References of "Clercx, Cécile"
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See detailLong-term outcomes in dogs with sinonasal aspergillosis treated with intranasal infusions of enilconazole
Schuller, S.; Clercx, Cécile ULg

in Journal of the American Animal Hospital Association (2007), 43(1, Jan-Feb), 33-38

Long-term outcomes ( mean 38 +/- 17 months) were evaluated in 27 dogs with sinonasal aspergillosis after successful medical treatment using intranasal infusions of 1% or 2% enilconazole ( 1%, n= 15; 2%, n ... [more ▼]

Long-term outcomes ( mean 38 +/- 17 months) were evaluated in 27 dogs with sinonasal aspergillosis after successful medical treatment using intranasal infusions of 1% or 2% enilconazole ( 1%, n= 15; 2%, n= 12). Long-term outcomes with both treatment protocols were good, with half of the dogs being asymptomatic throughout the follow-up period. The remaining dogs showed mild clinical signs compatible with chronic rhinitis/sinusitis. These clinical signs were interpreted as chronic lymphoplasmacytic rhinitis/sinusitis and episodes of bacterial rather than fungal infection. Three dogs had confirmed reinfection or relapse 2 to 36 months after clinical resolution. [less ▲]

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See detailImmunohistochemical characterisation of the inflammatory infiltrate associated with canine nasal carcinoma.
Vanherberghen, Morgane ULg; Day, M. J.; Gabriel, Alexandra et al

in Proceedings of the 17th Annual Congress of the ECVIM-CA (2007)

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See detailDistinct tissue cytokine and chemokine mRNA expression in canine sino-nasal aspergillosis and idiopathic lymphoplasmacytic rhinitis
Peeters, Dominique ULg; Peters, I. R.; Helps, C. R. et al

in Veterinary Immunology and Immunopathology (2007), 117

Idiopathic lymphoplasmacytic rhinitis (LPR) and sino-nasal aspergillosis (SNA) are among the most common causes of nasal discharge in dogs. The pathogenesis of both diseases is poorly understood. Some ... [more ▼]

Idiopathic lymphoplasmacytic rhinitis (LPR) and sino-nasal aspergillosis (SNA) are among the most common causes of nasal discharge in dogs. The pathogenesis of both diseases is poorly understood. Some have proposed that LPR is a chronic inflammatory response to an inhaled irritant, pollutant or allergen, but others suggest that most cases of LPR constitute undiagnosed cases of SNA. Local immune dysfunction is thought to permit opportunist infection in canine SNA. This study investigates the nature of the local tissue immune response mounted in canine LPR and SNA in order to determine whether these diseases have similar or distinct pathogenesis. Quantitative reverse transcriptase polymerase chain reaction was carried out on RNA isolated from nasal biopsies from diseased and control dogs, using specific assays designed to amplify messenger RNA (mRNA), encoding a panel of cytokines and chemokines. SNA was associated with significantly increased expression of mRNA encoding interleukin (IL)-6, IL-8, IL-10, IL-12p19, IL-12p35, IL-12p40, IL-18, IFN-gamma, TNF-alpha, TGF-beta, eotaxin-2 and all four monocyte chemoattractant proteins (MCPs) relative to controls. LPR was associated with significantly increased expression of mRNA encoding IL-5, IL-8, IL-10, IL-12p19, IL12p40, IL-18, TNF-alpha, TGF-(3, MCP-2 and MCP-3 relative to controls. There was significantly more expression of mRNA encoding IL-6, IL-8, IL-10, IL-12p35, IL-12p40, IL-18, IFN-gamma, TNF-alpha, TGF-(3 and all MCPs, and significantly less expression of IL-5 in dogs with SNA than in dogs with LPR. Thus, the profile of cytokine and chemokine gene expression in the nasal mucosa is different in dogs with LPR when compared to dogs with SNA. A partial Th2 immune response appears to be mounted in the nasal mucosa of dogs with LPR, whereas the mucosal immune response in canine SNA is of the Th1 type. Increase in IL-10 and TGF-(3 transcripts in dogs with SNA is thought to be implicated in the failure to clear the Aspergillus infection. These results constitute the first evidence that the pathogenesis of canine LPR and SNA is distinct. (C) 2007 Elsevier B.V All rights reserved. [less ▲]

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See detailHealth status of dogs referred to the consultation of clinical nutrition at the faculty of Liège
Lhoest, Estelle; Claeys, Stéphanie ULg; Saulnier-Troff, François et al

in Coenen, M.; Vervuert, I. (Eds.) Proceedings of the 11th ESVCN Congress (2007)

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See detailEffects of age and Ascaris suum aerosol exposure on the pro- and antigelatinolytic activity in serum and airways of cats
Leemans, Jérôme ULg; Kirschvink, N.; Billen, Frédéric et al

in Proceedings : 17th Congress of the European College of Veterinary Internal Medicine – Companion Animals, Budapest (2007)

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See detailPro- and antigelatinolytic activities in the serum and airways of cats with experimentally-induced asthma
Leemans, Jérôme ULg; Kirschvink; Clercx, Cécile ULg et al

in Proceedings : 25th Symposium of the Veterinary Comparative Respiratory Society (2007)

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See detailHigh resolution 16 row computed tomography examination of the canine thorax
De Busscher; Bolen, Géraldine ULg; Cavrenne et al

Poster (2007)

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See detailEffect of obesity on doxapram hydrochlorid-induced effects on whole body barometric plethysmography measurements in healthy Beagle dogs
Bolognin, M.; Bernaerts, Frederique ULg; Herpigny, F. et al

in 24th Symposium of the Veterinary Comarative Respiratory Society - Jena, Allemagne 8-10 octobre 2006 (2006, October 08)

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See detailInvestigation of airway reactivity by barometric whole body plethysmography in cats with spontaneous bronchial disease
Bernaerts, Frederique ULg; Merveille, Anne-Christine ULg; Bolognin, M. et al

in 24th Symposium of the Veterinary Comarative Respiratory Society - Jena, Allemagne 8-10 octobre 2006 (2006, October)

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See detailEffect of obesity in dogs on airway reactivity measured by barometric whole body plethysmography
Bernaerts, Frederique ULg; Bolognin, M.; Dehard, S. et al

in 16th ECVIM Meeting - Amsterdam - Nederlands - Septembre 2006 (2006, September)

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See detailInvestigation of the effect of salbutamol and prenisolone on lung function test in healthy dogs with experimentally induced airway inflammation
Bolognin, M.; Talavera, J.; Bernaerts, Frederique ULg et al

in 16th ECVIM Meeting - Amsterdam - Nederlands - Septembre 2006 (2006, September)

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See detailAbsence of bronchoprotective effects to a histamine challenge test of intravenous theophylline and salbutamol in healthy dogs
Talavera, J.; Bernaerts, Frederique ULg; Kirschvink, N. et al

in 16th ECVIM Meeting - Amsterdam - Nederlands - Septembre 2006 (2006, September)

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See detailA randomised double blinded placebo controlled study of spironolactone as adjunct to conventional congestive heart failure treatment in dogs: clinical, biochemical and neurohormonal parameters
Schuller, S.; Van Israel; Van Belle, S. et al

in 16th ECVIM Meeting - Amsterdam - Nederland - Septembre 2006 (2006, September)

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See detailA randomised double blinded placebo controlled study of spironolactone as adjunct to conventional congestive heart failure treatment in dogs: electrocardiographic, radiographic, echocardiographic and survival analysis
Van Israel, N.; Schuller, S.; Van Belle, S. et al

in 16th ECVIM Meeting - Amsterdam - Nederland - Septembre 2006 (2006, September)

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See detailSurgical treatment of canine nasal aspergillosis by rhinotomy combined with enilconazole infusion and oral itraconazole.
Claeys, Stéphanie ULg; Lefebvre, J.-B.; Schuller, S. et al

in Journal of Small Animal Practice (2006), 47(6), 320-4

OBJECTIVES: To evaluate the effectiveness of rhinotomy and surgical debridement associated with topical administration of 2 per cent enilconazole and oral itraconazole in dogs with severe or recurrent ... [more ▼]

OBJECTIVES: To evaluate the effectiveness of rhinotomy and surgical debridement associated with topical administration of 2 per cent enilconazole and oral itraconazole in dogs with severe or recurrent sinonasal aspergillosis. METHODS: A standard rhinotomy was performed on seven dogs. In the initial study, the bone flap was left attached cranially and replaced at the end of the procedure. In the main study group, the bone flap was discarded. Nasal passages were debrided and irrigated with enilconazole solution for one hour. Oral itraconazole was administered to four dogs for one month postoperatively. Follow-up rhinoscopy was performed in all dogs. RESULTS: All three dogs in the initial study had recurrence of the disease and two dogs had a second surgery to remove the flap. The main study group included four dogs in which the flap was initially removed, and the two dogs from the initial study that required a second surgery. At follow-up rhinoscopy, five dogs were free of aspergillus but had bacterial or inflammatory rhinitis and one dog had a small aspergilloma but was subsequently asymptomatic. Telephone follow-up revealed that four dogs were asymptomatic, one dog had intermittent sneezing and serous nasal discharge, and one dog had intermittent epistaxis. CLINICAL SIGNIFICANCE: Rhinotomy with removal of the flap combined with one-hour infusion of 2 per cent enilconazole and oral itraconazole resulted in satisfactory outcome in dogs with severe or recurrent aspergillosis. [less ▲]

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See detailAnalytical, physiologic, and clinical validation of a radioimmunoassay for measurement of procollagen type III amino terminal propeptide in serum and bronchoalveolar lavage fluid obtained from dogs
Schuler, S.; Valentin, S.; Remy, Bernadette et al

in American Journal of Veterinary Research (2006), 67(5), 749-755

OBJECTIVE: To validate a radioimmunoassay for measurement of procollagen type III amino terminal propeptide (PIIINP) concentrations in canine serum and bronchoalveolar lavage fluid (BALF) and investigate ... [more ▼]

OBJECTIVE: To validate a radioimmunoassay for measurement of procollagen type III amino terminal propeptide (PIIINP) concentrations in canine serum and bronchoalveolar lavage fluid (BALF) and investigate the effects of physiologic and pathologic conditions on PIIINP concentrations. SAMPLE POPULATION: Sera from healthy adult (n = 70) and growing dogs (20) and dogs with chronic renal failure (CRF; 10), cardiomyopathy (CMP; 12), or degenerative valve disease (DVD; 26); and sera and BALF from dogs with chronic bronchopneumopathy (CBP; 15) and healthy control dogs (10 growing and 9 adult dogs). PROCEDURE: A radioimmunoassay was validated, and a reference range for serum PIIINP (S-PIIINP) concentration was established. Effects of growth, age, sex, weight, CRF, and heart failure on S-PIIINP concentration were analyzed. In CBP-affected dogs, S-PIIINP and BALF-PIIINP concentrations were evaluated. RESULTS: The radioimmunoassay had good sensitivity, linearity, precision, and reproducibility and reasonable accuracy for measurement of S-PIIINP and BALF-PIIINP concentrations. The S-PIIINP concentration reference range in adult dogs was 8.86 to 11.48 mug/L. Serum PIIINP concentration correlated with weight and age. Growing dogs had significantly higher S-PIIINP concentrations than adults, but concentrations in CRF-, CMP-, DVD-, or CBP-affected dogs were not significantly different from control values. Mean BALF-PIIINP concentration was significantly higher in CBP-affected dogs than in healthy adults. CONCLUSIONS AND CLINICAL RELEVANCE: In dogs, renal or cardiac disease or CBP did not significantly affect S-PIIINP concentration; dogs with CBP had high BALF-PIIINP concentrations. Data suggest that the use of PIIINP as a marker of pathologic fibrosis might be limited in growing dogs. [less ▲]

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See detailDiagnosis of pharyngeal disorders in dogs: a retrospective study of 67 cases
Billen, Frédéric ULg; Day, M. J.; Clercx, Cécile ULg

in Journal of Small Animal Practice (2006), 47(3), 122-129

OBJECTIVES: To assess the frequency distribution of pharyngeal disorders and to compare clinical signs in diseases of the different pharyngeal areas. To review the investigation methods. METHODS: Medical ... [more ▼]

OBJECTIVES: To assess the frequency distribution of pharyngeal disorders and to compare clinical signs in diseases of the different pharyngeal areas. To review the investigation methods. METHODS: Medical records of 67 dogs presenting with abnormalities of the pharyngeal area were retrospectively reviewed and classified according to the anatomic area involved, i.e. the nasopharyngeal, oropharyngeal and laryngopharyngeal areas. Clinical signs, endoscopic findings and results of additional sampling were reviewed. RESULTS: Nasopharyngeal disorders were most frequently encountered (49 per cent), with choanal masses being the most frequent diagnosis (24 of 33), followed by laryngopharyngeal disorders (37.5 per cent) and oropharyngeal disorders (10.5 per cent). A rare condition, stenosis of the intrapharyngeal opening, was classified separately (3 per cent). An overall good correlation between matched cytology and histopathology samples was found. In all categories of diseases, clinical signs related to both the upper respiratory and digestive tracts were reported. CLINICAL SIGNIFICANCE: Pharyngeal disorders are more frequently localised in the nasopharyngeal area and include essentially choanal masses. The use of a flexible endoscope for retrograde rhinoscopy is essential for adequate investigation of the proximal nasopharyngeal area. Clinical signs do not allow differentiation of the pharyngeal disorder within the different pharyngeal areas. [less ▲]

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See detailRespiratory diseases
Clercx, Cécile ULg

in Suter, P. F.; Kohn, B. (Eds.) Praktikum der Hundklinik, 10th Edition (2006)

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See detailInhaled fluticasone reduces bronchial responsiveness and airway inflammation in cats with mild chronic bronchitis
Kirschvink, N; Leemans, Jérôme ULg; Delvaux, François et al

in Journal of Feline Medicine and Surgery (2006), 8(1), 45-54

This study investigated the effect of inhaled fluticasone on lower airway inflammation and bronchial responsiveness (BR) to inhaled carbachol in cats with very mild, chronic bronchitis (n = 5) that were ... [more ▼]

This study investigated the effect of inhaled fluticasone on lower airway inflammation and bronchial responsiveness (BR) to inhaled carbachol in cats with very mild, chronic bronchitis (n = 5) that were compared with healthy cats serving as controls (n = 6). Chest radiographs, BR tests performed non-invasively by barometric whole body plethysmography (BWBP) and bronchoalveolar lavage (BAL) were performed before and after treatment. BR was quantified by calculating the concentration of carbachol inducing bronchoconstriction (C-Penh300%), defined as a 300% increase of baseline Penh, an index of bronchoconstriction obtained by BWBP. BAL fluid was analyzed cytologically and the oxidant marker 8-iso-PGF2α was determined. At test 1, healthy cats and cats with bronchitis were untreated, whereas for test 2 inhalant fluticasone (250 μg once daily) was administrated for 2 consecutive weeks to cats with bronchitis. Control cats remained untreated. Inhaled fluticasone induced a significant increase in C-Penh300% and a significant decrease of BAL fluid total cells, macrophages, neutrophils and 8-iso-PGF2α in cats with bronchitis, whilst untreated control cats did not show significant changes over time. This study shows that a 2-week fluticasone treatment significantly reduced lower airway inflammation in very mild bronchitis. BR could be successfully monitored in cats using BWPB and decreased significantly in response to inhaled fluticasone. 8-Iso-PGF2α in BAL fluid was responsive to treatment and appeared as a sensitive biomarker of lower airway inflammation in cats. [less ▲]

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