References of "Bruyère, Olivier"
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See detailA review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes
Kucharz, E.J.; Kovalenko, V.; Szanto, S. et al

in Current Medical Research & Opinion (2016), 32(6), 997-1004

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm for knee osteoarthritis (OA) recommends symptomatic slow-acting drugs for ... [more ▼]

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm for knee osteoarthritis (OA) recommends symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) first line for the medium to long term management of OA, due to their ability to control pain, improve function, and delay joint structural changes. Among SYSADOAs, glucosamine is probably the most widely used intervention. In the present review of glucosamine for knee OA, we have investigated whether the evidence is greater for the patented crystalline glucosamine sulfate (pCGS) preparation (Rottapharm/Meda) than for other glucosamine formulations. Glucosamine is actually widely available in many forms, as the prescription-grade pCGS preparation, generic and over-the-counter formulations of glucosamine sulfate (GS) and food supplements containing glucosamine hydrochloride (GH), which vary substantially in molecular form, pharmaceutical formulation and dose regimens. Only pCGS is given as a highly bioavailable once daily dose (1500mg) with a proven pharmacological effect. pCGS consistently reaches the plasma levels of around 10 lM required to inhibit interleukin-1 induced expression of genes involved in the pathophysiology of joint inflammation and tissue destruction, compared with sub-therapeutic levels achieved with GH. It is evident, from careful consideration of the evidence base, that only the pCGS formulation of glucosamine reliably provides an effect size on pain that is higher than that of paracetamol and equivalent to that provided by non-steroidal antiinflammatory drugs. In comparison, the effect size on pain of non-crystalline GS preparations and GH from randomized controlled trials is repeatedly demonstrated to be zero. In addition, there is evidence that chronic administration of pCGS has disease-modifying effects, with a reduction in the need for total joint replacement surgery lasting for at least 5 years after treatment cessation. Consequently, the pCGS preparation (Rottapharm/Meda) is the logical choice, with demonstrated medium-term control of pain and lasting impact on disease progression. [less ▲]

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See detailAssessment of muscle mass, muscle strength and physical performance in clinical practice: An international survey
Bruyère, Olivier ULg; Beaudart, Charlotte ULg; Reginster, Jean-Yves ULg et al

in European Geriatric Medicine (2016), 7(3), 243-6

Introduction: Several tools are available for the assessment of muscle mass, muscle strength and physical performance in clinical research. However, few data are available on the usage of these tools in ... [more ▼]

Introduction: Several tools are available for the assessment of muscle mass, muscle strength and physical performance in clinical research. However, few data are available on the usage of these tools in clinical practice. Methods: This study aimed to assess their usage by means of a large online international survey. Since sarcopenia is a specific condition where the assessment of muscle mass, muscle strength and physical performance is important, the survey also assessed the tools used for the diagnosis of this geriatric syndrome. Results: The survey was completed by 255 clinicians from 55 countries across 5 continents. Among these clinicians with geriatrics, rheumatology and endocrinology as major fields of interest, 53.3% assess muscle mass in daily practice, 54.5% muscle strength and 71.4% physical performance. However, the tools used are very different and no single tool is used by all clinicians. The tools and the cut-off values used by clinicians to diagnose sarcopenia are also heterogeneous. Conclusion: Because some tools used for the assessment of muscle mass, muscle strength or physical performance in daily practice are less validated than others, a greater awareness from the clinicians of the importance of using appropriate tools is needed [less ▲]

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See detailIdentification des besoins des mères dans l’année suivant leur accouchement : une étude qualitative.
Slomian, Justine ULg; EMONTS, Patrick ULg; Vigneron, Lara et al

in 44èmes Assises Nationales des Sages-Femmes (2016, May)

Contexte de l’étude : La grossesse et l’accouchement sont deux étapes fondamentales dans la vie d’une femme. Plusieurs études ont montré que le malaise psychologique était relativement fréquent dans ... [more ▼]

Contexte de l’étude : La grossesse et l’accouchement sont deux étapes fondamentales dans la vie d’une femme. Plusieurs études ont montré que le malaise psychologique était relativement fréquent dans l’année suivant un accouchement. Objectifs : L’objectif de cette étude était de déterminé les besoins des mères dans l’année suivant leur accouchement (qu’elles aient vécu un épisode psychologique pathologique ou non). Méthode : Plusieurs étapes qualitatives ont été entreprises dans cette étude. Premièrement, nous avons conduit 22 entretiens individuels et un focus group réunissant des mères ayant vécu ou non un épisode de détresse psychologique. Nous avons ensuite mené deux autres focus : un avec des professionnels de la santé, l’autre avec des pères. Le but était de comparer les besoins maternels avec la perception des professionnels ainsi que des pères. Règles éthiques : Cette étude a reçu l’accord du comité d’éthique hospitalo-facultaire du CHU de Liège sous le numéro : 2015/48. Chaque participante a signé un formulaire de consentement éclairé quant à sa participation à l’étude ainsi qu’à l’autorisation de diffuser les résultats de façon confidentielle. Résultats : Les besoins des mères après leur accouchement ont été classés en 4 grandes catégories : le besoin d’information, le besoin de soutien psychologique, le besoin de partage d’expériences et le besoin de support matériel et pratique. Les femmes ne se sentent pas assez informées dans cette période de vie difficile. Elles ne se sentent pas non plus assez soutenues au point de vue psychologique mais également dans les tâches ménagères. Elles sont souvent fatiguées et se posent beaucoup de questions. Elles ont besoin de partager cette expérience de vie et elles ont besoin d’être rassurées et de se sentir comprises. Il semblerait qu’il y ait des différences de vécu d’expériences entre les mères et les professionnels mais également entre les mères et les pères. Conclusion : L’arrivée d’un bébé est une étape importante dans la vie d’une femme et d’un couple. Cela demande un remaniement tant sur les plans physique que psychologique et social. Les mères semblent ressentir un manque de support à différents niveaux au cours de la période postnatale. Cette étude procure des pistes pour répondre à leurs besoins et tenter de prévenir le risque de détresse psychologique dans la période postnatale. [less ▲]

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See detailQuelle est la place d’internet pour combler le besoin d’information des nouvelles mères ?
Slomian, Justine ULg; Bruyère, Olivier ULg; Reginster, Jean-Yves ULg et al

Poster (2016, May)

Contexte de l’étude : Les femmes autour de la grossesse et de la naissance expriment un besoin d’information. Internet est devenu l’un des moyens les plus importants de s’informer sur sa santé. De ... [more ▼]

Contexte de l’étude : Les femmes autour de la grossesse et de la naissance expriment un besoin d’information. Internet est devenu l’un des moyens les plus importants de s’informer sur sa santé. De nombreuses innovations dans la santé mobile révolutionnent les soins de santé actuels. Ces outils constituent une aide pour les médecins et permettent également de responsabiliser les patients par rapport à leur santé. Objectifs : Le but de cette étude est d’évaluer, chez des femmes francophones ayant des enfants de 0 à 2 ans, utilisant déjà internet, l’intérêt et le degré d’utilisation d’Internet pour des questions relatives à la période postnatale ; que cela concerne leur propre santé où celle de leur enfant. Méthode : Un sondage en ligne a été créé et diffusé largement via les réseaux sociaux. Toutes les femmes comprenant le français pouvait y répondre peu importe leur pays de résidence. Règles éthiques : L’étude a été approuvée par le comité d’éthique hospitalo-facultaire du CHU de Liège sous le numéro : 2013/254. La première page du questionnaire consistait en une explication de l’étude. La participation à l’enquête étant libre, nous avons donc considéré celle-ci comme le consentement du répondant. Résultats : 507 femmes ont répondu à ce sondage (8 femmes ont dû être éliminées de l’échantillon : 6 car le dernier enfant avait minimum 3 ans et 2 parce qu’elles étaient enceintes) : 74,5% des femmes habitaient en Belgique, 23,6% en France et 1,8% de pays divers (Canada, Luxembourg, Burkina Faso, Nouvelle Calédonie, Tunisie). Leur moyenne d’âge était de 30,5 ± 4,25 ans et 54,6% étaient des primipares. Parmi ces femmes, 90,2% ont utilisé internet pour répondre à des questions relatives à la période postnatale concernant leur enfant (82,3%) et/ou leur propre santé (71,3%). Ces femmes recherchent souvent des informations concernant l’allaitement maternel (75,2%), les aliments à introduire dans l’alimentation de l’enfant (62,1%), les dents (48,3%), les pics de croissance de l’enfant (43,4%), les petits boutons que les enfants peuvent présenter (38,2%), leur sexualité (30,7%) ou encore leur perte de poids (24,4%). Elles recherchent également des informations (23,3%) sur des questions plus « ponctuelles » de situation de la vie de tous les jours (ex : douleur de césarienne, sommeil de l’enfant, dépression postnatale, ...). Les raisons de ces recherches sont diverses mais les trois plus courantes sont le fait de vouloir trouver l’information par soi-même (87,3%), trouver des informations sur des symptômes présentés par l’enfant (79,6%) et compléter les informations fournies par un professionnels de la santé (65,2%). La majorité des femmes (90,9%) disent ne pas avoir un site unique de référence et recherche les informations sur différents sites. Beaucoup (81,1%) pensent que les professionnels de santé devraient suggérer des sites internet adaptés aux nouvelles mamans dans lesquels elles pourraient trouver des informations utiles pour leur post-partum et leur enfant. Les informations trouvées sur internet sembleraient avoir influencé la façon dont les femmes pensaient gérer leur enfant dans 51,8% des cas. Malgré qu’elles jugent que les informations qu’elles trouvent sur internet leur sont plutôt utiles (84,3%), elles n’attribuent qu’une note moyenne de 5,28 ± 1,68/10 quant à la qualité des informations qu’elles trouvent sur internet. Conclusion : Il existe un grand besoin d’information durant la période postnatale. Internet semblerait être une solution largement utilisée par les femmes pour combler ce besoin bien qu’elles ne semblent pas toujours satisfaites de la qualité des informations qu’elles y trouvent. Un site internet centralisé et contrôlé pourrait constituer une piste de solution à exploiter. [less ▲]

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See detailSelf-Medication Practice among Amateur Runners: Prevalence and Associated Factors
Locquet, Médéa ULg; Beaudart, Charlotte ULg; LARBUISSON, Robert ULg et al

in Journal of Sports Science & Medicine (2016), 15(2), 387-8

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See detailCross-cultural adaptation and validation of the victorian institute of sport assessment-patella questionnaire for French-speaking patients with patellar tendinopathy
Kaux, Jean-François ULg; Delvaux, François ULg; Oppong-Kyei, Julian et al

in Journal of Orthopaedic & Sports Physical Therapy (2016), 46(5), 384-393

Study Design Clinical measurement study. Background The Victorian Institute of Sports Assessment–Patellar tendinopathy questionnaire (VISA-P), originally developed in English, assesses the severity of ... [more ▼]

Study Design Clinical measurement study. Background The Victorian Institute of Sports Assessment–Patellar tendinopathy questionnaire (VISA-P), originally developed in English, assesses the severity of patellar tendinopathy symptoms. No French version of the questionnaire exists. Objectives The aim of our study was to translate the VISA-P in French and verify its psychometric properties. Methods The translation and cultural adaptation were performed according to international recommendations in six steps: initial translation, translation merging, back translation to the original language, expert committee to reach a pre-final version, test of the pre-final version, and expert committee appraisal of a final version. Afterwards, the psychometric properties the final French version (VISA-PF) were assessed in 92 subjects, divided into three groups: pathological subjects (n = 28), asymptomatic subjects (n = 22) and sports-risk subjects (n = 42). Results All members of the expert committee agreed with the final version. On a scale ranging from 0 to 100 (asymptomatic subject), the average scores of the VISA-PF obtained were 53 (± 17) for the pathological group, 99 (± 2) for the healthy group and 86 (± 14) for the sports-risk group. The test-retest reliability of the VISA-PF was excellent and good internal consistency. Correlations between the VISA-PF and diverging validity of the SF-36 were low and the correlation coefficient values measured between the VISA-PF scores and converged items of the SF-36 were higher. Conclusion The VISA-PF is understandable, valid and suitable for French-speaking patients with patellar tendinopathy. [less ▲]

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See detailPeanut-allergic patients in the MIRABEL survey: characteristics, allergists' dietary advice and lessons from real life
Deschildre, A; Elegbédé, CF; Just, J et al

in Clinical & Experimental Allergy : Journal of the British Society for Allergy & Clinical Immunology (2016), 46(4), 610-20

Background The MIRABEL survey is an observational study on peanut allergy in France, Belgium and Luxemburg. The objectives are to provide data on a large population, to analyse the consumer behaviour, to ... [more ▼]

Background The MIRABEL survey is an observational study on peanut allergy in France, Belgium and Luxemburg. The objectives are to provide data on a large population, to analyse the consumer behaviour, to study the presence of peanut traces in pre-packed foods with/without precautionary allergen labelling (PAL), and to combine these data to quantify allergic risk and produce a cost/benefit analysis. This paper reports a real-life observatory of 785 patients (< 16y: 86%): medical characteristics, eliciting doses (ED) in real life and in oral food challenges (OFC), factors associated with severe reactions, allergist dietary advice and patients’ anxiety regarding their allergy. Methods Age and symptoms at diagnosis, route of exposure, comorbidities, allergy tests, ED (OFC/real life; mg peanut protein), dietary advice about PAL, and anxiety score were recorded. Results Median age was 3 years; 85% were declared allergic. Severe/potentially severe reactions were reported in 30% of the allergic patients: serious systemic reaction (15%), laryngeal angioedema (8%), shock (4%) and acute asthma (3%); 66% had atopic dermatitis, 58% asthma. Median ara h 2 sIgE level was 11.5 kUA/L. Of the 278 OFCs, 225 were positive (median ED: 67.3 mg). Real-life ED was < 100 mg in 44.3%. Severe reactions were significantly more frequent in teenagers and adults (P = 0.004), asthmatic patients (P = 0.033), and patients who reacted to inhalation (P < 0.001). No significant association was found for OFC ED or ara h 2 sIgE. Factors associated with strict avoidance advice including PAL were OFC ED < 100 mg (P < 0.001), but not severe reaction history (P = 0.051) or asthma (P = 0.34). Anxiety was significantly associated with strict avoidance (P < 0.001). Conclusion and clinical relevance Severe/potentially severe reactions, allergic comorbidities, and low EDs in real life are frequent in peanut-allergic patients. Asthma, teenage/ adulthood and reaction to inhalation are associated with severe symptoms. PAL and criteria guiding dietary advice need to be improved. [less ▲]

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See detailAdaptation transculturelle et validation des questionnaires VISA-P et VISA-A en français
Kaux, Jean-François ULg; Delvaux, François ULg; Oppong-Kyei, Julian et al

in Science & Sports (2016), 31(2), 65-72

Objectives Patellar and calcaneal tendinopathies remain very common musculoskeletal disorders in athletes. The Victorian Institute of Sports Assessment – Patellar and – Achilles (VISA-P and VISA-A ... [more ▼]

Objectives Patellar and calcaneal tendinopathies remain very common musculoskeletal disorders in athletes. The Victorian Institute of Sports Assessment – Patellar and – Achilles (VISA-P and VISA-A), English questionnaires developed respectively to assess the severity of patellar and calcaneal tendinopathies. The purpose of our study was to validate a French version of these questionnaires. Materials and methods The French translation and intercultural adaptation of the VISA-P and the VISA-A are made according to international recommendations. For these adaptations, 92 (VISA-P) and 116 (VISA-A) subjects were recruited and divided into 3 groups (pathological, asymptotic and sporting risk), in order to test these psychometric properties. All these subjects also had to answer to the MOS SF-36 for the validity of construct. Results The mean VISA-PF scores were 99 for the healthy people, 53 for patients with patellar tendinopathy and 86 for the athletes. The VISA-PF shows excellent reliability with an inter-class correlation coefficient of 0.99. The internal consistency was 0.9 (Cronbach's alpha). The VISA-PF shows low correlations with the divergent sub-scales of the SF-36 and moderate correlations with the convergent sub-scales of the SF-36. The mean VISA-AF scores were 99 in the healthy group, 59 in the pathological group, and 94 in the group of athletes. The VISA-AF shows excellent reliability with an inter-class correlation coefficient of 0.99. The internal consistency was 0.92 (Cronbach's alpha). The VISA-AF shows low correlations with the divergent sub-scales of the SF-36 and moderate correlations with the convergent sub-scales of the SF-36. No floor and ceiling effects were detected during the evaluation of the two questionnaires. Conclusion The French versions of the VISA-P and VISA-A questionnaires are therefore French comprehensible adaptation, reliable and adapted to French-speaking patients suffering from patellar or calcaneal tendinopathies. [less ▲]

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See detailAge-standardized quality of life after hip or knee arthoplasty.
Neuprez, Audrey ULg; KURTH, William ULg; THIRION, Thierry ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 541-542

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See detailBrain-derived neurotrophic factor (BDNF) in normal healthy and hemodialyzed populations.
CAVALIER, Etienne ULg; CARLISI, Ignazia ULg; KOVACS, Stéphanie ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 512

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See detailEnglish translation and cross-cultural adaptation of the SarQuoL® questionnaire.
Beaudart, Charlotte ULg; Edwards, M.; Dennison, E.M. et al

in Osteoporosis International (2016, April), 27(Supplement 1), 221-222

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See detailPhysical and muscle performances among elderly nursing home residents.
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; Croisier, Jean-Louis ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 217

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See detailPrevalence of frailty among nursing home, according to different operational definitions.
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; GILLAIN, Sophie ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 216-217

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See detailPrevalence of concomitant bone and muscle wasting in patients from the SarcoPhAge study.
Locquet, Médéa ULg; Beaudart, Charlotte ULg; Reginster, Jean-Yves ULg et al

in Osteoporosis International (2016, April), 27(supplement 1), 129

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See detailThe future prevalence of sarcopenia in Europe
Ethgen, Olivier ULg; Tchoconte, C.; Beaudart, Charlotte ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 53-54

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