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See detailPlacental and Pituitary Growth Hormone Secretion During Pregnancy in Acromegalic Women
Beckers, Albert ULg; Stevenaert, Achille ULg; Foidart, Jean-Michel ULg et al

in Journal of Clinical Endocrinology and Metabolism (1990), 71(3), 725-31

It is now well established that during the second half of normal pregnancy, the human placenta secretes its specific GH variant (placental GH) in increasing amounts up to delivery. During the same period ... [more ▼]

It is now well established that during the second half of normal pregnancy, the human placenta secretes its specific GH variant (placental GH) in increasing amounts up to delivery. During the same period, pituitary GH secretion is progressively suppressed. The present study was aimed at clarifying the physiology of GH secretion in pregnant acromegalic women. Two young women remained acromegalic despite transphenoidal removal of their pituitary adenoma. Increased basal levels of GH and insulin-like growth factor-I (IGF-I) as well as paradoxical GH release after TRH injection were noted. Both women became pregnant and delivered term babies without any complication. In both patients, pituitary GH remained elevated during the entire pregnancy, contrary to the situation in normal women. Paradoxical GH release after TRH treatment was also present, whereas no response was observed in five normal control subjects. GH pulsatility studies revealed a highly pulsatile secretory pattern of pituitary GH, in contrast to that in normal woman, whose placental GH is secreted tonically. Tissue placental GH concentrations were within the range of levels in normal placentas. An increase in serum IGF-I in late pregnancy was also similar to that observed in normal pregnancy. These findings confirm that increased IGF-I levels are not pituitary GH dependent in late pregnancy. They add new evidence that adenomatous somatotrophs lack an IGF-I-dependent feedback regulation present in normal somatotrophs. [less ▲]

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See detailCyclical Cushing's disease and its successful control under sodium valproate.
Beckers, Albert ULg; Stevenaert, Achille ULg; Pirens, G. et al

in Journal of Endocrinological Investigation (1990), 13(11), 923-9

Several subgroups of Cushing's disease were recently described (anterior or intermediate lobe origin, hyper-or hypo-pulsatility of cortisol, presence or absence of response after GRH or TRH, cyclical ... [more ▼]

Several subgroups of Cushing's disease were recently described (anterior or intermediate lobe origin, hyper-or hypo-pulsatility of cortisol, presence or absence of response after GRH or TRH, cyclical Cushing's disease). We present here a detailed case report on a patient suffering from Cushing's disease whose endocrine functions were extensively investigated. Treatment with bromocriptine, as well as subsequent transsphenoidal surgery, were followed by rapid but transient reversal of symptoms. When clinical manifestations reoccurred, daily measurements of free urinary cortisol revealed a cyclic pattern of cortisol hyperexcretion. A study of ultradian rhythm revealed hyperpulsatility of cortisol secretion. More interestingly, a treatment with sodium valproate, a drug known to inhibit CRH production, was followed by a rapid and longstanding normalization of clinical and biological data for 2 years. Based on these data, and on information from the literature, the present case of Cushing's disease exhibits characteristics suggesting a possible hypothalamic origin. [less ▲]

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See detailLocalization of gonadotropins in pituitaries of various animals especies and in humans
Bastings, E.; Beckers, Albert ULg; Reznik, M. et al

in de la Cruz, L. F.; Garcia Luna, M. T. (Eds.) Recent advances in growth and reproduction (1990)

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See detailImmunocytochemical evidence that LH and FSH are produced by distinct cells in bovine pituitary.
Bastings, E.; Beckers, Albert ULg; Reznik, M. et al

in Theriogenology January (1990)

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See detailGonadotropin secretion in the bovine : localization of LH and FSH in pituitaries by electron microscopy.
Bastings, E.; Beckers, Albert ULg; Reznik, M. et al

in Journal of Endocrinological Investigation (1990)

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See detailCyclical Cushing's disease : a case report.
Velkeniers, B.; Beckers, Albert ULg; Stevenaert, Achille ULg et al

in Société Belge de Médecine Interne (1990)

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See detailThyrotropin-secreting pituitary adenomas : report of 7 cases.
Beckers, Albert ULg; Abs, R.; Mahler, C. et al

in Journal of Endocrinological Investigation (1990)

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See detailThe physiology of pituitary and placental GH function during pregnancy in acromegalic as compared on normal women
Beckers, Albert ULg; Frankenne, F.; Stevenaert, Achille ULg et al

in Endocrinology under 35, sienna italy - Abstract book (1990)

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See detailPerinatal growth hormone (GH) physiology : effect of GH-releasing factor on maternal and fetal secretion of pituitary and placental GH.
De Zegher, F.; Vanderschueren-Lodeweyckx, M.; Spitz, B. et al

in Journal of Clinical Endocrinology and Metabolism (1990), 71(2), 520-522

To study regulation of the secretion of human pituitary GH (hGH) and placental GH (hPGH) in the pregnant woman and human fetus, the GH-releasing factor Sermorelin [GRF-(l–29)-NH2] was administered to ... [more ▼]

To study regulation of the secretion of human pituitary GH (hGH) and placental GH (hPGH) in the pregnant woman and human fetus, the GH-releasing factor Sermorelin [GRF-(l–29)-NH2] was administered to pregnant women at term (n = 5), just before elective cesarean section; saline was administered in control studies (n = 5). The effects of GRF-(1–29)-NH2 administration on maternal and fetal serum concentrations of hGH and GRF-(l–29)-NH2 and maternal serum levels of hPGH were evaluated at birth. The mean time span between injection and birth was 20 min (range, 15–25 min). Cord serum hGH concentrations were similar in infants of GRF-(1–29)-NH2-injected mothers and control infants. GRF-(l–29)-NH2 elicited a consistent but small rise in maternal hGH serum concentrations (P = 0.08), whereas hPGH concentrations remained unaltered. Finally, GRF-(l–29)-NH2 concentrations were undetectable in cord serum, but readily detectable in concomitantly obtained maternal serum. In conclusion, these data suggest that hGH secretion in the pregnant woman at term is suppressed at the pituitary level, that GRF does not affect hPGH secretion, and that fetal hGH secretion is independent of circulating maternal GRF, probably because of lack of transplacental GRF passage. [less ▲]

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See detailA follicle-stimulating-hormone secreting pituitary adenoma treated with long acting repeatable bromocriptine.
Abs, R.; Beckers, Albert ULg; De Longueville, M.

in Journal of Endocrinological Investigation (1990), 13

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See detailAspects immunohistomchimiques dans l'étude des adénomes hypophysaires
Beckers, Albert ULg

Scientific conference (1989, November 25)

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See detailRythmes sécrétoires dans la maladie de Cushing
Beckers, Albert ULg

Scientific conference (1989, November 25)

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See detailAdénomes gonadotropes et thyréotropes
Beckers, Albert ULg

Scientific conference (1989, November 25)

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See detailAcromegaly
Beckers, Albert ULg

Scientific conference (1989, June 22)

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See detailVestibular habituation training for positional vertigo in elderly patients.
Norre, M. E.; Beckers, Albert ULg

in Archives of Gerontology & Geriatrics (1989), 8(2), 117-122

Positional vertigo can be successfully treated by exercises (Vestibular Habituation Training, VHT) in elderly patients as well as in younger ones. Provided the patients have been correctly selected, this ... [more ▼]

Positional vertigo can be successfully treated by exercises (Vestibular Habituation Training, VHT) in elderly patients as well as in younger ones. Provided the patients have been correctly selected, this type of treatment is the only way for an adequate treatment of such a type of vertigo. Application of VHT has to be recommended also in elderly people, as the results obtained are as favourable as those in younger people. Only a slower evolution is observed, which can be correlated with a more restricted activity pattern in the elderly. [less ▲]

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