References of "Brichant, Jean-François"
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See detailLes céphalées post-ponction durale: traitement et prévention
LENELLE, Laurence ULg; LAHAYE-GOFFART, Benoît ULg; DEWANDRE, Pierre-Yves ULg et al

in Revue Médicale de Liège (2011), 66(11), 575-580

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See detailThe volume of blood for epidural blood patch in obstetrics: a randomized, blinded clinical trial
Paech, M. J.; Doherty, D. A.; Christmas, T. et al

in Anesthesia and Analgesia (2011), 113(1), 126-33

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See detailAnesthésie pédiatrique et hôpital de jour: les grands problèmes des petits enfants
GROSJEAN, Valérie ULg; Veyckemans, F.; SEGHAYE, Marie-Christine ULg et al

in Revue Médicale de Liège (2011), 66(3), 135-139

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See detailAnesthésie et sécurité des procédures en dehors du bloc opératoire: "l'affaire de tous"
Jastrowicz, Julie ULg; Hallet, Claude ULg; Roediger, Laurence ULg et al

in Revue Médicale de Liège (2011), 66(1), 18-24

Due to important technological improvements, anesthesiological activity outside the operating theatre is increasing. Most of these procedures are performed for gastro- enterology procedures; other ... [more ▼]

Due to important technological improvements, anesthesiological activity outside the operating theatre is increasing. Most of these procedures are performed for gastro- enterology procedures; other procedures include medical ima- ging, electroconvulsive therapy or cardioversion. The practice of anesthesia at alternative sites is associated with logistical dif- ficulties with many constraints. Anesthesia will be requested if the procedure is likely to be unpleasant or painful, if the patient is not cooperative, or if the patient’s hemodynamic condition is unstable. The pre-anesthesia assessment, an adequate monito- ring and an appropriate choice of the anesthetic technique and drugs will be helpful in managing an anesthetic procedure too frequently neglected despite it is associated with risks similar to procedures performed in the operating theatre. [less ▲]

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See detailComparison of the Surgical Pleth Index (TM) with haemodynamic variables to assess nociception-anti-nociception balance during general anaesthesia
Bonhomme, Vincent ULg; Uutela, K.; Hans, Grégory ULg et al

in British Journal of Anaesthesia (2011), 106(1), 101-11

BACKGROUND: The Surgical Pleth Index (SPI) is proposed as a means to assess the balance between noxious stimulation and the anti-nociceptive effects of anaesthesia. In this study, we compared SPI, mean ... [more ▼]

BACKGROUND: The Surgical Pleth Index (SPI) is proposed as a means to assess the balance between noxious stimulation and the anti-nociceptive effects of anaesthesia. In this study, we compared SPI, mean arterial pressure (MAP), and heart rate (HR) as a means of assessing this balance. METHODS: We studied a standard stimulus [head-holder insertion (HHI)] and varying remifentanil concentrations (CeREMI) in a group of patients undergoing neurosurgery. Patients receiving target-controlled infusions were randomly assigned to one of the three CeREMI (2, 4, or 6 ng m(1)), whereas propofol target was fixed at 3 microg ml(1). Steady state for both targets was achieved before HHI. Intravascular volume status (IVS) was evaluated using respiratory variations in arterial pressure. Prediction probability (Pk) and ordinal regression were used to assess SPI, MAP, and HR performance at indicating CeREMI, and the influence of IVS and chronic treatment for high arterial pressure, as possible confounding factors. RESULTS: The maximum SPI, MAP, or HR observed after HHI correctly indicated CeREMI in one of the two patients [accurate prediction rate (APR)=0.5]. When IVS and chronic treatment for high arterial pressure were taken into account, the APR was 0.6 for each individual variable and 0.8 when all of them predicted the same CeREMI. That increase in APR paralleled an increase in Pk from 0.63 to 0.89. CONCLUSIONS: SPI, HR, and MAP are of comparable value at gauging noxious stimulation-CeREMI balance. Their interpretation is improved by taking account of IVS, treatment for chronic high arterial pressure, and concordance between their predictions. [less ▲]

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See detailPropofol anesthesia and sleep: a high-density EEG study.
Murphy, Michael; Bruno, Marie-Aurélie ULg; Riedner, Brady A et al

in Sleep (2011), 34(3), 283-91

STUDY OBJECTIVES: The electrophysiological correlates of anesthetic sedation remain poorly understood. We used high-density electroencephalography (hd-EEG) and source modeling to investigate the cortical ... [more ▼]

STUDY OBJECTIVES: The electrophysiological correlates of anesthetic sedation remain poorly understood. We used high-density electroencephalography (hd-EEG) and source modeling to investigate the cortical processes underlying propofol anesthesia and compare them to sleep. DESIGN: 256-channel EEG recordings in humans during propofol anesthesia. SETTING: Hospital operating room. PATIENTS OR PARTICIPANTS: 8 healthy subjects (4 males) INTERVENTIONS: N/A MEASUREMENTS AND RESULTS: Initially, propofol induced increases in EEG power from 12-25 Hz. Loss of consciousness (LOC) was accompanied by the appearance of EEG slow waves that resembled the slow waves of NREM sleep. We compared slow waves in propofol to slow waves recorded during natural sleep and found that both populations of waves share similar cortical origins and preferentially propagate along the mesial components of the default network. However, propofol slow waves were spatially blurred compared to sleep slow waves and failed to effectively entrain spindle activity. Propofol also caused an increase in gamma (25-40 Hz) power that persisted throughout LOC. Source modeling analysis showed that this increase in gamma power originated from the anterior and posterior cingulate cortices. During LOC, we found increased gamma functional connectivity between these regions compared to the wakefulness. CONCLUSIONS: Propofol anesthesia is a sleep-like state and slow waves are associated with diminished consciousness even in the presence of high gamma activity. CITATION: Murphy M; Bruno MA; Riedner BA; Boveroux P; Noirhomme Q; Landsness EC; Brichant JF; Phillips C; Massimini M; Laureys S; Tononi G; Boly M. Propofol anesthesia and sleep: a high-density EEG study. SLEEP 2011;34(3):283-291. [less ▲]

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See detailLinking sleep and general anesthesia mechanisms: this is no walkover
BONHOMME, Vincent ULg; BOVEROUX, Pierre ULg; Vanhaudenhuyse, Audrey ULg et al

in Acta Anaesthesiologica Belgica (2011), 62(3), 161-171

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See detailAnalgésie épidurale obstétricale et pseudoxanthome élastique : à propos d’un cas
Clanet, Matthieu; CHANTRAINE, Frédéric ULg; DEWANDRE, Pierre-Yves ULg et al

in Annales Françaises d'Anesthésie et de Réanimation (2011), 30(9), 685-7

Pseudoxanthoma elasticum is a rare inherited disorder of the elastic tissue characterised by multisystem manifestations. Skin, eyes, gastro-intestinal system and cardiovascular system are the major ... [more ▼]

Pseudoxanthoma elasticum is a rare inherited disorder of the elastic tissue characterised by multisystem manifestations. Skin, eyes, gastro-intestinal system and cardiovascular system are the major affected systems. We describe the anaesthetic management of a parturient affected by this disease. [less ▲]

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See detailEnd of life care in the operating room for non-heart-beating donors: organization at the University Hospital of Liege.
JORIS, Jean ULg; KABA, Abdourahmane ULg; LAUWICK, Séverine ULg et al

in Transplantation Proceedings (2011), 43(9), 3441-4

Non-heart-beating (NHB) organ donation has become an alternative source to increase organ supply for transplantation. A NHB donation program was implemented in our institution in 2002. As in many ... [more ▼]

Non-heart-beating (NHB) organ donation has become an alternative source to increase organ supply for transplantation. A NHB donation program was implemented in our institution in 2002. As in many institutions the end of life care of the NHB donor (NHBD) is terminated in the operating room (OR) to reduce warm ischemia time. Herein we have described the organization of end of life care for these patients in our institution, including the problems addressed, the solution proposed, and the remaining issues. Emphasis is given to our protocol elaborated with the different contributors of the chain of the NHB donation program. This protocol specifies the information mandatory in the medical records, the end of life care procedure, the determination of death, and the issue of organ preservation measures before NHBD death. The persisting malaise associated with NHB donation reported by OR nurses is finally documented using an anonymous questionnaire. [less ▲]

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See detailInfluence of anesthesia on cerebral blood flow, cerebral metabolic rate, and brain functional connectivity.
BONHOMME, Vincent ULg; BOVEROUX, Pierre ULg; HANS, Pol ULg et al

in Current Opinion in Anaesthesiology (2011), 24(5), 474-9

PURPOSE OF REVIEW: To describe recent studies exploring brain function under the influence of hypnotic anesthetic agents, and their implications on the understanding of consciousness physiology and ... [more ▼]

PURPOSE OF REVIEW: To describe recent studies exploring brain function under the influence of hypnotic anesthetic agents, and their implications on the understanding of consciousness physiology and anesthesia-induced alteration of consciousness. RECENT FINDINGS: Cerebral cortex is the primary target of the hypnotic effect of anesthetic agents, and higher-order association areas are more sensitive to this effect than lower-order processing regions. Increasing concentration of anesthetic agents progressively attenuates connectivity in the consciousness networks, while connectivity in lower-order sensory and motor networks is preserved. Alteration of thalamic sub-cortical regulation could compromise the cortical integration of information despite preserved thalamic activation by external stimuli. At concentrations producing unresponsiveness, the activity of consciousness networks becomes anticorrelated with thalamic activity, while connectivity in lower-order sensory networks persists, although with cross-modal interaction alterations. SUMMARY: Accumulating evidence suggests that hypnotic anesthetic agents disrupt large-scale cerebral connectivity. This would result in an inability of the brain to generate and integrate information, while external sensory information is still processed at a lower order of complexity. [less ▲]

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See detailLipomatous hypertrophy of the interatrial septum: the typical echographic aspect is worth being known
ROYER, Ludovic ULg; HANS, Grégory ULg; CANIVET, Jean-Luc ULg et al

in Acta Anaesthesiologica Belgica (2011), 62(3), 157-159

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See detailEVALUATION SANCTIONNANTE D’ÉTUDIANTS DANS UN DISPOSITIF SUSCITANT LA RÉFLEXIVITÉ EN 2E CYCLE D’ÉTUDES MÉDICALES DANS UN COURS DE « MÉDECINE PALLIATIVE ET DE FIN DE VIE » DONT LES MOYENS UTILISÉS SONT LE PORTFOLIO ÉLECTRONIQUE, LE TUTORAT ET DES COURS THÉORIQUES
Giet, Didier ULg; MASSART, Valérie ULg; Deum, Mélanie ULg et al

in Bulletin de l'ADMEE 2001/1 (2011)

Le cours de Médecine Palliative est dispensé aux étudiants en avant-dernière année des études médicales de 2e cycle par deux enseignants, Médecin Généraliste et Médecin Hospitalier. Ce cours est dispensé ... [more ▼]

Le cours de Médecine Palliative est dispensé aux étudiants en avant-dernière année des études médicales de 2e cycle par deux enseignants, Médecin Généraliste et Médecin Hospitalier. Ce cours est dispensé depuis 10 ans selon un format traditionnel ex cathedra. De nouveaux objectifs et de nouvelles modalités pédagogiques ont été introduits en 2010-2011. L’objectif principal est l’apprentissage réflexif des étudiants. Les outils pédagogiques sont le portfolio électronique, une vignette clinique évolutive, l’accompagnement à distance de chaque étudiant par un tuteur, des cours en présentiel. La pratique réflexive de chaque étudiant est évaluée au terme du dispositif selon des critères et des indicateurs préalablement communiqués. Des perspectives ont émergé sur base des analyses des forces et faiblesses. [less ▲]

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See detailL’évaluation de la réflexivité dans des portfolios électroniques dans le cadre d’un cours de Soins Palliatifs en formation médicale de base
Giet, Didier ULg; MASSART, Valérie ULg; Deum, Mélanie ULg et al

Conference (2011)

Le cours de Médecine Palliative est organisé en avant-dernière année des études médicales de 2e cycle par deux enseignants, Médecin Généraliste et Médecin Hospitalier. Ce cours a été dispensé pendant 10 ... [more ▼]

Le cours de Médecine Palliative est organisé en avant-dernière année des études médicales de 2e cycle par deux enseignants, Médecin Généraliste et Médecin Hospitalier. Ce cours a été dispensé pendant 10 ans selon un format traditionnel ex cathedra. Il était dispensé par de nombreux intervenants pluridisciplinaires. Une évaluation des enseignements a montré que les étudiants jugeaient les interventions trop théoriques, sans lien avec leurs questions et préoccupations. En conséquence, c’est la discipline « Médecine Palliative et de Soins de Vie » qui ne suscitaient pas d’intérêt. De nouveaux objectifs et de nouvelles modalités pédagogiques ont été introduits en 2010-2011 à l’attention de 100 étudiants. L’objectif principal est le développement chez les étudiants d’une attitude réflexive face à la discipline « Médecine Palliative ». Les outils pédagogiques introduits dans le dispositif sont le portfolio électronique, une vignette clinique évolutive, l’accompagnement à distance de chaque étudiant par un tuteur, des cours en présentiel. La pratique réflexive de chaque étudiant est évaluée au terme du dispositif, conjointement par les 2 enseignants sur base de critères et d’indicateurs. Voici une illustration des critères utilisés : - Intensité des interactions dans le carnet d’apprentissage électronique (et aux cours) - Pertinence des interventions - Engagement dans la tâche - Capacité réflexive (pertinence de l’analyse et de la régulation de la situation décrite dans la vignette) - Qualité de l’auto-évaluation et identification des éléments déclencheurs de progrès - Degré d’apprentissage (Bilan d’atteinte des objectifs fixés par le cours et décrits) La communication orale présentera le dispositif d’évaluation, les critères et les indicateurs utilisés, les premiers résultats de l’évaluation des étudiants, les perspectives de régulation du dispositif d’évaluation. [less ▲]

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See detailEffets respiratoires de l'anesthésie locorégionale
Brichant, Jean-François ULg

Conference (2010, September 07)

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See detailNorepinephrine and ephedrine do not counteract the increase in cutaneous microcirculation induced by spinal anaesthesia.
Lecoq, Jean-Pierre ULg; Brichant, Jean-François ULg; Lamy, Maurice ULg et al

in British Journal of Anaesthesia (2010), 105(2), 214-9

BACKGROUND: /st> Neuraxial anaesthesia improves tissue perfusion and tissue oxygen tension. Vasodilation induced by this technique may result in hypotension requiring the administration of vasoactive ... [more ▼]

BACKGROUND: /st> Neuraxial anaesthesia improves tissue perfusion and tissue oxygen tension. Vasodilation induced by this technique may result in hypotension requiring the administration of vasoactive drugs. The use of peripheral vasoconstrictors might counteract the improved tissue perfusion and its potentially beneficial effects. We therefore investigated the effect of i.v. norepinephrine and ephedrine on skin perfusion using laser-Doppler flowmetry (LDF) in patients during spinal anaesthesia. METHODS: /st> Skin blood flow expressed in perfusion units (PU) provided by LDF was measured simultaneously at the foot and the manubrium levels in 44 patients during spinal anaesthesia with a sensory level below T5. Norepinephrine infusion was then titrated to normalize mean arterial pressure (MAP) in 23 patients (Group NOR). Ephedrine (max. 10 mg) was administered in 21 patients (Group EPH). Changes in relative PU were compared between the two sites of measurements in each group during drug administration. The same doses of norepinephrine were assessed in 11 normal volunteers to assure comparable vasoreactivity at the foot and manubrium levels. RESULTS: /st> Spinal anaesthesia resulted in a 10% decrease in MAP (P<0.001), an increase in relative PU values at the foot level (P<0.001), and a decrease at the sternum level (P<0.05). Norepinephrine and ephedrine produced a significant increase in relative PU values at the foot level when compared with the sternum level (NOR: P=0.02; EPH: P=0.0035). In volunteers, norepinephrine decreased cutaneous perfusion similarly at the manubrium and foot levels. CONCLUSIONS: /st> Improved skin perfusion induced by spinal anaesthesia was not counteracted by the use of norepinephrine or ephedrine. [less ▲]

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See detailAnalysis of mortality and morbidity data
Brichant, Jean-François ULg

Conference (2010, January 08)

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See detailDefault network connectivity reflects the level of consciousness in non-communicative brain-damaged patients.
Vanhaudenhuyse, Audrey ULg; Noirhomme, Quentin ULg; Tshibanda, Luaba ULg et al

in Brain : A Journal of Neurology (2010), 133(Pt 1), 161-71

The 'default network' is defined as a set of areas, encompassing posterior-cingulate/precuneus, anterior cingulate/mesiofrontal cortex and temporo-parietal junctions, that show more activity at rest than ... [more ▼]

The 'default network' is defined as a set of areas, encompassing posterior-cingulate/precuneus, anterior cingulate/mesiofrontal cortex and temporo-parietal junctions, that show more activity at rest than during attention-demanding tasks. Recent studies have shown that it is possible to reliably identify this network in the absence of any task, by resting state functional magnetic resonance imaging connectivity analyses in healthy volunteers. However, the functional significance of these spontaneous brain activity fluctuations remains unclear. The aim of this study was to test if the integrity of this resting-state connectivity pattern in the default network would differ in different pathological alterations of consciousness. Fourteen non-communicative brain-damaged patients and 14 healthy controls participated in the study. Connectivity was investigated using probabilistic independent component analysis, and an automated template-matching component selection approach. Connectivity in all default network areas was found to be negatively correlated with the degree of clinical consciousness impairment, ranging from healthy controls and locked-in syndrome to minimally conscious, vegetative then coma patients. Furthermore, precuneus connectivity was found to be significantly stronger in minimally conscious patients as compared with unconscious patients. Locked-in syndrome patient's default network connectivity was not significantly different from controls. Our results show that default network connectivity is decreased in severely brain-damaged patients, in proportion to their degree of consciousness impairment. Future prospective studies in a larger patient population are needed in order to evaluate the prognostic value of the presented methodology. [less ▲]

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