Patrocles: a database of polymorphic miR-mediated gene regulation in vertebratesBaurain, Denis ; Hiard, Samuel ; Coppieters, Wouter et alScientific conference (2009, September 29) Detailed reference viewed: 11 (3 ULg) Origin and evolution of SR proteins in EukaryotesCalifice, Sophie ; Baurain, Denis ; Hanikenne, Marc et alPoster (2009, February 05) Detailed reference viewed: 20 (5 ULg) Patrocles: a database of polymorphic miRNA-mediated gene regulationHiard, Samuel ; Baurain, Denis ; Coppieters, Wouter et alPoster (2008, July) Detailed reference viewed: 12 (5 ULg) Patrocles: a database of polymorphic miRNA-mediated gene regulationHiard, Samuel ; Baurain, Denis ; Coppieters, Wouter et alConference (2008, March 03) Detailed reference viewed: 10 (3 ULg) Origin and distribution of Calvin cycle fructose and sedoheptulose bisphosphatases in Plantae and complex algae: A single secondary origin of complex red plastids and subsequent propagation via tertiary endosymbioses; ; Baurain, Denis et alin Protist (2007), 158(3), 263-276 Sedoheptulose-1,7-bisphosphatase (SBPase) and fructose-1,6-bisphosphatase (FBPase) are essential nuclear-encoded enzymes involved in land plant Calvin cycle and gluconeogenesis. In this study, we cloned ... [more ▼] Sedoheptulose-1,7-bisphosphatase (SBPase) and fructose-1,6-bisphosphatase (FBPase) are essential nuclear-encoded enzymes involved in land plant Calvin cycle and gluconeogenesis. In this study, we cloned seven SBP and seven FBP cDNAs/genes and established sequences from all lineages of photosynthetic eukaryotes, in order to investigate their origin and evolution. Our data are best explained by a single recruitment of plastid-targeted SBP in Plantae after primary endosymbiosis and a further distribution to algae with complex plastids. While SBP is universally found in photosynthetic lineages, its presence in apicomplexa, ciliates, trypanosomes, and ascomycetes is surprising given that no metabolic function beyond the one in the plastid Calvin cycle is described so far. Sequences of haptophytes, cryptophytes, diatoms, and peridinin-containing dinoflagellates (complex red lineage) strongly group together in the SBP tree and the same assemblage is recovered for plastid-targeted FBP sequences, although this is less supported. Both SBP and plastid-targeted FBP are most likely of red algal origin. Including phosphoribulokinase, fructose bisphosphate aldolase, and glyceraldehyde-3-phosphate dehydrogenase, a total of five independent plastid-related nuclear-encoded markers support a common origin of all complex rhodoplasts via a single secondary endosymbiosis event. However, plastid phylogenies are incongruent with those of the host cell, as illustrated by the cytosolic FBP isoenzyme. These results are discussed in the context of Cavalier-Smith's far-reaching chromalveolate hypothesis. In our opinion, a more plausible evolutionary scenario would be the establishment of a unique secondary rhodoplast and its subsequent spread via tertiary endosymbioses. (c) 2007 Elsevier GmbH. All rights reserved. [less ▲] Detailed reference viewed: 47 (4 ULg) Lack of resolution in the animal phylogeny: Closely spaced cladogeneses or undetected systematic errors?Baurain, Denis ; ; in Molecular Biology and Evolution (2007), 24(1), 6-9 A recent phylogenomic study reported that the animal phylogeny was unresolved despite the use of 50 genes. This lack of resolution was interpreted as "a positive signature of closely spaced cladogenetic ... [more ▼] A recent phylogenomic study reported that the animal phylogeny was unresolved despite the use of 50 genes. This lack of resolution was interpreted as "a positive signature of closely spaced cladogenetic events." Here, we propose that this lack of resolution is rather due to the mutual cancellation of the phylogenetic signal (historical) and the nonphylogenetic signal (due to systematic errors) that results from inadequate taxon sampling and/or model of sequence evolution. Starting with a data set of comparable size, we use 3 different strategies to reduce the nonphylogenetic signal: 1) increasing the number of species; 2) replacing a fast-evolving species by a slowly evolving one; and 3) using a better model of sequence evolution. In all cases, the phylogenetic resolution is markedly improved, in agreement with our hypothesis that the originally reported lack of resolution was artifactual. [less ▲] Detailed reference viewed: 21 (7 ULg) Phylogenomics: how far back in the past can we go?; Baurain, Denis ; in Pudritz, Ralph; Higgs, Paul; Stone, Jonathan (Eds.) Planetary Systems and the Origins of Life (2007) Detailed reference viewed: 9 (2 ULg) Phylogénomique des lignées photosynthétiquesBaurain, Denis ; ; Scientific conference (2006, December 22) Detailed reference viewed: 11 (3 ULg) Animal evolution — A fully-resolved phylogenomic tree argues against the Cambrian explosion hypothesis; ; Baurain, Denis ![]() Poster (2006, March) Detailed reference viewed: 24 (4 ULg) The animal phylogeny and the fundamental importance of taxon sampling; ; Baurain, Denis ![]() Scientific conference (2006, February 20) Detailed reference viewed: 13 (2 ULg) Vertebrate origins: does the tunic make the man?; Baurain, Denis ; in Medecine Sciences : M/S (2006), 22(8-9, AUG-SEP), 688-690 Detailed reference viewed: 5 (0 ULg) Assessing the effects of compositional heterogeneity on phylogenomic analysesBaurain, Denis ; ; Conference (2005, November 04) Detailed reference viewed: 7 (3 ULg) Application of the Lempel-Ziv complexity to the alignment-free sequence comparison of protein families; Baurain, Denis ![]() Scientific conference (2005, August 26) Detailed reference viewed: 13 (1 ULg) Le darwinisme peut-il tout expliquer ?Baurain, Denis ![]() Conference given outside the academic context (2005) Vus d'Europe, les procès opposant les farouches défenseurs du darwinisme à leurs pugnaces détracteurs ont de quoi faire sourire. Certes, il n'y a pas qu'aux Etats-Unis que l'on puisse encore trouver des ... [more ▼] Vus d'Europe, les procès opposant les farouches défenseurs du darwinisme à leurs pugnaces détracteurs ont de quoi faire sourire. Certes, il n'y a pas qu'aux Etats-Unis que l'on puisse encore trouver des Chrétiens fondamentalistes persuadés que Dieu a créé la Terre en six jours. En revanche, aucun gouvernement de nos contrées n'aurait l'idée saugrenue de faire interdire l'enseignement de la théorie de l'évolution dans nos écoles, ni même de l'autoriser à la condition expresse de la traiter sur le même pied que le créationnisme inspiré d'une lecture littérale de la Genèse. Cela dit, croire que le refus de l'évolution par "sélection naturelle des mutations favorables" se limite aux couches populaires de l'Amérique conservatrice serait inexact. En réalité, les plus acharnés des tenants du créationnisme pur et dur -- ou de son avatar à peine plus subtil, l'Intelligent Design -- sont généralement des intellectuels, voire dans certains cas des biologistes qui ont renoncé à toute carrière dans l'orthodoxie académique. Faut-il n'y voir qu'aveuglement religieux ? Sans doute, mais pas seulement... Originellement proposée en 1859, la théorie de l'évolution de Charles Darwin a profondément bouleversé la science et la société toute entière. Débarrassé de ses relents lamarckiens par August Weismann entre 1883 et 1888, le darwinisme, désormais qualifié de "néo-", s'est enrichi de la génétique de Gregor Mendel pour donner naissance en 1937, sous l'impulsion de Theodosius Dobzhansky, à la théorie synthétique de l'évolution. C'est dans cette incarnation "moderne" qu'il est devenu l'unique paradigme de la biologie contemporaine. Pourtant, loin des feux de la rampe, le couple infernal mutation/sélection ne satisfait pas tous les spécialistes. A quel point sa toute puissance peut-elle être mise en doute ? Dispose-t-on réellement de preuves de son efficacité, ou même tout simplement de son existence ? La diversité de la Vie sur Terre peut-elle s'expliquer par un principe aussi naïvement libéral ? C'est à ces questions et à quelques autres que nous tenterons de répondre au cours de cette conférence-débat, tout en tâchant de rester prudemment en dehors de toute considération métaphysique. Docteur en Sciences (Génétique Moléculaire Végétale), Denis BAURAIN est bioinformaticien à l'Université de Liège. Financées par le FNRS, ses recherches portent essentiellement sur l'histoire évolutive des premières cellules à noyau telle qu'on peut l'inférer à partir des séquences de gènes. [less ▲] Detailed reference viewed: 27 (5 ULg) Application of Lempel-Ziv complexity to alignment-free sequence comparison of protein families; Baurain, Denis ![]() Poster (2005, April) Detailed reference viewed: 16 (3 ULg) Why does the red algal plastid lineage lack plastocyanin?Baurain, Denis ; Demoulin, Vincent ![]() Conference (2005, February 03) Detailed reference viewed: 13 (3 ULg) The mitochondrial oxidative phosphorylation proteome of Chlamydomonas reinhardtii deduced from the genome sequencing projectCardol, Pierre ; ; et alin Plant Physiology (2005), 137(2), 447-459 Detailed reference viewed: 38 (11 ULg) A comparative inventory of metal transporters in the green alga Chlamydomonas reinhardtii and the red alga Cyanidioschizon merolaeHanikenne, Marc ; ; Demoulin, Vincent et alin Plant Physiology (2005), 137(2), 428-446 Detailed reference viewed: 56 (17 ULg) From protein interaction to cell population dynamics: A theoretical framework combining Boolean networks with Markov processes illustrated in an ovarian carcinoma; Baurain, Denis ; Barbason, Hervé ![]() Poster (2004, December) Detailed reference viewed: 22 (5 ULg) Condensé de biologie moléculaire à l'usage des biomathématiques et de la bioinformatiqueBaurain, Denis ![]() Scientific conference (2004, October 26) Detailed reference viewed: 13 (1 ULg) |
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