Isolation of the missing 5-end of the encoding region of the bovine leukemia virus cell receptor gene.

in Archives of Virology (1994), 138(3-4),

Enhancement of bovine leukemia virus-induced syncytia formation by di- and tripeptides.

in Virology (1993), 192(1),

Short hydrophobic peptides were previously shown to inhibit infectivity of para- and orthomyxoviruses. We tested the ability of a series of di- and tripeptides to interfere with cell fusion induced by ... [more ▼]

Short hydrophobic peptides were previously shown to inhibit infectivity of para- and orthomyxoviruses. We tested the ability of a series of di- and tripeptides to interfere with cell fusion induced by bovine leukemia virus (BLV). Peptides containing a hydrophobic contribution and/or a positive net charge strongly enhanced syncytia formation induced by BLV on CC81 indicator cells. The size of the multinucleated cells was strongly increased (up to 10-fold) in the presence of the enhancer peptides whereas no effect was observed on the indicator cells in the absence of BLV. The peptides thus amplified the fusion process initiated by BLV envelope glycoproteins. The effect was dose-dependent at concentrations ranging from 20 to 640 microM and did not result from an increased expression of BLV proteins. The peptides did not compete with anti-gp51 monoclonal antibodies for the recognition of eight well-defined epitopes of gp51. We consequently hypothesize that the enhancer peptides interact with the membrane of BLV-producing cells and/or indicator cells and propose a model based on molecular modeling. [less ▲]

In vivo infection of sheep by bovine leukemia virus mutants.

in Journal of virology (1993), 67(7),

Vaccination against animal retroviruses.

Book (1993)

Mapping Of B-Neutralizing And T-Helper Cell Epitopes On The Bovine Leukemia-Virus External Glycoprotein Gp51

in Journal of Virology (1993), 67(9),

Fusogenic Segments Of Bovine Leukemia-Virus And Simian Immunodeficiency Virus Are Interchangeable And Mediate Fusion By Means Of Oblique Insertion In The Lipid Bilayer Of Their Target-Cells

in Proceedings of the National Academy of Sciences of the United States of America (1992), 89(9),

Modified bovine leukemia virus (BLV) glycoproteins were expressed by using vaccinia virus recombinants, and their fusogenic capacities were examined by a syncytia-formation assay. This analysis indicates ... [more ▼]

Modified bovine leukemia virus (BLV) glycoproteins were expressed by using vaccinia virus recombinants, and their fusogenic capacities were examined by a syncytia-formation assay. This analysis indicates that (i) both BLV envelope glycoproteins gp51 and gp30 are necessary for cell fusion; (ii) insertion of the N-terminal segment of gp30 (fusion peptide) into the lipid bilayer in an oblique orientation, as predicted by computer conformational analysis, results in fusogenic capacities higher than insertion in a perpendicular or parallel orientation; and (iii) replacement of the BLV fusion peptide with its simian immunodeficiency virus counterpart does not modify the fusogenic capacity of the BLV glycoprotein. [less ▲]

Mutations In The Bovine Leukemia-Virus Tax Protein Can Abrogate The Long Terminal Repeat-Directed Transactivating Activity Without Concomitant Loss Of Transforming Potential

in Proceedings of the National Academy of Sciences of the United States of America (1992), 89(9),

Regulation endocrinienne et manipulation de la croissance bovine

in Cahiers Agricultures (1992), 1(2),

In vivo transfection of bovine leukemia provirus into sheep.

in Virology (1992), 189(2),

Recombinant Vaccinia Virus Expression Of The Bovine Leukemia-Virus Envelope Gene And Protection Of Immunized Sheep Against Infection

in Vaccine (1991), 9(3),