MDRD or CKD-EPI study equations for estimating prevalence of stage 3 CKD in epidemiological studies: which difference? Is this difference relevant?

in BMC Nephrology (2010), 11(8),

Background: Prevalence of stage 3 chronic kidney disease (CKD) is increasing according to the NHANES study. Prevalence has been calculated using the MDRD study equation for estimating glomerular ... [more ▼]

Background: Prevalence of stage 3 chronic kidney disease (CKD) is increasing according to the NHANES study. Prevalence has been calculated using the MDRD study equation for estimating glomerular filtration rate (GFR). Recently, a new estimator based on creatinine, the CKD-EPI equation, has been proposed which is presumed to better perform in normal GFR ranges. The aim of the study was to measure the difference in prevalence of stage 3 CKD in a population using either the MDRD or the CKD-EPI study equations. Methods: CKDscreening is organized in the Province of Liège, Belgium. On a voluntary basis, people aged between 45 and 75 years are invited to be screened. GFR is estimated by the MDRD study equation and by the "new" CKD-EPI equations. Results: The population screened consisted in 1992 people (47% of men). Mean serum creatinine was 0.86 ± 0.20 mg/dl. The prevalence of stage 3 CKD in this population using the MDRD or the CKD-EPI equations was 11.04 and 7.98%, respectively. The prevalence of stage 3 CKD is significantly higher with the MDRD study equation (p <0,0012). Conclusions: Prevalence of stage 3 CKDvaries strongly following the method used for estimating GFR, MDRD or CKDEPI study equations. Such discrepancies are of importance and must be confirmed and explained by additional studies using GFR measured with a reference method. [less ▲]

Consequences of laparoscopy on liver ischemia during portal triad clamping in a swine model

in Acta Gastro-Enterologica Belgica (2010), 73(1), 13

Interpretation of serum parathyroid hormone concentrations in dialysis patients: what do the KDIGO guidelines change for the clinical laboratory?

in Clinical Chemistry & Laboratory Medicine (2010), 48(6), 769-774

Evaluation meets Precision

in Sciencebook Europe (2010), 1

Component-resolved diagnosis in peanut and hazelnut allergy.

in Allergy (2010), 65(Suppl.92), 106

Corrélation aldostérone et parathormone en cas d'hyperparathyroïdie primaire vs secondaire?

in Annales de Biologie Clinique (2010), 68(6), 703-4

Les cibles thérapeutiques pour la PTH dans les nouvelles recommandations du KDIGO: la fin d'un cauchemar?

in Néphrologie & Thérapeutique (2010)

Urinary NGAL: Use of absolute value or ratio to creatinine?

in Acta Clinica Belgica (2010), 65-3

Introduction: Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a promising marker for the detection of acute kidney injury. This marker has been proposed for urinary measurement. However ... [more ▼]

Introduction: Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a promising marker for the detection of acute kidney injury. This marker has been proposed for urinary measurement. However, in the literature, authors indistinctly use "absolute" value or NGAL to creatinine ratio. Up to now, there are no strong arguments favouring for one. This question is of importance as this marker is sensed to be used only on urine random samples. To find an answer to this very practical matter, one approach could be to compare biological CV(intra-individual variation) of the "absolute" and ratio results. [less ▲]

PTH reference target for the follow-up of hemodialyzed patients and new KDIGO guidelines: the end of a nightmare?

in Acta Clinica Belgica (2010)

Mesure de la PTH chez le patient hémodialysé avec une trousse de 2ème ou de 3ème génération: impact pour le clinicien

in Néphrologie & Thérapeutique (2010)