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See detailInhibition of tumor growth and metastasis establishment by adenovirus-mediated gene transfer delivery of the antiangiogenic factor 16K hPRL
Nguyen, Ngoc-Quynh-Nhu ULg; Cornet, Anne ULg; Blacher, Silvia ULg et al

in Molecular Therapy : The Journal of the American Society of Gene Therapy (2007), 15(12), 2094-2100

Tumor metastases, the most fearsome aspect of cancer, are generally resistant to conventional therapies. Angiogenesis is a crucial aspect of tumor growth and metastatic dissemination. Antiangiogenic ... [more ▼]

Tumor metastases, the most fearsome aspect of cancer, are generally resistant to conventional therapies. Angiogenesis is a crucial aspect of tumor growth and metastatic dissemination. Antiangiogenic therapy, therefore, holds potential as an attractive strategy for inhibiting metastasis development. Human 16K PRL (16K hPRL), a potent inhibitor of angiogenesis, has been demonstrated to prevent tumor growth in two xenograft mouse models, but whether it also affects tumor metastasis is unknown. In this study we will investigate the ability of 16K hPRL to prevent the establishment of metastasis. We demonstrate that 16K hPRL administered via adenovirus-mediated gene transfer, inhibits tumor growth by 86% in a subcutaneous (SC) B16-F10 mouse melanoma model. Computer-assisted image analysis shows that 16K hPRL treatment results in a reduction of tumor-vessel length and width, leading to a 57% reduction of average vessel size. In a pre-established tumor model, moreover, 16K hPRL can significantly delay tumor development. Finally, for the first time, we provide evidence that 16K hPRL considerably reduces the establishment of B16-F10 metastasis in an experimental lung metastasis model. Both the number and size of metastases are reduced by 50% in 16K hPRL-treated mice. These results highlight a potential role for 16K hPRL in anticancer therapy for both primary tumors and metastases. [less ▲]

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See detailObservation of wall effects in activated carbon filters by x-ray µCT
Léonard, Angélique ULg; Wullens, Hilda; Blacher, Silvia ULg et al

in Mc Cann, H.; Johansen, G. A. (Eds.) Proceedings of the 5th World Congress on Industrial Process Tomography, Bergen, Norway, September 6-9, 2007 (2007, September)

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See detailWater desorption isotherms of resorcinol-formaldehyde and carbon xerogels
Léonard, Angélique ULg; Escalona, I.; Job, Nathalie ULg et al

Poster (2007, July 15)

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See detailBranching, aggregation, and phase separation during the gelation of tetraethoxysilane
Gommes, Cédric; Goderis, Bart; Pirard, Jean-Paul ULg et al

in Journal of Non-Crystalline Solids (2007), 353(24-25), 2495-2499

Time-resolved small-angle X-ray scattering is used to follow in situ the structuring of silica sols and gels in various chemical conditions. The acid-catalyzed and base-catalyzed polymerizations of TEOS ... [more ▼]

Time-resolved small-angle X-ray scattering is used to follow in situ the structuring of silica sols and gels in various chemical conditions. The acid-catalyzed and base-catalyzed polymerizations of TEOS, as well as the copolymerization of TEOS with organically modified trialkoxysilanes, are followed. The analysis points to the diversity of the mechanisms that govern the structuring of the reacting solutions, and most notably to the important role of physical forces. (C) 2007 Elsevier B.V.All rights reserved. [less ▲]

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See detailWater desorption isotherms of resorcinol-formaldehyde and carbon xerogels
Léonard, Angélique ULg; Escalona, Ivonne; Job, Nathalie ULg et al

in The American Carbon Society (Ed.) Proceedings of Carbon 2007 (2007, July)

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See detailRe-evaporation of adsorbed (toxic) compounds inside an activated carbon filter
Léonard, Angélique ULg; Blacher, Silvia ULg; Wullens, Hilda et al

in The American Carbon Society (Ed.) Proceedings of Carbon 2007 (2007, July)

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See detail3D image analysis of electron tomograms of clay/rubber nanocomposites
Gommes, Cédric ULg; Bons, A-J; BLACHER, Silvia ULg

Conference (2007, May)

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See detailCharacterization of dried banana chips quality by X-ray µ-CT
Léonard, Angélique ULg; Nimmol, Chatchai; Blacher, Silvia ULg et al

Conference (2007, April)

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See detailNon-destructive characterization of deer (Cervus Elaphus) antlers by X-ray microtomography coupled with image analysis
Léonard, Angélique ULg; Guiot, L. P.; Pirard, Jean-Paul ULg et al

in Journal of Microscopy-Oxford (2007), 225(Pt 3), 258-263

X-ray microtomography coupled with image analysis was tested as a non-destructive alternative method for the textural characterization of the trabecular part of deer antlers (Cervus Elaphus). As gas ... [more ▼]

X-ray microtomography coupled with image analysis was tested as a non-destructive alternative method for the textural characterization of the trabecular part of deer antlers (Cervus Elaphus). As gas adsorption and mercury intrusion cannot be applied on this soft and spongy material, its pore texture was, up to now, determined from histological sections that give only two-dimensional information. In this work, X-ray microtomography is used to scan entire or half pieces of antlers and three-dimensional image analysis is performed in order to assess the differences between samples collected at various antler locations. Results clearly show a porosity profile along the sample diameter. The pore size distribution is showed to be dependent on the sample original site. [less ▲]

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See detail3D image analysis characterization of dried banana
Léonard, Angélique ULg; Devahastin, Sakamon; Blacher, Silvia ULg

Conference (2007, February)

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See detailThe lymphatic ring assay: a new in vitro model of lymphangiogenesis
Bruyère, F; Melen, L; Blacher, Silvia ULg et al

Poster (2007)

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See detailVascular architecture of breast cancer xenographs over-expressing MT4-MMP
Chabottaux, V; Thiry, Marc ULg; Alvarez Gonzalez, M-L et al

Poster (2007)

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See detailVascular architecture of breast cancer xenographs over-expressing MT4-MMP
Chabottaux, V; Thiry, Marc ULg; Blacher, Silvia ULg et al

Poster (2007)

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See detailVascular architecture of breast cancer xenographs over-expressing MT4-MMP
Chabottaux, V; Thiry, Marc ULg; Blacher, Silvia ULg et al

Poster (2007)

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See detailCompressing some sol-gel materials reduces their stiffness: a textural analysis
Gommes, Cédric ULg; Job, Nathalie ULg; Blacher, Silvia ULg et al

in Studies in Surface Science and Catalysis (2007), 160

The mechanical behaviour of two series of silica and of resorcinol xerogels is analyzed by mercury porosimetry. The data are expressed as pressure-density curves, which enables textural information to be ... [more ▼]

The mechanical behaviour of two series of silica and of resorcinol xerogels is analyzed by mercury porosimetry. The data are expressed as pressure-density curves, which enables textural information to be obtained. In particular, it is shown that some of the analyzed samples exhibit a marked lowering of their mechanical stiffness upon compression. This observation is analyzed in terms of the collapse of the sample’s porosity and of the heterogeneity of the microstructure. [less ▲]

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See detailMultiscale image analysis of microcellular solids: application to hybrid silica xerogels
Gommes, Cédric ULg; Pirard, Jean-Paul ULg; Blacher, Silvia ULg

in Journal of Microscopy (2007), 226

A general methodology is proposed to characterize microcellular solids, the structure of which consists of a three-dimensional network of filamentary structures. The analysis is based on transmission ... [more ▼]

A general methodology is proposed to characterize microcellular solids, the structure of which consists of a three-dimensional network of filamentary structures. The analysis is based on transmission electron microscopy observation of the filaments individually and of their spatial arrangement. The micrographs are analyzed with greytone digital image analysis techniques, such as opening granulometry and correlation analysis. The methodology is applied to hybrid organic–inorganic low-density silica solids synthesized by the sol–gel method with an organically modified co-reactant. The quantitative impact of the coreactant on each structural level of the structure is assessed quantitatively. [less ▲]

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See detailCharacterization of dried banana porous structure by X-ray microtomography coupled with image analysis
Léonard, Angélique ULg; Blacher, Silvia ULg; Devahastin, Sakamon

in Chen, Guohua (Ed.) The proceedings of the 5th Asia-Pacific Drying Conference, Hong Kong, 13 – 15 August 2007, Vol. 1 (2007)

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