Biometrology of physical properties of skin in thyroid dysfunction.

in Journal of the European Academy of Dermatology & Venereology (2008), 22(10), 1173-1177

OBJECTIVE: There is ample clinical evidence that skin is responsive to physiopathological levels of circulating thyroid hormones. The aim of the study was to assess some physical changes of the skin in ... [more ▼]

OBJECTIVE: There is ample clinical evidence that skin is responsive to physiopathological levels of circulating thyroid hormones. The aim of the study was to assess some physical changes of the skin in the presence of moderate thyroid dysfunction. SETTING: University Hospital. PATIENTS AND METHODS: A total of 119 adults suffering from hypothyroidism or hyperthyroidism and 60 healthy controls were enrolled in this study. Hormonal dosages (TSH, fT3, fT4) were assessed in the serum. A series of biometrological assessments were also performed on the volar and dorsal aspects of the forearms. These included electrometric assessments (Nova Dermal Phase Meter, Corneometer), evaporimetry (Tewameter)), colorimetry (Mexameter), ultrasound shear wave propagation (Reviscometer) and squamometry X. Correlations were searched between each of the serum hormonal dosages and each of the biometrological parameters. RESULTS: The hormonal changes in the untreated patients with thyroid dysfunction were modest in intensity. A few outlier values with regard to the normal range were found for each biometrological parameter. No correlations were found between fT3 or fT4 and each of the physical parameters. By contrast, significant negative linear correlations were found between thyroid-stimulating hormone (TSH) and skin hydration measured by the Corneometer and the Nova DPM. CONCLUSION: This multipronged exploratory study shows that direct or indirect effects of TSH may influence the stratum corneum hydration. This correlation seemed very sensitive, as no other specific biophysical parameter was significantly correlated with the thyroid hormonal concentrations in the serum. However, our findings do not exclude the possibility of some other skin changes supervening in case of more severe thyroid dysfunction. The mechanism by which TSH alters the stratum corneum hydration is yet unknown. [less ▲]

Cartographie du registre français de l'acromégalie

in Congrès de la Société Française d'Endocrinologie : Lille, 1-4 octobre 2008 (2008)

Aryl Hydrocarbon Receptor interacting protein (AIP) mutations in a cohort of Brazilian Familial isolated pituitary adenomas : relation to aggressive behaviour

in XIV Simposo Internacinal de Neuroendocrinologia - Endocrinologia and Metabologia - Arquivos Brasileiros de Endocrinologia e Metabologia : Fevereiro 2008, 52, suplemento 1 (2008)

Occurrence of AIP Mutations in Sporidic Pituitary Adenomas and Familial Isolated Pituitary Adenomas Kindreds in Valencia, Spain

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

Familial Acromegaly : Family screening and assetment in the familial isolated pituitary adenoma (FIPA)

in 10th European Congress of Endocrinology - Abstract book (2008)

Aryl Hydrocarbon Receptor interacting Protein Gene Mutations in Bulgarian FIPA and Young Sporadic Pituitary Adenoma Patients

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

Aryl Hydrocarbon receptor interacting protein (AIP) expression in human pituitary adenomas

in 10th European Congress of Endocrinology - Abstract book (2008)

pasireotide LAR is effective in patients <ith acromegaly : interim results from a randomized, multicenter, pharmacokinetic/pharmacodynamic, Phase I Study

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

AIP protein expression can predict treatment response to somatostatin analogs in sporadic GH secreting adenomas in women

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

Les microprolactinomes : diagnostic clinique, biologique et radiologique

in Young, Jacques (Ed.) Hyperprolactinémies (2008)