References of "COUCKE, Philippe"
     in
Bookmark and Share    
Full Text
See detailExperience feed back committee and evaluation of weaknesses and critical
DELGAUDINE, Marie ULg; LENAERTS, Eric ULg; COUCKE, Philippe ULg

Poster (2010)

Radiotherapy is a powerful continuously evolving effective treatment tool. Our aim is to offer the best treatments and assure security for patients and personnel. A proactive quality approach copied from ... [more ▼]

Radiotherapy is a powerful continuously evolving effective treatment tool. Our aim is to offer the best treatments and assure security for patients and personnel. A proactive quality approach copied from the one implemented in the air transport industry has been established in our department. An Experience Feed Back Committee (EFBC) has been set up to identify, record and analyze systematically all reported precursor events. Our final objective is to test and strengthen the security of the organization and the quality of care for patients. [less ▲]

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailA phase I trial of sutent, a tyrosine kinase inhibitor combined with ionizing irradiation in rectal cancer: protocol KIRC 08-01
COUCKE, Philippe ULg

in Belgian Journal of Medical Oncology [=BJMO] (2010), 4(2), 65-66

Detailed reference viewed: 15 (7 ULg)
Full Text
Peer Reviewed
See detailVers une radiothérapie chirurgicale :nécessité d’une radiothérapie guidée par l’imagerie
COUCKE, Philippe ULg; WITHOFS, Nadia ULg; JANSEN, Nicolas ULg et al

in Revue Médicale de Liège (2010), 65(supp 1), 17-22

résumé : L’évolution extrêmement rapide en robotique et en informatique a permis l’avènement de techniques telles que le CcyberKnife®, capables d’appliquer en radiothérapie des doses dites «ablatives» et ... [more ▼]

résumé : L’évolution extrêmement rapide en robotique et en informatique a permis l’avènement de techniques telles que le CcyberKnife®, capables d’appliquer en radiothérapie des doses dites «ablatives» et ceci avec une précision chirurgicale. Ce type de traitement ablatif n’est pas réellement concevable avec des techniques conventionnelles en radiothérapie et des changements <br />majeurs de paradigmes ont eu lieu, particulièrement dans la méthodologie de définition de la cible et des marges ainsi que dans la manière dont on fractionne le traitement. Ggrâce à ces changements, on est à même de proposer aux patients des traitements <br />qui représentent un doublement au niveau de l’efficacité <br />biologique. Ppour obtenir une couverture optimale au niveau de la cible, tout en évitant les structures saines avoisinantes, il est donc impératif d’obtenir la meilleure définition possible de la cible tant au niveau de la l’extension de la lésion qu’au niveau de son «contenu», c’est-à-dire les caractéristiques métaboliques et fonctionnelles. Lla révolution technologique en cours dans le monde de l’imagerie métabolique et fonctionnelle va permettre d’utiliser l’information numérisée pour individualiser les traitements <br />et les adapter aux caractéristiques mêmes de la lésion ainsi qu’à son évolution au décours du traitement. [less ▲]

Detailed reference viewed: 85 (8 ULg)
Full Text
Peer Reviewed
See detailDoes radiation treatment delay affect survival in glioblastoma
Robe, Pierre ULg; Nguyen-Khac, Minh-Tuan ULg; Lenelle, Jacques ULg et al

in Surgical Neurology (2009), 72(5), 519

Detailed reference viewed: 65 (10 ULg)
Full Text
Peer Reviewed
See detailLa visio conférence pour combattre le cancer
Coucke, Philippe ULg

Article for general public (2009)

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailSymptom attribution and radiation thérapy for breast cancer : changes over time and associated psychological factors
Bonamis, O.; Liénard, A.; Coucke, Philippe ULg et al

in Psycho-oncology (2009, June), 18 (Suppl. 2)

Detailed reference viewed: 27 (0 ULg)
Full Text
Peer Reviewed
See detailANTICORPS MONOCLONAUX ET CANCER DU SEIN: Actualités thérapeutiques
Collignon, Joëlle ULg; Gennigens, Christine ULg; Rorive, Andrée ULg et al

in Revue Médicale de Liège (2009), 64(5-6), 279-83

About 9,500 new breast cancers are diagnosed in Belgium every year. Improvement of our knowledge of altered molecular events leading to the proliferation of tumor cells has resulted in the development of ... [more ▼]

About 9,500 new breast cancers are diagnosed in Belgium every year. Improvement of our knowledge of altered molecular events leading to the proliferation of tumor cells has resulted in the development of targeted therapies in subgroups of cancers. One of the first validation of targeted therapy is the anti-HER-2 monoclonal antibody trastuzumab (Herceptin) in patients with overexpression of human epidermal growth factor receptor type 2 (HER2) occurring in 20 to 25% of invasive breast carcinoma. Trastuzumab binds the extracellular juxtamembrane domain and is only active in tumor with HER2 gene amplification detected by fluorescence in situ hybridization (FISH). The results from randomized trials have rapidly lead to the approvement of the drug in the metastatic and then in the adjuvant setting. Another targeted therapy, also approved in the treatment of breast cancer, is the monoclonal antibody bevacizumab with an anti-VEGF (Vascular Endothelial Growth Factor) activity. We will review the benefit of these targeted therapies in breast cancer and their role in the treatment of breast cancer. [less ▲]

Detailed reference viewed: 409 (39 ULg)
Peer Reviewed
See detailDoes radiation treatment delay affect survival in glioblastoma ?
Robe, Pierre ULg; Nguyen Khac, Minh-Tuan ULg; Lenelle, Jacques ULg et al

Conference (2009, March 21)

Detailed reference viewed: 38 (9 ULg)
Full Text
Peer Reviewed
See detailA dosimetric selectivity intercomparison of HDR brachytherapy, IMRT and helical tomotherapy in prostate cancer radiotherapy
Hermesse, Johanne ULg; Biver, Sylvie; JANSEN, Nicolas ULg et al

in Strahlentherapie und Onkologie (2009), 185(11), 736-742

Background and Purpose: Dose escalation in order to improve the biochemical control in prostate cancer requires the application of irradiation techniques with high conformality. The dosimetric selectivity ... [more ▼]

Background and Purpose: Dose escalation in order to improve the biochemical control in prostate cancer requires the application of irradiation techniques with high conformality. The dosimetric selectivity of three radiation modalities is compared: high-dose-rate brachytherapy (HDR-BT), intensity-modulated radiation radiotherapy (IMRT), and helical tomotherapy (HT). <br />Patients and Methods: Ten patients with prostate adenocarcinoma treated by a 10-Gy HDR-BT boost after external-beam radiotherapy were investigated. For each patient, HDR-BT, IMRT and HT theoretical treatment plans were realized using common contour sets. A 10-Gy dose was prescribed to the planning target volume (PTV). The PTVs and critical organs’ dose-volume histograms obtained were compared using Student’s t-test. <br />Results: HDR-BT delivers spontaneously higher mean doses to the PTV with smaller cold spots compared to IMRT and HT. 33% of the rectal volume received a mean HDR-BT dose of 3.86 ± 0.3 Gy in comparison with a mean IMRT dose of 6.57 ± 0.68 Gy and a mean HT dose of 5.58 ± 0.71 Gy (p < 0.0001). HDR-BT also enables to better spare the bladder. The hot spots inside the urethra are greater with HDR-BT. The volume of healthy tissue receiving 10% of the prescribed dose is reduced at least by a factor of 8 with HDR-BT (p < 0.0001). <br />Conclusion: HDR-BT offers better conformality in comparison with HT and IMRT and reduces the volume of healthy tissue receiving a low dose. [less ▲]

Detailed reference viewed: 116 (22 ULg)
Full Text
Peer Reviewed
See detailA dosimetric study comparing breast radiotherapy planned in the prone versus supine positions and via conformal 3D versus IMRT techniques
Coucke, Philippe ULg

in Belgian Journal of Medical Oncology [=BJMO] (2009), 3(3), 117

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailDans l'ère des traitements systematiques efficaces, il devient primordial d'assurer le controle local
Coucke, Philippe ULg

in Onco : Revue Multidisciplinaire d'Oncologie (2009), 3(6), 206-207

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailTumor Margin after conservative breast cancer surgery for early disease: an issue or not ?
Coucke, Philippe ULg; Vavassis, Peter; Vanderick, JEAN ULg et al

in Belgian Journal of Medical Oncology [=BJMO] (2009), 3(3), 93-100

Summary is standard of care. However, the question is Conservative breast surgery (CBS), i.e. tumorec- whether this approach is able to consolidate local tomy (TUM), has replaced more radical surgical ... [more ▼]

Summary is standard of care. However, the question is Conservative breast surgery (CBS), i.e. tumorec- whether this approach is able to consolidate local tomy (TUM), has replaced more radical surgical control irrespective of the extent of the surgical approaches such as mastectomy (MAST) and margin. No consensus exists in the literature con-quadrantectomy (QUAD). The aim of surgeons is cerning what should be considered as a minimal to avoid recurrence and still obtain a good cos-and hence a safe margin. This review will summetic result. After CBS for early disease, adjuvant marize the published data in order to try to define radiation consisting of whole breast irradiation a pragmatic treatment approach. followed by a boost dose on the surgical bed is standard of care. However, the question is whether this approach is able to consolidate local control irrespective of the extent of the surgical margin. No consensus exists in the literature concerning what should be considered as a minimal and hence a safe margin. This review will summarize the published data in order to try to define a pragmatic treatment approach. [less ▲]

Detailed reference viewed: 50 (4 ULg)
Full Text
Peer Reviewed
See detailLa vieille dame qui prend un coup de jeune
Coucke, Philippe ULg

in Onco : Revue Multidisciplinaire d'Oncologie (2009), 3(3), 79-81

Detailed reference viewed: 16 (6 ULg)
Full Text
Peer Reviewed
See detailA phase I trial of sunitinib, a tyrosine kinase inhibitor (TKI) combined with ionizing irradiation in rectal cancer
Coucke, Philippe ULg

in Belgian Journal of Medical Oncology [=BJMO] (2009), 3(3), 117

Detailed reference viewed: 14 (2 ULg)
Full Text
Peer Reviewed
See detailCarninome intracanalaire (in situ) du sein : pouvons-nous raisonnablement éviter la radiothérapie pour certaines patientes opérées ?
Coucke, Philippe ULg; Barthelemy, Nicole ULg; Jansen, Nicolas ULg et al

in Revue Médicale de Liège (2008), 63(2), 75-81

Dans le cadre de la prise en charge multidisciplinaire du carcinome intracanalaire du sein (carcinome intra-canalaire in situ = DCIS = Ductal Carcinoma In Situ), on évoque souvent la possibilité de ... [more ▼]

Dans le cadre de la prise en charge multidisciplinaire du carcinome intracanalaire du sein (carcinome intra-canalaire in situ = DCIS = Ductal Carcinoma In Situ), on évoque souvent la possibilité de renoncer à la radiothérapie complémentaire après un geste de chirurgie conservatrice. S’il est vrai que la radiothérapie, dans ce contexte, n’apporte pas de bénéfice en survie, il n’en reste pas moins qu’on observe à long terme un effet bénéfique en contrôle local. Il existe un effet significativement marqué sur le taux de rechute de type DCIS et de type invasif dans les différentes études randomisées destinées à éclaircir la problématique du rôle de la radiothérapie. La question est de savoir si on peut distinguer un sous-groupe de patientes pour qui le contrôle local n’est pas modifié par l’adjonction d’une radiothérapie adjuvante. Pour l’instant, nous ne sommes pas à même de définir ce sous-groupe, car les critères de sélection n’ont pas été mis à l’épreuve dans le cadre d’un essai randomisé. Faute de ces données, il nous semble plus adéquat de proposer jusqu’à preuve du contraire, une radiothérapie aux patientes opérées, même si l’intervention est a priori radicale, mais conservatrice, et même si les facteurs pronostiques semblent plutôt favorables. Cependant, la radiothérapie n’est pas indiquée après une mastectomie. [less ▲]

Detailed reference viewed: 57 (5 ULg)