References of "Boniver, Jacques"
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See detailInteractions de cellules preleucemiques radio-induites et de greffe de moelle chez la Souris C57BL/Ka.
Humblet, Chantal ULg; Defresne, Marie-Paule ULg; Greimers, Roland ULg et al

in Comptes Rendus des Séances de la Société de Biologie et de ses Filiales (1987), 181(1), 82-7

The repopulation of thymus inoculated with radiation-induced preleukemia cells was studied in 400 R irradiated mice grafted with normal bone marrow cells. These marrow cells gave rise to an actively ... [more ▼]

The repopulation of thymus inoculated with radiation-induced preleukemia cells was studied in 400 R irradiated mice grafted with normal bone marrow cells. These marrow cells gave rise to an actively regenerating thymic progeny, as well as in 400 R treated mice receiving only a bone marrow graft. Moreover, the marrow graft did not prevent the progression of inoculated preleukemic cells towards lymphoma growth. [less ▲]

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See detailRelations entre la capacite de repeuplement thymique et de formation de lymphomes exprimee par des cellules preleucemiques radio-induites chez la Souris C57BL/Ka.
Rongy, A. M.; Defresne, Marie-Paule ULg; Greimers, Roland ULg et al

in Comptes Rendus des Séances de la Société de Biologie et de ses Filiales (1987), 181(1), 88-93

We have analyzed the repopulation of thymuses injected with preleukemic cells obtained at various interval after fractionated irradiation. Our results show that preleukemic cells can repopulate the thymus ... [more ▼]

We have analyzed the repopulation of thymuses injected with preleukemic cells obtained at various interval after fractionated irradiation. Our results show that preleukemic cells can repopulate the thymus transiently as normal thymocytes or they can proliferate in recipients. In all cases, preleukemic cells can give rise to donor lymphomas. [less ▲]

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See detailThe neuroendocrine thymus: Coexistence of oxytocin and neurophysin in the human thymus
Geenen, Vincent ULg; Legros, Jean-Jacques ULg; Franchimont, Paul et al

in Science (1986), 232

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See detailThe thymus as a neuroendocrine organ
Geenen, Vincent ULg; Legros, Jean-Jacques ULg; Defresne, Marie-Paule ULg et al

in Neuroendocrinology (1986)

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See detailImmunocytochemical demontration of hormones in cell granules of several human pituitary adenomas
Beckers, Albert ULg; Courtoy, R.; Stevenaert, Achille ULg et al

in Histochemical Journal (The) (1986), 18(1), 55

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See detailPhenotype of thymic lymphomas in the mouse.
Greimers, Roland ULg; Rongy, Anne Michel; Defresne, Marie-Paule ULg et al

in Leukemia Research (1986), 10(7), 777-82

The MP2 cell line was established from a murine leukemia virus-induced thymic lymphoma. Half of the cells were consistently L3T4 positive and less than 5% of the cells were Lyt-2 positive. Single cell ... [more ▼]

The MP2 cell line was established from a murine leukemia virus-induced thymic lymphoma. Half of the cells were consistently L3T4 positive and less than 5% of the cells were Lyt-2 positive. Single cell cloning on the basis of the presence or absence of Lyt-2 allowed the isolation of four clones with stable phenotypes: (1) Lyt-2-, L3T4-; (2) Lyt-2+, L3T4+; (3) Lyt-2-, L3T4+; (4) Lyt2+, L3T4-. These data are discussed in relation to tumour cell heterogeneity and to normal T-cell differentiation pathways. [less ▲]

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See detailEffects of marrow grafting on preleukemia cells and thymic nurse cells in C57BL/Ka mice after a leukemogenic split-dose irradiation.
Defresne, Marie-Paule ULg; Greimers, Roland ULg; Lenaerts, Patrick et al

in Journal of the National Cancer Institute (1986), 77(5), 1079-85

A split-dose regimen of whole-body irradiation (4 X 175 rad at weekly intervals) induced thymic lymphomas in C57BL/Ka mice after a latent period of 3-9 months. Meanwhile, preleukemia cells arose in the ... [more ▼]

A split-dose regimen of whole-body irradiation (4 X 175 rad at weekly intervals) induced thymic lymphomas in C57BL/Ka mice after a latent period of 3-9 months. Meanwhile, preleukemia cells arose in the thymus and bone marrow and persisted until the onset of lymphomas. Simultaneously, thymic lymphopoiesis was impaired; thymocyte numbers were subnormal and thymic nurse cells disappeared in a progressive but irreversible fashion. The depletion of these lymphoepithelial complexes, which are normally involved in the early steps of thymic lymphopoiesis, was related to altered prothymocyte activity in bone marrow and to damaged thymic microenvironment, perhaps as a consequence of the presence of preleukemia cells. The grafting of normal bone marrow cells after irradiation prevented the development of lymphomas. However, marrow reconstitution did not inhibit the induction of preleukemia cells. They disappeared from the thymus during the second part of the latent period. At the same time, thymic lymphopoiesis was restored; thymocytes and nurse cell numbers returned to normal as a consequence of the proliferation of grafted marrow-derived cells within the thymus. The results thus demonstrated an intimate relationship between preleukemia cells and an alteration of thymic lymphopoiesis, which particularly involved the nurse cell microenvironment. Some preleukemia cells in marrow-reconstituted, irradiated mice derived from the unirradiated marrow inoculate. Thus these cells acquired neoplastic potential through a factor present in the irradiated tissues. The nature of this indirect mechanism was briefly discussed. [less ▲]

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See detailIn situ characterization in freeze-fractured mouse thymuses of lymphoepithelial complexes ultrastructurally similar to isolated thymic nurse cells.
Defresne, Marie-Paule ULg; Goffinet, Gerhard ULg; Boniver, Jacques ULg

in Tissue & Cell (1986), 18(3), 321-30

Scanning and transmission electron microscopy of the cracked surfaces of cryofractured pre-fixed C57BL/Ka mouse thymus reveals the existence of cell complexes, distinct from the surrounding cell ... [more ▼]

Scanning and transmission electron microscopy of the cracked surfaces of cryofractured pre-fixed C57BL/Ka mouse thymus reveals the existence of cell complexes, distinct from the surrounding cell organization, in which groups of lymphocytes are delimited by large cytoplasmic sheets or envelopes. These complexes, located in the subcapsular and cortical regions, display morphological features similar to that of the thymic nurse cells (TNCs), which can be isolated from the mouse or human thymus enzymatically dissociated. They can be considered as dynamic systems able to modify their three-dimensional organization, namely with regard to intrathymic cellular traffic involved in T-lymphocyte maturation. [less ▲]

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See detailImmunocytochemical demonstration of hormones in cells granules of several human pituitary adenomas
Beckers, Albert ULg; Stevenaert, Achille ULg; Courtoy, R. et al

in Histochemical Journal (The) (1986)

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See detailThe neuroendocrine thymic microenvironment
Geenen, Vincent ULg; Legros, Jean-Jacques ULg; Adam, Francine et al

in Journal of Endocrinology (1986), 111 (Suppl.)

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See detailA propos d'un séminome médiastinal.
Gilis, F.; Massart, B.; LIFRANGE, Eric ULg et al

in Revue Médicale de Liège (1985), 40(11), 474-9

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See detailLocalisation ultrastructurale d'hormones hypophysaires par reaction immunocytochimique sur coupes fines d'adenomes.
Beckers, Albert ULg; Courtoy, R.; Reznik, Michel ULg et al

in Comptes Rendus des Séances de la Société de Biologie et de ses Filiales (1985), 179(3), 397-402

Human pituitary adenomas were fixed in glutaraldehyde and embedded in epon. Ultrathin sections were incubated either with anti-hGH, anti-hPRL or anti-hLH. They were incubated with second step goat anti ... [more ▼]

Human pituitary adenomas were fixed in glutaraldehyde and embedded in epon. Ultrathin sections were incubated either with anti-hGH, anti-hPRL or anti-hLH. They were incubated with second step goat anti-rabbit immunoglobulins linked to gold particles. Two PRL secreting adenomas, one GH and PRL secreting adenoma, one ACTH secreting adenoma and two non secreting adenomas were studied. The specificity and the limits of the method were discussed in relation with the results obtained in light microscopy with the PAP method. [less ▲]

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See detailImmunogold staining of pituitary hormones in human adenoma biopsies
courtoy, r; Beckers, Albert ULg; Stevenaert, Achille ULg et al

in Biology of the Cell (1985)

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See detailUltrastructural immunocytochemical localization of hormones in human pituitary adenomas
Beckers, Albert ULg; Courtoy, R.; Stevenaert, Achille ULg et al

in Neuroendocrinology letters (1985)

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See detailImmunogold staining of pituitary hormones in human adenoma biopsies.
Beckers, Albert ULg; Courtoy, R.; Reznik, Michel ULg et al

in Biology of the Cell (1985)

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See detailIsolation of follicular dendritic cells from human tonsils and adenoids. II. Immunocytochemical characterization.
Heinen, Ernst ULg; Lilet, Chantal ULg; Mason, D. Y. et al

in European Journal of Immunology (1984), 14(3), 267-73

Follicular dendritic cells (FDC) are specialized cells found only within lymphoid follicles. They bind immune complexes and play a role in the presentation of antigen to follicular B cells and in the ... [more ▼]

Follicular dendritic cells (FDC) are specialized cells found only within lymphoid follicles. They bind immune complexes and play a role in the presentation of antigen to follicular B cells and in the generation of B cell memory. In the present report the isolation of FDC from human tonsils and adenoids is described. These isolated cells have an unusual spherical arrangement and enclose lymphocytes within extensions of their membranes. Their ultrastructural features are similar to those observed in situ. The reactivity of isolated FDC with a number of monoclonal antibodies was analyzed by immunofluorescence and by immunostaining (at the electron microscopic level) with colloidal gold. In keeping with the results of previous investigations on tissue sections IgM, IgG and IgA (but not IgD) can be detected on the surface of isolated FDC, as can C3b receptors and the FDC-associated antigen detected by monoclonal antibody R4/23. The immunoglobulins associated with FDC are mostly embedded in an electron-dense material. The majority of the lymphoid cells enclosed within the membrane extensions of FDC are of B cell type. These results suggest that isolated FDC may be suitable for further in vitro investigation of their role in the humoral immune response. [less ▲]

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See detailThe basement membrane proteins laminin and type IV collagen in isolated villi in pre-eclampsia
Risteli, J.; Foidart, Jean-Michel ULg; Risteli, L. et al

in Placenta (1984), 5(6), 541-50

The distribution and concentrations of the basement membrane proteins laminin and type IV collagen were studied in isolated placental villi in normal pregnancy and in pre-eclampsia. In both cases these ... [more ▼]

The distribution and concentrations of the basement membrane proteins laminin and type IV collagen were studied in isolated placental villi in normal pregnancy and in pre-eclampsia. In both cases these proteins could be localized by immunofluorescence in the trophoblast and capillary basement membranes, and occasionally also in the matrix surrounding the capillaries. The basement membrane proteins were quantified by solubilizing the villi with proteolytic enzymes and by subsequently measuring the concentrations of two resistant domains of these proteins (7-S collagen and the fragment PI, representing type IV collagen and laminin, respectively) with specific radioimmunoassays. The ratio type IV collagen:laminin was significantly higher in pre-eclamptic samples than in the controls, most probably reflecting a decrease in laminin concentration in the villi in pre-eclampsia. Such a change in the chemical composition of placental basement membranes could weaken the attachment of trophoblast cells to the underlying basement membrane and also modify the permeability and exchange properties of the villi. [less ▲]

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