References of "Brichant, Jean-François"
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See detailLipomatous hypertrophy of the interatrial septum: the typical echographic aspect is worth being known
ROYER, Ludovic ULg; HANS, Grégory ULg; CANIVET, Jean-Luc ULg et al

in Acta Anaesthesiologica Belgica (2011), 62(3), 157-159

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See detailEVALUATION SANCTIONNANTE D’ÉTUDIANTS DANS UN DISPOSITIF SUSCITANT LA RÉFLEXIVITÉ EN 2E CYCLE D’ÉTUDES MÉDICALES DANS UN COURS DE « MÉDECINE PALLIATIVE ET DE FIN DE VIE » DONT LES MOYENS UTILISÉS SONT LE PORTFOLIO ÉLECTRONIQUE, LE TUTORAT ET DES COURS THÉORIQUES
Giet, Didier ULg; MASSART, Valérie ULg; Deum, Mélanie ULg et al

in Bulletin de l'ADMEE 2001/1 (2011)

Le cours de Médecine Palliative est dispensé aux étudiants en avant-dernière année des études médicales de 2e cycle par deux enseignants, Médecin Généraliste et Médecin Hospitalier. Ce cours est dispensé ... [more ▼]

Le cours de Médecine Palliative est dispensé aux étudiants en avant-dernière année des études médicales de 2e cycle par deux enseignants, Médecin Généraliste et Médecin Hospitalier. Ce cours est dispensé depuis 10 ans selon un format traditionnel ex cathedra. De nouveaux objectifs et de nouvelles modalités pédagogiques ont été introduits en 2010-2011. L’objectif principal est l’apprentissage réflexif des étudiants. Les outils pédagogiques sont le portfolio électronique, une vignette clinique évolutive, l’accompagnement à distance de chaque étudiant par un tuteur, des cours en présentiel. La pratique réflexive de chaque étudiant est évaluée au terme du dispositif selon des critères et des indicateurs préalablement communiqués. Des perspectives ont émergé sur base des analyses des forces et faiblesses. [less ▲]

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See detailL’évaluation de la réflexivité dans des portfolios électroniques dans le cadre d’un cours de Soins Palliatifs en formation médicale de base
Giet, Didier ULg; MASSART, Valérie ULg; Deum, Mélanie ULg et al

Conference (2011)

Le cours de Médecine Palliative est organisé en avant-dernière année des études médicales de 2e cycle par deux enseignants, Médecin Généraliste et Médecin Hospitalier. Ce cours a été dispensé pendant 10 ... [more ▼]

Le cours de Médecine Palliative est organisé en avant-dernière année des études médicales de 2e cycle par deux enseignants, Médecin Généraliste et Médecin Hospitalier. Ce cours a été dispensé pendant 10 ans selon un format traditionnel ex cathedra. Il était dispensé par de nombreux intervenants pluridisciplinaires. Une évaluation des enseignements a montré que les étudiants jugeaient les interventions trop théoriques, sans lien avec leurs questions et préoccupations. En conséquence, c’est la discipline « Médecine Palliative et de Soins de Vie » qui ne suscitaient pas d’intérêt. De nouveaux objectifs et de nouvelles modalités pédagogiques ont été introduits en 2010-2011 à l’attention de 100 étudiants. L’objectif principal est le développement chez les étudiants d’une attitude réflexive face à la discipline « Médecine Palliative ». Les outils pédagogiques introduits dans le dispositif sont le portfolio électronique, une vignette clinique évolutive, l’accompagnement à distance de chaque étudiant par un tuteur, des cours en présentiel. La pratique réflexive de chaque étudiant est évaluée au terme du dispositif, conjointement par les 2 enseignants sur base de critères et d’indicateurs. Voici une illustration des critères utilisés : - Intensité des interactions dans le carnet d’apprentissage électronique (et aux cours) - Pertinence des interventions - Engagement dans la tâche - Capacité réflexive (pertinence de l’analyse et de la régulation de la situation décrite dans la vignette) - Qualité de l’auto-évaluation et identification des éléments déclencheurs de progrès - Degré d’apprentissage (Bilan d’atteinte des objectifs fixés par le cours et décrits) La communication orale présentera le dispositif d’évaluation, les critères et les indicateurs utilisés, les premiers résultats de l’évaluation des étudiants, les perspectives de régulation du dispositif d’évaluation. [less ▲]

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See detailEffets respiratoires de l'anesthésie locorégionale
Brichant, Jean-François ULg

Conference (2010, September 07)

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See detailNorepinephrine and ephedrine do not counteract the increase in cutaneous microcirculation induced by spinal anaesthesia.
Lecoq, Jean-Pierre ULg; Brichant, Jean-François ULg; Lamy, Maurice ULg et al

in British Journal of Anaesthesia (2010), 105(2), 214-9

BACKGROUND: /st> Neuraxial anaesthesia improves tissue perfusion and tissue oxygen tension. Vasodilation induced by this technique may result in hypotension requiring the administration of vasoactive ... [more ▼]

BACKGROUND: /st> Neuraxial anaesthesia improves tissue perfusion and tissue oxygen tension. Vasodilation induced by this technique may result in hypotension requiring the administration of vasoactive drugs. The use of peripheral vasoconstrictors might counteract the improved tissue perfusion and its potentially beneficial effects. We therefore investigated the effect of i.v. norepinephrine and ephedrine on skin perfusion using laser-Doppler flowmetry (LDF) in patients during spinal anaesthesia. METHODS: /st> Skin blood flow expressed in perfusion units (PU) provided by LDF was measured simultaneously at the foot and the manubrium levels in 44 patients during spinal anaesthesia with a sensory level below T5. Norepinephrine infusion was then titrated to normalize mean arterial pressure (MAP) in 23 patients (Group NOR). Ephedrine (max. 10 mg) was administered in 21 patients (Group EPH). Changes in relative PU were compared between the two sites of measurements in each group during drug administration. The same doses of norepinephrine were assessed in 11 normal volunteers to assure comparable vasoreactivity at the foot and manubrium levels. RESULTS: /st> Spinal anaesthesia resulted in a 10% decrease in MAP (P<0.001), an increase in relative PU values at the foot level (P<0.001), and a decrease at the sternum level (P<0.05). Norepinephrine and ephedrine produced a significant increase in relative PU values at the foot level when compared with the sternum level (NOR: P=0.02; EPH: P=0.0035). In volunteers, norepinephrine decreased cutaneous perfusion similarly at the manubrium and foot levels. CONCLUSIONS: /st> Improved skin perfusion induced by spinal anaesthesia was not counteracted by the use of norepinephrine or ephedrine. [less ▲]

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See detailAnalysis of mortality and morbidity data
Brichant, Jean-François ULg

Conference (2010, January 08)

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See detailDefault network connectivity reflects the level of consciousness in non-communicative brain-damaged patients.
Vanhaudenhuyse, Audrey ULg; Noirhomme, Quentin ULg; Tshibanda, Luaba ULg et al

in Brain : A Journal of Neurology (2010), 133(Pt 1), 161-71

The 'default network' is defined as a set of areas, encompassing posterior-cingulate/precuneus, anterior cingulate/mesiofrontal cortex and temporo-parietal junctions, that show more activity at rest than ... [more ▼]

The 'default network' is defined as a set of areas, encompassing posterior-cingulate/precuneus, anterior cingulate/mesiofrontal cortex and temporo-parietal junctions, that show more activity at rest than during attention-demanding tasks. Recent studies have shown that it is possible to reliably identify this network in the absence of any task, by resting state functional magnetic resonance imaging connectivity analyses in healthy volunteers. However, the functional significance of these spontaneous brain activity fluctuations remains unclear. The aim of this study was to test if the integrity of this resting-state connectivity pattern in the default network would differ in different pathological alterations of consciousness. Fourteen non-communicative brain-damaged patients and 14 healthy controls participated in the study. Connectivity was investigated using probabilistic independent component analysis, and an automated template-matching component selection approach. Connectivity in all default network areas was found to be negatively correlated with the degree of clinical consciousness impairment, ranging from healthy controls and locked-in syndrome to minimally conscious, vegetative then coma patients. Furthermore, precuneus connectivity was found to be significantly stronger in minimally conscious patients as compared with unconscious patients. Locked-in syndrome patient's default network connectivity was not significantly different from controls. Our results show that default network connectivity is decreased in severely brain-damaged patients, in proportion to their degree of consciousness impairment. Future prospective studies in a larger patient population are needed in order to evaluate the prognostic value of the presented methodology. [less ▲]

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See detailSevrage tabagique en préopératoire: une période propice pour lutter contre l'inertie et le défaut d'observance
Deflandre, Eric; Degey, Y.; Clerdain, Anne-Michèle ULg et al

in Revue Médicale de Liège (2010), 65(5-6), 332-337

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See detailBreakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness.
Boveroux, Pierre ULg; Vanhaudenhuyse, Audrey ULg; Bruno, Marie-Aurélie ULg et al

in Anesthesiology (2010), 113(5), 1038-53

BACKGROUND: Mechanisms of anesthesia-induced loss of consciousness remain poorly understood. Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes ... [more ▼]

BACKGROUND: Mechanisms of anesthesia-induced loss of consciousness remain poorly understood. Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes during pharmacological modulation of the level of consciousness. METHODS: Low-frequency spontaneous blood oxygen level-dependent fluctuations were measured in 19 healthy volunteers during wakefulness, mild sedation, deep sedation with clinical unconsciousness, and subsequent recovery of consciousness. RESULTS: Propofol-induced decrease in consciousness linearly correlates with decreased corticocortical and thalamocortical connectivity in frontoparietal networks (i.e., default- and executive-control networks). Furthermore, during propofol-induced unconsciousness, a negative correlation was identified between thalamic and cortical activity in these networks. Finally, negative correlations between default network and lateral frontoparietal cortices activity, present during wakefulness, decreased proportionally to propofol-induced loss of consciousness. In contrast, connectivity was globally preserved in low-level sensory cortices, (i.e., in auditory and visual networks across sedation stages). This was paired with preserved thalamocortical connectivity in these networks. Rather, waning of consciousness was associated with a loss of cross-modal interactions between visual and auditory networks. CONCLUSIONS: Our results shed light on the functional significance of spontaneous brain activity fluctuations observed in functional magnetic resonance imaging. They suggest that propofol-induced unconsciousness could be linked to a breakdown of cerebral temporal architecture that modifies both within- and between-network connectivity and thus prevents communication between low-level sensory and higher-order frontoparietal cortices, thought to be necessary for perception of external stimuli. They emphasize the importance of thalamocortical connectivity in higher-order cognitive brain networks in the genesis of conscious perception. [less ▲]

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See detailSide effects of the addition of clonidine 75 microg or sufentanil 5 microg to 0.2% ropivacaine for labour epidural analgesia.
Dewandre, Pierre-Yves ULg; Decurninge, Valérie; Bonhomme, Vincent ULg et al

in International Journal of Obstetric Anesthesia (2010), 19(2), 149-54

BACKGROUND: Sufentanil 5 microg and clonidine 75 microg produce a similar reduction in minimum local anaesthetic concentration of ropivacaine. The aim of the present study was to compare the side effects ... [more ▼]

BACKGROUND: Sufentanil 5 microg and clonidine 75 microg produce a similar reduction in minimum local anaesthetic concentration of ropivacaine. The aim of the present study was to compare the side effects of two equianalgesic solutions by combining 0.2% ropivacaine with either sufentanil 5 microg or clonidine 75 microg for labour epidural analgesia. METHODS: In a prospective double-blind study, 60 women at 5 cm cervical dilatation were randomly allocated to receive 0.2% ropivacaine with either sufentanil 5 microg or clonidine 75 microg to initiate labour analgesia. The analgesic efficacy and side effects of the two mixtures were compared. RESULTS: Onset, duration and quality of analgesia and subsequent ropivacaine consumption were similar in the two groups. Hypotension was significantly more frequent and severe with clonidine than with sufentanil (systolic blood pressure <100 mmHg: 17/26 vs. 6/24, P <0.05; systolic blood pressure <90 mmHg: 5/26 vs. 0/24, P <0.05) resulting in more frequent ephedrine administration (11/26 vs. 2/24, P <0.05) and larger fluid requirements (1696 +/- 583 mL vs. 1264 +/- 407 mL, P < 0.05). Conversely, pruritus was more frequent with sufentanil than with clonidine (6/26 vs. 1/24, P <0.05). CONCLUSIONS: Hypotension occurs more frequently when clonidine is added to epidural ropivacaine instead of an equianalgesic dose of sufentanil. Therefore, clonidine cannot be recommended for routine administration for labour epidural analgesia. [less ▲]

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See detailAnesthésie locorégionale et anti-agrégants plaquettaires: le jeu en vaut-il la chandelle?
Senard, Marc ULg; Roediger, Laurence ULg; Hubert, Marie-Bernard ULg et al

in Praticien en Anesthésie Réanimation (Le) (2010), 14

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See detailManagement of severe preeclampsia
Brichant, Géraldine ULg; Dewandre, Pierre-Yves ULg; Foidart, Jean-Michel ULg et al

in Acta Clinica Belgica (2010), 65(3), 163-169

Features of severe preeclampsia include severe proteinuric hypertension and symptoms of central nervous system dysfunction, hepatocellular injury, thrombocytopenia, oliguria, pulmonary oedema ... [more ▼]

Features of severe preeclampsia include severe proteinuric hypertension and symptoms of central nervous system dysfunction, hepatocellular injury, thrombocytopenia, oliguria, pulmonary oedema, cerebrovascular accident and severe intrauterine growth restriction. Women with severe preeclampsia must be hospitalized to confirm the diagnosis, to assess the severity of the disease, to monitor the progression of the disease and to try to stabilize the disease. Severe preeclampsia may be managed expectantly, in selected cases. The objective of expectant management in these patients is to improve neonatal outcome. Expectant management is based on antihypertensive treatment and prevention of end organ dysfunction. Antihypertensive treatment improves maternal outcome but has the potential to be deleterious for the foetus. Plasma volume expansion has been suggested for severe preeclampsia but trials failed to show any benefit. Magnesium sulfate is the anticonvulsivant of choice to treat or prevent eclampsia when indicated. Antenatal corticosteroids are recommended in severely preeclamptic women with 26-34 weeks gestation. Timing of delivery is based upon gestational age, severity of preeclampsia, maternal and foetal risks. [less ▲]

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See detailManifestations hemodynamiques et respiratoires de la preeclampsie.
Brichant, Jean-François ULg; Brichant, Géraldine ULg; Dewandre, Pierre-Yves ULg et al

in Annales Françaises d'Anesthésie et de Réanimation (2010), 29

The hemodynamic and cardiovascular changes seen during PE vary according to the natural history of the disease, its severity and eventual therapeutic measures taken. In the early stages of pregnancy ... [more ▼]

The hemodynamic and cardiovascular changes seen during PE vary according to the natural history of the disease, its severity and eventual therapeutic measures taken. In the early stages of pregnancy, patients who will eventually develop PE, present with a blood pressure which even though within normal limits, is higher than in other women. Similarly, their cardiac output is higher with a normal or decreased peripheral vascular resistance. As soon as the clinical signs of the disease appear, the hemodynamic picture usually shifts toward that of a high peripheral resistance with low cardiac output. Sometimes however, a clinically hyperkinetic circulation may be demonstrated. In PE patients, cardiac preload pressures are usually normal even though the circulatory volumes are lower by 600 to 800ml when compared to those found in normal pregnancy. The cardiac function is however usually preserved during PE. PE induces an exaggerated capillary permeability. This results in the worsening of the airway edema which may render the intubation very difficult. The increased capillary permeability contributes, among other factors, to the heightened risk of acute pulmonary edema. It is not justified to administer an anti-hypertensive treatment to PE women presenting with only moderate hypertension. An anti-hypertensive treatment must only be initiated whenever the hypertension is severe (i.e. SBP>/=160mmHg and/or DBP>/=110mmHg) in order to reduce the risk of maternal complications. In the absence of objective comparative data assessing anti-hypertensive agents for the PE patient, the choice of therapy relies predominantly on the practitioners' own experience. Systematic circulatory volume expansion has not been proven to improve the maternal nor the neonatal prognosis. Such treatment is to be reserved solely for situations in which correcting a hypo-volemia is absolutely necessary. The treatment of acute pulmonary edema in a PE patient is symptomatic and includes the administration of vasodilating agents and of diuretics. A benefit in setting-up an invasive monitoring of the pulmonary artery occlusive pressure has not been demonstrated. The sonographic surveillance of the hemodynamic state can however be useful in these circumstances. [less ▲]

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See detailEffect of an intravenous infusion of lidocaine on cisatracurium-induced neuromuscular block duration: a randomized-controlled trial.
Hans, Grégory ULg; Defresne, Aline ULg; Ki, Bertille et al

in Acta Anaesthesiologica Scandinavica (2010), 54(10), 1192-6

BACKGROUND: Intravenous lidocaine can be used intraoperatively for its analgesic and antihyperalgesic properties but local anaesthetics may also prolong the duration of action of neuromuscular blocking ... [more ▼]

BACKGROUND: Intravenous lidocaine can be used intraoperatively for its analgesic and antihyperalgesic properties but local anaesthetics may also prolong the duration of action of neuromuscular blocking agents. We hypothesized that intravenous lidocaine would prolong the time to recovery of neuromuscular function after cisatracurium. METHODS: Forty-two patients were enrolled in this randomized, double-blind, placebo-controlled study. Before induction, patients were administered either a 1.5 mg/kg bolus of intravenous lidocaine followed by a 2 mg/kg/h infusion or an equal volume of saline. Anaesthesia was induced and maintained using propofol and remifentanil infusions. After loss of consciousness, a 0.15 mg/kg bolus of cisatracurium was administered. No additional cisatracurium injection was allowed. Neuromuscular function was assessed every 20 s using kinemyography. The primary endpoint was the time to spontaneous recovery of a train-of-four (TOF) ratio >/= 0.9. RESULTS: The time to spontaneous recovery of a TOF ratio >/= 0.9 was 94 +/- 15 min in the control group and 98 +/- 16 min in the lidocaine group (P=0.27). CONCLUSIONS: No significant prolongation of spontaneous recovery of a TOF ratio >/= 0.9 after cisatracurium was found in patients receiving intravenous lidocaine. [less ▲]

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See detailRegional analgesia
Brichant, Jean-François ULg

Conference (2009, December 18)

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See detailNeurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting
Diemunsch, P.; Joshi, G. P.; Brichant, Jean-François ULg

in British Journal of Anaesthesia (2009), 103(1), 7-13

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See detailTraitement de la prééclampsie sévère: jusqu'où, et pour quels risques/bénéfices?
PETIT, Philippe ULg; Top, Marlene; CHANTRAINE, Frédéric ULg et al

in Revue Médicale de Liège (2009), 64(12), 620-625

Detailed reference viewed: 107 (8 ULg)