References of "Beckers, Albert"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailLearning from recombinant GH treatment in obesity
Vandeva, S.; Rixhon, M.; Tichomirova, M. A. et al

in Obesity and Metabolism (2009), 5(3/4), 156-166

Obese and untreated growth hormone deficiency (GHD) patients have a number of similar clinical and biological abnormalities. Treatment with recombinant human growth hormone (rhGH) in GHD patients has ... [more ▼]

Obese and untreated growth hormone deficiency (GHD) patients have a number of similar clinical and biological abnormalities. Treatment with recombinant human growth hormone (rhGH) in GHD patients has proven effective in beneficially modulating body composition and certain cardiovascular risk factors, thus leading to the hypothesis that administration of rhGH in obese patients could show similar beneficial results. Hyperinsulinism and increased free fatty acid levels are the main factors causing reduced GH release in the setting of obesity. We reviewed the outcomes of 25 adult and paediatric clinical studies carried out in 1987-2009 that examined the effects of rhGH administration in the obese state. Body composition showed mainly a reduction in visceral abdominal fat, whereas total bodyweight increased or remained unchanged. Effects of rhGH on lipid and carbohydrate metabolic profiles in obese patients were heterogeneous. The increasing burden of obesity on one hand, the absence of definitive medical treatment on the other, give rise to grounds for considering rhGH as a possible therapeutic option if not in the general obese population, at least in patients with higher risk of cardiovascular morbidity and mortality. [less ▲]

Detailed reference viewed: 11 (1 ULg)
See detailAn analysis of the role of cyclin dependant kinase inhibitor 1B (CDKN1B) gene mutations in 86 families with familial isolated pituitary adenomas (FIPA)
Tichomirova, M. A.; Daly, Adrian ULg; Pujol, Julien ULg et al

in The Endocrine Society's 91st Annual Meeting : 10-13 juin 2009, Washington (2009)

Detailed reference viewed: 23 (7 ULg)
See detailTSH-secreting pituitary adenoma in a male patient with a novel missense AIP mutation
Fajardo Montanana, C.; Daly, Adrian ULg; Tichomirova, M. A. et al

in The Endocrine Society's 91st Annual Meeting : 10-13 juin 2009, Washington (2009)

Detailed reference viewed: 14 (1 ULg)
See detailHigh Incidence of AIP mutations in sporadic pituitary adenomas in young patients with macroadenomas
Tichomirova, M. A.; Daly, Adrian ULg; Barlier, A. et al

in The Endocrine Society's 91st Annual Meeting : 10-13 juin 2009, Washington (2009)

Detailed reference viewed: 23 (2 ULg)
See detailA phase II exploratory study of BIM23A760 in acromegalic patients : preliminary results of safety and efficacy after a single-dose administration
Lesage, C.; Seymour, C.; Urbanavicius, V. et al

in The Endocrine Society's 91st Annual Meeting : 10-13 juin 2009, Washington (2009)

Detailed reference viewed: 37 (0 ULg)
See detailCushing disease : Influence of microsurgery on hormonal balance
Vroonen, Laurent ULg; Martin, Didier ULg; Valdes Socin, Hernan Gonzalo ULg et al

in European Neuroendocrine Association - Workshop : Novel insights in the management of Cushing's syndrome (2009)

Detailed reference viewed: 18 (2 ULg)
See detailCushing disease : Pituitary microsurgery on hormonal balance
Stevenaert, Achille ULg; Vroonen, Laurent ULg; Perrin, G. et al

in European Neuroendocrine Association - Workshop : Novel insights in the management of Cushing's syndrome (2009)

Detailed reference viewed: 14 (1 ULg)
See detailThe Genetics in Cushing syndrome
Vandeva, S.; Daly, Adrian ULg; Vroonen, Laurent ULg et al

in European Neuroendocrine Association - Workshop : Novel experimental data on the pituitary and adrenal tumors responsible for Cushing's syndrome (2009)

Detailed reference viewed: 6 (0 ULg)
See detailCharacterization of prolatinomas resistant to dopaminergic agonists
Vroonen, Laurent ULg; Tamagno, G.; Naves, L. et al

in 19 Meeting of the Belgian Endocrine and Metabolic societies (2009)

Detailed reference viewed: 15 (2 ULg)
See detailElevated GH and normal IGF-1
Beckers, Albert ULg

in Acromegaly Consensus (2009)

Detailed reference viewed: 3 (0 ULg)
See detailElevated GH and normal IGF-1 : Discrepant biochemical results
Beckers, Albert ULg

Scientific conference (2009)

Detailed reference viewed: 16 (0 ULg)
See detailFunctioning Pituitary Adenomas
Beckers, Albert ULg; Daly, Adrian ULg

in Refetoff, Samuel; Weiss, Roy E (Eds.) Genetic diagnosis of endocrine disorders (2009)

Detailed reference viewed: 5 (3 ULg)
See detailFamilial Pituitary Adenomas : genotype and phenotype
Beckers, Albert ULg

in Growth Hormone related diseases and therapy : a molecular and physiological perspective for the Clinician (2009)

Detailed reference viewed: 6 (3 ULg)
See detailEpidémiologie des adénomes hypophysaires
Burlacu, M. C.; Daly, Adrian ULg; Beckers, Albert ULg

in Feuillets de Biologie (2009)

Les adénomes hypophysaires représentent une pathologie fréquente parmi les tumeurs cérébrales. Une étude liègoise récente a montré une prévalence des adénomes hypophysaires cliniquement actifs de 1:1064 ... [more ▼]

Les adénomes hypophysaires représentent une pathologie fréquente parmi les tumeurs cérébrales. Une étude liègoise récente a montré une prévalence des adénomes hypophysaires cliniquement actifs de 1:1064 habitants, nettement supérieure aux données antérieures. Tant dans les séries cliniques qu'autopsiques, les microadénomes à prolactine sont les adénomes prédominants. Les adénomes hypophysaires sont le plus souvent de présentation sporadique, mais des adénomes familiaux dans des formes isolées ou syndromiques sont également décrits. Les adénomes hypophysaires familiaux représentent 5 p.100 des adénomes hypophysaires et leur caractérisation clinique et génétique a été récemment enrichie par la description de la nouvelle entité FIPA (Familial Isolated Pituitary Adenomas) et des mutations du gène AIP (Aryl hydrocarbon receptor-Interactircg Protein). Bien que d'évolution habituellement bénigne, les adénomes hypophysaires sont caractérisés par une grande diversité clinique et génétique qui réclame des moyens diagnostiques et thérapeutiques spécifiques. [less ▲]

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailPituitary adenomas in young patients : when should we consider a genetic predisposition ?
Jaffrain-Rea, M. L.; Tichomirova, M.; Daly, A. F. et al

in Expert Review of Endocrinology & Metabolism (2009), 4(6), 529-531

Detailed reference viewed: 8 (3 ULg)
Full Text
Peer Reviewed
See detailCaractérisation clinique et génétique des adénomes hypophysaires familiaux isolés (FIPA).
Beckers, Albert ULg; Apetrii, P.; Daly, Adrian ULg et al

in Revue Médicale de Liège (2009), 64(S1), 15-19

Pituitary adenomas are common brain tumours at autopsy and radiological series of unselected population. Historically, few epidemiologic data regarding the prevalence of clinically apparent pituitary ... [more ▼]

Pituitary adenomas are common brain tumours at autopsy and radiological series of unselected population. Historically, few epidemiologic data regarding the prevalence of clinically apparent pituitary adenomas have been available. Recently, a cross-sectional study conducted in Liege, Belgium, noted that clinically-apparent pituitary adenomas occurred with a prevalence of 1:1064 inhabitants, which is 3.5-5 times the previously reported prevalence. Pituitary adenomas occur predominantly as sporadic tumors, but also in a familial setting or associated to some familial/isolated tumoral syndromes. The recent characterization of the novel clinical entity FIPA (Familial Isolated Pituitary Adenomas) increased the prevalence of familial pituitary adenomas which account now for about 5% of pituitary tumors. Distinct genetic mechanisms are continuously identified and increase our understanding of the complex clinical presentation and sometimes unpredictable evolution of pituitary adenomas. [less ▲]

Detailed reference viewed: 82 (7 ULg)
Full Text
Peer Reviewed
See detailHypopituitarisme consécutif aux atteintes cérébrales: le traumatisme cranien et l'hémorragie sous-arachnoidienne mis en cause.
Valdes Socin, Hernan Gonzalo ULg; Vroonen, Laurent ULg; Robe, Pierre ULg et al

in Revue Médicale de Liège (2009), 64(9), 457-463

Brain injuries namely traumatic brain injuries (TBI) and subarachnoid haemorrhage (SAH) are relevant causes of acquired adult hypopituitarism, perhaps more prevalent than ever believed. TBI represent a ... [more ▼]

Brain injuries namely traumatic brain injuries (TBI) and subarachnoid haemorrhage (SAH) are relevant causes of acquired adult hypopituitarism, perhaps more prevalent than ever believed. TBI represent a major health problem with an annual incidence of 300 cases per 100.000. SAH affects six new cases per 1.000.000 habitants in USA. In Belgium we estimate nearly 30.000 new TBI cases and 600 SAH cases per year. In the English literature, TBI secondary hypopituitarism has been well documented in 14 retrospective and prospective series accounting for 1.077 cases. In all these series the main pituitary deficits were: GH (14%), ACTH (14%), gonadotrope (18%), TSH (7%) and diabetes insipidus (4%). SAH was documented as a cause of hypopituitarism in three retrospective series accounting for 110 cases and in one prospective series. In all these series main pituitary deficits were GH (25%), ACTH (15%), gonadotrope (8.5%), TSH (6%) and diabetes insipidus (4%). In this review, we analyze recent data and discuss diagnostic and treatment features of secondary hypopituitarism due TBI and SAH. [less ▲]

Detailed reference viewed: 109 (7 ULg)
Full Text
See detailAdénomes hypophysaires, épidémiologie et génétique
Beckers, Albert ULg

in Chuchotis (2009), 27(printemps), 13

Detailed reference viewed: 8 (1 ULg)
Full Text
Peer Reviewed
See detailSyndromes paranéoplasiques endocriniens: diagnostic et prise en charge.
Valdes Socin, Hernan Gonzalo ULg; Niaourou, V.; Vandeva, S. et al

in Revue Médicale Suisse (2009), 5(214), 1668-74

Paraneoplastic endocrine syndromes define a group of secondary signs and symptoms associated to a neoplasia, independently from the location of the primary tumor or its metastases. Paraneoplastic or ... [more ▼]

Paraneoplastic endocrine syndromes define a group of secondary signs and symptoms associated to a neoplasia, independently from the location of the primary tumor or its metastases. Paraneoplastic or ectopic endocrine syndromes usually result from aberrant hormone precursors or hormone-like substances by tumours. Knowledge of paraneoplastic endocrine complications is important both for the early diagnosis of neoplasia and the prognosis of the patient. In this review we discuss almost all reported paraneoplastic endocrine syndromes. We analyze their prevalence, etiology, laboratory diagnosis and treatment. [less ▲]

Detailed reference viewed: 60 (2 ULg)