References of "CHARLIER, Corinne"
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See detailValidation of analytical method for the determination in serum of psychotropic drugs commonly prescribed in Rwanda by HPLC-DAD
Hahirwa, Innocent; Charlier, Corinne ULg; DENOOZ, Raphael ULg et al

in Acta Clinica Belgica (2013), 68(6), 479

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See detailEvaluation de l'exposition professionnelle aux cytostatiques des travailleurs de deux services du CHU de Liège
Rusu, Dorina; DUBOIS, Nathalie ULg; Surleraux, Cécile et al

in Acta Clinica Belgica (2013), 68(6), 472

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See detailEvaluation de l'exposition professionnelle aux cytostatiques des travailleurs de deux services du CHU de Liège
Rusu, Dorina; DUBOIS, Nathalie ULg; Surleraux, Cécile et al

in Acta Clinica Belgica (2013), 68(6), 472

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See detailQuantitative determination of non persistent endocrine disruptors in human urine
Dewalque, Lucas ULg; PIRARD, Catherine ULg; DUBOIS, Nathalie ULg et al

in Acta Clinica Belgica (2013), 68(6),

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See detailBlood lead, urinary lead, urinary δ-aminolevulinic acid and urinary porphyrins levels among people living in kinshasa, D.R. Congo : a pilot biomonitoring study
Mputu Malolo, Corneille-Liévin; Ndelo di Phanzu, Josaphat; Marini Djang'Eing'A, Roland ULg et al

in Acta Clinica Belgica (2013), 68(6), 475

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See detailApplication de la résonance magnétique nucléaire (RMN) en toxicologie judiciaire
Denooz, Raphaël ULg; Frederich, Michel ULg; Charlier, Corinne ULg et al

in Acta Clinica Belgica (2013), 68(6), 470

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See detailToxicité induite par les antidépresseurs : état des lieux
DEVILLE, Marine ULg; DENOOZ, Raphael ULg; Charlier, Corinne ULg

in Acta Psychiatrica Belgica (2013), 113(2), 17-21

Lors de l'instauration d'un traitement chez un patient dépressif, il est justifié de se poser la question de la toxicité en cas d'ingestion massive, telle que rencontrée dans les tentatives d'autolyse ... [more ▼]

Lors de l'instauration d'un traitement chez un patient dépressif, il est justifié de se poser la question de la toxicité en cas d'ingestion massive, telle que rencontrée dans les tentatives d'autolyse. Alors que les premiers antidépresseurs sont très toxiques à dose élevée, la recherche pharmaceutique a, à l'heure actuelle, mis à disposition des cliniciens des molécules plus sûres. En effet, si la toxicité cardiaque des ATC peut, à elle seule, mener à une issue fatale, les molécules récentes sont rarement mortelles lorsqu'elles sont ingérées seules, même à dose élevée, mais le risque de décès persiste lors d'intoxications polymédicamenteuses. Par ailleurs, les interactions entre différentes substances médicamenteuses ou alimentaires limitent également l'usage des IMAO, et accroissent le risque de toxicité du lithium, médicament à index thérapeutique étroit. [less ▲]

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See detailSevrage rapide aux opiacés sous anesthésie (RODA)
DUBOIS, Nathalie ULg; HALLET, Claude ULg; LUPPENS, David ULg et al

in Revue Médicale de Liège (2013), 68(5-6), 298-302

Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measure ... [more ▼]

Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measure the plasma concentrations of heroin metabolites and methadone during anesthesia and patient stay at the hospital in order to assess the amount of active substances at each protocol step. Plasma concentrations of antagonists were also quantified and compared to the recommended target values. Blood samples were drawn in 10 patients undergoing RODA at different times of the procedure (during anesthesia, in post-anesthesia care unit and in psychiatry unit). The plasma concentrations of heroin metabolites, methadone and antagonists were measured using a previously described method. Heroin active metabolites were no longer detected in the patient blood when he/she left the hospital; by contrast, methadone was still present at significant concentrations 3 days after the beginning of the detoxification procedure. Naltrexone analysis allowed us to adjust doses to insure opiate receptor blockade. [less ▲]

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See detailLa surveillance biologique de l'exposition aux produits chimiques en toxicologie industrielle et de l'environnement
MISTRETTA, Virginie ULg; Charlier, Corinne ULg

in Annales de Biologie Clinique (2013), 71(3), 257-267

Biological monitoring, also called biomonitoring, is a process to prevent and assess health risk for individuals exposed to chemical products present in environment or through workplace exposure ... [more ▼]

Biological monitoring, also called biomonitoring, is a process to prevent and assess health risk for individuals exposed to chemical products present in environment or through workplace exposure. Biomonitoring is most often a monitoring of exposure or of effect. The exposure monitoring is currently the most widespread in toxicology. It involves the determination in biological fluids of different biomarkers, most of which are biomarkers of internal dose. These biological indicators are typically measured in blood and urine, but other biological samples can be analyzed. They are used to assess the penetration of environmental pollutants into the body. Assay results are interpreted in relation to reference values which are adapted either to occupationally exposed populations, or to general population. This interpretation and the choice of appropriate biomarker of exposure are not always obvious. Biomonitoring has some limitations despite its many advantages. It is complementary to another health prevention approach: the monitoring of ambient air. To illustrate in practice the biomonitoring of exposure, several examples of toxics and their associated biomarkers are reviewed: benzene, toluene, styrene, polycyclic aromatic hydrocarbons, chloroform, 2-hexanone and hydrogen cyanide. [less ▲]

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See detailEnvironnement chimique et Santé
Charlier, Corinne ULg

Conference given outside the academic context (2012)

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See detailEvolution of the content of THC and other major cannabinoids in drug-type cannabis cuttings and seedlings during growth of plants
DE BACKER, Benjamin ULg; Maebe, Kevin; Verstraete, Alain G. et al

in Journal of Forensic Sciences (2012), 57(4), 918-922

In Europe, authorities frequently ask forensic laboratories to analyze seized cannabis plants to prove that cultivation was illegal (drug type and not fiber type). This is generally done with mature and ... [more ▼]

In Europe, authorities frequently ask forensic laboratories to analyze seized cannabis plants to prove that cultivation was illegal (drug type and not fiber type). This is generally done with mature and flowering plants. However, authorities are often confronted with very young specimens. The aim of our study was to evaluate when the chemotype of cannabis plantlets can be surely determined through analysis of eight major cannabinoids content during growth. Drug-type seedlings and cuttings were cultivated, sampled each week, and analyzed by high-performance liquid chromatography with diode array detection. The chemotype of clones was recognizable at any developmental stage because of high total Delta-9-tetrahydrocannabinol (THC) concentrations even at the start of the cultivation. Conversely, right after germination seedlings contained a low total THC content, but it increased quickly with plant age up, allowing chemotype determination after 3 weeks. In conclusion, it is not necessary to wait for plants’ flowering to identify drug-type cannabis generally cultivated in Europe. [less ▲]

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