References of "CAVALIER, Etienne"
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See detailParathormone and bone-specific alkaline phosphatase for the follow-up of bone turnover in hemodialysis patients : Is it so simple?
DELANAYE, Pierre ULg; DUBOIS, Bernard ULg; JOURET, François ULg et al

in Clinica Chimica Acta (2013), 417

Background: Chronic Kidney Disease (CKD) is associated with mineral and bone disorders (MBD). International guidelines suggest that levels of serum parathormone (PTH) or bone-specific alkaline phosphatase ... [more ▼]

Background: Chronic Kidney Disease (CKD) is associated with mineral and bone disorders (MBD). International guidelines suggest that levels of serum parathormone (PTH) or bone-specific alkaline phosphatase (b-ALP) can be used to evaluate MBD in dialysis patients. The evidence remains moderate and based on transversal studies. <br />Methods: We retrospectively investigated the variations of PTH (ΔPTH) and b-ALP (Δb-ALP) serum concentrations over a short (6-weeks) and a long (one-year) period in a monocentric hemodialysis population. The proportion of patients reaching the critical difference (CD) (50% for PTH and 25% for b-ALP) was calculated. <br />Results: Seventy-seven patientswere included. A significant correlation between PTHand b-ALP levelswas found at baseline (r=0.51). By contrast, no correlation was observed between ΔPTH and Δb-ALP over a 6-week interval (r=0.07). The CD for PTH and b-ALP was reached by 19 and 11 patients, respectively, with 2 patients showing consistent variations of both biomarkers. One year later, measurements were repeated in 48 survivors. <br />No correlation was found between ΔPTH and Δb-ALP (r=0.27). The CD for PTH or b-ALP was reached by 24 patients and 28 patients, respectively, with 6 patients (12.5%) showing opposite results for both biomarkers. <br />Conclusion: This study shows the lack of correlation between ΔPTH and Δb-ALP over time in patients under chronic hemodialysis. [less ▲]

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See detailVitamin D testing and clinical practice
CAVALIER, Etienne ULg

Conference (2013, January 31)

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See detailA randomised, double-blinded, placebo-controlled, parallel study of vitamin D3 supplementation with different schemes based on multiples of 25,000 IU doses
CAVALIER, Etienne ULg; Faché, W; Souberbielle, Jean-Caude

in International Journal of Endocrinology (2013)

Vitamin D (VTD) treatment is recommended in patients presenting different causes of diseases. To treat these patients, physicians rely on the different available pharmaceutical forms present in their ... [more ▼]

Vitamin D (VTD) treatment is recommended in patients presenting different causes of diseases. To treat these patients, physicians rely on the different available pharmaceutical forms present in their country. Unfortunately, even in a given country, there is no consensus on the best way to treat the patients. In Belgium, VTD is mostly prescribed as ampoules containing 25,000 IU of VTD. In this randomised controlled study, we evaluated whether four therapeutic schemes using multiples of 25,000 IU of VTD according to basal vitamin D concentration were able to increase or maintain the 25(OH)D serum level above 30 ng/mL. We randomized 175 subjects who received the drug () or placebo (). Total duration of the study was 12 weeks. Doses ranged from 4167 to 1667 IU/day. Blood sampling was performed at baseline and each 4 visits. In the treated (placebo) subjects, mean 25(OH)D serum concentration was 18.7 (19.1) ng/mL at baseline and 31.5 (20.7) ng/mL at w-12. At the end of the study, 57.1% of the subjects treated with VTD presented 25(OH)D serum concentration ≥30 ng/mL, whereas 94.3% were ≥20 ng/mL. In conclusion, the doses administered were safe and increased or maintained the 25(OH)D concentration ≥20 ng/mL. However, concentrations ≥30 ng/mL were only achieved in 57.1% of the subjects. [less ▲]

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See detailMDRD versus CKD-EPI equation to estimate glomerular filtration rate in kidney transplant recipients
Masson, I; Flamant, M; Maillard, N et al

Poster (2013)

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See detailAnnual meeting of the SBN/BVN
BOUQUEGNEAU, Antoine ULg; DELANAYE, Pierre ULg; CAVALIER, Etienne ULg et al

Conference (2013)

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See detailDeterminants of sclerostin concentration in hemodialysis patients.
DELANAYE, Pierre ULg; KRZESINSKI, Jean-Marie ULg; Warling, X et al

Poster (2013)

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See detailDéterminant physiologique du NGAL sanguin et discordance entre NGAL sanguin et urinaire.
DELANAYE, Pierre ULg; Claisse, G; Mehdi, M et al

Poster (2013)

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See detailDéterminant physiologique du NGAL sanguin et discordance entre NGAL sanguin et urinaire.
DELANAYE, Pierre ULg; Claisse, G; Mehdi, M et al

Poster (2013)

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See detailSkin color is relevant to vitamin D synthesis
LIBON, Florence ULg; CAVALIER, Etienne ULg; NIKKELS, Arjen ULg

in Dermatology (2013), 227(3), 250-4

BACKGROUND: Whether dark skin produces less vitamin D after UVB radiation than fair skin remains controversial. OBJECTIVE: To compare 25-hydroxyvitamin D [25-(OH)-D] levels after a single UVB exposure in ... [more ▼]

BACKGROUND: Whether dark skin produces less vitamin D after UVB radiation than fair skin remains controversial. OBJECTIVE: To compare 25-hydroxyvitamin D [25-(OH)-D] levels after a single UVB exposure in fair (phototype II-III) and black-skinned (phototype VI) volunteers. METHODS: Fair-skinned volunteers (n = 20, 4 males/16 females, mean age: 23.2 years) and black-skinned (n = 11, 6 males/5 females, mean age: 23.8 years) received a single total body UVB exposure (0.022 J/cm(2)). The 25-(OH)-D levels were measured on days 0, 2 and 6. RESULTS: On day 0, all volunteers were severely vitamin D deficient. On day 2, 25-(OH)-D levels of fair-skinned volunteers increased significantly (median: 11.9-13.3 ng/ml, p < 0.0001), but not in black-skinned people (median: 8.60-8.55 ng/ml, p = 0.843). Again, on day 6, 25-(OH)-D levels of fair-skinned volunteers increased significantly (median: 11.9-14.3 ng/ml, p < 0.0001), but not in black-skinned people (median: 8.60-9.57 ng/ml, p = 0.375). CONCLUSION: This study suggests that skin pigmentation negatively influences vitamin D synthesis. [less ▲]

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See detailLa vitamine D et la peau
LIBON, Florence ULg; CAVALIER, Etienne ULg; NIKKELS, Arjen ULg

in Revue Médicale de Liège (2013), 68(9), 458-464

Vitamin D is well known for its beneficial effects on phosphocalcic homeostasis. The discovery of the role of vitamin D in cancers, infections, cardiovascular or autoimmune pathologies have promoted ... [more ▼]

Vitamin D is well known for its beneficial effects on phosphocalcic homeostasis. The discovery of the role of vitamin D in cancers, infections, cardiovascular or autoimmune pathologies have promoted interest for this molecule. Skin and vitamin D are closely related. The skin is not only the site of vitamin D synthesis, but also a target organ as calcitriol plays an important hormonal and regulatory role, acting on cell proliferation, differentiation and immunomodulation. Furthermore, vitamin D influences the incidence and therapeutic response of certain dermatoses. In addition, many medical situations, mainly dermatological, require strict photoprotection and may therefore indirectly be responsible for a vitamin D deficiency in patients. The current role of vitamin D in skin cancers, inflammatory and autoimmune skin diseases is summarized. [less ▲]

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See detailIdentification of protein biomarkers associated with cardiac ischemia by a proteomic approach.
Fillet, Marianne ULg; Deroyer, Céline ULg; COBRAIVILLE, G. et al

in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (2013), 18(7), 614-24

Angina is chest pain induced by ischemia of the heart muscle, generally due to obstruction or spasm of the coronary arteries. People that suffer from average to severe cases of angina have an increased ... [more ▼]

Angina is chest pain induced by ischemia of the heart muscle, generally due to obstruction or spasm of the coronary arteries. People that suffer from average to severe cases of angina have an increased percentage of death before the age of 55, usually around 60%. Therefore, prevention of major complications, optimizing diagnosis, prognosis and therapeutics are of primary importance. The main objective of this study was to uncover biomarkers by comparing serum protein profiles of patients suffering from stable or unstable angina and controls. We identified by non-targeted proteomic approach and confirmed by the means of independent techniques, the differential expression of several proteins indicating significantly increased vascular inflammation response, disturbance in the lipid metabolism and in atherogenic plaques stability. [less ▲]

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See detailVitamine D et rein
CAVALIER, Etienne ULg; Thervet, Eric; Courbebaisse, Marie

in Presse Médicale (2013), 42

Le calcitriol et ses analogues inhibent le système rénineangiotensine- aldostérone, qui joue un rôle important dans le développement des lésions glomérulaires et tubulo-interstitielles et dans ... [more ▼]

Le calcitriol et ses analogues inhibent le système rénineangiotensine- aldostérone, qui joue un rôle important dans le développement des lésions glomérulaires et tubulo-interstitielles et dans l’apparition de la protéinurie, mais aussi l’activation de la voie NF-kB qui est connue pour favoriser la maladie rénale chronique en stimulant l’inflammation et la fibrogenèse. Les effets pléiotropes de la vitamine D sont également très intéressants pour le patient insuffisant rénal (diminution de la mortalité, de la protéinurie et effets anti-inflammatoires). De plus, l’administration de vitamine D native (cholécalciférol ou ergocalciférol) diminue les concentrations sériques de parathormone. La supplémentation en vitamine D native chez l’insuffisant rénal n’entraîne pas de toxicité ni d’augmentation du risque de calcification vasculaire malgré les effets hypercalcémiants et hyperphosphorémiants de cette molécule sous sa forme active. La vitamine D per se (c’est-à-dire sans apports calciques excessifs), aux doses habituellement utilisées en clinique, n’est pas associée à une augmentation du risque de lithiase urinaire. Dans le domaine de la transplantation rénale, les études expérimentales montrent un rôle protecteur des analogues de la vitamine D contre le rejet aigu, mais les études cliniques restent à ce jour principalement observationnelles. [less ▲]

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