References of "Beckers, Albert"
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See detailAbcès thyroïdien a streptocoque pneumoniae associé à un goitre nodulaire toxique. A propos d'un cas
Panas, N.; Zgheib, A.; Desaive, Claude ULg et al

in Semaine des Hôpitaux de Paris (La) (1991), 34

An unusual case of acute suppurative thyroiditis in association with toxic nodular goiter is reported by the authors. Surgical therapy was necessary due to the severity of the local and systemic ... [more ▼]

An unusual case of acute suppurative thyroiditis in association with toxic nodular goiter is reported by the authors. Surgical therapy was necessary due to the severity of the local and systemic inflammation induced by this association. [less ▲]

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See detailCV 205-502 : Een niewe lang-werkende dopamine-agonist voor de behandeling van hyperprolactinemie.
Verhelst, J.; Abs, R.; Beckers, Albert ULg et al

in Tijdschrift voor Geneeskunde (1991)

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See detailAcute effects of Parlodel-LAR and response to long-term treatment with bromocriptine in a patient with a follicle stimulating hormone-secreting pituitary adenoma.
Abs, R.; Parizel, P. M.; Beckers, Albert ULg

in Journal of Endocrinological Investigation (1991), 14(2), 135-8

A 68-year-old male patient presented with visual impairment due to a large pituitary tumor. After transsphenoidal adenomectomy the elevated serum FSH levels were lowered but not normalized. Deterioration ... [more ▼]

A 68-year-old male patient presented with visual impairment due to a large pituitary tumor. After transsphenoidal adenomectomy the elevated serum FSH levels were lowered but not normalized. Deterioration of the vision was detected five years later and tumor regrowth was evidenced. The patient was treated with the long-acting and repeatable form of bromocriptine (Parlodel-LAR). Three days after the first intramuscular injection it already resulted in an important improvement of the visual field defects. Serum FSH concentration was suppressed during a prolonged period, but no change in the size of the pituitary adenoma was recorded on CT scan. Long-term oral treatment with bromocriptine resulted in a sustained suppression of the serum FSH levels, without further visual improvement, but with a significant reduction of the volume of the adenoma. The rapid and prolonged effect of Parlodel-LAR upon the FSH secretion, with a possible correction of the visual field defects and a reduction of the tumor mass, could make this medication appropriate as adjunctive treatment in some gonadotroph cell adenomas. [less ▲]

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See detailImmunocytochemical evidence for production of luteinizing hormone and follicle-stimulating hormone in separate cells in the bovine.
Bastings, E.; Beckers, Albert ULg; Reznik, Michel ULg et al

in Biology of Reproduction (1991), 45(5), 788-96

In all mammalian females, follicular growth and maturation are essentially dependent on the pituitary gonadotropins, FSH and LH. These glycoprotein hormones have many similarities, but their action, based ... [more ▼]

In all mammalian females, follicular growth and maturation are essentially dependent on the pituitary gonadotropins, FSH and LH. These glycoprotein hormones have many similarities, but their action, based on high affinity binding to specific membrane receptors, are quite different. The purpose of this study was to perform a sensitive localization of FSH and LH in secretory granules of gonadotrophs using highly specific antisera. This morphological study included light microscopy (PAP) and electron microscopy (immunogold single and double labeling) procedures. Histologically, approximatively 11.5% of cells were positive for LH, whereas only 5.4% of cells were positive for FSH. With the electron microscope, single labeling allowed identification of morphologically distinct LH-containing cells and FSH-containing cells. Double immunostaining confirmed that no cells contained both hormones. The finding that FSH and LH are produced in separate pituitary cells is in agreement with recent studies that have suggested a specific role and regulatory process for gonadotropins in the bovine species. [less ▲]

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See detailAbcès thyroïdien a streptocoque pneumoniae associé à un goitre nodulaire toxique. A propos d'un cas
Panas, N.; Zgheib, A.; Desaive, Claude ULg et al

in Annales de Chirurgie (1991), 45(5), 429-31

An unusual case of acute suppurative thyroiditis in association with toxic nodular goiter is reported by the authors. Surgical therapy was necessary due to the severity of the local and systemic ... [more ▼]

An unusual case of acute suppurative thyroiditis in association with toxic nodular goiter is reported by the authors. Surgical therapy was necessary due to the severity of the local and systemic inflammation induced by this association. [less ▲]

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See detailMedico-surgical treatment of acromegaly.
Stevenaert, Achille ULg; Beckers, Albert ULg

in Journal of Endocrinological Investigation (1991)

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See detailCoexistence of Cushing's disease with uninodular adrenal hyperplasia.
Nobels, F.; Abs, R.; Beckers, Albert ULg

in Journal of Endocrinological Investigation (1991)

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See detailPresurgical Sandostatin treatment in acromegaly.
Stevenaert, Achille ULg; Beckers, Albert ULg

Conference (1991)

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See detailAcromegaly, multinodular goiter, and silent polyostotic fibrous dysplasia : a variant of the Mc Cune Albright syndrome.
Abs, R.; Beckers, Albert ULg; Stevenaert, Achille ULg et al

in Journal of Endocrinological Investigation (1990), 13(8), 671-675

A 36-year-old woman is reported with a possible variant of the McCune-Albright syndrome. The triad was incomplete because of the absence of skin pigmentation and since the sexual precocity was not evident ... [more ▼]

A 36-year-old woman is reported with a possible variant of the McCune-Albright syndrome. The triad was incomplete because of the absence of skin pigmentation and since the sexual precocity was not evident. The presence of a pituitary mass and the secretory dynamics of growth hormone and prolactin were suggestive of a mammosomatotroph cell adenoma. A toxic multinodular goiter was also associated, but unique was the spontaneous normalization of the thyroid function. Unusual was the silent evolution of the polyostotic fibrous dysplasia, which was only fortuitously discovered during magnetic resonance imaging of the pituitary region. Treatment of the acromegaly with the long-acting somatostatin analogue octreotide resulted in an important inhibition of the GH secretion and in a reduction of the volume of the pituitary adenoma. [less ▲]

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See detailPituitary microadenomas: diagnosis with two-and three-dimensional MR imaging at 1.5 T before and after injection of gadolinium.
Stadnik, T.; Stevenaert, Achille ULg; Beckers, Albert ULg et al

in Radiology (1990), 176(2), 419-428

The usefulness of different magnetic resonance (MR) imaging sequences (coronal and sagittal spin-echo [SE] and three-dimensional fast low-angle shot [3D FLASH]) in the detection of pituitary microadenomas ... [more ▼]

The usefulness of different magnetic resonance (MR) imaging sequences (coronal and sagittal spin-echo [SE] and three-dimensional fast low-angle shot [3D FLASH]) in the detection of pituitary microadenomas before and after gadolinium injection was prospectively evaluated in 28 patients with surgical confirmation. When evaluated separately, the most useful sequences in the detection of these microadenomas were coronal pregadolinium T1-weighted SE, coronal pregadolinium 3D FLASH, coronal postgadolinium T1-weighted SE, and coronal postgadolinium 3D FLASH. The combination of pre- and postgadolinium T1-weighted sequences with pre-and postgadolinium 3D FLASH sequences produced the highest number of true-positive findings (90%) and the lowest number of false-positive findings (5%). When a 1.5-T imaging unit with a high signal-to-noise ratio allowing useful three-dimensional acquisition is used, the authors advocate a coronal T1-weighted SE sequence, followed (if necessary) by a coronal 3D FLASH sequence, both without injection of gadolinium, in the diagnosis of pituitary microadenomas. When no confident diagnosis is reached, the same sequences should be performed after the injection of gadolinium. The sagittal pre- and postgadolinium T1-weighted SE and long-TR SE sequences are useful only in specific cases. [less ▲]

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See detailPlacental and Pituitary Growth Hormone Secretion During Pregnancy in Acromegalic Women
Beckers, Albert ULg; Stevenaert, Achille ULg; Foidart, Jean-Michel ULg et al

in Journal of Clinical Endocrinology and Metabolism (1990), 71(3), 725-31

It is now well established that during the second half of normal pregnancy, the human placenta secretes its specific GH variant (placental GH) in increasing amounts up to delivery. During the same period ... [more ▼]

It is now well established that during the second half of normal pregnancy, the human placenta secretes its specific GH variant (placental GH) in increasing amounts up to delivery. During the same period, pituitary GH secretion is progressively suppressed. The present study was aimed at clarifying the physiology of GH secretion in pregnant acromegalic women. Two young women remained acromegalic despite transphenoidal removal of their pituitary adenoma. Increased basal levels of GH and insulin-like growth factor-I (IGF-I) as well as paradoxical GH release after TRH injection were noted. Both women became pregnant and delivered term babies without any complication. In both patients, pituitary GH remained elevated during the entire pregnancy, contrary to the situation in normal women. Paradoxical GH release after TRH treatment was also present, whereas no response was observed in five normal control subjects. GH pulsatility studies revealed a highly pulsatile secretory pattern of pituitary GH, in contrast to that in normal woman, whose placental GH is secreted tonically. Tissue placental GH concentrations were within the range of levels in normal placentas. An increase in serum IGF-I in late pregnancy was also similar to that observed in normal pregnancy. These findings confirm that increased IGF-I levels are not pituitary GH dependent in late pregnancy. They add new evidence that adenomatous somatotrophs lack an IGF-I-dependent feedback regulation present in normal somatotrophs. [less ▲]

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See detailCyclical Cushing's disease and its successful control under sodium valproate.
Beckers, Albert ULg; Stevenaert, Achille ULg; Pirens, G. et al

in Journal of Endocrinological Investigation (1990), 13(11), 923-9

Several subgroups of Cushing's disease were recently described (anterior or intermediate lobe origin, hyper-or hypo-pulsatility of cortisol, presence or absence of response after GRH or TRH, cyclical ... [more ▼]

Several subgroups of Cushing's disease were recently described (anterior or intermediate lobe origin, hyper-or hypo-pulsatility of cortisol, presence or absence of response after GRH or TRH, cyclical Cushing's disease). We present here a detailed case report on a patient suffering from Cushing's disease whose endocrine functions were extensively investigated. Treatment with bromocriptine, as well as subsequent transsphenoidal surgery, were followed by rapid but transient reversal of symptoms. When clinical manifestations reoccurred, daily measurements of free urinary cortisol revealed a cyclic pattern of cortisol hyperexcretion. A study of ultradian rhythm revealed hyperpulsatility of cortisol secretion. More interestingly, a treatment with sodium valproate, a drug known to inhibit CRH production, was followed by a rapid and longstanding normalization of clinical and biological data for 2 years. Based on these data, and on information from the literature, the present case of Cushing's disease exhibits characteristics suggesting a possible hypothalamic origin. [less ▲]

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See detailLocalization of gonadotropins in pituitaries of various animals especies and in humans
Bastings, E.; Beckers, Albert ULg; Reznik, M. et al

in de la Cruz, L. F.; Garcia Luna, M. T. (Eds.) Recent advances in growth and reproduction (1990)

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See detailImmunocytochemical evidence that LH and FSH are produced by distinct cells in bovine pituitary.
Bastings, E.; Beckers, Albert ULg; Reznik, M. et al

in Theriogenology January (1990)

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See detailGonadotropin secretion in the bovine : localization of LH and FSH in pituitaries by electron microscopy.
Bastings, E.; Beckers, Albert ULg; Reznik, M. et al

in Journal of Endocrinological Investigation (1990)

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See detailCyclical Cushing's disease : a case report.
Velkeniers, B.; Beckers, Albert ULg; Stevenaert, Achille ULg et al

in Société Belge de Médecine Interne (1990)

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See detailThyrotropin-secreting pituitary adenomas : report of 7 cases.
Beckers, Albert ULg; Abs, R.; Mahler, C. et al

in Journal of Endocrinological Investigation (1990)

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