References of "Charlier, Corinne"
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See detailApplication de la résonance magnétique nucléaire (RMN) en toxicologie judiciaire
Denooz, Raphaël ULg; Frederich, Michel ULg; Charlier, Corinne ULg et al

in Acta Clinica Belgica (2013), 68(6), 470

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See detailRecensement des dosages d'alcool sanguin effectués dans le cadre de la sécurité routière
DEVILLE, Marine ULg; Charlier, Corinne ULg

in Acta Clinica Belgica (2013), 68(6), 479

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See detailToxicité induite par les antidépresseurs : état des lieux
DEVILLE, Marine ULg; DENOOZ, Raphael ULg; Charlier, Corinne ULg

in Acta Psychiatrica Belgica (2013), 113(2), 17-21

Lors de l'instauration d'un traitement chez un patient dépressif, il est justifié de se poser la question de la toxicité en cas d'ingestion massive, telle que rencontrée dans les tentatives d'autolyse ... [more ▼]

Lors de l'instauration d'un traitement chez un patient dépressif, il est justifié de se poser la question de la toxicité en cas d'ingestion massive, telle que rencontrée dans les tentatives d'autolyse. Alors que les premiers antidépresseurs sont très toxiques à dose élevée, la recherche pharmaceutique a, à l'heure actuelle, mis à disposition des cliniciens des molécules plus sûres. En effet, si la toxicité cardiaque des ATC peut, à elle seule, mener à une issue fatale, les molécules récentes sont rarement mortelles lorsqu'elles sont ingérées seules, même à dose élevée, mais le risque de décès persiste lors d'intoxications polymédicamenteuses. Par ailleurs, les interactions entre différentes substances médicamenteuses ou alimentaires limitent également l'usage des IMAO, et accroissent le risque de toxicité du lithium, médicament à index thérapeutique étroit. [less ▲]

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See detailSevrage rapide aux opiacés sous anesthésie (RODA)
DUBOIS, Nathalie ULg; HALLET, Claude ULg; LUPPENS, David ULg et al

in Revue Médicale de Liège (2013), 68(5-6), 298-302

Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measure ... [more ▼]

Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measure the plasma concentrations of heroin metabolites and methadone during anesthesia and patient stay at the hospital in order to assess the amount of active substances at each protocol step. Plasma concentrations of antagonists were also quantified and compared to the recommended target values. Blood samples were drawn in 10 patients undergoing RODA at different times of the procedure (during anesthesia, in post-anesthesia care unit and in psychiatry unit). The plasma concentrations of heroin metabolites, methadone and antagonists were measured using a previously described method. Heroin active metabolites were no longer detected in the patient blood when he/she left the hospital; by contrast, methadone was still present at significant concentrations 3 days after the beginning of the detoxification procedure. Naltrexone analysis allowed us to adjust doses to insure opiate receptor blockade. [less ▲]

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See detailLa surveillance biologique de l'exposition aux produits chimiques en toxicologie industrielle et de l'environnement
MISTRETTA, Virginie ULg; Charlier, Corinne ULg

in Annales de Biologie Clinique (2013), 71(3), 257-267

Biological monitoring, also called biomonitoring, is a process to prevent and assess health risk for individuals exposed to chemical products present in environment or through workplace exposure ... [more ▼]

Biological monitoring, also called biomonitoring, is a process to prevent and assess health risk for individuals exposed to chemical products present in environment or through workplace exposure. Biomonitoring is most often a monitoring of exposure or of effect. The exposure monitoring is currently the most widespread in toxicology. It involves the determination in biological fluids of different biomarkers, most of which are biomarkers of internal dose. These biological indicators are typically measured in blood and urine, but other biological samples can be analyzed. They are used to assess the penetration of environmental pollutants into the body. Assay results are interpreted in relation to reference values which are adapted either to occupationally exposed populations, or to general population. This interpretation and the choice of appropriate biomarker of exposure are not always obvious. Biomonitoring has some limitations despite its many advantages. It is complementary to another health prevention approach: the monitoring of ambient air. To illustrate in practice the biomonitoring of exposure, several examples of toxics and their associated biomarkers are reviewed: benzene, toluene, styrene, polycyclic aromatic hydrocarbons, chloroform, 2-hexanone and hydrogen cyanide. [less ▲]

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See detailEnvironnement chimique et Santé
Charlier, Corinne ULg

Conference given outside the academic context (2012)

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See detailDosage sérique des antimycosiques azolés
MISTRETTA, Virginie ULg; Charlier, Corinne ULg

Conference (2012, November 13)

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See detailEvolution of the content of THC and other major cannabinoids in drug-type cannabis cuttings and seedlings during growth of plants
DE BACKER, Benjamin ULg; Maebe, Kevin; Verstraete, Alain G. et al

in Journal of Forensic Sciences (2012), 57(4), 918-922

In Europe, authorities frequently ask forensic laboratories to analyze seized cannabis plants to prove that cultivation was illegal (drug type and not fiber type). This is generally done with mature and ... [more ▼]

In Europe, authorities frequently ask forensic laboratories to analyze seized cannabis plants to prove that cultivation was illegal (drug type and not fiber type). This is generally done with mature and flowering plants. However, authorities are often confronted with very young specimens. The aim of our study was to evaluate when the chemotype of cannabis plantlets can be surely determined through analysis of eight major cannabinoids content during growth. Drug-type seedlings and cuttings were cultivated, sampled each week, and analyzed by high-performance liquid chromatography with diode array detection. The chemotype of clones was recognizable at any developmental stage because of high total Delta-9-tetrahydrocannabinol (THC) concentrations even at the start of the cultivation. Conversely, right after germination seedlings contained a low total THC content, but it increased quickly with plant age up, allowing chemotype determination after 3 weeks. In conclusion, it is not necessary to wait for plants’ flowering to identify drug-type cannabis generally cultivated in Europe. [less ▲]

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See detailConsommation de cannabis - Point de vue du monde médical
Charlier, Corinne ULg

Conference given outside the academic context (2012)

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See detailPerturbateurs endocriniens à effet réprotoxique
Charlier, Corinne ULg

Scientific conference (2012, April 17)

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See detailApport des troponines T et I ultrasensibles dans le diabète
LE GOFF, Caroline ULg; LAURENT, Terry ULg; GARWEG, Christophe ULg et al

in Immuno-Analyse & Biologie Spécialisée [=IBS] (2012, February), 27(1), 40

Introduction : Le diabète atteint environ 3% de la population française. Or, cette maladie expose à l'apparition précoce de complications cardiovasculaires. Les troponines de nouvelles générations ... [more ▼]

Introduction : Le diabète atteint environ 3% de la population française. Or, cette maladie expose à l'apparition précoce de complications cardiovasculaires. Les troponines de nouvelles générations hautement sensibles pourraient être un bon outil diagnostic pour mettre en évidence des macroou micro-angiopathies non diagnostiquée chez ces patients. Le but de notre étude était de comparer la performance de la troponine T ultrasensible (hsTnT) (Roche Diagnostic) avec la troponine I ultrasensible (TnI II) (Abbott Diagnostic) chez le sujet diabétique. Matériel et méthodes : Vingt patients diabétiques (âge moyen : 52.6 ± 8.4 ans) ont été sélectionnés sur le critère d’un taux d’hémoglobine glyquée (HbA1c) élevé. Ces sujets ont été comparés à vingt sujets contrôles d’âge moyen : 60.05 ± 2.86 ans. Les patients atteints d’insuffisance rénale et d’affections cardiovasculaires ont été exclus. Les analyses ont été réalisées sur du plasma hépariné lithium. La hsTnT a été dosée par électrochemiluminescence sur le Modular E (Roche Diagnostic). Abbott utilise des microparticules chemiluminescentes pour le dosage de la TnI II sur l’ARCHITECT i. Résultats : Les sujets diabétiques ont un taux plasmatique de hsTnT représenté par les valeurs suivantes [médiane (1er quartile, 3ème quartile)] : 0,007 (0,03 ; 0,018) ng/mL ; alors que les sujets contrôles négatifs présentent les valeurs suivantes : 0,003 (0,003 ; 0,004) ng/mL. La différence de taux de hsTnT observée entre ces 2 populations est statistiquement significative (p = 0,000922). Pour la TnI II, on observe un taux plasmatique de: 0,004 (0,003 ; 0,075) ng/mL chez les sujets diabétiques et 0,002 (0,001 ; 0,005) ng/mL chez les sujets contrôles. La différence de taux de TnI II observée entre ces 2 populations n’est pas statistiquement significative (p > 0,005). Discussion-conclusion : Au décours d’un diabète, il apparait que les taux de hsTnT sont augmentés de façon significative par rapport au groupe des contrôles négatifs. Si les taux hsTnT augmentent chez le diabétique, il semblerait normal qu’il en soit de même pour la TnI II, vu que ces deux marqueurs sont intimement liés. Nous ne l’avons pas observé mais ceci peut être du à la plus faible performance analytique du dosage de la TnI II utilisé. Cette libération de hsTnT dans le sang peut être due aux micro- et macro-angiopathies au niveau des coronaires induites au cours d’un diabète. [less ▲]

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See detailEtude de l'imprégnation d'une population générale belge en bisphénol A, triclosan et 4-nonylphénol
PIRARD, Catherine ULg; SAGOT, Clémence ULg; DEVILLE, Marine ULg et al

in Annales de Toxicologie Analytique (2012), 24(4),

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See detailUrinary levels of bisphenol A, triclosan and 4-nonylphenol in a general Belgian population
PIRARD, Catherine ULg; SAGOT, Clémence ULg; DEVILLE, Marine ULg et al

in Environment International (2012), 48

Bisphenol A, triclosan and 4-nonylphenol are among the endocrine disruptors which are widely used in daily products. In this study, we reported total urinary levels of bisphenol A, triclosan and 4 ... [more ▼]

Bisphenol A, triclosan and 4-nonylphenol are among the endocrine disruptors which are widely used in daily products. In this study, we reported total urinary levels of bisphenol A, triclosan and 4-nonylphenol, in order to evaluate the baseline contamination of a general population in Belgium. Bisphenol A and triclosan were detected in respectively 97.7% and 74.6% of the samples examined demonstrating that the general Belgian population is extensively exposed to both chemicals. On the other hand, 4-nonylphenol was not detected in any urine samples analyzed, suggesting either low exposure, inadequate biomarker, or that urine is an inappropriate biological matrix for assessing exposure to nonylphenol commercial mixtures. Geometric mean concentration was determined for bisphenol A at 2.55μg/l and for triclosan at 2.70μg/l. No significant difference was observed between levels and gender for both bisphenol A and triclosan. When classified by age, the 20-39year group showed the highest triclosan levels, while all age groups seemed to be similarly exposed to bisphenol A. Both bisphenol A and triclosan urinary levels were not correlated with creatinine excretion in our healthy population, questioning the relevance of the creatinine adjustment in reporting these chemical levels. Bisphenol A levels in urine of people living in the same home and collected on the same time were fairly correlated, confirming the assumption that dietary intake would be the primary route of exposure. Triclosan urinary levels were not correlated with bisphenol A levels. [less ▲]

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