References of "Beckers, Albert"
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See detailLe conseil génétique en pathologie adénomateuse hypophysaire
Beckers, Albert ULg

in Annales d'Endocrinologie (2012)

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See detailAuto-immune gastritis characteristics in a large series of patients with auto-immune thyroiditis.
VALDES SOCIN, Hernan Gonzalo ULg; TOME, M.; LUTTERI, Laurence ULg et al

in XXIVth Belgian Week of Gastroenterology 2012 - Abstract book (2012)

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See detailAdrenal involvement in MEN1. Analysis of 715 cases from the Groupe d'etude des Tumeurs Endocrines database.
Gatta-Cherifi, B.; Chabre, O.; Murat, A. et al

in European Journal of Endocrinology (2012), 166(2), 269-279

Objective Limited data regarding adrenal involvement in multiple endocrine neoplasia type 1 (MEN1) is available. We describe the characteristics of MEN1-associated adrenal lesions in a large cohort to ... [more ▼]

Objective Limited data regarding adrenal involvement in multiple endocrine neoplasia type 1 (MEN1) is available. We describe the characteristics of MEN1-associated adrenal lesions in a large cohort to provide a rationale for their management. Methods Analysis of records from 715 MEN1 patients from a multicentre database between 1956 and 2008. Adrenal lesions were compared with those from a multicentre cohort of 144 patients with adrenal sporadic incidentalomas. Results Adrenal enlargement was reported in 20.4% (146/715) of patients. Adrenal tumours (>10 mm in size) accounted for 58.1% of these cases (10.1% of the whole patient cohort). Tumours were bilateral and >40 mm in size in 12.5 and 19.4% of cases respectively. Hormonal hypersecretion was restricted to patients with tumours and occurred in 15.3% of them. Compared with incidentalomas, MEN1-related tumours exhibited more cases of primary hyperaldosteronism, fewer pheochromocytomas and more adrenocortical carcinomas (ACCs; 13.8 vs 1.3%). Ten ACCs occurred in eight patients. Interestingly, ACCs occurred after several years of follow-up of small adrenal tumours in two of the eight affected patients. Nine of the ten ACCs were classified as stage I or II according to the European Network for the Study of Adrenal Tumors. No evident genotype/phenotype correlation was found for the occurrence of adrenal lesions, endocrine hypersecretion or ACC. Conclusions Adrenal pathology in MEN1 differs from that observed in sporadic incidentalomas. In the absence of relevant symptoms, endocrine biology can be restricted to patients with adrenal tumours and should focus on steroid secretion including the aldosterone-renin system. MEN1 is a high-risk condition for the occurrence of ACCs. It should be considered regardless of the size of the tumour. [less ▲]

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See detailProlactinomas Resistant to Standard Doses of Cabergoline : A multicenter study of 92 patients
VROONEN, Laurent ULg; Jaffrain-Rea, ML; PETROSSIANS, Patrick ULg et al

in European Journal of Endocrinology (2012), 167

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See detailLe dysfonctionnement thyroïdien : interrelations génétique - environnement
Tome, M; Chami, R; Petrossias et al

in Revue Médicale de Liège (2012), 67(5-6), 314-318

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See detailComplications cardiaques de l'acromégalie : cas rare de cardiopathie dilatée
Devoitille, A.; Beckers, Albert ULg; Pierard, Luc ULg

in Revue Médicale de Liège (2012), 67(4), 174-178

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See detailGenetics of familial pituitary tumors
Beckers, Albert ULg

Scientific conference (2011, December 01)

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See detailThe Clinical characteristics of pituitary adenomas in patients with primary hyperparathyroidism (PHPT) with and without MEN1 mutation
Rostomyan, Liliya ULg; Tichomirowa, M.; Kirdyankina, N. et al

in ENEA Munich - abstract book (2011, December)

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See detailClinical characterization of cabergoline resistant prolactinomas : a multicenter experience on 92 patients
VROONEN, Laurent ULg; Jaffrain-Rea, M. L.; PETROSSIANS, Patrick ULg et al

in ENEA Munich - abstract book (2011, December)

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See detailLe Secret des Géants
Beckers, Albert ULg

Scientific conference (2011, November 18)

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See detailEpidemiology and genetics of FIPA
Beckers, Albert ULg

Scientific conference (2011, November 18)

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See detailMedical treatment of pituitary adenomas
Beckers, Albert ULg

Scientific conference (2011, November 18)

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See detailPrise en charge de l'acromégalie 2011
Livadariu, Elena; Auriemma, R.; Cloix, L. et al

in Mises au point cliniques d'Endocrinologie, nutrition et métabolisme 2011 (2011, November)

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See detailFaut-il utiliser la radiothérapie dans les adénomes hypophysaires ?
Beckers, Albert ULg

Scientific conference (2011, October)

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See detailLe syndrome Thyro-Gastrique: de l’auto-immunité thyroïdienne aux tumeurs gastriques neuroendocriniennes.
VALDES SOCIN, Hernan Gonzalo ULg; BECKERS, Albert ULg

Scientific conference (2011, June 17)

THE THYRO-GASTRIC SYNDROME: FROM THYROID AUTOIMMUNITY TO NEUROENDOCRINE GASTRIC TUMORS. In 1849, Prof Addison described a fatal case of anemia, or anemia perniciosa. Dr Biermer expanded this original ... [more ▼]

THE THYRO-GASTRIC SYNDROME: FROM THYROID AUTOIMMUNITY TO NEUROENDOCRINE GASTRIC TUMORS. In 1849, Prof Addison described a fatal case of anemia, or anemia perniciosa. Dr Biermer expanded this original description in 1872. Nowadays, this pathological condition associating a megaloglastic anemia associated with a metabolic polyneuropathy is recognized as Biermer disease. Biermer anemia or anemia perniciosa and its associated polyneuropathy are the consequence of vitamine B12 malabsorption, due to autoimmune gastritis. Autoimmune gastritis is caused by lymphocitc infiltration and the generation of parietal gastric antibodies and intrinsic factor antibodies. Parietal gastric antibodies are cytotoxic: they specifically recognize the gastric proton pump, causing mucosal gastric atrophia and acloridia. This pathological condition can later degenerate into gastrin enterochromaffin cell hyperplasia , progressing to gastrin neuroendocrine tumors in nearly 10% of cases. In 1912 Dr Hakaru Hashimoto described the thyroid of four women affected by a struma lymphomatosa. This disease was later recognized as Hashimoto thyroiditis, being one of the most frequent causes of autoimmune hypothyroidism. Thyroid peroxodase (TPO) autoantibodies and lymphocytic infiltration are responsible for autoimmune thyroiditis and subsequent thyroid destruction. The thyrogastric syndrome was described in the seventies, in patients which the serum crossreacted both with parietal gastric antigens and thyroid TPO antigens. Whereas autoimmune polyendocrinopathies type 1 and 2 are rare, the real prevalence of the thyrogastric autoimmune syndrome is unknown. We conducted a prospective study to determine the prevalence of vitamine B12 malabsorption and gastric autoimmunity in patients with Hashimoto Thyroiditis seen in our clinical practice. A second end point of the study was to analyse gastric histological characteristics in such patients. A total of 240 consecutive patients with Hashimoto Thyroiditis were studied in our clinic from 2008 to 2009. Patients underwent TSH, FT4, FT3, ATPO, ATG, parietal cell autoantibodies (PCA), intrinsic factor antibodies (IFA), gastrine, vitamin B12 determinations and thyroid ultrasound. Patients with PCA and/or IFA were invited to have a gastric endoscopy and biopsies for histology and immunohistochemical studies. Patients with Hashimoto thyroiditis and gastric autoimmunity had a mean age of 52±19 years (28F/4M) at inclusion. Mean TSH was 21 ±28 µUI/ml (0.5-4) and 47% (15/32) of patients received levothyroxine treatment. Mean thyroid volume was 9.2±7 ml. Parietal cell autoantibodies were present in 13% (32/240). Intrinsic factor autoantibodies were found in 37.5% (6/16).In 3/6 patients with intrinsic factor antibodies we did not found PCA. Hypergastrinemia (>120 pg/ml) was present in 37 % (12/32) of patients with a mean of 323±507pg/ml. No patient had megaloblastic anemia, whereas only two patients had macrocytosis. Vitamine B12 was less than 200 pg/ml in 18% (6/32) of patients. A total of 59% (19/32) with PCA underwent a gastroscopy, with mucosal abnormalities in 79% (15/19) gastroscopies. Gastric and duodenal biopsies shown in 68% (13/19) histological signs of lymphocitosis infiltration, 42% (8/19) had signs of metaplasia and ECC hyperplasia and 21% (4/19) had signs of mucosal atrophy. Interestingly, H. pylori infection was found in 16% (3/19) of patients. No gastric carcinoid was found in this prospective series. In this oral presentation, we discuss the potential role of cross reacting epitopes between gastric proton pump ATP ase, thyroid autoantibodies and H pylori suggesting some physiopathological clues to explain this syndrome. Although the prevalence of the thyrogastric syndrome seems higher in our study, much of the previous studies were retrospective. Moreover, in these previous studies the physiopathological role of H pylori was not explored. Interestingly, in our experience, H. pylori can mimick gastric autoimmunity but this is reversible, after eradication. The high prevalence of autoimmune gastritis and vitamin B12 deficiency in this series provide a strong rationale for an early serologic screening and gastroscopic diagnosis in patients with Hashimoto's thyroiditis. The physiopathological model of the thyrogastric , or as already suggested gastro-thyroideal syndrome, shoud be revised in light of these new data. References H Valdes-Socin, L Lutteri, A Latta, L Vroonen, D Betea, P Petrossians, V Geenen, A Beckers. Prévalence de gastrite auto-immune et études histologiques dans une série prospective de 240 patients avec thyroïdite de Hashimoto. Abstract book. ENEA (Liège) 2010. H Valdes-Socin, L Lutteri, A Latta, L Vroonen, D Betea, P Petrossians, V Geenen, A Beckers. Prévalence de gastrite auto-immune et études histologiques dans une série prospective de 240 patients avec thyroïdite de Hashimoto. In XXVII Congrès de la SFE Abstract book. Annales d’Endocrinologie (Paris) 2010. H Valdes-Socin, A Beckers. Conférence pour médecins généralistes: «Le syndrome thyro-gastrique : de la carence en vitamine B12 aux tumeurs carcinoïdes de l’estomac». 18 mai 2011 à 20H00. Lieu : « Centre d’Endocrinologie d’Oupeye », Rue du Roi Albert, 261 – 4680 Oupeye. [less ▲]

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See detailLe secret des géants
Beckers, Albert ULg

Scientific conference (2011, June 09)

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See detailEpidemiologie et génétique des adénomes hypophysaires
Beckers, Albert ULg

Scientific conference (2011, June 09)

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See detailEpidemiology and genetics of FIPA
Beckers, Albert ULg

Scientific conference (2011, June 06)

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See detailGenetics of pituitary tumor
Beckers, Albert ULg

Scientific conference (2011, June)

Detailed reference viewed: 18 (7 ULg)