References of "Coignoul, Freddy"
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See detailDistemper in seals stranded on the Belgian coast during 1998 summer
Jauniaux, Thierry ULg; Desmecht, M.; Van Gompel, J. et al

in annual proceeding (1999)

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See detailPost mortem investigations on a fin whale Balaenoptera physalus stranded along the Belgian coast
Jauniaux, Thierry ULg; Charlier, G.; Desmecht, M. et al

in Proceeding of the 13th Annual conference of the European Cetacean Society (1999)

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See detailDetection of Tryptase in Bovine Mast Cells: Comparison of Enzyme- and Immuno-Histochemistry
Jolly, Sandra ULg; Coignoul, Freddy ULg; Gabriel, Annick ULg et al

in Journal of Comparative Pathology (1999), 120(3), 269-79

Mast cell (MC) phenotypes may vary with respect to tissue site, sensitivity to degranulating agents, dependency on T lymphocytes and, above all, the composition of their granules. Proteinases (either ... [more ▼]

Mast cell (MC) phenotypes may vary with respect to tissue site, sensitivity to degranulating agents, dependency on T lymphocytes and, above all, the composition of their granules. Proteinases (either trypsin-like or chymotrypsin-like) are granule constituents which provide an important means of distinguishing subtypes of MCs in man and rodents. The purpose of this study was to compare the distribution of MC trypsin-like protease (tryptase) in a variety of bovine tissues with the aim of examining MC heterogeneity. Tryptase was found in MCs regardless of their location within tissues. With respect to tryptase content, bovine MC distribution resembled more that of human and canine tissues than that of mice and rats. Comparison of the results yielded by enzyme- and immuno-histochemical staining suggested that a tryptase-negative, dual-specific chymase-positive MC subset occurred, at least in duodenal lamina propria, around bronchioles and within alveolar septa. The study also suggested that monoclonal antibodies raised against human tryptase can be used for quantitation of bovine tryptase in biological fluids; this offers a promising tool for evaluating the role of MC activation in disease. [less ▲]

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See detailHistopathological pattern and humoral immune response to a crude exo-antigen and purified keratinase of Microsporum canis in symptomatic and asymptomatic infected cats.
Mignon, Bernard ULg; Coignoul, Freddy ULg; Leclipteux, T. et al

in Medical Mycology (1999), 37(1), 1-9

In order to understand better the mechanisms involved in the diverse clinical patterns in Microsporum canis-infected cats, the histopathological features were compared in symptomatic and asymptomatic ... [more ▼]

In order to understand better the mechanisms involved in the diverse clinical patterns in Microsporum canis-infected cats, the histopathological features were compared in symptomatic and asymptomatic infected cats. Additionally, the IgG immune response to a crude exo-antigen and purified keratinase of M. canis was studied by ELISA in cats of various clinical and mycological status. Acute and subacute perifolliculitis and folliculitis occurred more frequently in symptomatic than asymptomatic cats. The latter usually displayed signs of chronic inflammation and a marked infiltration of superficial dermis by mast cells, which would suggest that these animals present similarities to chronically dermatophytic humans or animals. When using a crude M. canis antigen, all infected cats were shown to have significantly higher levels of specific IgG when compared to culture negative and mechanical carrier-cats. In these non-infected animals, specific IgG was more frequently detected in adults than in young animals. No difference in anti-crude antigen specific IgG was observed between symptomatic and asymptomatic infected cats, indicating that the presence of IgG is probably unrelated to the clinical status of cats. Anti-keratinase specific IgG was only detected in one of the infected cats. [less ▲]

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See detailMolecular and Clinicopathological Diagnosis of Non-Wildebeest Associated Malignant Catarrhal Fever in Belgium
Desmecht, Daniel ULg; Cassart, Dominique ULg; Rollin, Frédéric ULg et al

in Veterinary Record : Journal of the British Veterinary Association (1999), 144(14), 388

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See detailEtat actuel des transplantations d'organes: place à la xénotransplantation?
Franssen, Colette ULg; Lambrigts, D.; Degesves, S. et al

in Revue Médicale de Liège (1998), 53(2), 97-102

In the last few years, transplantation was an area of intense research activity. However, there is a worldwide shortage of donor organs for clinical transplantations. Currently, interest in ... [more ▼]

In the last few years, transplantation was an area of intense research activity. However, there is a worldwide shortage of donor organs for clinical transplantations. Currently, interest in xenotransplantation research is growing not only because of the increased demand for organs but also because of advances in molecular biology techniques that make possible the genetic or immunological manipulations of the animal donor rather than the human recipient. The better definitions of the mechanisms responsible for xenograft rejection should facilitate appropriate therapeutic strategies for long xenograft survival. [less ▲]

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See detailPractical protocol for large marine mammals necropsy and beach management
Jauniaux, Thierry ULg; Garcia Hartmann, M.; Coignoul, Freddy ULg

in meeting report (1998)

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See detailStranding in Belgium
Jauniaux, Thierry ULg; Coignoul, Freddy ULg

in meeting report (1998)

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See detailLesions of morbillivirus infection in a fin whale (Balaenoptera physalus) stranded along the Belgian coast
Jauniaux, Thierry ULg; Charlier, G.; Desmecht, M. et al

in Veterinary Record : Journal of the British Veterinary Association (1998), 143(15), 423-424

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See detailPathological investigations on guillemots (Uria aalge) stranded on the Belgian coast during the winter of 1993-94
Jauniaux, Thierry ULg; Brosens, L.; Meire, P. et al

in Veterinary Record : Journal of the British Veterinary Association (1998), 143(14), 387-390

Pathological investigations were carried out on 67 guillemots (Uria aalge) washed up on the Belgian coast between November 1993 and March 1994. Emaciation and acute haemorrhagic gastroenteropathy were ... [more ▼]

Pathological investigations were carried out on 67 guillemots (Uria aalge) washed up on the Belgian coast between November 1993 and March 1994. Emaciation and acute haemorrhagic gastroenteropathy were observed in more than 70 per cent of the birds. There was no statistical relationship between the level of oil contamination and the severity of the lesions. Differences in bodyweight were accounted for by age, sex, emaciation, and acute haemorrhagic gastroenteropathy. The birds had a severe weight deficit but the concentrations of pollutants were below acutely toxic levels. [less ▲]

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See detailPostmortem Investigations on Winter Stranded Sperm Whales from the Coasts of Belgium and the Netherlands
Jauniaux, Thierry ULg; Brosens, L.; Jacquinet, E. et al

in Journal of Wildlife Diseases (1998), 34(1), 99-109

During winter 1994-95, four and three sperm whales (Physeter macrocephalus) were stranded along the Belgian and the Dutch coasts, respectively. Necropsies and tissue samplings were collected 24 hrs post ... [more ▼]

During winter 1994-95, four and three sperm whales (Physeter macrocephalus) were stranded along the Belgian and the Dutch coasts, respectively. Necropsies and tissue samplings were collected 24 hrs post mortem. Lesions on several whales included round and linear skin scars, ventral skin abrasions, acute skin ulcers, acute ulcerative stomatitides, acute to chronic external otitides, and passive visceral congestion. In addition, these sperm whales appeared to be debilitated with severe weight deficit, had blubber thickness reduction, the absence of abdominal fat, and the intestinal tracts were almost empty. Three categories of lesions and their possible relation with the stranding were evaluated. Cutaneous scars observed on the seven whales appeared to have no relation with the stranding. The poor body condition and acute integument ulcerative lesions were present before the stranding. Ventral skin abrasions and visceral passive congestion were caused by the strandings. Absence of food in the alimentary tracts, evidence of weight loss and blubber thickness reduction were compatible with an extended presence of the sperm whales in the North Sea, where adequate food is not available. This might lead to progressive weakness, predisposing the animals to secondary pathogens such as viral diseases. Finally, the coastal configuration of the southern North Sea makes it a trap for sperm whales which have entered the area during their wanderings. [less ▲]

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See detailPremière mise en évidence en Belgique de particules ressemblant à des circovirus.
Duchatel, Jean-Pierre ULg; Jauniaux, Thierry ULg; Vandersanden F et al

in Annales de Médecine Vétérinaire (1998), 142

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See detailTissue examination for diatom detection in by-caught cetaceans
Jauniaux, Thierry ULg; Nowosad, A.; Garcia Hartmann, M. et al

in annual proceeding (1997)

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See detailEcotoxicological and pathological studies of common guillemots Uria aalge beached on the Belgian coast during six successive wintering periods (1989-90 to 1994-95)
Debacker, Virginie ULg; Holsbeek, Ludo; Tapia, German et al

in Diseases of Aquatic Organisms (1997), 29(3), 159-168

During 6 successive wintering periods, 727 common guillemots Uria aalge were recovered from Belgian beaches. One-third of the birds were already dead; the rest passed through rehabilitation centres where ... [more ▼]

During 6 successive wintering periods, 727 common guillemots Uria aalge were recovered from Belgian beaches. One-third of the birds were already dead; the rest passed through rehabilitation centres where they eventually died. All birds were monitored for general condition (body mass, fat reserves), eventual status of oiling and pathological changes (cachexia, acute hemorrhagic gastroenteropathy); 339 birds were sampled for trace metals (total and organic Hg, Cu, Zn, Fe, Cd) and PCB (polychlorinated biphenyl) analysis. Oiling is still a major cause of death for wintering pelagic seabirds: half of the birds showed signs of external or internal oiling, probably a still greater number of oiled birds never reach the shores. Although a low body mass can be considered a normal winter condition for wintering guillemots, pathology results showed that three-quarters of the studied animals were in a state of cachexia with emaciated pectoral muscle and lowered muscle lipid content. Elevated levels of Cu, Zn, Hg and PCBs were linked to the state of cachexia and may well represent an additional stress factor leading to the debilitation and death of part of the wintering guillemot population. [less ▲]

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See detailLesions observed on stranded seabirds along the Belgian coast from 1992 to 1995
Jauniaux, Thierry ULg; Brosens, L.; Coignoul, Freddy ULg

in ICES Journal of Marine Science (1997), 54(4), 714-717

From 1992 to 1995, dead seabirds found on Belgian beaches were collected and various tissues of 241 birds were sampled for histopathological, bacteriological, parasitological, and toxicological ... [more ▼]

From 1992 to 1995, dead seabirds found on Belgian beaches were collected and various tissues of 241 birds were sampled for histopathological, bacteriological, parasitological, and toxicological investigations. The most common species examined was the guillemot (Uria aalge). Necropsies revealed cachexia (severe emaciation), acute haemorrhagic gastro-enteropathy and oil contamination in many of these birds. Statistical analyses were performed in order to explore correlations of these with biological parameters such as age, sex, and origin (pelagic or non-pelagic). The pelagic origin of seabirds were associated with the three main findings. Oil contamination was associated with acute gastro-enteropathy and cachexia, and cachexia was more prevalent among juveniles. Finally, cachexia and acute gastro-enteropathy were strongly associated. It is possible that oiled pelagic seabirds become cachectic and die of acute gastro-enteropathy. (C) 1997 International Council for the Exploration of the Sea. [less ▲]

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See detailEtude clinique et anatomopathologique de l'infection expérimentale de lapins par une souche virale amyxomateuse isolée en Belgique
Marlier, Didier ULg; Coignoul, Freddy ULg; Boucraut-Baralon, Corine et al

in Annales de Médecine Vétérinaire (1997), 141

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See detailObservations on the Helminths of Harbour Porpoises (Phocoena Phocoena) and Common Guillemots (Uria Aalge) from the Belgian and German Coasts
Brosens, L.; Jauniaux, Thierry ULg; Siebert, U. et al

in Veterinary Record : Journal of the British Veterinary Association (1996), 139(11), 254-7

Between February 1990 and July 1991, 18 harbour porpoises (Phocoena phocoena) and 248 common guillemots (Uria aalge), found dead along the Belgian and German coasts, were examined for their burden of ... [more ▼]

Between February 1990 and July 1991, 18 harbour porpoises (Phocoena phocoena) and 248 common guillemots (Uria aalge), found dead along the Belgian and German coasts, were examined for their burden of helminths. A total of three species were found in the guillemots (one cestode, one nematode and one pentastomid), and six species in the porpoises (one trematode, one cestode and four nematodes). Among the guillemots the burden of helminths was not statistically different between juvenile and adult birds. The deaths of the birds were apparently not related to the parasite infections. In contrast, the adult porpoises were more heavily parasitised than the juveniles, except for one young porpoise stranded on the Belgian coast. In the porpoises, four species of parasites had a pathological effect and Torynurus convolutus was responsible for the death of one animal from the Belgian coast and three from the German coast. [less ▲]

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See detailA Morphometric and Functional Study of the Toxicity of Atmospheric Ammonia in the Extrathoracic Airways in Pigs
Urbain, B.; Gustin, Pascal ULg; Charlier, G. et al

in Veterinary Research Communications (1996), 20(4), 381-399

The effects of atmospheric ammonia (NH3) on the nasal and tracheal mucosa of pigs were investigated by morphometric and functional methods. Pigs were exposed to four concentrations of NH3 [5 (control), 25 ... [more ▼]

The effects of atmospheric ammonia (NH3) on the nasal and tracheal mucosa of pigs were investigated by morphometric and functional methods. Pigs were exposed to four concentrations of NH3 [5 (control), 25, 50 and 100 ppm] for 6 days in a specially designed air-pollutant exposure chamber. Samples were taken from the turbinates and the trachea, and the respiratory mucosa was examined by light and scanning electron microscopy. Dose-response curves to carbachol and isoproterenol were constructed using isolated strips of tracheal smooth muscle, with or without epithelium. In pigs exposed to ammonia, considerable mucosal injuries were observed in the turbinates but not in the trachea. The number of neutrophils in the epithelial layer and in the lamina propria, and epithelial hyperplasia were closely and significantly correlated with the concentrations of ammonia (r = 0.894, p < 0.001; r = 0.727, P < 0.001; and r = 0.818, p < 0.001, respectively). Except for the lamina propria, all these changes were significant (p < 0.05) at ammonia concentrations as low as 25 ppm. The percentage of the surface of the turbinate mucosa that was ciliated tended to decrease with increasing ammonia concentration (r = 0.439, p < 0.082). Ammonia induced smooth-muscle hyperresponsiveness to carbachol with a close linear correlation between individual values of the carbachol-induced maximal effect and the NH3 concentrations (r = 0.526, p < 0.003). While mechanical destruction of the epithelium induced an increase in Emax in the control group, no difference was observed between the intact and denuded strips from animals exposed to ammonia. The response to isoproterenol was not influenced by ammonia. It was concluded that quantitative histological analysis of the inflammatory infiltration and epithelial hyperplasia in the turbinates is a useful tool for quantifying the effects of atmospheric pollutants in pigs; a 6-day exposure to ammonia induces nasal irritation and functional disturbances of the tracheal smooth-muscle contractions at concentrations as low as 25 ppm [less ▲]

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See detailBronchopulmonary and Disseminated Granulomatous Disease Associated with Aspergillus Fumigatus and Candida Species Infection in a Golden Retriever
Clercx, Cécile ULg; Mc Entee, Kathleen ULg; Snaps, Frédéric ULg et al

in Journal of the American Animal Hospital Association (1996), 32(2, Mar-Apr), 139-45

A seven-year-old, female golden retriever was referred for a paroxysmal, chronic cough and dyspnea, dysphagia, facial pruritus, anterior uveitis, and deteriorating general condition. A severe, mixed ... [more ▼]

A seven-year-old, female golden retriever was referred for a paroxysmal, chronic cough and dyspnea, dysphagia, facial pruritus, anterior uveitis, and deteriorating general condition. A severe, mixed interstitial and alveolar pattern, with poorly defined amorphous lesions, was seen on thoracic radiographs. Multiple, whitish nodules disseminated on the hyperemic respiratory mucosa were noted on bronchoscopy. Escherichia coli and Aspergillus fumigatus were cultured from the bronchoalveolar lavage. Granulomatous lesions in numerous organs were identified during necropsy, and Aspergillus fumigatus and Candida spp. were cultured from lung and kidney tissues. Microscopic granulomatous lesions were compatible with mycotic infection; however fungal organisms were not observed. [less ▲]

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