References of "Beckers, Albert"
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See detailThyroïde et grossesse
Beckers, Albert ULg

Scientific conference (1996, October)

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See detailLes processus expansifs endosellaires non adénomateux
Beckers, Albert ULg

Scientific conference (1996, September)

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See detailPresurgical Octreotide: Treatment in Acromegaly
Stevenaert, Achille ULg; Beckers, Albert ULg

in Metabolism : Clinical and Experimental (1996), 45(8 Suppl. 1), 72-4

One hundred seventy-two acromegalics who were operated on using the trans-sphenoidal approach underwent long-term follow-up evaluation. Sixty-four received 100 micrograms octreotide subcutaneously three ... [more ▼]

One hundred seventy-two acromegalics who were operated on using the trans-sphenoidal approach underwent long-term follow-up evaluation. Sixty-four received 100 micrograms octreotide subcutaneously three times daily: for 3 to 6 weeks before surgery in 14 patients (group 1); and for 3 to 9 months in 41 and for 13 to 39 months in nine (n = 50, group 2). In 18 group 2 patients, the dose was increased stepwise to 500 micrograms three times daily because of incomplete suppression of growth hormone (GH)/insulin-like growth factor-1 (IGF-1). Tumor shrinkage was seen in 60% within 3 weeks, being nearly maximal by 3 to 4 months. More group 2 patients had greater than 25% tumor shrinkage (14 of 48 v 1 of 14 in group 1). Clinical response was excellent or good in 89%. Decrease in soft-tissue swelling and weight loss, and improved vitality, performance, carbohydrate metabolism, and cardiovascular function, facilitated anesthetic and surgical management; tumor removal was easy in virtually all cases. In all 64 patients, GH levels decreased by > or = 50%, and to < 2 micrograms/L in three of 14 patients initially and 25 of 50 patients after more prolonged treatment. IGF-1 levels decreased to normal in seven of 14 group 1 and 31 of 50 group 2 patients. Light and electron microscopy showed that adenomatous tissue exposed to octreotide had lysosomal accumulation, amyloid deposition, mild to moderate perivascular fibrosis, and moderate size reduction in both cytoplasmic and nuclear areas, with virtually no cellular complications. Remission with enclosed adenomas was greater (p < .05) than for the 108 patients not treated with octreotide; there was no difference for invasive adenomas. Octreotide use for 3 to 4 months before surgery can be recommended. [less ▲]

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See detailPathologies hypophysaires
Beckers, Albert ULg

Scientific conference (1996, April 23)

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See detailLes adénomes hypophysaires gonadotropes
Beckers, Albert ULg

Scientific conference (1996, March 03)

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See detailAspect diagnostic du nodule thyroïdien isolé
Beckers, Albert ULg

Scientific conference (1996, January 20)

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See detailCabergoline, a new long-acting dopamine agonist, in the treatment of acromegaly
Abs, R.; Verhelst, J.; Verbessem, G. et al

in 10th international Congress of Endocrinology - Abstract book (1996)

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See detailLes adénomes gonadotropes
Beckers, Albert ULg; Stevenaert, Achille ULg

in Revue Française d'Endocrinologie Clinique, Nutrition, et Métabolisme (La) (1996), 37(4-5), 299-305

Les adénomes hypophysaires gonadotropes qui sont parmi les plus fréquents, ont été identifiés récemment; on estime aujourd'hui qu'environ 80 % des adénomes hypophysaires dits non-sécrétants sont en fait ... [more ▼]

Les adénomes hypophysaires gonadotropes qui sont parmi les plus fréquents, ont été identifiés récemment; on estime aujourd'hui qu'environ 80 % des adénomes hypophysaires dits non-sécrétants sont en fait gonadotropes. Étant donné l'absente de symptomatologie spécifique, ils ne sont souvent reconnus que lorsqu'ils sont volumineux, ayant déjà entraîné un syndrome neurologique, une compression du chiasma optique. Dans la plupart des cas il est possible de les identifier grâce aux produits de sécrétion ou encore par méthodes d'immunohistochimie ou encore par la détection de l'ARN messager correspondant aux sous-unités hormonales. Le traitement reste essentiellement neuro-chirurgical (chirurgie trans-sphénoidale) car, dans la plupart des cas, les agonistes dopaminergiques et les analogues agonistes ou antagonistes de GnRH sont inefficaces. [less ▲]

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See detailAcromégalie et polypes coliques
Beckers, Albert ULg; Delhougne, B.; Deneux, C. et al

in Beckers, Albert (Ed.) Acromégalie : Les conséquences de l'hypersomatropisme (1996)

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See detailProcessus expansifs non adénomateux intrasellaires
rohmer, v; chanson, p; Dupas, B. et al

in Annales d'Endocrinologie (1996), 54(4), 264

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See detailDopamine D2 receptor gene expression in growth hormone-producing pituitary adenomas
Tabarin, A.; Carrié, F.; Ronci, N. et al

in 4th International Pituitary Congress of Endocrinology - Abstract book (1996)

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See detailTwo years or replacement therapy in 148 adults with growth hormone déficiency in Belgium
Verhelst, J.; Abs, R.; Mockel, J. et al

in 10th international Congress of Endocrinology - Abstract book (1996)

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See detailDopamine D2 receptor gene expression in growth hormone-producing pituitary adenomas
Tabarin, A.; Carrie, F.; Beckers, Albert ULg et al

in 10th international Congress of Endocrinology - Abstract book (1996)

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See detailAbsence d'effet de l'octréotide sur les concentrations plasmatiques de l'hormone de croissance placentaire
Caron, P.; Igout, A.; Hennen, Georges ULg et al

in Annales d'Endocrinologie (1996), 57(4), 335

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See detailPlacental growth hormone secretion is not influenced in vivo by octreotide therapy
Caron, P.; Igout, A.; Hennen, Georges ULg et al

in 10th international Congress of Endocrinology - Abstract book (1996)

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See detailThe treatment of prolactinomas with cabergoline
Beckers, Albert ULg; Louis, O.; Verhelst, J. et al

in 10th international Congress of Endocrinology - Abstract book (1996)

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See detailGrowth hormone secretion during pregnancy in an acromegalic woman
Petrossians, Patrick ULg; Chanson, P.; Schaison, G. et al

in 10th international Congress of Endocrinology - Abstract book (1996)

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See detailAcromégalie : Les conséquences de l'hypersomatropisme
Beckers, Albert ULg

Book published by Sandoz (1996)

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See detailThe prevalence of colonic polyps in acromegaly : a prospective colonoscopic and pathological study in 103 patients.
Delhougne, B.; Deneux, C.; Abs, R. et al

in Journal of Clinical Endocrinology and Metabolism (1995), 80(11), 3223-3226

Patients with acromegaly are reported to be at risk of developing adenomatous colonic polyps, which are considered to be preneoplastic lesions. This assumption is, however, usually drawn from results ... [more ▼]

Patients with acromegaly are reported to be at risk of developing adenomatous colonic polyps, which are considered to be preneoplastic lesions. This assumption is, however, usually drawn from results obtained in rather small series of patients or without a control group. We, therefore, undertook a prospective colonoscopic and pathological study comprising 103 acromegalic patients and 138 nonacromegalic control subjects referred for irritable bowel syndrome. The prevalence of adenomatous colonic polyps was significantly increased in acromegalic patients compared to that in control subjects (22.3% vs. 8.0%; P = 0.0024). The significance was similarly present in male acromegalic patients (28.6% vs. 5.5% in male control subjects; P = 0.0026), but was absent in female acromegalic patients. The prevalence of colonic polyps was also significantly increased in the group of acromegalic patients under 55 yr of age (20.0% vs. 3.0% in the control group of the same age; P = 0.0026). Other characteristics of adenomatous colonic polyps in acromegaly were the multiplicity and the presence proximal to the splenic flexure. No difference in the duration of acromegaly was found between patients with or without adenomatous polyps. The prevalence of hyperplastic colonic polyps was also significantly increased to 24.3% in acromegalic patients vs 4.4% in control subjects (P < 0.001). In conclusion, in view of the increased incidence of adenomatous colonic polyps, colonoscopy should be part of the follow-up examination in acromegaly. [less ▲]

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