References of "Coignoul, Freddy"
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See detailNorth Sea seabirds and marine mammals: pathology and ecotoxicology
Debacker, Virginie ULg; Coignoul, Freddy ULg; Das, Krishna ULg et al

Report (2004)

Les Bancs de Flandres accueillent, en hiver, une importante population d'oiseaux pélagiques. Dans le passé, ils étaient également largement fréquentés par les mammifères marins. De nos jours, on ne les ... [more ▼]

Les Bancs de Flandres accueillent, en hiver, une importante population d'oiseaux pélagiques. Dans le passé, ils étaient également largement fréquentés par les mammifères marins. De nos jours, on ne les observe que très rarement et, chaque année, quelques-uns d'entre eux et des centaines d'oiseaux sont trouvés échoués le long de la côte flamande. Ces espèces doivent être protégées, et le but de ce projet de recherche est d'étudier l'état de santé de leurs populations, son évolution temporelle, les pathologies observées et les contaminants associés, ainsi que les causes possibles de mortalités inhabituelles. La nuisance d'origine humaine la plus importante pour les oiseaux marins semble être la pollution par les hydrocarbures, mais les causes effectives des échouages des oiseaux qui ne sont pas mazoutés, et de la rareté des mammifères, restent inconnues (autres pollutions chimiques, diminution de la nourriture disponible, maladies... ?). [less ▲]

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See detailModulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene.
Grobet, Luc ULg; Pirottin, Dimitri ULg; Farnir, Frédéric ULg et al

in Genesis (2003), 35(4), 227-38

By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular ... [more ▼]

By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular hypertrophy of the same magnitude as that observed for constitutive myostatin knockout mice. This formally demonstrates that striated muscle is the production site of functional myostatin and that this member of the TGFbeta family of growth and differentiation factors regulates muscle mass not only during early embryogenesis but throughout development. It indicates that myostatin antagonist could be used to treat muscle wasting and to promote muscle growth in man and animals. [less ▲]

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See detailEchouage de mammifères marins : guide d'intervention et procédures d'autopsie
Jauniaux, Thierry ULg; Garcia-Hartmann, M.; Haelters, J. et al

in Annales de Médecine Vétérinaire (2002), 146(5, OCT-NOV), 261-276

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See detailHow to get the most information out of your necropsy
Jauniaux, Thierry ULg; Coignoul, Freddy ULg

in COST Meeting proceedings (2002)

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See detailPost-mortem findings and causes of death of harbour porpoises (Phocoena phocoena) stranded from 1990 to 2000 along the coastlines of Belgium and northern France
Jauniaux, Thierry ULg; Petitjean, D.; Brenez, C. et al

in Journal of Comparative Pathology (2002), 126(4), 243-253

Between the,ears 1990 and 2000, an attempt was made to determine the causes of death of 55 harbour porpoises stranded along the Belgian and northern French coasts. From 1990 to 1996, only five carcasses ... [more ▼]

Between the,ears 1990 and 2000, an attempt was made to determine the causes of death of 55 harbour porpoises stranded along the Belgian and northern French coasts. From 1990 to 1996, only five carcasses were collected as against seven in 1997, eight in 1998, 27 in 1999 and eight in 2000. The sex ratio was normal and most of the animals were juvenile. The most common findings were emaciation, severe parasitosis and pneumonia. A few cases of fishing net entanglement were observed. The main microscopical lesions were acute pneumonia, massive lung oedema, enteritis, hepatitis and gastritis. Encephalitis was observed in six cases. No evidence of morbillivirus infection was detected. Pneumonia was associated with bacteria or parasites, or both. The causes of death and the lesions were similar to those previously reported in other countries bordering the North Sea. The cause of the increased numbers of carcasses in 1999 was unclear but did not include viral epizootics or net entanglement. A temporary increase in the porpoise populatiou in the southern North Sea may have been responsible. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailMorbillivirus in common seals stranded on the coasts of Belgium and northern France during summer 1998
Jauniaux, Thierry ULg; Boseret, Géraldine ULg; Desmecht, M. et al

in Veterinary Record : Journal of the British Veterinary Association (2001), 148(19), 587-591

Sixteen common seals (Phoca vitulina) were stranded on the Belgian and northern French coasts during the summer of 1998. Eleven (10 pups and one adult) were sampled for histopathological ... [more ▼]

Sixteen common seals (Phoca vitulina) were stranded on the Belgian and northern French coasts during the summer of 1998. Eleven (10 pups and one adult) were sampled for histopathological, immunohistochemical, serological. bacteriological, parasitological and virological investigations. The main gross findings were severe emaciation, acute haemorrhagic enteritis, acute pneumonia, interstitial pulmonary emphysema and oedema, and chronic ulcerative stomatitis. Microscopical lung findings were acute to subacute pneumonia with interstitial oedema and emphysema. Severe lymphocytic depletion was observed in lymph nodes. Severe acute to subacute meningoencephalitis was observed in one animal. Specific staining with two monoclonal antibodies directed against canine distemper virus (CDV) and phocine distemper virus was observed in a few lymphocytes in the spleen and lymph nodes of three seals. Anti-CDV neutralising antibodies were detected in sera from six animals. Seven of the seals were positive by reverse transcriptase-PCR for the morbillivirus phosphoprotein gene. The lesions observed were consistent with those in animals infected by a morbillivirus, and demonstrated that distemper has recently recurred in North Sea seals. [less ▲]

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See detailMorbillivirus infections in marine mammals stranded along the Belgian and Northern French coasts between 1990 and 2000
Jauniaux, Thierry ULg; Boseret, Géraldine ULg; Coignoul, Freddy ULg

in Proceedings 14th biennal conference on the biology of marine mamals (2001)

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See detailEffect of Intravenous Platelet-Activating Factor on Bovine Pulmonary Mast Cells
Jolly, Sandra ULg; Thomas, Cédric; Genicot, Bruno et al

in Journal of Comparative Pathology (2001), 125(Aug-Oct), 81-89

The effect of platelet-activating factor (PAF) on bovine pulmonary mast cells (MCs) was investigated in calves aged 1-4 months. PAF was administered over a 5-min period at a rate of 50 ng/kg/min to six ... [more ▼]

The effect of platelet-activating factor (PAF) on bovine pulmonary mast cells (MCs) was investigated in calves aged 1-4 months. PAF was administered over a 5-min period at a rate of 50 ng/kg/min to six animals, which were killed approximately 10 min later. No macroscopical lesions were observed in the lung tissue of five control calves. On semi-thin toluidine-blue stained sections, MC cytoplasm showed profuse deep-blue granulation. In the lung tissues of PAF-treated calves, striking interstitial, alveolar and interlobular oedema and emphysema were observed. MC granules occurred at the periphery of the cytoplasm and MC nuclei were easily detectable. Moreover, the number of granules in the MC cytoplasm was remarkably low. A few granules with some metachromatic material were sometimes detected outside the cell limits. Ultrastructurally, the matrix pattern of the MC granules in lung tissues of control calves was either amorphous or granular. In lung tissues of the PAF-treated calves, the granular matrix pattern was pronounced, varying from fine- to coarse-grained, and the MCs were of reduced size, with many filiform processes and exocytotic vesicles. These findings indicate that pulmonary MC degranulation was induced by PAF in healthy calves. [less ▲]

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See detailComparative Pathogenesis of Acute and Latent Infections of Calves with Bovine Herpesvirus Types 1 and 5
Meyer, Gilles; Lemaire, Mylène; Ros, C. et al

in Archives of Virology (2001), 146(4), 633-52

This study was conducted to compare the pathogenesis of acute and latent infections with closely related bovine herpesvirus types 1 (BHV-1) and 5 (BHV-5) in their natural host. Two groups of eight calves ... [more ▼]

This study was conducted to compare the pathogenesis of acute and latent infections with closely related bovine herpesvirus types 1 (BHV-1) and 5 (BHV-5) in their natural host. Two groups of eight calves were inoculated intranasally with BHV-1 or BHV-5. Although BHV-1 and BHV-5 similarly replicate in the nasal mucosa after inoculation, both viruses differ markedly in their ability to cause disease, BHV-5 being responsible of some fatal encephalitis while BHV-1 inducing rhinotracheitis. Virus isolation and immunohistochemistry demonstrated that BHV-5 replicates extensively in neurons of the central nervous system (CNS) and in respiratory cells of lungs, tracheal and nasal mucosae. Invasion of the CNS likely occurs through the trigeminal and olfactory pathways. Both groups developed cross-neutralising antibodies during this experiment suggesting partial clinical cross-protection afforded by the two infections. Three months after primary infection, experimental reactivation showed that BHV-5 was able to establish latency in the trigeminal ganglia but also the CNS of surviving calves. Moreover, laboratory findings suggested that BHV-5 could also persist in the tracheal and nasal mucosae. These results indicate that, after primary infection, BHV-1 and BHV-5 displayed similar biological features and consequently need to be considered together for the control of BHV-1 infection. [less ▲]

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See detailPathology of morbillivirus infections in marine mammals
Jauniaux, Thierry ULg; Coignoul, Freddy ULg

in Annales de Médecine Vétérinaire (2001), 145(2), 76-

Morbillivirus infections were described since 1988 in marine mammals including pinnipeds and cetaceans. Since, numerous outbreaks, responsible for thousands marine mammals death, as well as sporadic cases ... [more ▼]

Morbillivirus infections were described since 1988 in marine mammals including pinnipeds and cetaceans. Since, numerous outbreaks, responsible for thousands marine mammals death, as well as sporadic cases, have occurred in various populations from North Atlantic, Mediterranean Sea, Baikal Lake, Caspian Sea, and recently from northern Pacific. Clinical signs and macroscopic lesions are similar between species infected by morbillivirus and are close to those reported in dog with canine distemper. Under microscope, characteristic les ions are interstitial bronchopneumonia, lymphoid depletion and subacute encephalitis. Syncytia and inclusion bodies are frequently observed in lesions and epithelia. Lymphoid depletion promotes secondary infections by opportunistic pathogens, responsible in many cases of the animals death. Various parameters explain the high sensibility of certain population such as the species, the naive immunological status and vectors intervention for the disease. [less ▲]

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See detailHeavy Metals Contamination and Body Condition of Wintering Guillemots (Uria Aalge) at the Belgian Coast from 1993 to 1998
Debacker, Virginie ULg; Jauniaux, Thierry ULg; Coignoul, Freddy ULg et al

in Environmental Research (2000), A84(3), 310-317

A sample of 166 common guillemots (Uria aalge) recovered from Belgian beaches during five wintering seasons, from 1993-1994 to 1997-1998, were examined. At necropsy, postmortem examination including body ... [more ▼]

A sample of 166 common guillemots (Uria aalge) recovered from Belgian beaches during five wintering seasons, from 1993-1994 to 1997-1998, were examined. At necropsy, postmortem examination including body mass, fat reserves, presence or not of intestinal contents, eventual status of oiling, and pathological changes (cachexia, acute hemorrhagic gastroenteropathy (GEAH)) was attributed to each individual. Mild to severe cachexia, a pathology characterized by moderate to severe atrophy of the pectoral muscle as well as reduced amounts or absence of subcutaneous and/or abdominal fat, was observed for most specimens (85.8%). Heavy metal analyses (Cu, Zn, Fe, Cd, Ni, Cr, and Pb) of the tissues (typically liver, kidney, and pectoral muscle) were performed, and total lipids were determined (liver and pectoral muscle). The guillemots collected at the Belgian coast exhibited higher Cu and Zn concentrations compared to individuals collected in more preserved areas of the North Sea such as the northern colonies. A general decrease of their total body mass as well as liver, kidney, and pectoral muscle mass was associated to increasing cachexia severity. Moreover, significantly increasing heavy metal levels (Cu and Zn) in the tissues as well as depleted muscle lipid contents were observed parallel to increasing cachexia severity. On the contrary the organs' total metal burden barely correlates to this status. These observations tend to indicate a general redistribution of heavy metals within the organs as a result of prolonged starvation and protein catabolism (cachectic status). Such a redistribution could well be an additional stress to birds already experiencing stressfull conditions (starvation, oiling). [less ▲]

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See detailEnzyme-Histochemical Detection of a Chymase-Like Proteinase within Bovine Mucosal and Connective Tissue Mast Cells
Jolly, Sandra ULg; Detilleux, Johann ULg; Coignoul, Freddy ULg et al

in Journal of Comparative Pathology (2000), 122(Feb-Apr), 155-162

The presence of chymase-like proteinase in bovine mast cells was investigated by an enzyme-histochemical technique (naphthol-AS-D-chloroacetate as substrate) in normal skin, primary bronchus, lung and ... [more ▼]

The presence of chymase-like proteinase in bovine mast cells was investigated by an enzyme-histochemical technique (naphthol-AS-D-chloroacetate as substrate) in normal skin, primary bronchus, lung and duodenum. The counts and distribution of chymase-positive and toluidine blue-positive mast cells were compared by means of successive staining. Mast cells with chymase-like activity were detected in all areas, but their proportion was greater in connective than mucosal tissues, with the exception of the skin. These results contrast with those obtained in rodents, in which chymase-like proteinases are detected in all tissues and also in all mast cells. Bovine mast cells are closer to those of human beings, in which chymase-containing mast cells predominate in connective tissues, including skin. The results suggest that more than one chymase subset is present, at least in duodenum. The possible occurrence of dual-specific chymase mast cells, as in other ruminants, is discussed. [less ▲]

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See detailPathological Findings in Two Fin Whales (Balaenoptera Physalus) with Evidence of Morbillivirus Infection
Jauniaux, Thierry ULg; Charlier, G.; Desmecht, M. et al

in Journal of Comparative Pathology (2000), 123(2-3, Aug-Oct), 198-201

Two immature female fin whales stranded on the Belgian and French coastlines, were examined post mortem. The main gross findings were massive parasitic infestation, associated with a large thrombus in one ... [more ▼]

Two immature female fin whales stranded on the Belgian and French coastlines, were examined post mortem. The main gross findings were massive parasitic infestation, associated with a large thrombus in one whale, and severe emaciation. Microscopical investigations revealed multinucleated syncytia with large intranuclear inclusion bodies in various tissues, and positive immunolabelling for morbillivirus antigens. Other evidence of morbillivirus infection was provided by the demonstration of specific viral structures in syncytia and in cell cultures, and the detection of neutralizing antibodies to canine distemper virus. To the authors>> knowledge, this is the first firm report of morbillivirus infection in baleen whales. [less ▲]

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See detailExperimental Infection of Specific Pathogen-Free New Zealand White Rabbits with Five Strains of Amyxomatous Myxoma Virus
Marlier, Didier ULg; Cassart, Dominique ULg; Boucraut-Baralon, C. et al

in Journal of Comparative Pathology (1999), 121(4), 369-84

Myxomatosis is a specific disease of the European rabbit (Oryctolagus cuniculus) due to a virus belonging to the genus Leporipoxvirus. Forty-seven years after its deliberate introduction into Europe, the ... [more ▼]

Myxomatosis is a specific disease of the European rabbit (Oryctolagus cuniculus) due to a virus belonging to the genus Leporipoxvirus. Forty-seven years after its deliberate introduction into Europe, the clinical aspects and the epizootiology of myxomatosis have changed. Two forms (nodular and amyxomatous) of the disease have been identified to date. A comparative study was made of the clinical signs, pathogenesis and gross lesions observed in male specific pathogen-free New Zealand White rabbits inoculated with five strains of amyxomatous myxoma virus. All five strains induced the characteristic amyxomatous myxomatosis clinical syndrome with clinical signs that differed only in intensity. The varying clinical intensity, together with the results of virological examination question the virulence of at least three of the five strains. Genomic analysis confirmed that the five strains came from the Lausanne strain introduced in 1952 in France and not from an unnoticed introduction of a Californian strain of myxoma virus. No link was found between the amyxomatous myxoma virus strains and the SG33 vaccine strain. 1999 Harcourt Publishers Ltd. [less ▲]

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