References of "Charlier, Corinne"
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See detailDeterminants of serum concentrations of 1,1 dichloro 2,2 bis (p-chlorophenyl)ethylene and polychlorinated biphenyls among French women in the CECILE study
Bachelet, D.; Truong, T.; Verner, M.-A. et al

in Environmental Research (2011), 111

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See detailLifestyle Behaviours and Plasma Vitamin C and β-Carotene Levels from ELAN Population (Liège, Belgium)
PINCEMAIL, Joël ULg; Vanbelle, Sophie ULg; Degrune, Fabien et al

in Journal of Nutrition and Metabolism (2011), 2011

Several factors, including fruit and vegetables intakes, have been shown to significantly influence the plasma concentrations of the two antioxidants vitamin C and β-carotene. Deficiency levels of 6 mg/L ... [more ▼]

Several factors, including fruit and vegetables intakes, have been shown to significantly influence the plasma concentrations of the two antioxidants vitamin C and β-carotene. Deficiency levels of 6 mg/L (34.2 μM) for vitamin C and of 0.22 mg/L (0.4 μM) for β-carotene have been suggested below which cardiovascular risk might be increased. The present study performed on 897 presumably healthy subjects aged 40–60 years aimed to examine how modifiable lifestyle factors may be related to vitamin C and/or β-carotene deficiency. Gender, smoking, lack of regular physical activity and of daily fruit consumption (≥2/day), and social status (in particular, unemployment) were found to be significant risk factors for vitamin C deficiency. For β-carotene deficiency, the same factors were identified except social status; moreover, overweight and OC use in women were also found to have a deleterious effect. For non exposed subjects, the probability of developing vitamin C deficiency was 4% in men and 2.4% in women. This probability increased to 66.3% for men and to 44.3% for women (and even to 50.4% under OC use), when all risk factors were present. For β-carotene deficiency, the corresponding probabilities were equal to 29.7% in men and 13.7% in women (no risk factor present), and to 86.1% for men and 69.9% (91.6% for OC use) for women (all factors present), respectively [less ▲]

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See detailBlood, urine, and hair kinetic analysis following an acute lead intoxication
Ho, Thi Thanh Giang ULg; KEUTGENS, Aurore ULg; SCHOOFS, Roland et al

in Journal of Analytical Toxicology (2011), 35(1), 60-64

A case of lead exposure resulting from the accidental ingestion of a lead-containing solution is reported. Because of clinical management rapidly performed through chelation therapy by 2,3 ... [more ▼]

A case of lead exposure resulting from the accidental ingestion of a lead-containing solution is reported. Because of clinical management rapidly performed through chelation therapy by 2,3-dimercaptopropane sulfonate sodium and meso-2,3-dimercaptosuccinic acid, blood lead levels of this 51-year-old patient were moderate (412.9 μg/L) and no clinical symptoms were observed. Numerous blood and urine samples were collected for kinetic analysis of lead elimination. However, we report the first case in which hair samples were analyzed to determine the excretion level of lead after acute intoxication. [less ▲]

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See detailToxicologie clinique et médico-légale
Renaux, André; Renaux - Muylkens, Isabelle; Charlier, Corinne ULg et al

in Beauthier, Jean-Pol (Ed.) Traité de Médecine légale (2011)

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See detailQuantification in postmortem blood and identification in urine of tramadol and its two main metabolites in two cases of lethal tramadol intoxication
De Backer, Benjamin ULg; Renardy, Françoise ULg; Denooz, Raphaël ULg et al

in Journal of Analytical Toxicology (2010), 34(9), 599-604

Tramadol has been extensively prescribed for two decades. It is an opioid analgesic considered to induce fewer side effects than other compounds of this class. However, serious complications may occur in ... [more ▼]

Tramadol has been extensively prescribed for two decades. It is an opioid analgesic considered to induce fewer side effects than other compounds of this class. However, serious complications may occur in case of intoxication. We report here two cases of fatal intoxication due to tramadol ingestion. Tramadol, O-desmethyltramadol (ODT) and N-desmethyltramadol (NDT) were quantitatively and qualitatively determined in postmortem blood and urine, respectively. An HPLC method coupled with fluorescence detection was validated using total error approach for the analysis of tramadol, ODT, and NDT in blood. In case1, concentrations of tramadol and its metabolites were 7.7 mg/L (tramadol), 1.33 mg/L (ODT), and 0.6mg/L (NDT). In case 2, concentrations found were 48.34 mg/L (tramadol), 2.43 mg/L (ODT), and 10.09 mg/L (NDT). Opposite ratios of ODT/NDT concentrations observed in different cases were suggested to be useful for the evaluation of the delay between ingestion and death. However, the changes in metabolites levels may also be explained by pharmacokinetic interactions and quantitative differences in the activity of the cytochrome-P450 2D6. Interestingly, norfluoxetine was detected in sub-therapeutic levels in case 2. Most of these aspects in tramadol-related fatalities are reviewed in this paper, and an overview of fatal intoxications due to tramadol is presented. [less ▲]

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See detailInterest of routine dosage of meropenem in difficult to treat infections
Frippiat, Frédéric ULg; Bensahi, Ilham; Denooz, Raphael ULg et al

Poster (2010, October 23)

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See detailTOLERANCE INTERVALS AS CONTROL CHART: COMPARISON TO CLASSIC SHEWHART X̅-R CONTROL CHART
Marini Djang'Eing'A, Roland ULg; Lambert, Véronique; Denooz, Raphael ULg et al

Poster (2010, September)

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See detailDétermination de la composition de l'héroïne par UHPLC/MS-MS
DUBOIS, Nathalie ULg; CHARLIER, Corinne ULg

Conference (2010, June)

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See detailUPLC MS/MS method for the determination of bupropion and its main metabolites in human whole blood
Denooz, Raphael ULg; Mercerolle, M.; Lachatre, C. et al

in Journal of Analytical Toxicology (2010), 34(5), 280-286

A selective and sensitive ultra-performance liquid chromatography (UPLC)–electrospray ionization-tandem mass spectrometry (MS) method for simultaneous determination of bupropion and its main metabolites ... [more ▼]

A selective and sensitive ultra-performance liquid chromatography (UPLC)–electrospray ionization-tandem mass spectrometry (MS) method for simultaneous determination of bupropion and its main metabolites, hydroxybupropion, erythrohydrobupropion, and threohydrobupropion, in human whole blood is presented. The sample preparation consists of cleanup protein precipitation with methanol combined with a solid-phase extraction on Oasis HLB cartridges. Analytes were separated on a Waters Acquity UPLC® BEH phenyl column using a binary mobile phase consisting of ammonium formate buffer (2 mM, pH 4) and acetonitrile. Detection was performed on a Waters Acquity UPLC system coupled to a Quattro Premier triple-quadrupole MS in positive ion selected reaction monitoring. Internal standards were bupropion-d9 and hydroxybupropion-d6. Linearity was from 5 to 1000 ng/mL for bupropion and from 10 to 2000 ng/mL for metabolites. Accuracy profiles (80–120%), precision (< 15%), and limits of detection (1 ng/mL for bupropion and 2 ng/mL for metabolites) were also evaluated and responded to all criteria of validation. The aim of this study was to compare this presented method with a previously described method developed on a classic liquid chromatography–tandem MS system. [less ▲]

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See detailQuantitative determination of cannabinoids in serum by UHPLC/MS-MS
Dubois, Nathalie ULg; Paccou, A.; DE BACKER, Benjamin ULg et al

Poster (2010, April)

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See detailMICROPOLLUTANTS ISSUES: A MODELLING STUDY OF HEAVY METALS WITHIN TWO FRENCH BASINS AND A TEST APPLICATION TO COCAINE IN BELGIUM
Deliège, Jean-François ULg; Everbecq, Etienne ULg; Grard, Aline ULg et al

Poster (2010, April)

European policies (European Framework Directive: Water 2000/60/CE, Directive 76/464/CE) impose to reduce the releases of about a hundred substances in surface water. In the last years, the AQUAPOLE has ... [more ▼]

European policies (European Framework Directive: Water 2000/60/CE, Directive 76/464/CE) impose to reduce the releases of about a hundred substances in surface water. In the last years, the AQUAPOLE has been involved in two studies related to this matter. First, on the request and with the financial support of both the French Ministry of Environment and ONEMA (“Office National de l’Eau et des Milieux Aquatiques”), INERIS (“Institut National de l’Environnement Industriel et des Risques”) drew up the guidelines of a methodology allowing fixing the local Limit Values to Emission so as to abide by the quality standards on the whole watershed. Within this context, INERIS wishes to test the use of pollutant transfer models on pilot sub-basins. The PEGASE model has been used to simulate micropollutants on two concrete use cases (1): (iii) in the Meuse sub-basin, managed by the French Water Agency Rhine-Meuse, for simulations concerning cadmium and zinc; (iv) in the Adour sub-basin, managed by the French Water Agency Adour-Garonne, for simulations applied to cadmium and copper. The choice of each substances and sub-basins was made by mutual agreement between INERIS, the concerned Water Agencies, and the AQUAPOLE. A major selection criterion for the substances and the sub-basins was the availability of data (sources and in situ measurements). For the second study, the PEGASE model has been adapted to describe the cocaine’s behaviour (using a stable metabolite of the cocaine in the environment: the benzoylecgonine (BZE)) in waste water, waste water treatment plants (WWTP) and surface water (2). The cocaine is newly described in the model as an additional micropollutant (PEGASE already treats numerous heavy metals), thanks to the implementation of new state variable equations and their specific parameterizations. Simulations of BZE have been done in the Walloon and Flemish regions, where many measurements from the COWAT project (3) were available. The first results are showing good agreement between calculated and measured values. The ability of the model to simulate the fate of studied micropollutants (cadmium, zinc, copper, and the cocaine derivatives) in surface waters should be enhanced and extended to other substances and basins. Moreover, additional data still have to be collected and measured. [less ▲]

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See detailPerturbateurs endocriniens reprotoxiques : ennemis de la fertilité chez l'Homme
Charlier, Corinne ULg

Conference (2010, March 16)

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See detailIntérêt du dosage des sulfamidés hypoglycémiants: de la vérification de la compliance au diagnostic différentiel des hyperinsulinismes
Denooz, Raphael ULg; Charlier, Corinne ULg

in Revue Médicale de Liège (2010), 65(9), 493-497

Plus de cinquante ans après leur mise sur le marché, les sulfamidés hypoglycémiants font toujours partie du traitement de base du diabète non insulinodépendant. A côté de leurs remarquables propriétés ... [more ▼]

Plus de cinquante ans après leur mise sur le marché, les sulfamidés hypoglycémiants font toujours partie du traitement de base du diabète non insulinodépendant. A côté de leurs remarquables propriétés pharmacologiques, ces produits ont, à différentes reprises, été tenus responsables d’hypoglycémies sévères survenant de manière inexpliquée chez des sujets non diabétiques. Ce type d’hypoglycémie, qualifiée de factice, est notamment fréquemment retrouvée dans le syndrome de Munchausen, trouble psychiatrique poussant le malade à mimer une pathologie. Cette hypoglycémie est associée à un hyperinsulinisme endogène simulant une pathologie endocrine très rare, l’insulinome. Nous souhaitons faire connaître aux Cliniciens l’intérêt de la recherche et du dosage sanguin des sulfamidés hypoglycémiants dans le cadre du diagnostic différentiel des hyperinsulinismes. La mise en évidence d’une hypoglycémie induite par ces médicaments constitue un élément intéressant pour orienter le diagnostic et éventuellement éviter une pancréatectomie en cas de forte suspicion d’insulinome. La méthode analytique développée au laboratoire s’appuie sur la chromatographie liquide ultra performante couplée à la spectrométrie de masse tandem (UPLC -MS -MS ). Par cette technique, on peut mettre en évidence dans le sang une dizaine de sulfonylurées et le répaglinide. Elle constituera à l’avenir une méthode de choix face à toute suspicion de mésusage des sulfonylurées. [less ▲]

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See detailAssessment of exposure to persistent organochlorine compounds in epidemiological studies on breast cancer : a literature review and perspectives for the CECILE study
Bachelet, D.; Verner, M.-A.; Guihenneuc-Jouyaux, C. et al

in Acta Clinica Belgica (2010), 65(1), 49-57

Breast cancer is the most frequent neoplastic disease in women representing 50,000 new cases each year in France. The well-established risk factors, as those related to the reproductive history, cannot ... [more ▼]

Breast cancer is the most frequent neoplastic disease in women representing 50,000 new cases each year in France. The well-established risk factors, as those related to the reproductive history, cannot account for all cases of breast cancer. Other environmental or lifestyle factors need to be explored in depth. Persistent organochlorine compounds (OCs) have attracted attention because of their endocrine disrupting properties that make them possible risk factors for breast cancer, but most epidemiological studies did not report an association between OC concentrations in blood or adipose tissue and breast cancer risk. In these studies, OC levels were measured in biological samples obtained at the time of cancer diagnosis or only a few years before. In this paper, we review the studies on dichlorodiphenyltrichloroethane (DDT) and polychlorobiphenyl (PCB) exposures in relation to breast cancer. We discuss the relevance of OC biological measurements as lifelong exposure indicators, and we describe a new method for assessing exposure to OCs in epiderniological studies. Most studies were carried out recently and reported OC concentrations that were substantially lower than those reported during the 1960s and 1970s. We make the assumption that these OC levels were not reliable indicators, as they were not measured during etiologically relevant periods in a woman's lifetime, i.e. during the prenatal period, the puberty or the period before a first full-term pregnancy, which are regarded as key periods of vulnerability of mammary gland cells to carcinogens. This may have resulted in non differential exposure misclassification and hence in the absence of an observed association between OC levels and breast cancer in most epidemiological studies. Physiologically-based pharmacokinetic (PBPK) models allow estimating persistent organic pollutant lifetime toxicokinetics profiles retrospec- tively in women, by taking into account individual differences in metabolism and key events that affect OC kinetics such as lactation and weight variations. PBPK models will be applied to the participants of a large French population-based case-control study including 1080 cases and 1055 controls. Exposure misclassification could have prevented from observing an association between exposure to OCs and breast cancer risk. PBPK models could be used as a novel way of assessing exposure to OCs and to investigate the impact of internal exposure at different time windows on breast cancer incidence. [less ▲]

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See detailLe Cannabis: historique, culture et modes d'utilisation
Theunis, Laetitia ULg; De Backer, Benjamin ULg; Charlier, Corinne ULg

in Regards croisés sur le Cannabis (2010)

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See detailQuantification in postmortem blood and identification in urine of tramadol and its two main metabolites in two cases of lethal tramadol intoxication
De Backer, Benjamin ULg; Renardy, Françoise ULg; Denooz, Raphael ULg et al

in Mitteilungsblatt der Gesellschaft für Toxikologische und Forensische Chemie (2010), 77(3), 252

Detailed reference viewed: 60 (5 ULg)