References of "Bastin, Christine"
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See detailSelf-appraisal and medial prefrontal activation in early stage Alzheimer’s disease.
Genon, Sarah ULg; Collette, Fabienne ULg; Angel, Lucie et al

Conference (2012)

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See detailDissociation entre recollection et familiarité dans la maladie d’Alzheimer: Etude des bases cérébrales en imagerie par résonance magnétique fonctionnelle
Bastin, Christine ULg; Genon, Sarah ULg; Collette, Fabienne ULg et al

Conference (2012)

1. Matériels et méthodes. Les difficultés mnésiques des patients à un stade léger d’une maladie d’Alzheimer sont marquées par une atteinte sévère de la récupération consciente des informations dans leur ... [more ▼]

1. Matériels et méthodes. Les difficultés mnésiques des patients à un stade léger d’une maladie d’Alzheimer sont marquées par une atteinte sévère de la récupération consciente des informations dans leur contexte d’apprentissage (recollection). Par contre, la reconnaissance des informations sur base d’un sentiment de familiarité (savoir qu’une information a été rencontrée auparavant sans récupérer son contexte d’apprentissage) est relativement préservée (Dalla Barba, 1997; Rauchs et al., 2007). L’objectif de cette étude était de révéler les substrats cérébraux des processus de recollection et familiarité dans la maladie d’Alzheimer au moyen d’une tâche de mémoire associative analysée selon les principes de la Procédure de Dissociation des Processus (Jacoby, 1991). Pendant une acquisition en IRM fonctionnelle, 26 patients avec une maladie d’Alzheimer probable à un stade léger et 17 témoins âgés ont étudié des paires de mots, puis ont dû les reconnaître parmi des paires recombinées (deux mots vus mais pas ensemble) et des paires nouvelles. 2. Résultats. Les analyses comportementales ont indiqué que 10 patients Alzheimer avaient des indices de recollection nuls (AD-), tandis que 16 autres patients présentaient des processus de recollection résiduels (AD+) bien que significativement moins importants que les témoins. Par contre, le score estimant la contribution des processus de familiarité était équivalent dans les trois groupes. L’analyse de l’activité cérébrale a montré que, chez les patients AD+ comme chez les témoins, la recollection activait le cortex cingulaire postérieur. Cependant, cette région était fonctionnellement connectée à l’hippocampe, au cortex pariétal inférieur et au cortex préfrontal dorsolatéral uniquement chez les témoins. Par ailleurs, dans les trois groupes, la familiarité activait le sillon intrapariétal. 3. Conclusion. Cette étude montre un déficit sévère de recollection et une relative préservation de la familiarité chez des patients Alzheimer. Lorsque les patients possèdent des capacités résiduelles de recollection, celles-ci sont soutenues par le cortex cingulaire postérieur comme chez les personnes âgées saines. Cependant, une perturbation de la connectivité fonctionnelle entre le cortex cingulaire postérieur et des régions impliquées dans la mémoire relationnelle, les aspects subjectifs de la recollection et les processus de monitoring post-récupération suggère que la qualité de la recollection résiduelle des patients Alzheimer est dégradée. 4. Références. Dalla Barba, G. (1997). Recognition memory and recollective experience in Alzheimer's disease. Memory, 5, 657-672. Jacoby, L.L. (1991). A process dissociation framework: Separating automatic from intentional uses of memory. Journal of Memory and Language, 30, 513-541. Rauchs, G., Piolino, P., Mézenge, F., Landeau, B., Lalevée, C., Pélerin, A. et al. (2007). Autonoetic consciousness in Alzheimer's disease: Neuropsychological and PET findings using an episodic learning and recognition task. Neurobiology of Aging, 28, 1410-1420. [less ▲]

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See detailThe influence of cognitive reserve on inter-individual variability in resting-state cerebral metabolism in normal aging
Bastin, Christine ULg; Yakushev, Igor; Bahri, Mohamed Ali ULg et al

in Frontiers in Human Neuroscience (2012)

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See detailCognitive reserve impacts on inter-individual variability in resting-state cerebral metabolism in normal aging
Bastin, Christine ULg; Yakushev, Igor; Bahri, Mohamed Ali ULg et al

in NeuroImage (2012), 63

There is a great deal of heterogeneity in the impact of aging on cognition and cerebral functioning. One potential factor contributing to individual differences among the elders is the cognitive reserve ... [more ▼]

There is a great deal of heterogeneity in the impact of aging on cognition and cerebral functioning. One potential factor contributing to individual differences among the elders is the cognitive reserve, which designates the partial protection from the deleterious effects of aging that lifetime experience provides. Neuroimaging studies examining task-related activation in elderly people suggested that cognitive reserve takes the form of more efficient use of brain networks and/or greater ability to recruit alternative networks to compensate for age-related cerebral changes. In this multi-centre study, we examined the relationships between cognitive reserve, as measured by education and verbal intelligence, and cerebral metabolism at rest (FDG-PET) in a sample of 74 healthy older participants. Higher degree of education and verbal intelligence was associated with less metabolic activity in the right posterior temporoparietal cortex and the left anterior intraparietal sulcus. Functional connectivity analyses of resting-state fMRI images in a subset of 41 participants indicated that these regions belong to the default mode network and the dorsal attention network respectively. Lower metabolism in the temporoparietal cortex was also associated with better memory abilities. The findings provide evidence for an inverse relationship between cognitive reserve and resting-state activity in key regions of two functional networks respectively involved in internal mentation and goal-directed attention. [less ▲]

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See detailMémoire associative dans le vieillissement normal : Effet de l’unification des associations
Simon, Jessica ULg; Collette, Fabienne ULg; Genon, Sarah ULg et al

in Proceedings of the XIIème Colloque International sur le Vieillissement Cognitif (2012)

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See detailRelation entre la réserve cognitive et le métabolisme cérébral au repos dans le vieillissement normal.
Bastin, Christine ULg; Yakushev, Igor; Bahri, Mohamed Ali ULg et al

in Proceedings of the XIIème Colloque International sur le Vieillissement Cognitif (2012)

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See detailAssociative memory in normal aging: The effect of unitization
Simon, Jessica ULg; Collette, Fabienne ULg; Genon, Sarah ULg et al

in Proceedings of the first joint meeting of the Belgian Association for Psychological Sciences (BAPS) and the Sociedad Española de Psicología Experimental (SEPEX) (2012)

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See detailThe role of the salience of fluency in recognition memory in Alzheimer’s disease
Bastin, Christine ULg; Salmon, Eric ULg; Willems, Sylvie ULg

in Proceedings of the First joint meeting of the Belgian Association for Psychological Sciences (BAPS) and the Sociedad Española de Psicología Experimental (SEPEX) (2012)

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See detailDissociation entre recollection et familiarité dans la maladie d'Alzheimer : Etude des bases cérébrales en imagerie par résonance magnétique fonctionnelle.
Bastin, Christine ULg; Genon, Sarah ULg; Collette, Fabienne ULg et al

in Proceedings of the 11th Reunion Francophone sur la Maladie d’Alzheimer et les Syndromes Apparentés (2012)

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See detailNormal and pathological aging and memory
Bastin, Christine ULg

Scientific conference (2012)

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See detailEpisodic memory in normal aging and Alzheimer’s disease
Bastin, Christine ULg

Scientific conference (2012)

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See detailNeural bases of deficits of episodic memory in Alzheimer’s disease
Bastin, Christine ULg

Scientific conference (2012)

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See detailEpisodic memory in Alzheimer’s disease
Bastin, Christine ULg

Scientific conference (2012)

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See detailFrontal and posterior cingulate metabolic impairment in the behavioural variant of frontotemporal dementia with impaired autonoetic consciousness
Bastin, Christine ULg; Feyers, Dorothée ULg; Souchay, Céline et al

in Human Brain Mapping (2012), 33

Although memory dysfunction is not a prominent feature of the behavioural variant of frontotemporal dementia (bv-FTD), there is evidence of specific deficits of episodic memory in these patients. They ... [more ▼]

Although memory dysfunction is not a prominent feature of the behavioural variant of frontotemporal dementia (bv-FTD), there is evidence of specific deficits of episodic memory in these patients. They also have problems monitoring their memory performance. The objective of the present study was to explore the ability to consciously retrieve own encoding of the context of events (autonoetic consciousness) and the ability to monitor memory performance using feeling-of-knowing (FOK) in bv-FTD. Analyses of the patients’ cerebral metabolism (FDG-PET) allowed an examination of whether impaired episodic memory in bv-FTD is associated with the frontal dysfunction characteristic of the pathology or a dysfunction of memory-specific regions pertaining to Papez’s circuit. Data were obtained from 8 bv-FTD patients and 26 healthy controls. Autonoetic consciousness was evaluated by Remember responses during the recognition memory phase of the FOK experiment. As a group, bv-FTD patients demonstrated a decline in autonoetic consciousness and FOK accuracy at the chance level. While memory monitoring was impaired in most (7) patients, 4 bv-FTD participants had individual impairment of autonoetic consciousness. They specifically showed reduced metabolism in the anterior medial prefrontal cortex, the left dorsolateral prefrontal cortex (near the superior frontal sulcus), parietal regions and the posterior cingulate cortex. These findings were tentatively interpreted by considering the role of the metabolically impaired brain regions in self-referential processes, suggesting that the bv-FTD patients’ problem consciously retrieving episodic memories may stem at least partly from deficient access to and maintenance/use of information about the self. [less ▲]

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See detailAging effect on recollection and familiarity processes
Collette, Fabienne ULg; Angel, Lucie; Bastin, Christine ULg et al

Scientific conference (2011, December 22)

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See detailSleep contributes to the strengthening of some memories over others, depending on hippocampal activity at learning.
Rauchs, Géraldine; Feyers, Dorothée ULg; Landeau, Brigitte et al

in Journal of Neuroscience (2011), 31(7), 2563-2568

Memory consolidation benefits from sleep. Besides strengthening some memory traces, another crucial, albeit overlooked, function of memory is also to erase irrelevant information. Directed forgetting is ... [more ▼]

Memory consolidation benefits from sleep. Besides strengthening some memory traces, another crucial, albeit overlooked, function of memory is also to erase irrelevant information. Directed forgetting is an experimental approach consisting in presenting “to be remembered” and “to be forgotten” information, that allows selectively decreasing or increasing the strength of individual memory traces according to the instruction provided at learning. This paradigm was used in combination with fMRI to determine, in Humans, what specifically triggers at encoding sleep-dependent compared to time-dependent consolidation. Our data indicate that relevant items which subjects strived to memorize are consolidated during sleep to a greater extend than items that participants did not intend to learn. This process appears to depend on a differential activation of the hippocampus at encoding, which acts as a signal for the offline reprocessing of relevant memories during post-learning sleep episodes. [less ▲]

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