References of "Clercx, Cécile"
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See detailConcentration of allergen-specific IgE in serum and bronchoalveolar lavage fluid in dogs with eosinophilic bronchopneumopathy and dogs with chronic bronchitis.
Peyron, Clémence ULg; Derer, Michal; Day, M. J. et al

in Proceedings of the 19th Annual Congress of the ECVIM-CA (2009)

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See detailComparison of the value of measurement of serum galactomannan and Aspergillus-specific antibodies in the diagnosis of canine sino-nasal aspergillosis.
Billen, Frédéric ULg; Peeters, Dominique ULg; Peters, I. R. et al

in Veterinary Microbiology (2009), 133(4), 358-65

Serology is currently used for the diagnosis of canine sino-nasal aspergillosis (SNA). However, the accuracy of serological testing using commercially available, standardized purified antigen preparations ... [more ▼]

Serology is currently used for the diagnosis of canine sino-nasal aspergillosis (SNA). However, the accuracy of serological testing using commercially available, standardized purified antigen preparations of Aspergillus (CAPurAspAg) has only been poorly documented. The aim of the present study was to assess the diagnostic value of an agar-gel double immunodiffusion (AGDD) test and an anti-Aspergillus IgG ELISA, using CAPurAspAg and the commercially available Platelia test for the detection of serum galactomannan. Sera from 17 dogs with SNA, 18 dogs with a nasal tumour (NT), 11 dogs with lymphoplasmacytic rhinitis (LPR) and 33 control dogs were tested with the 3 methods. AGDD result was positive in 76.5% of dogs with SNA, whereas all sera from dogs with non-fungal nasal disease and control dogs were negative. A positive IgG ELISA result was obtained in 88% of dogs with SNA and in 18% of dogs with LPR. All patients with NT and control dogs had a negative IgG ELISA result. The Platelia test was positive in 24% of dogs with SNA, 11% of dogs with NT, 9% of dogs with LPR and 24% of control dogs. The results of this study suggest that (1) the detection of serum Aspergillus-specific antibodies with AGDD or ELISA, using CAPurAspAg, provides excellent specificity and good sensitivity, (2) the specificity is higher for AGDD (100%) than for ELISA (96.8%) while sensitivity is higher for ELISA (88.2%) than for AGDD (76.5%) and (3) serum galactomannan quantification with the Plateliat test is unreliable for the diagnosis of canine SNA. [less ▲]

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See detailAn Immunohistochemical Study of the Inflammatory Infiltrate Associated with Nasal Carcinoma in Dogs and Cats.
Vanherberghen, Morgane ULg; Day, M. J.; Gabriel, Alexandra et al

in Journal of Comparative Pathology (2009), 141(1)

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See detailCharacterisation of the acute and reversible airway inflammation induced by cadmium chloride inhalation in healthy dogs and evaluation of the effects of salbutamol and prednisolone.
Bolognin, M.; Kirschvink, N.; Leemans, Jérôme ULg et al

in Veterinary Journal (2009), 179(3), 443-450

The aims of this study were firstly to characterise a model of subclinical and reversible bronchial inflammation induced by cadmium chloride inhalation in healthy dogs and then to examine the effect of ... [more ▼]

The aims of this study were firstly to characterise a model of subclinical and reversible bronchial inflammation induced by cadmium chloride inhalation in healthy dogs and then to examine the effect of prednisolone or salbutamol treatment on the resulting bronchitis. The model characterisation and the effects of treatment were studied using clinical symptoms, haematology, thoracic radiography, bronchoscopy and bronchoalveolar lavage, barometric whole-body plethysmography and histamine broncho-provocation tests. In addition, the activity of matrix metalloproteinases (MMP)-2 and -9 were determined in serum and bronchoalveolar lavage fluid (BALF). Cadmium inhalation induced: (1) a transient bronchial inflammation, dominated by neutrophils; (2) a neutrophilia of the blood that persisted for up to 4weeks; (3) a transient increased bronchial reactivity, and (4) a significant increase in MMP-9 activity in the BALF. Prednisolone treatment reduced the influx of inflammatory cells into the BALF, but not significantly, had no effect on pulmonary function, and did not reduce of airway hypersensitivity. Salbutamol had almost no effect on any of the parameters investigated. [less ▲]

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See detailRespiratory diseases
Clercx, Cécile ULg

in Suter, P. F.; Kohn, B. (Eds.) Praktikum der Hundklinik, 10th Edition (2009)

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See detailCellular composition of bronchial brushings obtained from dogs with experimental chronic bronchitis
Bolognin, M.; Tual, Charlotte ULg; Day, M. J. et al

in 18th ECVIM Meeting - Gent - Belgique - 2-5 septembre 2008 (2008, September 02)

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See detailClinical and functional investigation in an experimental model of chronic bronchitis in dogs
Bolognin, M.; Bourguignon, V.; Hofman, A. C. et al

in 18th ECVIM Meeting - Gent - Belgique - 2-5 septembre 2008 (2008, September 02)

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See detailClinical efficacy of intrasinusal administration of bifonazole cream through perendoscopically placed catheters alone or in combination with enilconazole irrigation in canine sinonasal aspergillosis.
Billen, Frédéric ULg; Guieu, Liz-Valérie; Bernaerts, Frédérique et al

in Proceedings of the 18th ECVIM-CA Congress (2008, September)

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See detailComparison of three serological tests for the diagnosis of canine sino-nasal aspergillosis.
Billen, Frédéric ULg; Peeters, Dominique ULg; Peters, Iain et al

in Proceedings of the 18th ECVIM-CA Congress (2008, September)

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See detailPrimary ciliary dyskinesia and situs inversus in a young dog.
Cavrenne, Romain; De Busscher, Virginie; Bolen, Géraldine ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2008), 163(2), 54-5

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See detailClinical and functional responses to inhaled salmeterol in experimentally asthmatic cats with allergen-induced bronchospasm
Bernaerts, Frederique ULg; Leemans, Jérôme ULg; Kirschvink, N. et al

in Proceedings : 18th Congress European College of Veterinary Internal Medicine – companion animals (2008)

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See detailBarometric whole-body plethysmographic measurements in dogs suffering from brachycephalic airway obstruction syndrome.
Bernaerts, Frederique ULg; Talavera, J.; Leemans, J. et al

in Veterinary Journal (2008)

The clinical features of brachycephalic airway obstructive disease in 11 brachycephalic dogs are described in this study. The respiratory strategy was assessed before (n = 11) and after (n = 6) surgery ... [more ▼]

The clinical features of brachycephalic airway obstructive disease in 11 brachycephalic dogs are described in this study. The respiratory strategy was assessed before (n = 11) and after (n = 6) surgery using barometric whole-body plethysmography (BWBP), with the relationship between BWBP variables and the severity of the clinical signs assessed by the use of a respiratory score based on clinical, radiographic and endoscopic findings. Partial collapse of the left main bronchus was a common finding not previously described as part of the brachycephalic airway obstructive disease syndrome. Epiglottic cysts, laryngeal granulomas and nasopharyngeal turbinates in English Bulldogs were other previously unreported findings. No significant correlation between the respiratory score and any of the BWBP variables was detected. Compared to healthy dogs, brachycephalic dogs had a significantly lower Te/Ti ratio (expiratory time over inspiratory time), peak inspiratory flow (PIF) per kg bodyweight (BW), significantly higher peak expiratory flow (PEF) per kg BW, PEF/PIF, and enhanced pause. These variations are compatible with upper airway obstructions primarily in the extrathoracic airways. Following surgery, a significant decrease in PEF/PIF was detected. The study showed that BWBP could be used to characterise the respiratory strategy in brachycephalic dogs before and after surgery. [less ▲]

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See detailComparison of bronchoalveolar lavage cytospins and smears in dogs and cats.
Dehard, Sandrine ULg; Bernaerts, Frederique ULg; Peeters, Dominique ULg et al

in Journal of the American Animal Hospital Association (2008), 44(6), 285-94

Differences in the cytological interpretation of bronchoalveolar lavage fluid (BALF) after cytospin preparation (CP) or manual smearing of pelleted cells preparation (MSP) were investigated in client ... [more ▼]

Differences in the cytological interpretation of bronchoalveolar lavage fluid (BALF) after cytospin preparation (CP) or manual smearing of pelleted cells preparation (MSP) were investigated in client-owned dogs and cats with inflammatory or infectious lower respiratory disease. Bronchoalveolar lavage fluid from healthy cats was also examined. With MSP, cell lysis was more frequently observed, and cellular distribution was more heterogeneous throughout the slide. When samples from healthy and diseased animals were considered together, a significantly greater percentage of neutrophils was seen on CP than on MSP slides (P<0.002). Cytospin preparations were considered of better quality in all individual comparisons. Cytospin preparation is advised in the evaluation of BALF with low total cell count. When only MSPs are evaluated, clinicians should be aware that differential neutrophil counts may underestimate the counts found on CP slides. [less ▲]

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See detailTreatment of 46 cats with porcine insulin zinc suspension – a prospective study
Michiels, L.; Boari, A.; Bewig, K. et al

in Journal of Feline Medicine and Surgery (2008)

This prospective, multicentre, non-blinded, open study followed 46 cats with diabetes mellitus during treatment with porcine lente insulin (also known as porcine insulin zinc suspension, Caninsulin ... [more ▼]

This prospective, multicentre, non-blinded, open study followed 46 cats with diabetes mellitus during treatment with porcine lente insulin (also known as porcine insulin zinc suspension, Caninsulin, Intervet) for 16+/-1 weeks (stabilization phase), with additional monitoring of some cats (n=23) for a variable period. At least three of the following were present at initial presentation: appropriate history of clinical signs consistent with diabetes mellitus, glucosuria, blood glucose greater than 15 mmol/l and fructosamine greater than 380 micromol/l. Insulin treatment was started at a dose rate of 0.25-0.5 IU/kg body weight twice daily, with a maximum starting dose of 2 IU/injection. Twenty-eight of the cats were classed as reaching clinical stability during the study, in 23 of these cats this was during the stabilization phase. Seven cats went into remission during the stabilization phase and one of the cats in week 56. Clinical signs of hypoglycaemia, significantly associated with a dose of 3 units or 0.5 IU/kg or more per cat (twice daily), were observed in nine of the 46 cats during the stabilization phase and concomitant biochemical hypoglycaemia was recorded in most cases. Biochemical hypoglycaemia, recorded in 6% of the blood glucose curves performed during the stabilization phase, was significantly associated with a dose rate of 0.75 IU/kg or more twice daily. This further highlights the need for cautious stepwise changes in insulin dose. The protocol used in the present study is suitable for and easy to use in practice. This study confirmed the efficacy and safety of porcine lente insulin (Caninsulin) in diabetic cats under field conditions. [less ▲]

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See detailWhole Blood and Tissue Fungal DNA Quantification in the Diagnosis of Canine Sino-Nasal Aspergillosis
Peeters, Dominique ULg; Peters, I. R.; Helps, C. R. et al

in Veterinary Microbiology (2008), 128(1-2), 194-203

Various combinations of tests are used to confirm the diagnosis of canine sino-nasal aspergillosis (SNA) because false-positive and false-negative results can occur with each test. Therefore, the aim of ... [more ▼]

Various combinations of tests are used to confirm the diagnosis of canine sino-nasal aspergillosis (SNA) because false-positive and false-negative results can occur with each test. Therefore, the aim of this study was to evaluate whether detection of fungal DNA in blood and nasal tissue samples was of value in the clinical diagnosis of this disease. Four groups were included in the study (dogs with SNA, lymphoplasmacytic rhinitis or nasal neoplasia, and control animals). Real-time PCR assays detecting DNA from all Penicillium and Aspergillus species (PenAsp assay) or species-specific DNA from A. fumigatus, A. terreus, A. flavus and A. niger were applied to whole blood and nasal tissue samples. Results obtained by PCR were compared between the groups. Sensitivity, specificity, positive and negative predictive values (PPV and NPV) for fungal DNA detection were compared with those for alternative diagnostic procedures including histopathology, serology and fungal culture. Significantly more fungal DNA was detected by the PenAsp assay in tissue biopsies from dogs with SNA than in the three other groups. Sensitivity, specificity, PPV and NPV for this method were 1.00, 0.06, 0.32 and 1.00. A. fumigatus DNA was detected in seven tissue biopsies from dogs with SNA and in one biopsy from a dog with a nasal tumour. Sensitivity, specificity, PPV and NPV for this diagnostic test were 0.50, 0.97, 0.87 and 0.82. No significant difference was found between the groups with respect to the amount of DNA detected in blood by the PenAsp assay. Sensitivity, specificity, PPV and NPV for this method were 0.71, 0.24, 0.31 and 0.64. A. fumigatus DNA was detected in the blood of three dogs with SNA and sixteen dogs without SNA. Sensitivity, specificity, PPV and NPV for this diagnostic tool were 0.21, 0.45, 0.15 and 0.54. Detection of A. fumigatus DNA in nasal tissue had the highest specificity, PPV and NPV but sensitivity of this method was low. Detection of fungal DNA in whole blood was of no value in the diagnosis of SNA. [less ▲]

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See detailEffect of fish oil supplementation in a model of a feline asthma
Kirschvink, N.; Leemans, Jérôme ULg; Delvaux, F. et al

in Acta Physiologica (2008), 192(662 Suppl), 10

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See detailReverse sneezing / rhinitis, bacterial / rhinitis, lymphoplasmacytic / sinusitis and other sinus disorders
Clercx, Cécile ULg

in Sellon, Rance (Ed.) The Veterinary Clinical Advisor (2008)

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See detailClinical and functional responses to inhaled albuterol, ipratropium bromide and combination of both in ascaris suum-sensitized cats with allergen-induced bronchospasm
Leemans, Jérôme ULg; Kirschvink, N.; Cambier, Carole ULg et al

in Proceedings: 26th Annual Symposium of the Veterinary and Comparative Respiratory Society (2008)

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