References of "Bureau, Fabrice"
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See detailInvestigation of the innate immunity in the lower respiratory tract in exercising horses
Frellstedt, Linda ULg; Gosset, Philippe; Desmet, Christophe ULg et al

in Proceedings of the 1st Scientific Meeting of the Faculty of Veterinary Medicine (2011)

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See detailEffects of formoterol and ipratropium bromide on repeated cadmium inhalation -induced pulmonary inflammation and emphysema in rats
Zhang, Whenhui; Fievez, Laurence ULg; Zhang, F. et al

in European Journal of Pharmacology (2010), 25(647), 178-187

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See detailInterferon Response Factor 3 is required for airway allergy to house dust mite in mice
Marichal, Thomas ULg; Bedoret Denis; Mesnil, Claire ULg et al

in Short Book of the Annual Congress of the Euopean Respiratory Society (ERS), Barcelone (2010, September)

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See detailGenomic expression evaluation: introduction and perspectives
Ramery, Eve ULg; Bureau, Fabrice ULg; Guyot, Hugues ULg et al

Conference (2010, July)

In a way, disease could be considered as the result of gene expression deregulation. Knowing what genes are expressed in a particular cell or tissue and how they are regulated allow to better understand ... [more ▼]

In a way, disease could be considered as the result of gene expression deregulation. Knowing what genes are expressed in a particular cell or tissue and how they are regulated allow to better understand disease mechanisms. Transcriptomic is the study of the expression of the entire genome. This technical challenge has been rendered possible as different species’ genomes began to be sequenced. Several techniques have rendered efficient this process of measuring simultaneously the expression level of a large number of genes. To date, micro-array technology is probably the best known. However, with the development of more affordable techniques, sequencing/ resequencing could compete with microarrays in the future. All together, these techniques open new ways for early diagnosis and prognosis for the practioner ‘in the field’. [less ▲]

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See detailCharacterization of pentraxin 3 in the horse and its expression in airways.
Ramery, Eve ULg; Fievez, Laurence ULg; Fraipont, Audrey ULg et al

in Veterinary Research (2010), 41(2), 18

The long pentraxin 3 (PTX3) plays an important role in host defence and its over-expression may contribute to airway injury. The aim of the present study was therefore to characterize in more detail PTX3 ... [more ▼]

The long pentraxin 3 (PTX3) plays an important role in host defence and its over-expression may contribute to airway injury. The aim of the present study was therefore to characterize in more detail PTX3 and its expression in the horses airway. Six healthy horses and six horses affected by recurrent airway obstruction (R.A.O.) were submitted to a dusty environment challenge. PTX3 DNA and cDNA were cloned and sequenced. PTX3 expression was evaluated by RT-qPCR, western blotting and immuno-histochemistry in bronchoalveolar lavage fluid (BALF) cells, BALF supernatant and bronchial epithelial cells. An alternative splicing of the second exon of PTX3 occurred, resulting in two forms of the protein: spliced (32 kDa) and full length (42 kDa). PTX3 was detected in BALF macrophages, neutrophils and bronchial epithelial cells. It was over-expressed in the BALF supernatant from R.A.O.-affected horses in crisis. However, dust was unable to induce PTX3 in BALF cells ex vivo, indicating that dust is an indirect inducer of PTX3. Dust exposure in-vivo induced PTX3 in BALF macrophages but there was no significant difference between healthy and R.A.O.-affected horses. Conversely, PTX3 was over-expressed in the bronchial epithelial cells from R.A.O-affected horses in crisis. These data indicate a differential regulatory mechanism in inflammatory and bronchial epithelial cells and offer therapeutically interesting perspectives. [less ▲]

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See detailLes macrophages interstitiels, gardiens de l'homeostasie immune pulmonaire.
Bedoret, Denis; Bureau, Fabrice ULg; Desmet, Christophe ULg

in Medecine Sciences : M/S (2010), 26(3), 229-31

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See detailViral induction of Zac1b through TLR3- and IRF3-dependent pathways
Warzée, Barbara ULg; Mesnil, Claire ULg; Hober, D. et al

in Molecular Immunology (2010), 48(1-3), 119-127

Zinc finger protein regulator of apoptosis and cell cycle arrest (Zac1) is a transcription factor able to induce apoptosis or cell cycle arrest through independent pathways. In spite of the important ... [more ▼]

Zinc finger protein regulator of apoptosis and cell cycle arrest (Zac1) is a transcription factor able to induce apoptosis or cell cycle arrest through independent pathways. In spite of the important potential functions attributed to Zac1, little is known of its physiological regulation and biological function. We discovered that variant Zac1b was expressed in murine embryonic fibroblasts (MEFs) treated with polyriboinosinic polyribocytidylic acid [poly(I:C)], a synthetic double-stranded RNA. This regulation occurred mainly through Toll-Like Receptor 3 (TLR3)- and Interferon Regulatory Factor 3 (IRF3)-dependent pathways. As TLR3 and IRF3 are central activators of antiviral immunity, we hypothesized that Zac1 may be implicated in antiviral responses. In line with this notion, we observed that Zac1b was expressed in MEFs infected with Encephalomyocarditis virus (EMCV). We also observed that Zac1-deficient MEFs were less sensitive to EMCV-induced cell death than wild-type MEFs. However, Zac1 gene inactivation had no effect on the survival of mice infected with EMCV. In conclusion, this study describes for the first time a transcriptional regulation of Zac1b, induced by synthetic dsRNA and RNA viruses, the functional significance of which remains to be further investigated. [less ▲]

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See detailInterferon Response Factor 3 is essential for house dust mite-induced airway allergy
Marichal, Thomas ULg; Bedoret, Denis; Mesnil, Claire ULg et al

in Journal of Allergy and Clinical Immunology (The) (2010), 126(4), 836-844

IRF3, mainly known as a central orchestrator of antiviral responses, is required for proallergic functions of dendritic cells in response to aeroallergens. Thus, this study demonstratively identifies a ... [more ▼]

IRF3, mainly known as a central orchestrator of antiviral responses, is required for proallergic functions of dendritic cells in response to aeroallergens. Thus, this study demonstratively identifies a new pathway potentially implicated in the etiology of airway allergy [less ▲]

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See detailSirtuin inhibition modulates endotoxin-induced lung inflammation
Fernandez, C. A.; Fievez, Laurence ULg; Bureau, Fabrice ULg et al

in Shortbook: Annual Congress of the European Respiratory Society (ERS) (2010)

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See detailEffects of ipratropium bromide on repeated cadmium inhalation-induced lune inflammation and airspace enlargement in rats
Zhang, W. H.; Fievez, Laurence ULg; Cheu, Esteban ULg et al

in Fundamental & Clinical Pharmacology (2010), 10

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See detailAnti-inflammatory effects of formoterol and ipratropium bromide against acute cadmium-induced pulmonary inflammation in rats.
Zhang, W.; Fievez, Laurence ULg; Cheu, Esteban ULg et al

in European Journal of Pharmacology (2010), 628(1-3), 171-178

In this study, the anti-inflammatory properties of formoterol and ipratropium bromide, alone or in combination, were investigated in a rat model of acute pulmonary inflammation induced by cadmium ... [more ▼]

In this study, the anti-inflammatory properties of formoterol and ipratropium bromide, alone or in combination, were investigated in a rat model of acute pulmonary inflammation induced by cadmium inhalation. Airway resistance and inflammatory responses, including matrix metalloproteinease-2 (MMP-2) and matrix metalloproteinease-9 (MMP-9) activities, were evaluated. Compared to values obtained in rats exposed to cadmium, pretreatment by bronchodilators administered alone significantly prevented the cadmium-induced increase of airway resistance. Formoterol elicited a significant decrease in total cell number, neutrophil and macrophage counts in bronchoalveolar lavage fluid, whereas ipratropium bromide reduced neutrophil numbers. The two compounds administered alone significantly attenuated the lung lesions associated with parenchyma inflammatory cell influx and congestion observed in the cadmium group. The increased MMP-9 activity was significantly attenuated. Although only formoterol induced a decrease protein concentration in bronchoalveolar lavage fluid, both compounds inhibited the pulmonary edema by reducing wet-to-dry weight ratio which returned to values similar to those recorded in the sham group. All the effects of formoterol on the cadmium-induced inflammatory responses were reversed by propranolol. Similar anti-inflammatory effects were obtained in rats pretreated with ilomastat which showed a significant reduction on inflammatory cell infiltration and MMP-9 activity in bronchoalveolar lavage fluid. Neither synergistic nor additive effects were obtained when the two bronchodilators were administered in combination. In conclusion, formoterol and ipratropium bromide partially protect the lungs against the inflammation by reducing neutrophilic infiltration. This protective effect is associated with reduced MMP-9 activity known to play an important pro-inflammatory role in acute inflammatory process. [less ▲]

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See detailLa vaccination contre les mammites à Staphylococcus aureus chez la vache laitière
Wallemacq, Hugues; Girard, B.; Lekeux, Pierre ULg et al

in Annales de Médecine Vétérinaire (2010), 154(1), 16-29

Staphylococcus (S.) aureus is a major pathogen for mastitis in dairy cattle. In most cases, S. aureus causes long-lasting subclinical and chronic bovine mastitis and leads to significant economic losses ... [more ▼]

Staphylococcus (S.) aureus is a major pathogen for mastitis in dairy cattle. In most cases, S. aureus causes long-lasting subclinical and chronic bovine mastitis and leads to significant economic losses by reducing the quantity and the quality of the milk produced. The pathogenesis of S. aureus mastitis includes the ability to persist within host cells and involves multiple virulence factors including toxins, surface proteins and polysaccharides. The numerous vaccines that have been developed induce a specific immune response against these different factors. These different vaccine approaches are described and classified depending on the target antigen used. Moreover, some recent vaccine strategies against human S. aureus infections are also discussed and could eventually be used for the design of new bovine vaccines. Although most of bovine vaccines induce specific humoral response, to date, no vaccine has been described to protect efficiently against experimental and naturally occurred bovine S. aureus mastitis. In conclusion, this type of immune response and the broad antigenic variability of S. aureus strains can partially explain the lack of protection observed during most of vaccine trials. [less ▲]

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See detailCytokine expression by Aspergillus fumigatus stimulated peripheral blood mononuclear cells from dogs with sino-nasal aspergillosis.
Vanherberghen, Morgane ULg; Bureau, Fabrice ULg; Peters, I. R. et al

in Proceedings of the 20th Annual Congress of the ECVIM-CA (2010)

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See detailA crucial role forlung interstitial macrophages in preventing airway allergy
Bedoret, Denis; Wallemacq, Hugues ULg; Marichal, Thomas ULg et al

in Short book of the Annual Congress of the European Respiratory Society (ERS), Vienne (2009)

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See detailLung interstitial macrophages prevent the development of respiratory allergy
Bedoret, D.; Wallemacq, Hugues ULg; Marichal, Thomas ULg et al

in Proceedings of The Keystone Symposia: Allergy and Asthma. Keystone, Colorado, USA (2009)

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See detailIRF3 is required for induction of allergic airway inflammation by dendritic cells
Marichal, Thomas ULg; Bedoret, Denis; Goriely, S et al

Poster (2009)

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See detailIRF3 is required for the induction of allergic airway inflammation by lung dendritic cells in a mouse model of house dust mite-induced atopic asthma
Marichal, Thomas ULg; Bedoret, Denis; Goriely, M. et al

in Abstracts of the 17th Annual European Respiratory Society Congress, Vienna, Austria (2009)

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See detailIRF3 is required for induction of allergic airway inflammation by dendritic cells
Marichal, Thomas ULg; Bedoret, Denis; Goriely, M. et al

Conference (2009)

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See detailEssential role of sirtuins in the pathogenesis of allergic airway inflammation
Legutko, Agnieszka ULg; Marichal, Thomas ULg; Fievez, Laurence ULg et al

in Short book of the Annual Congress of the European Respiratory Society (ERS), Vienne (2009)

Detailed reference viewed: 31 (6 ULg)