References of "Clercx, Cécile"
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See detailDetection of Alternaria and Cladosporium DNA in nasal mucosa from dogs with idiopathic lymphoplasmacytic rhinitis
Mercier, Elise ULg; Peters, Iain; Billen, Frédéric ULg et al

in Proceedings of the 21st ECVIM-CA congress (2011, September 06)

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See detailHigh serum transforming growth factor-beta 1 concentration in West Highland white terriers : a key to the breed predisposition in canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Heikkilä, H.P.; Jespers, P et al

in Proceedings of the 21st ECVIM-CA Congress (2011, September)

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See detailDipeptidyl peptidase IV activity in plasma of dogs : physiological determinants and effect of heart failure
Gomez, Nelson; Matheeussen, V.; Tamborini, A. et al

in 21th ECVIM Meeting - Séville, Espagne - du 6 au 10 septembre 2011 (2011, September)

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See detailFeline asthma – the (European) perspective
Clercx, Cécile ULg

in Proceedings of the Congress of International Society of Feline Medicine (ISFM) - Vienna - Austria - 23rd-26th June 2011 (2011, June)

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See detailTracheal washing and bronchoalveolar lavage-how, when and why ?
Clercx, Cécile ULg

in Proceedings of the Congress of International Society of Feline Medicine (ISFM) - Vienna - Austria - 23rd-26th June 2011 (2011, June)

See detailTracheoscopy and bronchoscopy-how, when and why ?
Clercx, Cécile ULg

in Proceedings of the Congress of International Society of Feline Medicine (ISFM) - Vienna - Austria - 23rd-26th June 2011 (2011, June)

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See detailBehandelingsmogelijkheden bij tracheacollaps, bronchiaal collaps en bronchomalacie
Clercx, Cécile ULg

in Proceedings of the UKG Zomercongress - 17th June 2011 (2011, June)

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See detailChronische bronchitis bij de hond
Clercx, Cécile ULg

in Proceedings of the UKG Zomercongress - 17th June 2011 (2011, June)

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See detailUse of expression microarray to identify potential biomarkers of idiopathic pulmonary fibrosis in dogs
Krafft, Emilie ULg; Heikkilä, H.P.; Vanherberghen, Morgane ULg et al

in Proceedings of 29th ACVIM Forum (2011, June)

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See detailGene expression profiles in canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Heikkilä, HP; Vanherberghen, Morgane ULg et al

in Proceedings of the 29th ACVIM Forum (2011, June)

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See detailAspergillosis
Clercx, Cécile ULg

in Proceedings of the 24th Program -Symposium on diseases of small animals - Portoroz - Slovenia (2011, April)

See detailBacterial Bronchopneumonia
Clercx, Cécile ULg

in Proceedings of the 24th Program - Symposium on diseases of small animals - Portoroz - Slovenia (2011, April)

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See detailChronic bronchopulmonary diseases in dogs
Clercx, Cécile ULg

in Proceedings of the 24th Program - Topical Symposium on diseases of small animals - Portoroz - Slovenia (2011, April)

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See detailApproach of patients with lower tract disease
Clercx, Cécile ULg

in Proceedings of the 24thProgram - Topical Symposium on diseases of small animals - Portoroz - Slovenia (2011, April)

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See detailLes avancées de la recherche en pathologie respiratoire
Clercx, Cécile ULg

Scientific conference (2011, February)

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See detailEffect of short-term oral and inhaled corticosteroids on airway inflammation and responsiveness in a feline acute asthma model
Leemans, Jérôme; Kirschvink, Nathalie; Clercx, Cécile ULg et al

in Veterinary Journal (2011)

The objective of this study was to investigate whether high-dose inhaled fluticasone propionate (FP), alone or in combination with salmeterol (SAL), is as effective as oral prednisolone in reducing airway ... [more ▼]

The objective of this study was to investigate whether high-dose inhaled fluticasone propionate (FP), alone or in combination with salmeterol (SAL), is as effective as oral prednisolone in reducing airway inflammation and obstruction in cats with experimentally-induced acute asthma. Six cats sensitised to Ascaris suum (AS) were enrolled in a prospective controlled therapeutic trial and underwent four aerosol challenges, at 1-month intervals with AS allergen. The allergen - stimulated animals received four consecutive days treatment with either oral prednisolone at 1mg/kg twice daily, 500μg of FP inhaled twice daily, or a combination of FP/SAL at 500μg/50μg inhaled twice daily, respectively, according to a randomised cross-over design. Treatment-related changes in lung function, airway responsiveness (AR) and bronchoalveolar lavage fluid (BALF) cytology were assessed. Barometric whole-body plethysmography (BWBP) was used for the assessment of respiratory variables and AR. No significant differences in respiratory rate or Penh (an estimate of airflow limitation measured by BWBP) were detected among treatment groups. Allergen-induced airway hyper-responsiveness was significantly inhibited by all three steroid treatments (P<0.05). The mean BALF eosinophil percentage (±SEM) was lower after oral and inhaled corticosteroid treatment and these changes were significant for groups receiving prednisolone and the FP/SAL combination. Findings suggest high-dose FP, particularly in combination with SAL, is effective in ameliorating airway inflammation and hyper-responsiveness in this model of acute feline asthma, and highlight the potential use of these drugs in cats experiencing acute exacerbations of the naturally occurring disease. [less ▲]

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See detailCCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs.
Merveille, Anne-Christine ULg; Davis, Erica E; Becker-Heck, Anita et al

in Nature Genetics (2011), 43(1), 72-8

Primary ciliary dyskinesia (PCD) is an inherited disorder characterized by recurrent infections of the upper and lower respiratory tract, reduced fertility in males and situs inversus in about 50% of ... [more ▼]

Primary ciliary dyskinesia (PCD) is an inherited disorder characterized by recurrent infections of the upper and lower respiratory tract, reduced fertility in males and situs inversus in about 50% of affected individuals (Kartagener syndrome). It is caused by motility defects in the respiratory cilia that are responsible for airway clearance, the flagella that propel sperm cells and the nodal monocilia that determine left-right asymmetry. Recessive mutations that cause PCD have been identified in genes encoding components of the outer dynein arms, radial spokes and cytoplasmic pre-assembly factors of axonemal dyneins, but these mutations account for only about 50% of cases of PCD. We exploited the unique properties of dog populations to positionally clone a new PCD gene, CCDC39. We found that loss-of-function mutations in the human ortholog underlie a substantial fraction of PCD cases with axonemal disorganization and abnormal ciliary beating. Functional analyses indicated that CCDC39 localizes to ciliary axonemes and is essential for assembly of inner dynein arms and the dynein regulatory complex. [less ▲]

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See detailFeline bronchial syndrome
Clercx, Cécile ULg

in Proceedings of the 24th Program - Topical Symposium on diseases of small animals - Portoroz - Slovenia (2011)

Detailed reference viewed: 7 (0 ULg)
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See detailSerum and bronchoalveolar lavage fluid endothelin-1 concentrations as diagnostic biomarkers of canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Heikkilä, H. P.; Jespers, P. et al

in Journal of Veterinary Internal Medicine (2011)

Background: Diagnosis of canine idiopathic pulmonary fibrosis (IPF) is challenging. Endothelin-1 (ET1) is a biomarker of IPF in humans, but whether ET1 can detect and differentiate IPF from other canine ... [more ▼]

Background: Diagnosis of canine idiopathic pulmonary fibrosis (IPF) is challenging. Endothelin-1 (ET1) is a biomarker of IPF in humans, but whether ET1 can detect and differentiate IPF from other canine respiratory diseases is unknown. Objective: To evaluate whether measurement of the concentration of ET1 in serum and bronchoalveolar lavage fluid (BALF) can be used to distinguish canine IPF from chronic bronchitis (CB) and eosinophilic bronchopneumopathy (EBP). Animals: Twelve dogs with IPF, 10 dogs with CB, 6 dogs with EBP, 13 privately owned healthy West Highland White Terriers (WHWT), and 9 healthy Beagle dogs. Methods: Prospective, case control study. ET1 concentration was determined by ELISA in serum and in BALF. Results: No significant difference in serum ET1 concentration was detected between healthy Beagle dogs and WHWT. Serum ET1 concentration was higher in dogs with IPF (median interquartile range; 2.32 pg/mL, 2.05-3.38) than healthy Beagle dogs (1.28, 1.07-1.53; P < .001), healthy WHWT (1.56, 1.25-1.85; P < .001), dogs with EBP (0.94 0.68-1.01; P = .001), and dogs with CB (1.54 0.74-1.82; P = .005). BALF ET1 concentration was below the detection limit in healthy WHWT and in dogs with CB, whereas it was measurable in all dogs with IPF. A cut-off serum concentration of 1.8 pg/mL had a sensitivity of 100% and a specificity of 81.2% for detection of IPF, with an area under the receiver operating characteristic curve of 0.818. Conclusions and Clinical Importance: Serum ET1 can differentiate dogs with IPF from dogs with EBP or CB. ET1 can be detected in BALF of dogs with IPF. [less ▲]

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