References of "Blacher, Silvia"
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See detailRole of co-reactants during the formation of silica gels assessed by in situ SAXS
Gommes, Cédric ULg; goderis, bart; Pirard, Jean-Paul ULg et al

Conference (2006, August)

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See detailStudy of the dynamics of water adsorption on activated carbon by a combination of high resolution x-ray microtomography and breakthrough measurements
Lodewyckx, Peter; Wullens, Hilda; Léonard, Angélique ULg et al

in Proceedings of Carbon 2006 (2006, July)

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See detailMembrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases
Chabottaux, Vincent; Sounni, Nor Eddine ULg; Pennington, C. J. et al

in Cancer Research (2006), 66(10), 5165-5172

Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct membrane-associated MMPs. Although the contribution of MT1-MMP during different steps of cancer progression has been ... [more ▼]

Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct membrane-associated MMPs. Although the contribution of MT1-MMP during different steps of cancer progression has been well documented, the significance of other MT-MMPs is rather unknown. We have investigated the involvement of MT4-MMP, a glycosylphosphatidylinositol-anchored protease, in breast cancer progression. Interestingly, immunohistochemical analysis shows that MT4-MMP production at protein level is strongly increased in epithelial cancer cells of human breast carcinomas compared with normal epithelial cells. Positive staining for MT4-MMP is also detected in lymph node metastases. In contrast, quantitative reverse transcription-PCR analysis reveals similar MT4-MMP mRNA levels in human breast adenocarcinomas and normal breast tissues. Stable transfection of MT4-MMP cDNA in human breast adenocarcinoma MDA-MB-231 cells does not affect in vitro cell proliferation or invasion but strongly promotes primary tumor growth and associated metastases in RAG-1 immunodeficient mice. We provide for the first time evidence that MT4-MMP overproduction accelerates in vivo tumor growth, induces enlargement of i.t. blood vessels, and is associated with increased lung metastases. These results identify MT4-MMP as a new putative target to design anticancer strategies. [less ▲]

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See detailEarlier onset of tumoral anglogenesis in matrix metalloproteinase-19-deficient mice
Jost, M.; Folgueras, A. R.; Frerart, F. et al

in Cancer Research (2006), 66(10), 5234-5241

Among matrix metalloproteinases (MMP), MMP-19 displays unique structural features and tissue distribution. In contrast to most MMPs, MMP-19 is expressed in normal human epidermis and down-regulated during ... [more ▼]

Among matrix metalloproteinases (MMP), MMP-19 displays unique structural features and tissue distribution. In contrast to most MMPs, MMP-19 is expressed in normal human epidermis and down-regulated during malignant transformation and dedifferentiation. The contribution of MMP-19 during tumor angiogenesis is presently unknown. In an attempt to give new insights into MMP-19 in vivo functions, angiogenic response of mutant mice lacking MMP-19 was analyzed after transplantation of murine malignant PDVA keratinocytes and after injection of Matrigel supplemented with basic fibroblast growth factor. In situ hybridization and immunohistochemical analysis revealed that MMP-19 is produced by host mesenchymal cells but not by endothelial capillary cells or CD11b-positive inflammatory cells. Based on a new computer-assisted method of quantification, we provide evidence that host MMP-19 deficiency was associated with an increased early angiogenic response. In addition, increased tumor invasion was observed in MMP-19-/- mice. We conclude that, in contrast to most MMPs that promote tumor progression, MMP-19 is a negative regulator of early steps of tumor angiogenesis and invasion. These data highlight the requirement to understand the individual functions of each MMP to improve anticancer strategies. [less ▲]

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See detailCaractérisation de matériaux poreux par analyse d'images 3D
Blacher, Silvia ULg; Gommes, Cédric ULg; Léonard, Angélique ULg et al

Conference (2006, February)

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See detailUse of x-ray microtomography to visualise dynamic adsorption of organic vapour and water vapour on activated carbon
Lodewyckx, Peter; Blacher, Silvia ULg; Léonard, Angélique ULg

in Adsorption (2006), 12(1), 19-26

X-ray microtomography coupled with image analysis was used to quantify the adsorption of vapours on activated carbon beds. This technique was tested using three different challenges: CCl4, water vapour ... [more ▼]

X-ray microtomography coupled with image analysis was used to quantify the adsorption of vapours on activated carbon beds. This technique was tested using three different challenges: CCl4, water vapour and a mixture of water- and organic vapour. It is shown that the used technique allows determining the adsorption front progress in the case of organic vapour and mixture of water and organic vapour whereas the existence of this front was not so obvious in the case of water vapour. Experimental results obtained for organic vapours were interpreted on the basis of the Wheeler-Jonas equation: a good agreement was found between experimental and theoretical breakthrough times. [less ▲]

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See detailPlasminogen activator inhibitor type 1 (PAI-1) controls bone marrow-dependent and independent vascularization
Jost, M; Maillard, C; Lecomte, J et al

Poster (2006)

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See detaillymphatic ring assay: a new in vitro model of lymphangiogenesis
Bruyère, F; Melen, L; Blacher, Silvia ULg et al

Poster (2006)

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See detailThe lymphatic ring assay: a new in vitro model of lymphangiogenesis
Bruyère, F; Melen, L; Blacher, Silvia ULg et al

Conference (2006)

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See detailThe lymphatic ring assay: a new in vitro model of lymphangiogenesis
Bruyère, F; Melen, L; Blacher, Silvia ULg et al

Poster (2006)

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See detailThe porous structure of biodegradable scaffolds obtained with supercritical CO2 as foaming agent
Blacher, Silvia ULg; Calberg, Cédric ULg; Kerckhofs, Greet ULg et al

in Studies in Surface Science and Catalysis (2006), 160

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See detailThe porous structure of biodegradable scaffolds obtained with supercritical CO(2) as foaming agent
Blacher, Silvia ULg; Calberg, Cédric ULg; Kerckhofs, Greet ULg et al

in Studies in Surface Science and Catalysis (2006), 160

Poly(epsilon-caprolactone) foams were prepared, via a batch process, by using supercritical CO(2) as foaming agent. Their porous structure was characterized through helium and mercury pycnometry, scanning ... [more ▼]

Poly(epsilon-caprolactone) foams were prepared, via a batch process, by using supercritical CO(2) as foaming agent. Their porous structure was characterized through helium and mercury pycnometry, scanning electron microscopy (SEM) and X-ray microtomography observations coupled with image analysis. The pore size distributions obtained by these two latter techniques show that the pore structure is more homogeneous when the foaming process is performed under a high CO(2) saturation pressure (higher than 250 bars). [less ▲]

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See detailStructure of Silica Xerogels Synthesized with Organoalkoxysilane Co-reactants Hints at Multiple Phase Separation
Gommes, Cédric ULg; Basiura, Monika; Goderis, Bart et al

in Journal of Physical Chemistry B (2006), 110

The microstructure of hybrid silica xerogels synthesized by the base-catalyzed polymerization of tetraethoxysilane (TEOS) in ethanol in the presence of 3-aminopropyltriethoxysilane (AES) and of 3-(2 ... [more ▼]

The microstructure of hybrid silica xerogels synthesized by the base-catalyzed polymerization of tetraethoxysilane (TEOS) in ethanol in the presence of 3-aminopropyltriethoxysilane (AES) and of 3-(2-aminoethylamino)- propyltrimethoxysilane (EDAS) as co-reactants, and dried in subcritical conditions, is analyzed. A thorough structural characterization of the samples is performed combining nitrogen adsorption, small-angle X-ray scattering (SAXS), and transmission electron microscopy coupled with digital image analysis. The use of these methods shows that, for both co-reactants, the xerogels are made of macropores supported by filaments, with each filament being formed of smaller structures. The quantitative impact of the additive on each structural level is assessed. The data are compared with a previous time-resolved SAXS study conducted during the formation of the gels (J. Phys. Chem. B 2004, 108, 8983-8991). The results are analyzed in the framework of a double phase separation model. [less ▲]

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See detailPlasminogen activator inhibitor type I (PAI-1) controls bone marrow-dependent and independent vascularization
Jost, M.; Maillard, Catherine ULg; Lambert, Vincent ULg et al

in Acta Clinica Belgica (2006), 61(2, MAR-APR), 87

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See detailHigh-resolution X-ray microtomography to determine the kinetics of water vapour adsorption
Lodewyckx, Peter; Léonard, Angélique ULg; Blacher, Silvia ULg

Conference (2005, October)

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See detailStudy of the connectivity properties of Bioglass®-filled polylactide foam scaffolds by image analysis and impedance spectroscopy
Blacher, Silvia ULg; Maquet, Véronique; Jérôme, Robert ULg et al

in Acta Biomaterialia (2005), 1(5), 565-574

The porous structure of two series of poly(d,l-lactide)/Bioglass® composite foams prepared by thermal-induced phase separation was investigated by image analysis and impedance spectroscopy. Polymer ... [more ▼]

The porous structure of two series of poly(d,l-lactide)/Bioglass® composite foams prepared by thermal-induced phase separation was investigated by image analysis and impedance spectroscopy. Polymer solutions of either low or high molecular weight containing different concentrations (up to 50 wt.%) of Bioglass® particles of mean particle size d < 5 µm were studied. The morphology of both macro- and micropores was studied by scanning electron microscopy and image analysis of both neat and composite foams (containing 10-50 wt.% Bioglass®). The pore connectivity of both neat polymer and composite foams was characterized by impedance spectroscopy in relation with their transport properties. The influence of the foam composition (i.e., polymer molecular weight and concentration of Bioglass®) on pore microstructure was studied using these non-destructive methods. It was found that addition of Bioglass® particles has a pronounced effect on pore orientation, leading to increasing loss of order of pore structure, especially for low-molecular weight PDLLA foams. [less ▲]

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See detailQuantitative Morphological Studies of mesoporous Catalysts at Nanometer Scale Resolution
Ziese, Ulrike; Gommes, Cédric ULg; BLACHER, Silvia ULg et al

Poster (2005, August)

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See detailPhase separation during silica gel formation followed by time-resolved SAXS
Gommes, Cédric; Blacher, Silvia ULg; Goderis, Bart et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (2005), 238(1-4), 141-145

Time-resolved small angle X-ray scattering data are collected during the formation of silica gels from the base catalyzed polymerization of tetraethoxysilane in ethanol with 3-(2-aminoethylamino ... [more ▼]

Time-resolved small angle X-ray scattering data are collected during the formation of silica gels from the base catalyzed polymerization of tetraethoxysilane in ethanol with 3-(2-aminoethylamino)propyltrimethoxysilane and 3-aminopropyltriethoxysilane as additives. It is shown that a polymerization-induced spinodal demixing occurs during the gel formation. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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