References of "Clercx, Cécile"
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See detailProphylactic effects of omega-3 polyunsaturated fatty acids and luteolin on airway hyperresponsiveness and inflammation in cats with experimentally-induced asthma.
Leemans, Jérôme ULg; Cambier, Carole ULg; Chandler, T. et al

in Veterinary Journal (2010)

The aim of this study was to assess the preventive effects of omega-3 polyunsaturated fatty acids (omega3 PUFA) and luteolin supplementation on allergen-induced inflammation in eight Ascaris suum (AS ... [more ▼]

The aim of this study was to assess the preventive effects of omega-3 polyunsaturated fatty acids (omega3 PUFA) and luteolin supplementation on allergen-induced inflammation in eight Ascaris suum (AS)-sensitised cats. Airway responsiveness (AR) tests were performed and venous blood and bronchoalveolar lavage fluid (BALF) collected before and following a single (AS-stimulated) allergen exposure, as well as at the end of a 4-week treatment period, which was followed by a second AS-challenge. The omega6/omega3 fatty acid ratio in erythrocyte membranes, BALF cytology, AR to carbachol, and BALF lipoxin A(4) (LXA(4)), an endogenous inhibitor of inflammation, were assessed at each time point. Compared to respective unstimulated values, AS-challenged cats exhibited a significant rise in BALF eosinophil percentage and there was a trend to increased BALF total cell counts, increased AR and reduced BALF LXA(4) concentrations. The significant decrease in the blood omega6/omega3 ratio seen after supplementation demonstrated that omega3 PUFA were efficiently absorbed. No changes in BALF cytology were found between untreated and treated AS-stimulated cats, but BALF LXA(4) levels were significantly elevated and AR significantly decreased following supplement intake. The study suggests that omega3-luteolin supplementation may have some beneficial effects on AR through a LXA(4)-dependent pathway in cats with experimentally-induced asthma. [less ▲]

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See detailSerum endothelin-1 concentration in terrier dogs with idiopathic pulmonary fibrosis.
Krafft, Emilie ULg; Heikkilä, H.; Jespers et al

in Proceedings of the 35th Annual WSAVA Congress (2010)

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See detailEndothelin-1 as a serum biomarker in idiopathic pulmonary fibrosis in dogs
Krafft, Emilie ULg; Heikkilä, H.P.; Jespers, P. et al

in Proceedings of the 20th ECVIM-CA Congress (2010)

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See detailIs transforming growth factor- beta 1 involved in the pathogenesis of IPF in dogs ?
Krafft, Emilie ULg; Heikkilä, H. P.; De Lorenzi, D. et al

in Proceedings of the 20th Annual Congress of the ECVIM-CA (2010)

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See detailFunctional response to inhaled salbutamol and/or ipratropium bromide in Ascaris suum-sensitised cats with allergen-induced bronchospasms
Leemans, Jérôme; Kirschvink, N.; Clercx, Cécile ULg et al

in Veterinary Journal (2010)

Knowledge about the use of inhaled bronchodilators in cats with so-called 'feline asthma' is limited and relies on the experience of clinicians treating these patients. A randomised controlled four-way ... [more ▼]

Knowledge about the use of inhaled bronchodilators in cats with so-called 'feline asthma' is limited and relies on the experience of clinicians treating these patients. A randomised controlled four-way crossover study was therefore designed to compare the effects of salbutamol (SAL, 100 μg), ipratropium bromide (IB, 20 μg) and a combination of both (SAL/IB, 100 μg/20 μg), delivered through a pressurised metered-dose inhaler (pMDI) connected to a spacing chamber, on allergen-induced bronchospasms in five Ascaris suum (AS)-sensitised cats. Four AS bronchial provocation challenges were carried out at 1 week intervals, followed by one of four treatment protocols: SAL, IB, SAL/IB or control (untreated). Enhanced pause (Penh), an estimator of airflow limitation measured by barometric whole-body plethysmography, was repeatedly assessed within 120 min following the administration of each treatment protocol. Responses to inhaled medications were evaluated by calculating the area under the time-response curves (AUC) from 0 to 60 or 120 min after drug administration (AUC(0-60), AUC(0-120)), as well as the times required for half-recovery (T(50%)) or for returning to nearly basal conditions (T(20%)). No significant differences were found among the four study groups, with reference to the mean AUC(0-60), T(20%) and T(50%) values of Penh (P>0.05). Mean AUC(0-120) values of Penh were similar between the bronchodilators tested, but were significantly lower than those in the untreated group. It was concluded that inhalation of SAL, IB and SAL/IB via pMDI failed to improve most Penh-derived parameters, which suggested that these bronchodilators were of limited efficacy in reversing allergen-induced bronchospasm in cats. However, further studies using a larger number of animals are warranted to investigate if different drugs or delivery devices or higher dosages may be more effective [less ▲]

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See detailToll- and nod- like receptors mRNA expression in canine sino-nasal aspergillosis and idiopathic lymphoplasmacytic rhinosinusitis.
Mercier, Elise ULg; Peters, I. R.; Clercx, Cécile ULg et al

in Proceedings of the 20th Annual Congress of the ECVIM-CA (2010)

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See detailCytokine expression by Aspergillus fumigatus stimulated peripheral blood mononuclear cells from dogs with sino-nasal aspergillosis.
Vanherberghen, Morgane ULg; Bureau, Fabrice ULg; Peters, I. R. et al

in Proceedings of the 20th Annual Congress of the ECVIM-CA (2010)

Detailed reference viewed: 48 (17 ULg)
See detailChronic cough in cats
Clercx, Cécile ULg

in Proceedings of the Fecava Congress, Lille, France, Nov 27th-30th, 2009 (2009, November)

See detailClinical diagnosis of rhinosinusal diseases
Clercx, Cécile ULg

in Proceedings of the Fecava Congress, Lille, France, Nov 27th-30th, 2009 (2009, November)

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See detailNasal aspergillosis in dogs
Clercx, Cécile ULg

in Proceedings of the 55th Annual Conference of the German Small Animal Veterinary Association (2009, November)

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See detailChronic bronchopulmonary diseases in dogs : an overview
Clercx, Cécile ULg

in Proceedings of the 55th Annual Conference of the German Small Animal Veterinary Association (2009, November)

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See detailFactors influencing total cell count in bronchoalveolar lavage fluid obtained in healthy dogs and dogs with respiratory conditions
Lavoué, Rachel ULg; Delvaux, François ULg; Massart, L. et al

in 19h ECVIM Meeting - Porto, Portugal - 8-10 septembre 2009 (2009, September 08)

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See detailActivity of metalloproteinases MMP2 and MMP9 in matched serum and bronchoalveolar lavage fluid samples in a dog model of airway inflammation
Manens, Jefferson ULg; Bolognin, M.; Leemans, J. et al

in 19h ECVIM Meeting - Porto, Portugal - 8-10 septembre 2009 (2009, September 08)

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See detailProcollagen Type-III aminoterminal peptide in serum, bronchoalveolar lavage fluid and bronchial brush specimens in a model of chronic bronchitis in dogs
Lonneux, M.; Bolognin, M.; Jespers, P. et al

in 19h ECVIM Meeting - Porto, Portugal - 8-10 septembre 2009 (2009, September 08)

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See detailDetection of a new mutation responsible for primary ciliary dyskinesia in a pedigree of old English Sheepdogs
Merveille, Anne-Christine ULg; Bataille, G.; Davis, E. et al

in 19h ECVIM Meeting - Porto, Portugal - 8-10 septembre 2009 (2009, September)

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See detailRespiratory Disease : Chronic nasal discharge in dogs and cats: only one symptom, several causes
Clercx, Cécile ULg; De Lorenzi, D.

in Proceedings of the 61st SCIVAC National Congress (2009, March)

See detailRespiratory Disease : Pulmonary function tests
Clercx, Cécile ULg

in Proceedings of the 61st SCIVAC National Congress (2009, March)

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See detailA pilot study comparing the antispasmodic effects of inhaled salmeterol, salbutamol and ipratropium bromide using different aerosoldevices on muscarinic bronchoconstriction in healthy cats
Leemans, Jérôme ULg; Kirschvink, Nathalie; Bernaerts, Frederique ULg et al

in Veterinary Journal (2009), 180

This study compared the duration and magnitude of the antispasmodic effects of salmeterol SLM), salbutamol (SAL), ipratropium bromide (IB) and the combination of SAL and IB (SAL/IB) against carbachol ... [more ▼]

This study compared the duration and magnitude of the antispasmodic effects of salmeterol SLM), salbutamol (SAL), ipratropium bromide (IB) and the combination of SAL and IB (SAL/IB) against carbachol-induced bronchoconstriction in healthy cats, and investigated the gain in efficacy using a two or fourfold increase in drug dosages. The drug regimens used were: (1) LM 25 lg, SAL 100 lg, IB 20 lg and SAL/IB 100 lg/20 lg for bronchodilators delivered by a metered-dose inhaler (MDI); (2) SAL 3.75 mg and IB 62.5 lg for nebulised (NEB) medications. To monitor the bronchodilator effect, airway responsiveness was assessed at different time points using barometric whole-body plethysmography and calculation of the concentration of inhaled carbachol inducing a 300% increase of baseline Penh (enhanced pause), an estimator of airflow limitation Maximum C-Penh300 was recorded 15 min after NEB SAL, IB MDI, NEB IB and 1 h after SAL MDI and 4 h after SLM MDI, respectively. C-Penh300 was significantly different from control values (without treatment) up to 24 h for SLM MDI, 8 h for IB MDI and 4 h for other drugs. In terms of efficacy, SAL/IB MDI showed a synergistic antispasmodic effect at 15 min, 4 h and 8 h after administration. A fourfold increase of the initial dose of IB MDI and NEB IB significantly increased C-Penh300. Despite a fourfold dose increase, SLM displayed the weakest degree of bronchoprotection compared to other bronchodilators. The study provides evidence that inhaled bronchodilators are efficient at preventing muscarinic-induced bronchospasm in healthy cats and that SAL and IB appear to be short-acting bronchodilators in contrast to SLM. [less ▲]

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See detailComparison of gene expression in canine sino-nasal aspergillosis and idiopathic lymphoplasmacytic rhinitis: a microarray study
Vanherberghen, Morgane ULg; Bureau, Fabrice ULg; Peters, IR et al

in Proceedings of the 19th Annual ECVIM-CA Congress (2009)

Detailed reference viewed: 50 (15 ULg)