References of "Clercx, Cécile"
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See detailFibrosis and pulmonary function tests - New therapeutic options for respiratory diseases.
Clercx, Cécile ULg

in Proceedings of the Meeting of German specialists in internal medicine (ECVIM-CA-Internal Medicine) - Viernheim - 3rd December 2011 (2011, December)

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See detailInvestigation of cytokine expression in canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Heikkilä, HP; Vanherberghen, Morgane ULg et al

in Proceeding of 29th VCRS Symposium (2011, November 02)

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See detailSalmeterol or doxycycline do not inhibit acute bronchospasm and airway inflammation in cats with experimentally-induced asthma
Leemans, J.; Kirschvink, N.; Bernaerts, Frederique ULg et al

in Veterinary Journal (2011)

The objective of this study was to determine if inhaled salmeterol, a long-acting β2-adrenergic agonist, and oral doxycycline, a tetracycline antibiotic displaying matrix metalloproteinase (MMP ... [more ▼]

The objective of this study was to determine if inhaled salmeterol, a long-acting β2-adrenergic agonist, and oral doxycycline, a tetracycline antibiotic displaying matrix metalloproteinase (MMP) inhibitory activity, reduce airway inflammation and obstruction in cats with experimentally-induced asthma. Eight Ascaris suum (AS)-sensitised cats were enrolled in a prospective study in which they underwent four AS-challenges at 1 month intervals. The challenged animals were given no treatment or were treated on 4 consecutive days with either: (1) oral prednisolone (1 mg/kg twice daily), (2) inhaled salmeterol (50 μg twice daily), or (3) oral doxycycline (5 mg/kg twice daily), according to a randomised cross-over design. Inhibition of allergen-induced early (EAR) and late (LAR) asthmatic reactions were assessed by barometric whole-body plethysmography. Cytology and measurement of MMP-2 and -9 activities were carried out on bronchoalveolar lavage fluid (BALF). Although none of the treatments prevented the EAR, prednisolone treatment inhibited the LAR. Relative to untreated cats, the eosinophil percentage and MMP-2 activity in BALF were significantly reduced following prednisolone treatment (P < 0.05). Short-term therapy with either salmeterol or doxycycline had no effect on the EAR or LAR or on airway inflammation. Given the chronic nature of this disease in cats, long-term therapy may be required to produce more favourable functional and clinical outcomes. [less ▲]

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See detailCardiac troponin and natriuretic peptide in canine emergencies with a systemic inflammatory response syndrome
Gommeren, Kris ULg; Desmas, I.; Garcia, Alexandra ULg et al

in Proceedings of 21st ECVIM Meeting (2011, September 06)

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See detailDetection of Alternaria and Cladosporium DNA in nasal mucosa from dogs with idiopathic lymphoplasmacytic rhinitis
Mercier, Elise ULg; Peters, Iain; Billen, Frédéric ULg et al

in Proceedings of the 21st ECVIM-CA congress (2011, September 06)

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See detailHigh serum transforming growth factor-beta 1 concentration in West Highland white terriers : a key to the breed predisposition in canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Heikkilä, H.P.; Jespers, P et al

in Proceedings of the 21st ECVIM-CA Congress (2011, September)

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See detailDipeptidyl peptidase IV activity in plasma of dogs : physiological determinants and effect of heart failure
Gomez, Nelson; Matheeussen, V.; Tamborini, A. et al

in 21th ECVIM Meeting - Séville, Espagne - du 6 au 10 septembre 2011 (2011, September)

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See detailFeline asthma – the (European) perspective
Clercx, Cécile ULg

in Proceedings of the Congress of International Society of Feline Medicine (ISFM) - Vienna - Austria - 23rd-26th June 2011 (2011, June)

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See detailTracheal washing and bronchoalveolar lavage-how, when and why ?
Clercx, Cécile ULg

in Proceedings of the Congress of International Society of Feline Medicine (ISFM) - Vienna - Austria - 23rd-26th June 2011 (2011, June)

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See detailTracheoscopy and bronchoscopy-how, when and why ?
Clercx, Cécile ULg

in Proceedings of the Congress of International Society of Feline Medicine (ISFM) - Vienna - Austria - 23rd-26th June 2011 (2011, June)

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See detailBehandelingsmogelijkheden bij tracheacollaps, bronchiaal collaps en bronchomalacie
Clercx, Cécile ULg

in Proceedings of the UKG Zomercongress - 17th June 2011 (2011, June)

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See detailChronische bronchitis bij de hond
Clercx, Cécile ULg

in Proceedings of the UKG Zomercongress - 17th June 2011 (2011, June)

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See detailUse of expression microarray to identify potential biomarkers of idiopathic pulmonary fibrosis in dogs
Krafft, Emilie ULg; Heikkilä, H.P.; Vanherberghen, Morgane ULg et al

in Proceedings of 29th ACVIM Forum (2011, June)

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See detailGene expression profiles in canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Heikkilä, HP; Vanherberghen, Morgane ULg et al

in Proceedings of the 29th ACVIM Forum (2011, June)

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See detailAspergillosis
Clercx, Cécile ULg

in Proceedings of the 24th Program -Symposium on diseases of small animals - Portoroz - Slovenia (2011, April)

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See detailBacterial Bronchopneumonia
Clercx, Cécile ULg

in Proceedings of the 24th Program - Symposium on diseases of small animals - Portoroz - Slovenia (2011, April)

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See detailChronic bronchopulmonary diseases in dogs
Clercx, Cécile ULg

in Proceedings of the 24th Program - Topical Symposium on diseases of small animals - Portoroz - Slovenia (2011, April)

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See detailApproach of patients with lower tract disease
Clercx, Cécile ULg

in Proceedings of the 24thProgram - Topical Symposium on diseases of small animals - Portoroz - Slovenia (2011, April)

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See detailLes avancées de la recherche en pathologie respiratoire
Clercx, Cécile ULg

Scientific conference (2011, February)

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See detailEffect of short-term oral and inhaled corticosteroids on airway inflammation and responsiveness in a feline acute asthma model
Leemans, Jérôme; Kirschvink, Nathalie; Clercx, Cécile ULg et al

in Veterinary Journal (2011)

The objective of this study was to investigate whether high-dose inhaled fluticasone propionate (FP), alone or in combination with salmeterol (SAL), is as effective as oral prednisolone in reducing airway ... [more ▼]

The objective of this study was to investigate whether high-dose inhaled fluticasone propionate (FP), alone or in combination with salmeterol (SAL), is as effective as oral prednisolone in reducing airway inflammation and obstruction in cats with experimentally-induced acute asthma. Six cats sensitised to Ascaris suum (AS) were enrolled in a prospective controlled therapeutic trial and underwent four aerosol challenges, at 1-month intervals with AS allergen. The allergen - stimulated animals received four consecutive days treatment with either oral prednisolone at 1mg/kg twice daily, 500μg of FP inhaled twice daily, or a combination of FP/SAL at 500μg/50μg inhaled twice daily, respectively, according to a randomised cross-over design. Treatment-related changes in lung function, airway responsiveness (AR) and bronchoalveolar lavage fluid (BALF) cytology were assessed. Barometric whole-body plethysmography (BWBP) was used for the assessment of respiratory variables and AR. No significant differences in respiratory rate or Penh (an estimate of airflow limitation measured by BWBP) were detected among treatment groups. Allergen-induced airway hyper-responsiveness was significantly inhibited by all three steroid treatments (P<0.05). The mean BALF eosinophil percentage (±SEM) was lower after oral and inhaled corticosteroid treatment and these changes were significant for groups receiving prednisolone and the FP/SAL combination. Findings suggest high-dose FP, particularly in combination with SAL, is effective in ameliorating airway inflammation and hyper-responsiveness in this model of acute feline asthma, and highlight the potential use of these drugs in cats experiencing acute exacerbations of the naturally occurring disease. [less ▲]

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