recognition phase compared to those which were not recognized. Results show that older adults display a heightened activity in the right middle frontal gyrus, medial cingulate and paracingulate left gyri as well as in the precuneus, bilaterally when they engage recollection processes. Given that activations in these areas did not correlate with performance, they could be interepreted either as dedifferentiation or as an attempt of the ageing brain to compensate for a less elaborate encoding. However, no increase of activity was associated with familiarity processes in older adults, possibly because they are less demanding regarding attentional resources. (a) Bugaiska, A., Clarys, D., Jarry, C., Taconnat, L., Tapia, G., Vanneste, S., & Isingrini, M. (2007). The effect of aging in recollective experience: the processing speed and executive functioning hypothesis. Consciousness and Cognition, 16(4), 797-808. doi: 10.1016/j.concog.2006.11.007 (b) Duverne, S., Motamedinia, S., & Rugg, M. D. (2009). The relationship between aging, performance, and the neural correlates of successful memory encoding. Cerebral Cortex, 19(3), 733-744. doi:10.1093/cercor/bhn122 [less ▲]

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