References of "COUCKE, Philippe"
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See detailIdentification of predictive markers based on functional imaging of metastatic spreading at the time of surgery after neoadjuvant radiotherapy
LALLEMAND, François ULg; Leroi, Natacha ULg; Bahri, Mohamed Ali ULg et al

Poster (2015, January 27)

Neoadjuvant radiotherapy (NeoRT) improves tumor local control and tumor resection in many cancers. The timing between the end of the NeoRT and surgery are driven by the occurrence of side effects or the ... [more ▼]

Neoadjuvant radiotherapy (NeoRT) improves tumor local control and tumor resection in many cancers. The timing between the end of the NeoRT and surgery are driven by the occurrence of side effects or the tumor downsizing. Some studies demonstrated that the timing of surgery and the RT schedule could influence tumor dissemination. Our aim is to evaluate with functional MRI the impact of the radiation treatment on the tumor microenvironment and subsequently to determine the best timing to perform surgery. We used a model of NeoRT, 4T1 cells were implanted in the flank of BalbC mice. Seven days after, tumors were irradiated with 2x5Gy than we surgically removed this lesion 11 days after RT. Diffusion Weighted (DW) and Dynamic Contrast Enhancement (DCE) -MRI was performed every 2 days during 11 days between RT and surgery. We developed a homemade “portacath” specifically dedicated for mice and for repetitive I.V. contrast agent injection. For DW-MRI, we performed sequences with 10 different B-value to achieve IntraVoxel Incoherent Motion analysis. For DCE-MRI, we used FSEMS sequence for keeping the same slices as with DW-MRI. For both images, we performed analysis on the entire tumor volume. We obtained very promising preliminary results showing good uniformity in the ADC (Attenuation Diffusion Coefficient). We succeeded to follow mice with imaging during the 11 days without major troubles. We observed less variability of the ADC signal during the 11 days in the irradiated tumors compared to the control. The signal to noise ratio was relatively poor for the diffusion sequence and need to be improved. For the first time, we demonstrate the feasibility of repetitive MRI functional imaging in a mice model of NeoRT. These results open perspectives for studying modifications of the tumor microenvironment induced by neoadjuvant RT. The techniques need to be improved and correlated to the tumor dissemination in function of the RT schedule and timing of surgery. [less ▲]

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See detailTransfer of communication skills to the workplace: Impact of a 38-hour communication skills training program designed for radiotherapy teams
Merckaert, Isabelle; Delevallez, France; Gibon, Anne-Sophie et al

in Journal of Clinical Oncology (2015), 33(8), 901-909

Purpose This study assessed the efficacy of a 38-hour communication skills training program designed to train a multidisciplinary radiotherapy team. Methods Four radiotherapy teams were randomly assigned ... [more ▼]

Purpose This study assessed the efficacy of a 38-hour communication skills training program designed to train a multidisciplinary radiotherapy team. Methods Four radiotherapy teams were randomly assigned to a training program or a waiting list. Assessments were scheduled at baseline and after training for the training group and at baseline and 4 months later for the waiting list group. Assessments included an audio recording of a radiotherapy planning session to assess team members’ communication skills and expression of concerns of patients with breast cancer (analyzed with content analysis software) and an adapted European Organisation for Research and Treatment of Cancer satisfaction with care questionnaire completed by patients at the end of radiotherapy. Results Two hundred thirty-seven radiotherapy planning sessions were recorded. Compared with members of the untrained teams, members of the trained teams acquired, over time, more assessment skills (P = .003) and more supportive skills (P = .050) and provided more setting information (P = .010). Over time, patients interacting with members of the trained teams asked more open questions (P = .022), expressed more emotional words (P = .025), and exhibited a higher satisfaction level regarding nurses’ interventions (P = .028). Conclusion The 38-hour training program facilitated transfer of team member learned communication skills to the clinical practice and improved patients’ satisfaction with care. [less ▲]

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See detailOncologie et revalidation physique
Leclerc, Anne-France ULg; Foidart-Dessalle, Marguerite ULg; COUCKE, Philippe ULg et al

in Abstract Book du Colloque "Femmes et Santé" (Université d'Hiver) (2015, January 26)

Le cancer constitue une maladie fréquente en Belgique puisqu'un homme sur trois et une femme sur quatre sont confrontés à la maladie avant l'âge de septante-cinq ans (Fondation Registre du Cancer, 2008 ... [more ▼]

Le cancer constitue une maladie fréquente en Belgique puisqu'un homme sur trois et une femme sur quatre sont confrontés à la maladie avant l'âge de septante-cinq ans (Fondation Registre du Cancer, 2008). La détection précoce et l'amélioration des traitements du cancer, généralement une combinaison de chirurgie, radiothérapie, chimiothérapie, hormonothérapie et thérapie ciblée, ont permis une augmentation du taux de survie. Cependant, ces traitements peuvent être à l'origine de nombreux effets secondaires, non seulement précoces, mais également tardifs, réduisant la qualité de vie. De nombreux programmes de réhabilitation après cancer sont basés sur la psychothérapie et le support social uniquement, or ceux-ci n'agissent généralement pas sur les problèmes physiques encourus par les patients tels que la fatigue, la prise de poids et la diminution des capacités fonctionnelles. C'est pourquoi nous émettons l'hypothèse qu'une revalidation physique, associée à des séances psycho-éducatives et constituant ainsi une prise en charge multidisciplinaire, permettrait d'améliorer d'autant plus la qualité de vie et le bien-être tant physique que psychologique des patients ayant été traités pour un cancer. [less ▲]

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See detailThe timing of surgery after neoadjuvant radiotherapy influences tumor dissemination in a preclinical model
Leroi, Natacha ULg; Sounni, Nor Eddine ULg; Van Overmeire, Eva et al

in Oncotarget (2015)

Neoadjuvant radiotherapy (neoRT) used in cancer treatments aims at improving local tumor control and patient overall survival. The neoRT schedule and the timing of the surgical treatment (ST) are ... [more ▼]

Neoadjuvant radiotherapy (neoRT) used in cancer treatments aims at improving local tumor control and patient overall survival. The neoRT schedule and the timing of the surgical treatment (ST) are empirically based and influenced by the clinician’s experience. The current study examines how the sequencing of neoRT and ST affects metastatic dissemination. In a breast carcinoma model, tumors were exposed to different neoRT schedules (2x5Gy or 5x2Gy) followed by surgery at day 4 or 11 post- RT. The impact on the tumor microenvironment and lung metastases was evaluated through immunohistochemical and flow cytometry analyses. After 2x5Gy, early ST (at day 4 post-RT) led to increased size and number of lung metastases as compared to ST performed at day 11. Inversely, after 5x2Gy neoRT, early ST protected the mice against lung metastases. This intriguing relationship between tumor aggressiveness and ST timing could not be explained by differences in classical parameters studied such as hypoxia, vessel density and matrix remodeling. The study of tumor-related inflammation and immunity reveals an increased circulating NK cell percentage following neoRT as compared to non irradiated mice. Then, radiation treatment and surgery were applied to tumor-bearing NOD/SCID mice. In the absence of NK cells, neoRT appears to increase lung metastatic dissemination as compared to non irradiated tumor-bearing mice. Altogether our data demonstrate that the neoRT schedule and the ST timing affect metastasis formation in a pre-clinical model and points out the potential role of NK cells. These findings highlight the importance to cautiously tailor the optimal window for ST following RT. [less ▲]

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See detailAnxiety at the first radiotherapy session for non-metastatic breast cancer: Key communication and communication-related predictors.
Lewis, Florence; Merckaert, Isabelle; Lienard, Aurore et al

in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (2015), 114(1), 35-41

BACKGROUND AND PURPOSE: Patients may experience clinically relevant anxiety at their first radiotherapy (RT) sessions. To date, studies have not investigated during/around the RT simulation the key ... [more ▼]

BACKGROUND AND PURPOSE: Patients may experience clinically relevant anxiety at their first radiotherapy (RT) sessions. To date, studies have not investigated during/around the RT simulation the key communication and communication-related predictors of this clinically relevant anxiety. MATERIAL AND METHODS: Breast cancer patients (n=227) completed visual analog scale (VAS) assessments of anxiety before and after their first RT sessions. Clinically relevant anxiety was defined as having pre- and post-first RT session VAS scores 4cm. Communication during RT simulation was assessed with content analysis software (LaComm), and communication-related variables around the RT simulation were assessed with questionnaires. RESULTS: Clinically relevant anxiety at the first RT session was predicted by lower self-efficacy to communicate with the RT team (OR=0.65; p=0.020), the perception of lower support received from the RT team (OR=0.70; p=0.020), lower knowledge of RT-associated side effects (OR=0.95; p=0.057), and higher use of emotion-focused coping (OR=1.09; p=0.013). CONCLUSIONS: This study provides RT team members with information about potential communication strategies, which may be used to reduce patient anxiety at the first RT session. [less ▲]

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See detailRespiratory Motion, Anterior Heart Displacement and Heart Dosimetry: Comparison Between Prone (Pr) and Supine (Su) Whole Breast Irradiation
Lakosi, Ferenc; GULYBAN, Akos ULg; Janvary, Levente et al

in Pathology Oncology Research (2015)

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See detailProgramme de revalidation multidisciplinaire post-cancer du sein : analyse des bénéfices éventuels sur la fonction physique et la qualité de vie
LECLERC, Anne-France ULg; FOIDART-DESSALLE, Marguerite ULg; COUCKE, Philippe ULg et al

in AFPSA - 8e congrès francophone, Psychologie de la Santé - Evolutions sociales, innovations & politiques - Résumé des communications (2014, December 16)

Introduction : Le cancer du sein ainsi que ses traitements sont à l'origine de nombreux effets secondaires indésirables. L'objectif de l'étude est de déterminer les bénéfices éventuels, tant sur le plan ... [more ▼]

Introduction : Le cancer du sein ainsi que ses traitements sont à l'origine de nombreux effets secondaires indésirables. L'objectif de l'étude est de déterminer les bénéfices éventuels, tant sur le plan physique que psychologique, d’un programme de revalidation multidisciplinaire chez des femmes ayant été traitées pour un cancer du sein. Méthodologie : 122 patientes ont été recrutées, 61 faisant partie du groupe contrôle et 61 du groupe traité. Celui-ci a bénéficié d’une revalidation de trois mois comprenant un entraînement physique supervisé et diverses sessions psycho-éducatives. Les évaluations, effectuées avant et après la prise en charge, ont inclus des mesures anthropométriques et de composition corporelle, une évaluation des capacités fonctionnelles et différents questionnaires. Résultats : Au terme des trois mois, l’état de santé (qualité de vie), le rôle fonctionnel, l’état émotionnel et les fonctions physiques, cognitives et sociales s’améliorent significativement au sein du groupe traité. Cette observation s’applique également aux symptômes de fatigue, d'insomnie, de douleur, de dyspnée, de perte d'appétit, d’anxiété et de dépression ainsi qu'aux paramètres physiques obtenus par l'intermédiaire des évaluations fonctionnelles. Au sein du groupe contrôle, ces améliorations n’apparaissent pas et une augmentation significative de l'indice de masse corporelle et du pourcentage de graisse corporelle est observée. Conclusion : Cette étude préliminaire montre ainsi la faisabilité et les effets bénéfiques d’une prise en charge multidisciplinaire chez des femmes au terme de leurs traitements pour le cancer du sein. [less ▲]

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See detailMédecin paternaliste versus patient soumis et crédule : un scénario obsolète
COUCKE, Philippe ULg

in Healtcare executive (2014), 80(decembre-janvier), 23-25

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See detailLes défis colossaux auxquels la santé publique va devoir faire face !
COUCKE, Philippe ULg

in Onco : Revue Multidisciplinaire d'Oncologie (2014)

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See detailanxiety at the first radiotherapy session for non-metastatic brest cancer: key communication and communication-related predictors
Lewis, Florence; Merckaert, Isabelle; Liénard, Aurore et al

in Radiotherapy & Oncology (2014)

Background and purpose Patients may experience clinically relevant anxiety at their first radiotherapy (RT) sessions. To date, studies have not investigated during/around the RT simulation the key ... [more ▼]

Background and purpose Patients may experience clinically relevant anxiety at their first radiotherapy (RT) sessions. To date, studies have not investigated during/around the RT simulation the key communication and communication-related predictors of this clinically relevant anxiety. Material and methods Breast cancer patients (n = 227) completed visual analog scale (VAS) assessments of anxiety before and after their first RT sessions. Clinically relevant anxiety was defined as having pre- and post-first RT session VAS scores ⩾4 cm. Communication during RT simulation was assessed with content analysis software (LaComm), and communication-related variables around the RT simulation were assessed with questionnaires. Results Clinically relevant anxiety at the first RT session was predicted by lower self-efficacy to communicate with the RT team (OR = 0.65; p = 0.020), the perception of lower support received from the RT team (OR = 0.70; p = 0.020), lower knowledge of RT-associated side effects (OR = 0.95; p = 0.057), and higher use of emotion-focused coping (OR = 1.09; p = 0.013). Conclusions This study provides RT team members with information about potential communication strategies, which may be used to reduce patient anxiety at the first RT session. [less ▲]

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See detailOrthanc - Logiciel libre pour l'imagerie médicale en milieu hospitalier
JODOGNE, Sébastien ULg; LENAERTS, Eric ULg; COUCKE, Philippe ULg et al

in Communications de la Conférence Francophone en Gestion et Ingénierie des Systèmes Hospitaliers (GISEH 2014) (2014, July)

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See detailThe development of a safety culture: a fanciful hope in the health care sector ?
COUCKE, Philippe ULg

in Belgian Journal of Medical Oncology [=BJMO] (2014), 8(3), 66-71

Detailed reference viewed: 38 (10 ULg)