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See detailCross-cultural adaptation and validation of the VISA-P questionnaire in French
Kaux, Jean-François ULg; Delvaux, François ULg; Oppong-Kyei, Julian et al

in European Journal of Sports Medicine (2015, September), 3(Suppl 1), 112

Introduction: The Victorian Institute of Sports Assessment–Patellar (VISA-P), originally developed for English-speaking patients, assesses the severity of patellar tendinopathy symptoms. Although this ... [more ▼]

Introduction: The Victorian Institute of Sports Assessment–Patellar (VISA-P), originally developed for English-speaking patients, assesses the severity of patellar tendinopathy symptoms. Although this questionnaire has already been translated into different languages, it has never been adapted for French-speaking patients, which is surprising. Indeed, French is not only spoken by most than 275 millions of people all around the world. The aim of our study was to validate a French version and verify its psychometric properties. Materials and Methods: The translation and cultural adaptation were performed according to international recommendations in six steps: initial translation, translation merging, back translation to the original language, expert committee review to test the pre-final version, and expert committee appraisal. Once the final French version (VISA-PF) was obtained, certain psychometric properties were assessed in 92 subjects were included and divided into three groups: pathological subjects (n = 28), asymptomatic subjects (n = 22) and sports-risk subjects (n = 42). Results: The different members of the expert committee agreed with the final version. The average scores of the VISA-PF obtained were 53 (± 17) for the pathological group, 99 (± 2) for the healthy group and 86 (± 14) for the sports-risk group. The test-retest reliability of the VISA-PF was excellent with an intra-class correlation coefficient of 0.99 and good internal consistency (α = 0.9). Correlations between the VISA-PF and diverging measures of the SF-36 were low and the correlation coefficient values measured between the VISA-PF scores and converged items of the SF-36 were higher. Conclusion: The VISA-PF is understandable, reliable and suitable for French-speaking patients with patellar tendinopathy. [less ▲]

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See detailValidation of the French translation of the VISA-A
Kaux, Jean-François ULg; Delvaux, François ULg; Oppong-Kyei, Julian et al

in European Journal of Sports Medicine (2015, September), 3(Suppl 1), 112-113

Introduction : The Victorian Institute of Sports Assessment– Achilles (VISA-A) was designed to evaluate the clinical severity of Achilles tendinopathy. It has been developed in English and therefore is ... [more ▼]

Introduction : The Victorian Institute of Sports Assessment– Achilles (VISA-A) was designed to evaluate the clinical severity of Achilles tendinopathy. It has been developed in English and therefore is not adapted for French-speaking patients. Although this questionnaire has already been translated into different languages but not in French. French is spoken by most than 275 millions of people and is one of the 2 official languages of the International Olympic Committee, and one of the 6 official languages and one of the 2 working languages of the United Nation Organisation. The aim of this study was to translate this questionnaires into French and to study its reliability and validity. Methods : The questionnaire was translated into French (VISA-AF) according to the "guidelines for the process of cross-cultural adaptation of self-report measures" using six steps: translation, synthesis, back translation, expert committee review, pretesting, and appraisal of the adaptation process by the expert committee. Once the final versions obtained, several psychometric proprieties such as test-retest fidelity, internal coherence, construct validity and floor and ceiling effects were evaluated. We recruited 116 subjects who were distributed in 3 groups: pathological patients (n=31), at risk athletes (n=63), healthy people (n=22). Results : The questionnaire was approved by the expert committee after the pre-final version test. On a scale ranging from 0 (theoretical minimum) to 100 (asymptomatic subject), the average scores of the VISA-PF obtained were 59 (± 18) for the pathological group, 99 (± 1) for the healthy group and 94 (± 7) for the sports-risk group. The VISA-A-F shows excellent reliability. The VISA-AF shows low correlations with the divergent sub-scales of the SF-36 and moderate correlations with the convergent sub-scales of the SF-36. No floor and ceiling effects were detected during the evaluation of the two questionnaires. Conclusion : The French versions of the VISA-A is equivalent to its original version and is reliable and valid questionnaire for French speaking patients with Achilles tendinopathy. [less ▲]

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See detailOne injection of platelet-rich plasma associated to a submaximal eccentric protocol to treat chronic jumper's knee
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Bruyère, Olivier ULg et al

in The Journal of sports medicine and physical fitness (2015), 55(9), 953-61

INTRODUCTION: Jumper's knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons ... [more ▼]

INTRODUCTION: Jumper's knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons. METHODS: Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments were made before infiltration of PRP, and 6 weeks and 3 months after the infiltration, using a 10--point Visual Analogic Scale, clinical examinations with a pressure algometer, algofunctional scores (IKDC and VISA--P), functional assessments (isokinetic and optojump evaluations) and imagery (ultrasounds and MRI). The PRP was obtained with an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a standardised sub--maximal eccentric reeducation. RESULTS: Pain during daily activities significantly decreased with time. During functional evaluation, it decreased as well, but without significant functional improvement. No improvements in the imagery measurements were observed. Younger patients seemed to be more susceptible to have an improvement of pain by the PRP infiltration. CONCLUSION: This study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol can improve symptoms of chronic jumper's knee in patients non--responsive to classical conservative treatments. [less ▲]

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See detailOne-year follow-up of platelet-rich plasma infiltration to treat chronic proximal patellar tendinopathies
Kaux, Jean-François ULg; Bruyère, Olivier ULg; Croisier, Jean-Louis ULg et al

in European Journal of Sports Medicine (2015, September), 3(Suppl 1), 113

Introduction: Infiltration of Platelet-Rich Plasma (PRP) may be considered as a recent therapeutic option for chronic tendinopathies. The aim of this study is to evaluate the clinical status and the ... [more ▼]

Introduction: Infiltration of Platelet-Rich Plasma (PRP) may be considered as a recent therapeutic option for chronic tendinopathies. The aim of this study is to evaluate the clinical status and the return to sports activities in patients with chronic upper patellar tendinopathies. Material and methods : Twenty subjects with chronic upper patellar tendinopathy benefited from 1 infiltration of PRP. The follow-up (up to 1 year) was assessed by means of a Visual Anologue Scale (VAS), the International Knee Documentation Committee (IKDC) form and the Victorian Institute of Sport Assessment (VISA-P) score. Moreover, subjects had to answer an information questionnaire concerning their life and sports activities. Results : Seventy percents of the patients reported a favourable evolution with decrease of pain, and returned to sports activities. With time, VAS dropped significantly and both IKDC and VISA-P scores improved also significantly. Conclusion : This study confirms that a local injection of PRP coupled with a program of eccentric rehabilitation for treating a chronic jumper's knee, improves pain symptoms and the functionalities of the subjects’ knee up to 1 year after injection. [less ▲]

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See detailOne-year follow-up of platelet-rich plasma infiltration to treat chronic proximal patellar tendinopathies
Kaux, Jean-François ULg; Bruyère, Olivier ULg; Croisier, Jean-Louis ULg et al

in Acta Orthopaedica Belgica (2015), 81(2), 251-256

Infiltration of Platelet-Rich Plasma (PRP) may be considered as a recent therapeutic option for chronic tendinopathies. The aim of this study is to evaluate the clinical status and the return to sports ... [more ▼]

Infiltration of Platelet-Rich Plasma (PRP) may be considered as a recent therapeutic option for chronic tendinopathies. The aim of this study is to evaluate the clinical status and the return to sports activities in patients with chronic proximal patellar tendinopathies. Twenty subjects with chronic proximal patellar tendinopathy benefited from 1 infiltration of PRP coupled with a standardized eccentric rehabilitation. The follow-up (up to 1 year) was assessed by means of a Visual Anologue Scale (VAS), the International Knee Documentation Committee (IKDC) form and the Victorian Institute of Sport Assessment (VISA-P) score. Moreover, subjects had to answer an information questionnaire concerning their life and sports activities. Seventy percents of the patients reported a favourable evolution with decrease of pain, and returned to sports activities. With time, VAS dropped significantly and both IKDC and VISA-P scores improved also significantly. This study confirms that a local injection of PRP coupled with a program of eccentric rehabilitation for treating a chronic jumper’s knee, improves pain symptoms and the functionaliti [less ▲]

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See detailFinancement de la santé et recouvrement des coûts : le lourd fardeau des ménages congolais. Résultats des comptes nationaux de la santé.
Manzambi Kuwekita, Joseph ULg; Eloko Eya Matangelo, Gérard; Bruyère, Olivier ULg et al

in Journal d’Épidémiologie et de Santé Publique (2015), 15(Mars 2015), 15-27

This study examines the share and allocation of household expenditure in health financing, as presented by the National Health Account figures. These figures are based on a national survey carried out in ... [more ▼]

This study examines the share and allocation of household expenditure in health financing, as presented by the National Health Account figures. These figures are based on a national survey carried out in 2010 among 11,000 households, 2,200 people living with HIV/AIDS, 183 institutions, 42 mutual funds, 18 companies and using the balance sheets of 1,300 companies. Total household health expenditure per capita per year amounted to U.S. $ 4.50. Routine health expenditure is covered by the households (40%) and international cooperation (45%) through direct payment without cost sharing (93.7%). A hospital stay is warranted in case of nutritional deficiencies (34%), malaria (12%) and mental disorders (10%). 82% of outpatient care is related to malaria (71%) and mental disorders (12.5 %). In conclusion, the observation that 71.58% of hospitals expenditure, 96.49% of ambulatory care centres expenditure, 98.48% of medical and diagnosis laboratories expenditure, 72.42% of pharmacies expenditures come from households’ out of pocket expenses calls for the establishment of solidarity mechanisms in the health sector. Outpatient malaria care consumes as much as 71% of household expenditure, and we therefore need to strengthen prevention, treatment and focus on monitoring progress. The fact that nutritional deficiencies are the leading cause of people seeking hospital care suggests that efforts are needed to improve their living conditions of households. Mental disorders are the third leading cause of hospital recourse and this pathology should therefore be included in the minimum and supplementary package of activities. [less ▲]

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See detailComment optimiser l’efficience de l’aide internationale, dans le domaine de la santé, en République Démocratique du Congo
Manzambi Kuwekita, Joseph ULg; Bruyère, Olivier ULg; Guillaume, Michèle ULg et al

in Santé Publique : Revue Multidisciplinaire pour la Recherche et l'Action (2015), 27(Janvier-Févier), 129-134

Analysis of national health insurance accounts in the Democratic Republic of Congo (DRC) clearly shows the importance of international sanitary aid, particularly for the funding of general referral ... [more ▼]

Analysis of national health insurance accounts in the Democratic Republic of Congo (DRC) clearly shows the importance of international sanitary aid, particularly for the funding of general referral hospitals, the management of inpatients with AIDS, administration of health zones and funding of preventive care providers. It The targeted changes described in this article could possibly optimize the efficiency of international aid for the DRC population, mainly for disorders considered to be a health care priority (i.e. malaria, AIDS, tuberculosis) as well as in the fight against malnutrition. Recommendations target the implementation of procedures for control of food chain security, changes in lifestyle and dietary habits of the population but also comprise extensive restructuring of the health care administration. A dramatic change of the structure in charge of drug distribution as well as eradication of the transfer of part of public health structure income to public health administrative personnel could result in the allocation of significant funds to the fight against the most important diseases. Better collaboration between the various departments in charge of health care professional training, together with enhanced responsibility of health care personnel is essential. Independent and respected non-governmental organizations should be involved in an audit process, targeting all aspects of the current DRC health system. Eventually, in an equal opportunity perspective, taking into consideration the very high degree of poverty of DRC inhabitants, implementation of health insurance programmes, use of generic drugs and generalization of micro-credit initiatives should also be implemented. [less ▲]

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See detailDairy products & Bone Health: Turning facts and beliefs into clinical practice
Bruyère, Olivier ULg

in Osteoporosis International (2015, March), 26(S1), 383

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See detailPhysical rehabilitation in musculoskeletal conditions: which method?
Bruyère, Olivier ULg

in Osteoporosis International (2015, March), 26(S1), 68

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See detailConcordance between muscle mass assessed by bioelectrical impedance analysis and by dual energy X-ray absorptionmetry among elderly people: a cross-sectional study
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; Dardenne, Nadia ULg et al

in BMC Musculoskeletal Disorders (2015), 16(1), 60-67

BACKGROUND: Besides magnetic resonance imaging, dual energy X-ray absorptiometry (DXA) seems the most reliable tool to evaluate body composition and is often considered as the gold standard in clinical ... [more ▼]

BACKGROUND: Besides magnetic resonance imaging, dual energy X-ray absorptiometry (DXA) seems the most reliable tool to evaluate body composition and is often considered as the gold standard in clinical practice. Bioelectrical impedance analysis (BIA) could provide a simpler, portative, and less expensive alternative. Because the body composition assessment by BIA is device-dependent, the aim of this study was to appraise the concordance between the specific bioelectrical impedance device InBody S10 and DXA for the body composition evaluation. METHODS: Body composition, included appendicular lean mass divided by height squared (ALM/ht2) was measured by DXA (Hologic QDR Discovery device) and by BIA (InBody S10 Biospace device). Agreement between tools was assessed by means of the Bland Altman method and reliability was determined using the IntraClass Coefficient (ICC). ICC was also computed to assess the reliability of the test-retest performed by the same operator or by two different ones. RESULTS: A total of 219 subjects were enrolled in this study (mean age: 43.7 +/- 19.1 years old, 51.6% of women). For the ALM/ht2, reliability of the test-retest of the BIA was high with an ICC of 0.89 (95%CI: 0.86-0.92) when performed by the same operator and an ICC of 0.77 (95%CI: 0.72-0.82) when performed by two different operators. Agreement between ALM/ht2 assessed by DXA and BIA was low (ICC = 0.37 (95%CI: 0.25-0.48)). Mean ALM/ht2 was 9.19 +/- 1.39 kg/m2 with BIA and 7.34 +/- 1.34 kg/m2 with DXA, (p < 0001). A formula developed using a multiple regression analysis, and taking into account muscle mass assessed by BIA, as well as sex and body mass index, explains 89% of the ALM/ht2 assessed by DXA. CONCLUSIONS: Although our results show that the measure of ALM/ht2 by BIA is reliable, the agreement between DXA and BIA is low. Indeed, BIA seems to overestimate ALM/ht2 compared to DXA and, consequently, it is important to use an adapted formula to obtain measurement of the appendicular lean mass by BIA close to that measured by DXA. [less ▲]

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See detailEpidémiologie de la lithiase urinaire sur base d'une analyse morpho-constitutionnelle
Castiglione, Vincent ULg; JOURET, François ULg; Bruyère, Olivier ULg et al

in Néphrologie & Thérapeutique (2015), 11

Urolithiasis is a common condition, with a prevalence of 10% and a male/female ratio above 1 according to large national series. Various types of urinary stones have been described upon their mineral ... [more ▼]

Urolithiasis is a common condition, with a prevalence of 10% and a male/female ratio above 1 according to large national series. Various types of urinary stones have been described upon their mineral content and/or their morphology. Hence, a combined morpho-constitutional (M-C) classification has been proposed. In order to detail the prevalence of urolithiasis in general and of each M-C type in particular upon age and gender in Belgium, we retrospectively studied the database of a reference center for urolithiasis analysis. Between 2010 and 2013, 2195 stones were characterized. We excluded 45 nonbiological stones and 281 stones, which originated from outside the study zone. Among 1869 stones,1293 (69.2%) affected men. Prevalence peak of urolithiasis was observed between 50–60 years of age in both genders. The M-C analysis was available for 1854 stones (99.2%): multiple morphological types were concomitantly identified in 49.3%. In the whole population, the main mineral constituent was whewellite (54.4%), mainly organized as type Ia (94%). Weddellite was found in 19.8%, with an equal distribution between types IIa and IIb. Uric acid was the 3rd most frequent constituent in man, with a similar distribution between IIIa and IIIb. Phosphate was uncommon in man (8.2%), but frequent in woman (26.6%) with a type IVa1 organization. Prevalence of M-C types changes with aging, i.e. decrease of weddellite and increase of whewellite and uric acid in both genders. This retrospective analysis of a single-center database of urinary stones helps characterize the M-C epidemiology of urolithiasis in Belgium. [less ▲]

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See detailMirabel: An integrated project for risk and cost/benefit analysis of peanut allergy
Crépet, A.; Papadopoulos, A.; Elegbede, C.F. et al

in Regulatory Toxicology & Pharmacology [=RTP] (2015), 71

Food allergy is a major public health issue. However, no regulatory measures exist when allergens are present at trace levels and the different risk components are poorly described. Thus, knowledge on ... [more ▼]

Food allergy is a major public health issue. However, no regulatory measures exist when allergens are present at trace levels and the different risk components are poorly described. Thus, knowledge on exposure components such as the allergens present in foods and the consumption behaviour of allergic consumers and models to estimate the related risk need to be enriched. Mirabel proposes for the first time studying each risk component using an integrated approach in order to improve the quality of life of the allergic population. Field surveys were conducted in order to fill in the current gaps in unintentional allergen traces in food, allergic consumers’ food behaviour, threshold doses of allergic reaction, allergy symptoms and severity. The aim is also to propose methodological and operational tools to quantify allergic risk, to test management scenarios and to produce a cost/benefit analysis. Medical data on the peanut allergies of 785 patients were collected in the MIRABEL survey and 443 patients answered the food consumption questionnaire. The population surveyed was mostly paediatric – 86% were children under 16 years of age, with a high percentage of males (60%). This project will generate tangible results on peanut allergen exposure and risk which could be used in future risk assessment work and particularly to provide science-based guidance to set up concentration limits for peanut traces on packages. [less ▲]

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See detailRelationship between isometric strength of six lower limb muscle groups and motor skills among nursing home residents
Buckinx, Fanny ULg; Croisier, Jean-Louis ULg; Reginster, Jean-Yves ULg et al

in Journal of Frailty & Aging (2015), 4(4), 184-7

Abstract: This research aimed to assess the correlation between isometric muscle strength of the lower limb and motor skills. This is a cross sectional study performed among volunteer nursing home ... [more ▼]

Abstract: This research aimed to assess the correlation between isometric muscle strength of the lower limb and motor skills. This is a cross sectional study performed among volunteer nursing home residents included in the SENIOR (Sample of Elderly Nursing home Individuals: an Observational Research) cohort. The present analysis focused on isometric muscle strength of 6 lower limb muscle groups (i.e. knee extensors, knee flexors, hip abductors, hip extensors, ankle flexors and ankle extensors), assessed using a validated hand-held dynamometer (i.e. the MicroFET2 device), and motor skills evaluated using the Tinetti test, the Timed Up and Go test, the Short Physical Performance Battery test (SPPB) and the walking speed. The relationship between all these parameters was tested by means of a multiple correlation, adjusted on age, sex and body mass index. 450 nursing home residents (69.8% of women) with a mean age of 83.1±9.4 years were included in this study. Our results showed a significant inverse correlation between lower limb muscle strength and the time required to perform the TUG test or gait speed, except for ankle flexors and ankle extensors. The relationship between the Tinetti test or the SPPB score, and lower limb muscle strength was significant, except for ankle flexors and ankle extensors. In conclusion, a positive association between lower limb muscle strength of the four main muscle groups and motor skills of the elderly nursing residents was found in this research. Therefore, special attention should be given to these muscle groups during rehabilitation programs. [less ▲]

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See detailTraduction française du Neurophysiology of Pain Questionnaire
Osinski, Thomas; Barde-Cabusson; Brasseur, Pauline et al

Conference (2015)

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See detailAssessment and determinants of aesthetic discomfort in hand osteoarthritis
Neuprez, Audrey ULg; Bruyère, Olivier ULg; Dardenne, Nadia ULg et al

in Annals of the Rheumatic Diseases (2015), 74

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See detailEstimation of sarcopenia prevalence using various assessment tools
Beaudart, Charlotte ULg; Reginster, Jean-Yves ULg; Slomian, Justine ULg et al

in Experimental Gerontology (2015), 61

BACKGROUND: Sarcopenia is defined as a progressive and generalized loss of muscle mass with either a loss of muscle strength or a loss of physical performance but there is no recommendation regarding the ... [more ▼]

BACKGROUND: Sarcopenia is defined as a progressive and generalized loss of muscle mass with either a loss of muscle strength or a loss of physical performance but there is no recommendation regarding the diagnostic tools that have to be used. In this study, we compared the prevalence of sarcopenia assessed using different diagnostic tools. METHODS: To measure muscle mass, muscle strength and physical performance, we used for each outcome two different diagnostic tools. For muscle mass, we used Dual Energy X-Ray Absorptiometry (DXA) and bio-electrical impedance analysis (BIA); for muscle strength, we used a hydraulic dynamometer and a pneumatic dynamometer; for physical performance we used the Short Physical Performance Battery test (SPPB test) and the walk speed. Eight diagnostic groups were hereby established. RESULTS: A total of 250 consecutive subjects were recruited in an outpatient clinic in Liège, Belgium. Estimated prevalence of sarcopenia varied from 8.4% to 27.6% depending on the method of diagnosis used. Regarding muscle mass, BIA systematically overestimated muscle mass compared to DXA (mean estimated prevalence with BIA=12.8%; mean prevalence with DXA=21%). For muscle strength, the pneumatic dynamometer diagnosed twice more sarcopenic subjects than the hydraulic dynamometer (mean estimated prevalence with PD=22.4%; mean estimated prevalence with HD=11.4%). Finally, no difference in prevalence was observed when the walking speed or the SPPB test was used. A weak overall kappa coefficient was observed (0.53), suggesting that the 8 methods of diagnosis are moderately concordant. CONCLUSION: Within the same definition of sarcopenia, prevalence of sarcopenia is highly dependent on the diagnostic tools used. [less ▲]

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See detailCost-effectiveness of vitamin D and calcium supplementation in the treatment of elderly women and men with osteoporosis.
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa; Bruyère, Olivier ULg et al

in European journal of public health (2015), 25(1), 20-25

BACKGROUND: The supplementation with vitamin D and calcium has been recommended for elderly, specifically those with increased risk of fractures older than 65 years. This study aims to assess the cost ... [more ▼]

BACKGROUND: The supplementation with vitamin D and calcium has been recommended for elderly, specifically those with increased risk of fractures older than 65 years. This study aims to assess the cost-effectiveness of vitamin D and calcium supplementation in elderly women and men with osteoporosis and therefore to assess if this recommendation is justified in terms of cost-effectiveness. METHODS: A validated model for economic evaluations in osteoporosis was used to estimate the cost per quality-adjusted life-year (QALY) gained of vitamin D/calcium supplementation compared with no treatment. The model was populated with cost and epidemiological data from a Belgian health-care perspective. Analyses were conducted in women and men with a diagnosis of osteoporosis (i.e. bone mineral density T-score </=-2.5). A literature search was conducted to describe the efficacy of vitamin D and calcium in terms of fracture risk reduction. RESULTS: The cost per QALY gained of vitamin D/calcium supplementation was estimated at euro40 578 and euro23 477 in women and men aged 60 years, respectively. These values decreased to euro7912 and euro10 250 at the age of 70 years and vitamin D and calcium supplementation was cost-saving at the age of 80 years, meaning that treatment cost was less than the costs of treating osteoporotic fractures of the no-treatment group. CONCLUSION: This study suggests that vitamin D and calcium supplementation is cost-effective for women and men with osteoporosis aged over 60 years. From an economic perspective, vitamin D and calcium should therefore be administrated in these populations including those also taking other osteoporotic treatments. [less ▲]

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